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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rutinoside
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Accession:CHEBI:26587 term browser browse the term
Synonyms:related_synonym: rutinosides

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diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 [Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]		 CTD PMID:21477647 PMID:32061149 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]		 CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein] CTD PMID:30779474 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin multiple interactions
increases expression		 ISO [Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein		 CTD PMID:29481770 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]		 CTD PMID:24954035 PMID:29481770 PMID:32050098 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]		 CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 EXP
ISO		 Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein		 CTD PMID:22093918 PMID:29481770 PMID:30623541 PMID:30779474 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP
ISO		 Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]		 CTD PMID:22093918 PMID:29481770 PMID:30098279 PMID:30623541 PMID:30779474 PMID:31095933 PMID:32050098 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Fabp9 fatty acid binding protein 9 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 2:93,803,503...93,807,069
Ensembl chr 2:93,803,449...93,807,069 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions		 ISO Hesperidin results in decreased activity of G6PD protein
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]		 CTD PMID:16427799 PMID:25130191 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gck glucokinase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity
multiple interactions		 ISO
EXP		 Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein		 CTD PMID:29481770 PMID:30779474 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein] CTD PMID:28935427 PMID:32050098 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]		 CTD PMID:17400256 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]		 CTD PMID:17400256 PMID:21820093 PMID:30623541 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lep leptin decreases expression
multiple interactions		 EXP Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein		 CTD PMID:21820093 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mir126b microRNA 126b multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] CTD PMID:32050098 NCBI chr 3:4,042,488...4,042,560 JBrowse link
G Mir181a2 microRNA 181a-2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 3:23,150,352...23,150,468
Ensembl chr 3:23,150,352...23,150,468 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases secretion		 ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein		 CTD PMID:19110045 PMID:20138977 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 EXP Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein		 CTD PMID:31095933 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein] CTD PMID:28935427 PMID:32050098 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA] CTD PMID:22093918 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:12512693 PMID:22093918 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]		 CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP		 Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]		 CTD PMID:16101151 PMID:19110045 PMID:30098279 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 9:84,203,094...84,321,269
Ensembl chr 9:84,203,072...84,319,874 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393 		JBrowse link
G Tfeb transcription factor EB multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr 9:15,208,141...15,264,101
Ensembl chr 9:15,207,822...15,214,596 		JBrowse link
G Tnc tenascin C multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:17400256 PMID:28935427 PMID:30623541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 5:169,288,419...169,293,137
Ensembl chr 5:169,288,871...169,293,137 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression		 ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1		 CTD PMID:17400256 PMID:30991044 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
rutin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein] CTD PMID:25478064 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Acly ATP citrate lyase decreases activity ISO Rutin results in decreased activity of ACLY protein CTD PMID:17032037 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein] CTD PMID:24117263 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases localization
multiple interactions		 ISO Rutin results in decreased localization of AHR protein
Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]		 CTD PMID:21756928 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein] CTD PMID:22426011 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO Rutin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179 		JBrowse link
G Atxn2 ataxin 2 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612 		JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression		 ISO Rutin affects the expression of BAX protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
Rutin results in increased expression of BAX protein		 CTD PMID:15975156 PMID:28811126 PMID:29522708 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of BBC3 mRNA] CTD PMID:27239252 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
decreases expression		 ISO
EXP		 Rutin affects the expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]
Rutin results in decreased expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]
Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]		 CTD PMID:15975156 PMID:19557821 PMID:26062544 PMID:28811126 PMID:29522708 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA] CTD PMID:26062544 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein] CTD PMID:22426011 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity		 ISO
EXP		 Rutin affects the cleavage of CASP3 protein
Rutin results in increased cleavage of CASP3 protein
Rutin inhibits the reaction [Cholesterol, Dietary results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]
Rutin results in increased expression of CASP3 mRNA
Rutin results in increased activity of CASP3 protein		 CTD PMID:15975156 PMID:24726691 PMID:24908156 PMID:25129099 PMID:26091902 PMID:27239252 PMID:28811126 PMID:29315975 PMID:29522708 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO
EXP		 Rutin results in increased activity of CASP7 protein
Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]		 CTD PMID:24726691 PMID:25129099 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA
Rutin results in increased expression of CASP8 mRNA		 CTD PMID:26091902 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
Rutin inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]		 CTD PMID:19833193 PMID:21605616 PMID:25478064 PMID:25753322 PMID:29743444 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Rutin binds to and results in decreased activity of CBR1 protein; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:11306090 PMID:18579125 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
Rutin results in decreased secretion of CCL2 protein
Rutin results in decreased expression of CCL2 mRNA		 CTD PMID:21756928 PMID:21967610 PMID:25478064 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression		 EXP Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CCL5 mRNA] CTD PMID:28693884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein] CTD PMID:24117263 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO [Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA
Rutin results in decreased expression of CCND1 mRNA		 CTD PMID:26091902 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd68 Cd68 molecule decreases expression EXP Rutin results in decreased expression of CD68 protein CTD PMID:28693884 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Rutin inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 mRNA] CTD PMID:15652231 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 decreases expression EXP Rutin results in decreased expression of CX3CL1 mRNA CTD PMID:28693884 NCBI chr19:10,644,267...10,654,861
Ensembl chr19:10,644,244...10,653,800 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases secretion
decreases expression		 ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]
Rutin results in decreased secretion of CXCL10 protein
Rutin results in decreased expression of CXCL10 mRNA		 CTD PMID:21756928 PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression
multiple interactions		 EXP Rutin results in decreased expression of CXCL12 mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CXCL12 mRNA]		 CTD PMID:28693884 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Rutin results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Rutin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Rutin results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA] CTD PMID:26062544 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113 		JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Rutin results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA] CTD PMID:26062544 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions		 ISO
EXP		 Rutin results in increased expression of FN1 protein
Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]		 CTD PMID:24117263 PMID:26408079 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein] CTD PMID:24908156 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Rutin results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:12,796,383...12,997,817
Ensembl chr 6:12,796,383...12,997,817 		JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Rutin results in increased expression of GDNF mRNA CTD PMID:28693884 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein] CTD PMID:25478064 PMID:25753322 PMID:26062544 PMID:27239252 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein] CTD PMID:25478064 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 ISO
EXP		 Rutin results in decreased activity of GSR protein
Rutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]		 CTD PMID:15782287 PMID:21605616 PMID:25753322 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein CTD PMID:22902988 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA CTD PMID:28693884 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein] CTD PMID:20015448 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 EXP Lipopolysaccharides promotes the reaction [Rutin results in increased expression of IL10 mRNA]
Rutin results in increased expression of IL10 mRNA; Rutin results in increased expression of IL10 protein		 CTD PMID:28693884 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il18 interleukin 18 multiple interactions
decreases expression		 EXP Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Rutin results in decreased expression of IL18 mRNA		 CTD PMID:22426011 PMID:28693884 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]
Rutin results in decreased expression of IL1B mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL1B mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:15652231 PMID:18958421 PMID:19557821 PMID:22426011 PMID:28693884 PMID:29315975 PMID:29522708 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
Rutin results in decreased expression of IL6 mRNA; Rutin results in decreased expression of IL6 protein
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL6 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]
Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:15652231 PMID:18958421 PMID:21756928 PMID:22426011 PMID:25753322 PMID:26062544 PMID:27239252 PMID:28693884 PMID:29743444 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Insr insulin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
multiple interactions		 ISO
EXP		 Rutin results in decreased expression of IRS1 protein
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]		 CTD PMID:20015448 PMID:22426011 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 EXP Rutin results in increased expression of ITGAM protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of ITGAM protein]		 CTD PMID:28693884 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA] CTD PMID:26062544 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein] CTD PMID:22426011 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO Rutin results in decreased expression of JUN protein
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]		 CTD PMID:20015448 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO Rutin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517 		JBrowse link
G Lep leptin multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K5 mRNA] CTD PMID:26062544 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]
Rutin results in decreased phosphorylation of MAPK1 protein		 CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]
Rutin results in decreased phosphorylation of MAPK3 protein		 CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Rutin results in decreased expression of and results in decreased activity of MMP2 protein
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]		 CTD PMID:26408079 PMID:29743444 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO Rutin results in decreased expression of MMP9 mRNA
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]		 CTD PMID:16304905 PMID:29743444 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions		 EXP Rutin results in increased expression of MRC1 protein
[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein		 CTD PMID:28693884 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP		 Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]
[Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein		 CTD PMID:22902988 PMID:31412289 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:19557821 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] CTD PMID:22426011 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Rutin results in decreased expression of NOS2 mRNA; Rutin results in decreased expression of NOS2 protein
Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:11500931 PMID:12512693 PMID:22902988 PMID:25080890 PMID:25753322 PMID:28693884 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA] CTD PMID:25129099 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082 		JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA] CTD PMID:25129099 NCBI chr14:77,380,264...77,402,007
Ensembl chr14:77,380,262...77,401,996 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA] CTD PMID:25129099 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression ISO Rutin results in decreased expression of PNPLA3 mRNA CTD PMID:17032037 NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression		 EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein]
Rutin results in increased expression of PON1 mRNA		 CTD PMID:25478064 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein] CTD PMID:25478064 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein] CTD PMID:22426011 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein] CTD PMID:25478064 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO
EXP		 [Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
Rutin results in decreased expression of PTGS2 mRNA
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]		 CTD PMID:11500931 PMID:15652231 PMID:19557821 PMID:21756928 PMID:22902988 PMID:25080890 PMID:25753322 PMID:28693884 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [Glucose affects the localization of RELA protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Rutin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]		 CTD PMID:19557821 PMID:21756928 PMID:29522708 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Rutin results in increased expression of SIRT1 mRNA; Rutin results in increased expression of SIRT1 protein CTD PMID:30365940 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 increases expression
multiple interactions		 EXP Rutin results in increased expression of SLAMF1 protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of SLAMF1 protein]		 CTD PMID:28693884 NCBI chr13:90,184,545...90,219,170
Ensembl chr13:90,184,569...90,219,217 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein] CTD PMID:19605544 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein] CTD PMID:19605544 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects localization
multiple interactions		 ISO Rutin affects the localization of SLCO2B1 protein
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Cholic Acid]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Taurocholic Acid]		 CTD PMID:24285294 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA] CTD PMID:27239252 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA] CTD PMID:27239252 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein] CTD PMID:22426011 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein] CTD PMID:22902988 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Rutin inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Rutin results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of STAT3 mRNA]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein] CTD PMID:22426011 PMID:26062544 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]		 CTD PMID:22902988 PMID:24117263 PMID:27239252 PMID:28693884 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]
Rutin results in decreased expression of TNF mRNA; Rutin results in decreased expression of TNF protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]		 CTD PMID:14654164 PMID:18958421 PMID:19557821 PMID:21605616 PMID:21756928 PMID:22426011 PMID:22902988 PMID:25753322 PMID:28693884 PMID:29743444 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO		 Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TP53 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TRP53 protein]		 CTD PMID:27239252 PMID:29522708 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25080890 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO Rutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein] CTD PMID:20015448 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Rutin inhibits the reaction [Cyclophosphamide results in increased activity of XDH protein] CTD PMID:25753322 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          oxygen atom 19400
            oxygen molecular entity 19400
              organooxygen compound 18856
                carbohydrates and carbohydrate derivatives 12248
                  carbohydrate derivative 11874
                    glycosyl compound 10926
                      glycoside 9219
                        rhamnosylglucoside 150
                          rutinoside 150
                            4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                            5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside 0
                            5-hydroxy-2-methylchromone-7-O-rutinoside 0
                            5-hydroxy-6-methoxy-2-methylchromone-7-O-rutinoside 0
                            cyanidin 3-O-rutinoside + 0
                            cyanidin 3-O-rutinoside 5-O-beta-D-glucoside 0
                            delphinidin 3-O-rutinoside-7-O-beta-D-glucoside 0
                            diosmin 20
                            eriocitrin 0
                            formononetin 7-O-rutinoside 0
                            hesperidin + 57
                            kaempferol-3-rutinoside 0
                            methyl hesperidin 0
                            narirutin 0
                            pectolinarin 0
                            pelargonidin 3-O-rutinoside 0
                            pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside 0
                            quercetin 3-(2G-xylosylrutinoside) 0
                            rutin 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            heteroorganic entity 19229
                              organochalcogen compound 18933
                                organooxygen compound 18856
                                  carbohydrates and carbohydrate derivatives 12248
                                    carbohydrate 12248
                                      carbohydrate derivative 11874
                                        glycosyl compound 10926
                                          glycoside 9219
                                            rhamnosylglucoside 150
                                              rutinoside 150
                                                4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside 0
                                                5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside 0
                                                5-hydroxy-2-methylchromone-7-O-rutinoside 0
                                                5-hydroxy-6-methoxy-2-methylchromone-7-O-rutinoside 0
                                                cyanidin 3-O-rutinoside + 0
                                                cyanidin 3-O-rutinoside 5-O-beta-D-glucoside 0
                                                delphinidin 3-O-rutinoside-7-O-beta-D-glucoside 0
                                                diosmin 20
                                                eriocitrin 0
                                                formononetin 7-O-rutinoside 0
                                                hesperidin + 57
                                                kaempferol-3-rutinoside 0
                                                methyl hesperidin 0
                                                narirutin 0
                                                pectolinarin 0
                                                pelargonidin 3-O-rutinoside 0
                                                pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside 0
                                                quercetin 3-(2G-xylosylrutinoside) 0
                                                rutin 110
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