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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aminoglutethimide
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Accession:CHEBI:2654 term browser browse the term
Definition:A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Synonyms:exact_synonym: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
 related_synonym: 2-(p-Aminophenyl)-2-ethylglutarimide;   3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine;   DL-Aminoglutethimide;   Formula=C13H16N2O2;   InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);   InChIKey=ROBVIMPUHSLWNV-UHFFFAOYSA-N;   SMILES=CCC1(CCC(=O)NC1=O)c1ccc(N)cc1;   alpha-(p-Aminophenyl)-alpha-ethylglutarimide;   aminoglutethimidum;   aminoglutetimida;   p-Aminoglutethimide
 xref: CAS:125-84-8;   DrugBank:DB00357;   Drug_Central:164;   HMDB:HMDB0014501;   KEGG:C07617;   KEGG:D00574;   LINCS:LSM-1409
 xref_mesh: MESH:D000616
 xref: PMID:11916226;   PMID:17602675;   PMID:24350727;   Patent:US2848455;   Reaxys:210656;   Wikipedia:Aminoglutethimide


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aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1 decreases expression ISO Aminoglutethimide results in decreased expression of ACP1 protein CTD PMID:26102013 NCBI chr 6:47,506,380...47,522,021
Ensembl chr 6:47,506,380...47,522,021 		JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B decreases expression ISO Aminoglutethimide results in decreased expression of ANP32B protein CTD PMID:26102013 NCBI chr 5:65,538,872...65,561,305
Ensembl chr 5:60,743,443...60,765,717 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO Aminoglutethimide results in decreased expression of BASP1 protein CTD PMID:26102013 NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 decreases expression ISO Aminoglutethimide results in decreased expression of BCAP31 protein CTD PMID:26102013 NCBI chr  X:156,548,911...156,581,002
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Aminoglutethimide results in increased expression of CCT4 protein CTD PMID:26102013 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Aminoglutethimide results in decreased expression of CCT6A protein CTD PMID:26102013 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Aminoglutethimide results in decreased expression of CCT7 protein CTD PMID:26102013 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580 		JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Aminoglutethimide results in increased expression of COMT protein CTD PMID:26102013 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression ISO Aminoglutethimide results in decreased expression of CUTA protein CTD PMID:26102013 NCBI chr20:5,022,956...5,024,580
Ensembl chr20:5,022,956...5,024,552 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Aminoglutethimide results in decreased expression of CYP17A1 mRNA CTD PMID:16935330 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity 		ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]
Aminoglutethimide results in decreased activity of CYP19A1 protein
Aminoglutethimide results in increased activity of CYP19A1 protein 		CTD PMID:15242824 PMID:15968818 PMID:16935330 PMID:17910019 PMID:20087668 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions 		ISO Aminoglutethimide results in decreased expression of FSHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde] 		CTD PMID:9208491 PMID:22285649 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A increases expression ISO Aminoglutethimide results in increased expression of GATD3 protein CTD PMID:26102013 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885 		JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase decreases expression ISO Aminoglutethimide results in decreased expression of GNS protein CTD PMID:26102013 NCBI chr 7:56,889,148...56,923,173
Ensembl chr 7:56,889,232...56,923,151 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Aminoglutethimide results in increased expression of GPX1 protein CTD PMID:26102013 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsn gelsolin decreases expression ISO Aminoglutethimide results in decreased expression of GSN protein CTD PMID:26102013 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Aminoglutethimide results in increased expression of H1-2 protein CTD PMID:26102013 NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635 		JBrowse link
G H2ac12 H2A clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2AC12 protein CTD PMID:26102013 NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941 		JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression ISO Aminoglutethimide results in increased expression of H2AZ1 protein CTD PMID:26102013 NCBI chr 2:226,355,668...226,357,984
Ensembl chr 2:226,355,708...226,358,485 		JBrowse link
G H2bc12 H2B clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2BC12 protein CTD PMID:26102013 NCBI chr17:47,181,477...47,181,940 JBrowse link
G H3c13 H3 clustered histone 13 increases expression ISO Aminoglutethimide results in increased expression of H3C13 protein CTD PMID:26102013 NCBI chr17:41,531,502...41,531,971
Ensembl chr 2:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr 2:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr17:183,795,504...183,809,469
Ensembl chr 2:183,795,504...183,809,469 		JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Aminoglutethimide results in decreased expression of HMGB2 protein CTD PMID:26102013 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140 		JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Aminoglutethimide results in decreased expression of HNRNPH1 protein CTD PMID:26102013 NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO [Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA CTD PMID:16935330 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Aminoglutethimide results in decreased expression of HSD17B10 protein CTD PMID:26102013 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions
decreases expression 		ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Aminoglutethimide results in decreased expression of HSD17B4 mRNA 		CTD PMID:16935330 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Aminoglutethimide results in decreased expression of HSD17B7 mRNA CTD PMID:9231770 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Aminoglutethimide results in increased expression of HSPA1A protein CTD PMID:26102013 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Aminoglutethimide results in increased expression of HYOU1 protein CTD PMID:26102013 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Aminoglutethimide results in decreased expression of IMPDH2 protein CTD PMID:26102013 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions 		ISO Aminoglutethimide results in decreased expression of LHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde] 		CTD PMID:9208491 PMID:22285649 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lmna lamin A/C decreases expression ISO Aminoglutethimide results in decreased expression of LMNA protein CTD PMID:26102013 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lmnb2 lamin B2 decreases expression ISO Aminoglutethimide results in decreased expression of LMNB2 protein CTD PMID:26102013 NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Aminoglutethimide results in decreased expression of MCM3 protein CTD PMID:26102013 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [Aminoglutethimide co-treated with Hydrogen Peroxide] results in increased oxidation of MPO protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide CTD PMID:20199096 PMID:26102013 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myo18a myosin XVIIIa decreases expression ISO Aminoglutethimide results in decreased expression of MYO18A protein CTD PMID:26102013 NCBI chr10:62,654,218...62,755,465
Ensembl chr10:62,654,281...62,755,468 		JBrowse link
G Npm3 nucleophosmin/nucleoplasmin, 3 decreases expression ISO Aminoglutethimide results in decreased expression of NPM3 protein CTD PMID:26102013 NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Aminoglutethimide results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nup210 nucleoporin 210 decreases expression ISO Aminoglutethimide results in decreased expression of NUP210 protein CTD PMID:26102013 NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874 		JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression 		ISO [Aminoglutethimide co-treated with 17 alpha-Hydroxyprogesterone Caproate] results in decreased expression of PGR protein
Aminoglutethimide results in decreased expression of PGR protein 		CTD PMID:8565696 PMID:9208491 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Aminoglutethimide results in increased expression of PITPNB protein CTD PMID:26102013 NCBI chr12:45,249,308...45,298,388
Ensembl chr12:45,249,333...45,298,314 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Aminoglutethimide results in decreased expression of PPP1CA protein CTD PMID:26102013 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Aminoglutethimide results in increased expression of PRDX3 protein CTD PMID:26102013 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression ISO Aminoglutethimide results in decreased expression of PSMB4 protein CTD PMID:26102013 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Rtraf RNA transcription, translation and transport factor decreases expression ISO Aminoglutethimide results in decreased expression of RTRAF protein CTD PMID:26102013 NCBI chr15:4,447,243...4,457,973
Ensembl chr15:4,442,573...4,457,972 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Aminoglutethimide results in decreased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Ssb small RNA binding exonuclease protection factor La decreases expression ISO Aminoglutethimide results in decreased expression of SSB protein CTD PMID:26102013 NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
increases expression 		ISO Aminoglutethimide results in decreased expression of STAR mRNA
Aminoglutethimide results in increased expression of STAR mRNA 		CTD PMID:10960482 PMID:16935330 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO Aminoglutethimide results in decreased expression of TPT1 protein CTD PMID:26102013 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Ubc ubiquitin C increases expression ISO Aminoglutethimide results in increased expression of UBC protein CTD PMID:26102013 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K decreases expression ISO Aminoglutethimide results in decreased expression of UBE2K protein CTD PMID:26102013 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
G Wdr1 WD repeat domain 1 increases expression ISO Aminoglutethimide results in increased expression of WDR1 protein CTD PMID:26102013 NCBI chr14:76,470,238...76,504,086
Ensembl chr14:72,257,956...72,291,766 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta increases expression ISO Aminoglutethimide results in increased expression of YWHAQ protein CTD PMID:26102013 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      application 20617
        pharmaceutical 20413
          drug 20413
            antineoplastic agent 18066
              aminoglutethimide 54
                (R)-aminoglutethimide 0
                (S)-aminoglutethimide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            inorganic hydride 18601
                              pnictogen hydride 18587
                                nitrogen hydride 18502
                                  azane 18261
                                    ammonia 18260
                                      organic amino compound 18260
                                        aromatic amine 15828
                                          anilines 14561
                                            substituted aniline 14194
                                              aminoglutethimide 54
                                                (R)-aminoglutethimide 0
                                                (S)-aminoglutethimide 0
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