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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rhamnosylglucoside
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Accession:CHEBI:26548 term browser browse the term
Synonyms:related_synonym: rhamnosylglucosides


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diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]
CTD PMID:21477647 PMID:32061149 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]
CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]
CTD PMID:23665045 PMID:32061149 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
CTD PMID:23665045 PMID:32061149 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]
CTD PMID:23665045 PMID:32061149 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
hesperidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] CTD PMID:32627286 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:28935427 PMID:30779474 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein] CTD PMID:30779474 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions
increases expression
ISO [Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein
CTD PMID:29481770 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]
CTD PMID:24954035 PMID:29481770 PMID:32050098 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]
CTD PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression EXP Hesperidin results in increased expression of BMP2 mRNA CTD PMID:21820093 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
EXP
ISO
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein
CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] CTD PMID:22093918 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP
ISO
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]
CTD PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] CTD PMID:30368987 PMID:30811821 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] CTD PMID:30779474 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] CTD PMID:17400256 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Fabp9 fatty acid binding protein 9 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] CTD PMID:32050098 NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] CTD PMID:16427799 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity
multiple interactions
ISO Hesperidin results in decreased activity of G6PD protein
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]
CTD PMID:16427799 PMID:25130191 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gck glucokinase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] CTD PMID:16427799 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity
multiple interactions
ISO
EXP
Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein
CTD PMID:29481770 PMID:30066062 PMID:30779474 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22093918 PMID:30098279 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] CTD PMID:22093918 PMID:30098279 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] CTD PMID:16427799 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein] CTD PMID:28935427 PMID:32050098 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] CTD PMID:32050098 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17400256 PMID:22074828 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
CTD PMID:17400256 PMID:30066062 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] CTD PMID:17400256 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
CTD PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lep leptin decreases expression
multiple interactions
EXP Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein
CTD PMID:21820093 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] CTD PMID:19110045 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] CTD PMID:19110045 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mir126b microRNA 126b multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] CTD PMID:32050098 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir181a2 microRNA 181a-2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] CTD PMID:32050098 NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases secretion
ISO Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein
CTD PMID:19110045 PMID:20138977 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein
CTD PMID:31095933 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein] CTD PMID:28935427 PMID:32050098 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA] CTD PMID:22093918 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:12512693 PMID:22093918 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] CTD PMID:30368987 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:28935427 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] CTD PMID:30779474 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]
CTD PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] CTD PMID:30368987 PMID:30811821 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]
CTD PMID:16101151 PMID:19110045 PMID:30098279 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] CTD PMID:30811821 NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32050098 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] CTD PMID:16427799 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] CTD PMID:16427799 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] CTD PMID:32050098 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Tfeb transcription factor EB multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] CTD PMID:30368987 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tnc tenascin C multiple interactions EXP Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] CTD PMID:30368987 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Hesperidin results in increased expression of TNFRSF25 mRNA CTD PMID:24633329 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] CTD PMID:30066062 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO Hesperidin results in increased expression of TRADD mRNA CTD PMID:24633329 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1
CTD PMID:17400256 PMID:30991044 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
rutin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein] CTD PMID:25478064 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acly ATP citrate lyase decreases activity ISO Rutin results in decreased activity of ACLY protein CTD PMID:17032037 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA] CTD PMID:19557821 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein] CTD PMID:24117263 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor decreases localization
multiple interactions
ISO Rutin results in decreased localization of AHR protein
Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
CTD PMID:21756928 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein] CTD PMID:22426011 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO Rutin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Atxn2 ataxin 2 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA] CTD PMID:25129099 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479
JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA] CTD PMID:25129099 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression
ISO Rutin affects the expression of BAX protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
Rutin results in increased expression of BAX protein
CTD PMID:15975156 PMID:28811126 PMID:29522708 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of BBC3 mRNA] CTD PMID:27239252 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
decreases expression
ISO
EXP
Rutin affects the expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]
Rutin results in decreased expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]
Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]
CTD PMID:15975156 PMID:19557821 PMID:26062544 PMID:28811126 PMID:29522708 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA] CTD PMID:26062544 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of BRAF protein] CTD PMID:32864822 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein] CTD PMID:22426011 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity
ISO
EXP
Rutin affects the cleavage of CASP3 protein
Rutin results in increased cleavage of CASP3 protein
Rutin inhibits the reaction [Cholesterol, Dietary results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]
Rutin results in increased expression of CASP3 mRNA
Rutin results in increased activity of CASP3 protein
CTD PMID:15975156 PMID:24726691 PMID:24908156 PMID:25129099 PMID:26091902 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO
EXP
Rutin results in increased activity of CASP7 protein
Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]
CTD PMID:24726691 PMID:25129099 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO [Rutin binds to Zinc] which results in increased expression of CASP8 mRNA
Rutin results in increased expression of CASP8 mRNA
CTD PMID:26091902 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions ISO
EXP
Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
Rutin inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]
CTD PMID:19833193 PMID:21605616 PMID:25478064 PMID:25753322 PMID:29743444 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO Rutin binds to and results in decreased activity of CBR1 protein; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:11306090 PMID:18579125 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion
decreases expression
ISO
EXP
Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
Rutin results in decreased secretion of CCL2 protein
Rutin results in decreased expression of CCL2 mRNA
CTD PMID:21756928 PMID:21967610 PMID:25478064 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
EXP Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CCL5 mRNA] CTD PMID:28693884 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein] CTD PMID:24117263 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA
Rutin results in decreased expression of CCND1 mRNA
CTD PMID:26091902 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd68 Cd68 molecule decreases expression EXP Rutin results in decreased expression of CD68 protein CTD PMID:28693884 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Rutin inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 mRNA] CTD PMID:15652231 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 decreases expression EXP Rutin results in decreased expression of CX3CL1 mRNA CTD PMID:28693884 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases secretion
decreases expression
ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]
Rutin results in decreased secretion of CXCL10 protein
Rutin results in decreased expression of CXCL10 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression
multiple interactions
EXP Rutin results in decreased expression of CXCL12 mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CXCL12 mRNA]
CTD PMID:28693884 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Rutin results in increased expression of CYP19A1 protein CTD PMID:29899696 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Rutin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Rutin results in decreased activity of CYP1B1 protein CTD PMID:16271822 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA] CTD PMID:26062544 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA] CTD PMID:25129099 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Rutin results in increased expression of ESR2 protein CTD PMID:29899696 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA] CTD PMID:26062544 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions
ISO
EXP
Rutin results in increased expression of FN1 protein
Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]
CTD PMID:24117263 PMID:26408079 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein] CTD PMID:24908156 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression EXP Rutin results in increased expression of FSHR protein CTD PMID:29899696 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression EXP Rutin results in increased expression of GDNF mRNA CTD PMID:28693884 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein] CTD PMID:25478064 PMID:25753322 PMID:26062544 PMID:27239252 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein] CTD PMID:25478064 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
ISO
EXP
Rutin results in decreased activity of GSR protein
Rutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]
CTD PMID:15782287 PMID:21605616 PMID:25753322 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein CTD PMID:22902988 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA CTD PMID:28693884 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein] CTD PMID:20015448 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP Lipopolysaccharides promotes the reaction [Rutin results in increased expression of IL10 mRNA]
Rutin results in increased expression of IL10 mRNA; Rutin results in increased expression of IL10 protein
CTD PMID:28693884 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 multiple interactions
decreases expression
EXP Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Rutin results in decreased expression of IL18 mRNA
CTD PMID:22426011 PMID:28693884 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]
Rutin results in decreased expression of IL1B mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL1B mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]
CTD PMID:15652231 PMID:18958421 PMID:19557821 PMID:22426011 PMID:28693884 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
Rutin results in decreased expression of IL6 mRNA; Rutin results in decreased expression of IL6 protein
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL6 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]
Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:15652231 PMID:18958421 PMID:21756928 PMID:22426011 PMID:25753322 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression
multiple interactions
ISO
EXP
Rutin results in decreased expression of IRS1 protein
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]
CTD PMID:20015448 PMID:22426011 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
EXP Rutin results in increased expression of ITGAM protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of ITGAM protein]
CTD PMID:28693884 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jak1 Janus kinase 1 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA] CTD PMID:26062544 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein] CTD PMID:22426011 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Rutin results in decreased expression of JUN protein
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]
CTD PMID:20015448 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO Rutin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
JBrowse link
G Lep leptin multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K5 mRNA] CTD PMID:26062544 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK1 protein]
Rutin results in decreased phosphorylation of MAPK1 protein
CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK3 protein]
Rutin results in decreased phosphorylation of MAPK3 protein
CTD PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir100 microRNA 100 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR100 mRNA] CTD PMID:32864822 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR125B1 mRNA] CTD PMID:32864822 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052
JBrowse link
G Mir1306 microRNA 1306 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR1306 mRNA] CTD PMID:32864822 NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719
JBrowse link
G Mir152 microRNA 152 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR152 mRNA] CTD PMID:32864822 NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020
JBrowse link
G Mir181c microRNA 181c multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR181C mRNA] CTD PMID:32864822 NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628
JBrowse link
G Mir185 microRNA 185 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR185 mRNA] CTD PMID:32864822 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Mir195 microRNA 195 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR195 mRNA] CTD PMID:32864822 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924
JBrowse link
G Mir196c microRNA 196c multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR196C mRNA] CTD PMID:32864822 NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085
JBrowse link
G Mir199a2 microRNA 199a-2 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR199A2 mRNA] CTD PMID:32864822 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063
JBrowse link
G Mir204 microRNA 204 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR204 mRNA] CTD PMID:32864822 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
JBrowse link
G Mir208b microRNA 208b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR208B mRNA] CTD PMID:32864822 NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749
JBrowse link
G Mir211 microRNA 211 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR211 mRNA] CTD PMID:32864822 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644
JBrowse link
G Mir22 microRNA 22 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR22 mRNA] CTD PMID:32864822 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir26b microRNA 26b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR26B mRNA] CTD PMID:32864822 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
JBrowse link
G Mir296 microRNA 296 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR296 mRNA] CTD PMID:32864822 NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915
JBrowse link
G Mir30c1 microRNA 30c-1 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR30C1 mRNA] CTD PMID:32864822 NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325
JBrowse link
G Mir3558 microRNA 3558 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3558 mRNA] CTD PMID:32864822 NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864
JBrowse link
G Mir3584 microRNA 3584 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3584 mRNA] CTD PMID:32864822 NCBI chr 1:246,786,249...246,786,329 JBrowse link
G Mir3588 microRNA 3588 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3588 mRNA] CTD PMID:32864822 NCBI chr11:16,245,611...16,245,716
Ensembl chr11:16,245,611...16,245,716
JBrowse link
G Mir365b microRNA 365b multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR365B mRNA] CTD PMID:32864822 NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351
JBrowse link
G Mir494 microRNA 494 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR494 mRNA] CTD PMID:32864822 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
JBrowse link
G Mir6216 microRNA 6216 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR6216 mRNA] CTD PMID:32864822 NCBI chr 3:44,756,861...44,756,938
Ensembl chr 3:44,756,861...44,756,938
JBrowse link
G Mir664-2 microRNA 664-2 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR664-2 mRNA] CTD PMID:32864822 NCBI chr13:96,793,099...96,793,157
Ensembl chr13:96,793,099...96,793,157
JBrowse link
G Mir760 microRNA 760 multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of MIR760 mRNA] CTD PMID:32864822 NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Rutin results in decreased expression of and results in decreased activity of MMP2 protein
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]
CTD PMID:26408079 PMID:29743444 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO Rutin results in decreased expression of MMP9 mRNA
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]
CTD PMID:16304905 PMID:29743444 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrc1 mannose receptor, C type 1 increases expression
multiple interactions
EXP Rutin results in increased expression of MRC1 protein
[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein
CTD PMID:28693884 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]
[Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein
CTD PMID:22902988 PMID:31412289 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:19557821 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein] CTD PMID:22426011 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP
ISO
Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Rutin results in decreased expression of NOS2 mRNA; Rutin results in decreased expression of NOS2 protein
Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:11500931 PMID:12512693 PMID:22902988 PMID:25080890 PMID:25753322 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA] CTD PMID:25129099 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA] CTD PMID:25129099 NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA] CTD PMID:25129099 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 decreases expression ISO Rutin results in decreased expression of PNPLA3 mRNA CTD PMID:17032037 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression
EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein]
Rutin results in increased expression of PON1 mRNA
CTD PMID:25478064 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon3 paraoxonase 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein] CTD PMID:25478064 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein] CTD PMID:22426011 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein] CTD PMID:25478064 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA] CTD PMID:25129099 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
[Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
Rutin results in decreased expression of PTGS2 mRNA
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
CTD PMID:11500931 PMID:15652231 PMID:19557821 PMID:21756928 PMID:22902988 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein] CTD PMID:22426011 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions EXP Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A mRNA]; Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A protein] CTD PMID:32864822 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [Glucose affects the localization of RELA protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Rutin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]
CTD PMID:19557821 PMID:21756928 PMID:29522708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Rutin results in increased expression of SIRT1 mRNA; Rutin results in increased expression of SIRT1 protein CTD PMID:30365940 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 increases expression
multiple interactions
EXP Rutin results in increased expression of SLAMF1 protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of SLAMF1 protein]
CTD PMID:28693884 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein] CTD PMID:19605544 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein] CTD PMID:19605544 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein] CTD PMID:19605544 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects localization
multiple interactions
ISO Rutin affects the localization of SLCO2B1 protein
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Cholic Acid]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Taurocholic Acid]
CTD PMID:24285294 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA] CTD PMID:27239252 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA] CTD PMID:27239252 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein] CTD PMID:22426011 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein] CTD PMID:22902988 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Rutin inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP Rutin results in increased expression of STAR protein CTD PMID:29899696 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of STAT3 mRNA]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein] CTD PMID:22426011 PMID:26062544 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]
CTD PMID:22902988 PMID:24117263 PMID:27239252 PMID:28693884 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA] CTD PMID:25129099 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]
Rutin results in decreased expression of TNF mRNA; Rutin results in decreased expression of TNF protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]
CTD PMID:14654164 PMID:18958421 PMID:19557821 PMID:21605616 PMID:21756928 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TP53 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TRP53 protein]
CTD PMID:27239252 PMID:29522708 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA] CTD PMID:25129099 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25080890 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO Rutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein] CTD PMID:20015448 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Rutin inhibits the reaction [Cyclophosphamide results in increased activity of XDH protein] CTD PMID:25753322 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          oxygen atom 19445
            oxygen molecular entity 19445
              organooxygen compound 19014
                carbohydrates and carbohydrate derivatives 12341
                  carbohydrate derivative 11947
                    glycosyl compound 10977
                      glycoside 9260
                        rhamnosylglucoside 176
                          flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]s 0
                          gypsogenin 3-O-rhamnosylglucosiduronic acid 0
                          rutinoside + 176
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          glycoside 9260
                                            rhamnosylglucoside 176
                                              flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]s 0
                                              gypsogenin 3-O-rhamnosylglucosiduronic acid 0
                                              rutinoside + 176
paths to the root