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G |
Oat |
ornithine aminotransferase |
multiple interactions |
EXP |
Rhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] |
CTD |
PMID:2827574 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression |
ISO |
baohuoside I results in decreased expression of ABCB11 mRNA; baohuoside I results in decreased expression of ABCB11 protein |
CTD |
PMID:35802278 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases expression |
ISO |
baohuoside I results in decreased expression of ABCC2 mRNA; baohuoside I results in decreased expression of ABCC2 protein |
CTD |
PMID:35802278 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
baohuoside I results in decreased phosphorylation of AKT1 protein baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:25119583 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt1s1 |
AKT1 substrate 1 |
multiple interactions decreases phosphorylation |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] baohuoside I results in decreased phosphorylation of AKT1S1 protein |
CTD |
PMID:25119583 |
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NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
increases expression increases secretion |
EXP ISO |
baohuoside I results in increased expression of ALPL mRNA baohuoside I results in increased secretion of ALPL protein |
CTD |
PMID:17764702 PMID:35802278 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
baohuoside I results in increased expression of BAX protein |
CTD |
PMID:22687635 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
baohuoside I results in decreased expression of BCL2 protein |
CTD |
PMID:22687635 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression |
EXP |
baohuoside I results in increased expression of BGLAP mRNA |
CTD |
PMID:17764702 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Braf |
B-Raf proto-oncogene, serine/threonine kinase |
decreases phosphorylation multiple interactions |
ISO |
baohuoside I results in decreased phosphorylation of BRAF protein baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein] |
CTD |
PMID:25119583 |
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NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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G |
Casp3 |
caspase 3 |
increases cleavage increases activity |
ISO |
baohuoside I results in increased cleavage of CASP3 protein baohuoside I results in increased activity of CASP3 protein |
CTD |
PMID:19289254 PMID:22687635 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
baohuoside I results in increased activity of CASP8 protein |
CTD |
PMID:19289254 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity increases cleavage |
ISO |
baohuoside I results in increased activity of CASP9 protein baohuoside I results in increased cleavage of CASP9 protein |
CTD |
PMID:19289254 PMID:22687635 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Col1a2 |
collagen type I alpha 2 chain |
increases expression |
EXP |
baohuoside I results in increased expression of COL1A2 mRNA |
CTD |
PMID:17764702 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases expression |
ISO |
baohuoside I results in increased expression of CYP7A1 mRNA; baohuoside I results in increased expression of CYP7A1 protein |
CTD |
PMID:35802278 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] |
CTD |
PMID:25119583 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] baohuoside I results in decreased phosphorylation of EGFR protein |
CTD |
PMID:25119583 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
baohuoside I binds to and results in increased degradation of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein] |
CTD |
PMID:35802278 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases secretion |
ISO |
baohuoside I results in increased secretion of GOT1 protein |
CTD |
PMID:35802278 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
increases secretion |
ISO |
baohuoside I results in increased secretion of GPT protein |
CTD |
PMID:35802278 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation |
ISO |
baohuoside I results in decreased phosphorylation of GSK3B protein |
CTD |
PMID:25119583 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] baohuoside I results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:25119583 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] baohuoside I results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:25119583 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
baohuoside I results in decreased expression of MKI67 protein |
CTD |
PMID:25119583 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] baohuoside I results in decreased phosphorylation of MTOR protein |
CTD |
PMID:25119583 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
baohuoside I results in decreased expression of NOS2 |
CTD |
PMID:19289254 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions decreases expression |
ISO |
baohuoside I results in decreased expression of and results in decreased activity of and affects the localization of NR0B2 protein; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein] baohuoside I results in decreased expression of NR0B2 mRNA baohuoside I results in decreased expression of NR0B2 mRNA; baohuoside I results in decreased expression of NR0B2 protein |
CTD |
PMID:35802278 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
decreases expression |
ISO |
baohuoside I results in decreased expression of NR1H4 mRNA; baohuoside I results in decreased expression of NR1H4 protein |
CTD |
PMID:35802278 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
baohuoside I results in increased cleavage of PARP1 protein Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein]; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein] |
CTD |
PMID:19289254 PMID:22687635 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
decreases phosphorylation |
ISO |
baohuoside I results in decreased phosphorylation of PDPK1 protein |
CTD |
PMID:25119583 |
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NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO |
baohuoside I results in decreased expression of PTGS2 [baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein] |
CTD |
PMID:19289254 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Slc10a1 |
solute carrier family 10 member 1 |
increases expression |
ISO |
baohuoside I results in increased expression of SLC10A1 protein baohuoside I results in increased expression of SLC10A1 mRNA; baohuoside I results in increased expression of SLC10A1 protein |
CTD |
PMID:35802278 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
decreases expression |
ISO |
baohuoside I results in decreased expression of SLCO1A1 mRNA |
CTD |
PMID:35802278 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Tnfrsf11b |
TNF receptor superfamily member 11B |
increases expression |
EXP |
baohuoside I results in increased expression of TNFRSF11B mRNA |
CTD |
PMID:17764702 |
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NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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G |
Tnfsf11 |
TNF superfamily member 11 |
decreases expression |
EXP |
baohuoside I results in decreased expression of TNFSF11 mRNA |
CTD |
PMID:17764702 |
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NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
baohuoside I results in decreased expression of VEGFA |
CTD |
PMID:19289254 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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