CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: aminoglutethimide
Accession: CHEBI:2654
browse the term
Definition: A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Synonyms: exact_synonym: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
related_synonym: 2-(p-Aminophenyl)-2-ethylglutarimide; 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine; DL-Aminoglutethimide; Formula=C13H16N2O2; InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17); InChIKey=ROBVIMPUHSLWNV-UHFFFAOYSA-N; SMILES=CCC1(CCC(=O)NC1=O)c1ccc(N)cc1; alpha-(p-Aminophenyl)-alpha-ethylglutarimide; aminoglutethimidum; aminoglutetimida; p-Aminoglutethimide
xref: Beilstein:210656; CAS:125-84-8; DrugBank:DB00357; Drug_Central:164; HMDB:HMDB0014501; KEGG:C07617; KEGG:D00574; LINCS:LSM-1409
xref_mesh: MESH:D000616
xref: PMID:11916226; PMID:17602675; PMID:24350727; Patent:US2848455; Reaxys:210656; Wikipedia:Aminoglutethimide
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Acp1
acid phosphatase 1, soluble
decreases expression
ISO
Aminoglutethimide results in decreased expression of ACP1 protein
CTD
PMID:26102013
NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588
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Anp32b
acidic nuclear phosphoprotein 32 family member B
decreases expression
ISO
Aminoglutethimide results in decreased expression of ANP32B protein
CTD
PMID:26102013
NCBI chr 4:46,450,926...46,472,657
Ensembl chr 4:46,450,902...46,472,657
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Basp1
brain abundant, membrane attached signal protein 1
decreases expression
ISO
Aminoglutethimide results in decreased expression of BASP1 protein
CTD
PMID:26102013
NCBI chr15:25,363,363...25,413,850
Ensembl chr15:25,363,363...25,413,850
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Bcap31
B cell receptor associated protein 31
decreases expression
ISO
Aminoglutethimide results in decreased expression of BCAP31 protein
CTD
PMID:26102013
NCBI chr X:72,729,784...72,761,464
Ensembl chr X:72,729,784...72,759,781
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Cct4
chaperonin containing TCP1 subunit 4
increases expression
ISO
Aminoglutethimide results in increased expression of CCT4 protein
CTD
PMID:26102013
NCBI chr11:22,940,593...22,953,336
Ensembl chr11:22,940,519...22,953,780
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Cct6a
chaperonin containing TCP1 subunit 6A
decreases expression
ISO
Aminoglutethimide results in decreased expression of CCT6A protein
CTD
PMID:26102013
NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212
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Cct7
chaperonin containing TCP1 subunit 7
decreases expression
ISO
Aminoglutethimide results in decreased expression of CCT7 protein
CTD
PMID:26102013
NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457
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Comt
catechol-O-methyltransferase
increases expression
ISO
Aminoglutethimide results in increased expression of COMT protein
CTD
PMID:26102013
NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
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Cuta
cutA divalent cation tolerance homolog
decreases expression
ISO
Aminoglutethimide results in decreased expression of CUTA protein
CTD
PMID:26102013
NCBI chr17:27,156,946...27,158,847
Ensembl chr17:27,152,793...27,158,543
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
multiple interactions
ISO
Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]
CTD
PMID:16935330
NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Aminoglutethimide results in decreased expression of CYP17A1 mRNA
CTD
PMID:16935330
NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions decreases activity increases activity
ISO
Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] Aminoglutethimide results in decreased activity of CYP19A1 protein Aminoglutethimide results in increased activity of CYP19A1 protein
CTD
PMID:15242824 PMID:15968818 PMID:16935330 PMID:17910019 PMID:20087668
NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
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Fshb
follicle stimulating hormone beta
decreases expression multiple interactions
ISO EXP
Aminoglutethimide results in decreased expression of FSHB protein Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD
PMID:9208491 PMID:22285649
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
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Gatd3a
glutamine amidotransferase like class 1 domain containing 3A
increases expression
ISO
Aminoglutethimide results in increased expression of GATD3 protein
CTD
PMID:26102013
NCBI chr10:77,997,900...78,005,589
Ensembl chr10:77,997,900...78,005,616
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Gns
glucosamine (N-acetyl)-6-sulfatase
decreases expression
ISO
Aminoglutethimide results in decreased expression of GNS protein
CTD
PMID:26102013
NCBI chr10:121,200,995...121,233,159
Ensembl chr10:121,200,995...121,233,154
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Gpx1
glutathione peroxidase 1
increases expression
ISO
Aminoglutethimide results in increased expression of GPX1 protein
CTD
PMID:26102013
NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
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Gsn
gelsolin
decreases expression
ISO
Aminoglutethimide results in decreased expression of GSN protein
CTD
PMID:26102013
NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
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H1f2
H1.2 linker histone, cluster member
increases expression
ISO
Aminoglutethimide results in increased expression of H1-2 protein
CTD
PMID:26102013
NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350
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H2ac12
H2A clustered histone 12
increases expression
ISO
Aminoglutethimide results in increased expression of H2AC12 protein
CTD
PMID:26102013
NCBI chr13:22,219,292...22,219,813
Ensembl chr13:22,219,334...22,219,738
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H2az1
H2A.Z variant histone 1
increases expression
ISO
Aminoglutethimide results in increased expression of H2AZ1 protein
CTD
PMID:26102013
NCBI chr 3:137,570,248...137,572,683
Ensembl chr 3:137,570,248...137,572,683
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H2bc12
H2B clustered histone 12
increases expression
ISO
Aminoglutethimide results in increased expression of H2BC12 protein
CTD
PMID:26102013
NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515
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H3c11
H3 clustered histone 11
increases expression
ISO
Aminoglutethimide results in increased expression of H3C7 protein
CTD
PMID:26102013
NCBI chr13:21,967,085...21,967,567
Ensembl chr13:21,967,130...21,967,540
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H3c3
H3 clustered histone 3
increases expression
ISO
Aminoglutethimide results in increased expression of H3C13 protein
CTD
PMID:26102013
NCBI chr13:23,929,025...23,929,504
Ensembl chr13:23,928,956...23,929,585
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H4c12
H4 clustered histone 12
increases expression
ISO
Aminoglutethimide results in increased expression of H4C8 protein
CTD
PMID:26102013
NCBI chr13:21,934,315...21,934,723
Ensembl chr13:21,934,364...21,934,675
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Hmgb2
high mobility group box 2
decreases expression
ISO
Aminoglutethimide results in decreased expression of HMGB2 protein
CTD
PMID:26102013
NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
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Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
decreases expression
ISO
Aminoglutethimide results in decreased expression of HNRNPH1 protein
CTD
PMID:26102013
NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
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Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
multiple interactions
ISO
[Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA
CTD
PMID:16935330
NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
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Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
decreases expression
ISO
Aminoglutethimide results in decreased expression of HSD17B10 protein
CTD
PMID:26102013
NCBI chr X:150,784,892...150,787,438
Ensembl chr X:150,784,841...150,787,438
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Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
multiple interactions decreases expression
ISO
Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA] Aminoglutethimide results in decreased expression of HSD17B4 mRNA
CTD
PMID:16935330
NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
decreases expression
ISO
Aminoglutethimide results in decreased expression of HSD17B7 mRNA
CTD
PMID:9231770
NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810
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Hspa1a
heat shock protein 1A
increases expression
ISO
Aminoglutethimide results in increased expression of HSPA1A protein
CTD
PMID:26102013
NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
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Hyou1
hypoxia up-regulated 1
increases expression
ISO
Aminoglutethimide results in increased expression of HYOU1 protein
CTD
PMID:26102013
NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
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Impdh2
inosine monophosphate dehydrogenase 2
decreases expression
ISO
Aminoglutethimide results in decreased expression of IMPDH2 protein
CTD
PMID:26102013
NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783
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Lhb
luteinizing hormone beta
decreases expression multiple interactions
ISO EXP
Aminoglutethimide results in decreased expression of LHB protein Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD
PMID:9208491 PMID:22285649
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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Lmna
lamin A
decreases expression
ISO
Aminoglutethimide results in decreased expression of LMNA protein
CTD
PMID:26102013
NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
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Lmnb2
lamin B2
decreases expression
ISO
Aminoglutethimide results in decreased expression of LMNB2 protein
CTD
PMID:26102013
NCBI chr10:80,737,197...80,754,079
Ensembl chr10:80,737,037...80,754,079
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Mcm3
minichromosome maintenance complex component 3
decreases expression
ISO
Aminoglutethimide results in decreased expression of MCM3 protein
CTD
PMID:26102013
NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
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Mpo
myeloperoxidase
multiple interactions
ISO
[[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [Aminoglutethimide co-treated with Hydrogen Peroxide] results in increased oxidation of MPO protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide
CTD
PMID:20199096 PMID:26102013
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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Myo18a
myosin XVIIIA
decreases expression
ISO
Aminoglutethimide results in decreased expression of MYO18A protein
CTD
PMID:26102013
NCBI chr11:77,654,066...77,756,806
Ensembl chr11:77,654,072...77,756,806
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Npm3
nucleoplasmin 3
decreases expression
ISO
Aminoglutethimide results in decreased expression of NPM3 protein
CTD
PMID:26102013
NCBI chr19:45,736,173...45,738,004
Ensembl chr19:45,736,173...45,738,030
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Aminoglutethimide results in increased activity of NR1I2 protein
CTD
PMID:21068194
NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
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Nup210
nucleoporin 210
decreases expression
ISO
Aminoglutethimide results in decreased expression of NUP210 protein
CTD
PMID:26102013
NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811
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Pgr
progesterone receptor
multiple interactions decreases expression
ISO
[Aminoglutethimide co-treated with 17 alpha-Hydroxyprogesterone Caproate] results in decreased expression of PGR protein Aminoglutethimide results in decreased expression of PGR protein
CTD
PMID:8565696 PMID:9208491
NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
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Pitpnb
phosphatidylinositol transfer protein, beta
increases expression
ISO
Aminoglutethimide results in increased expression of PITPNB protein
CTD
PMID:26102013
NCBI chr 5:111,478,563...111,536,225
Ensembl chr 5:111,478,629...111,536,225
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Ppp1ca
protein phosphatase 1 catalytic subunit alpha
decreases expression
ISO
Aminoglutethimide results in decreased expression of PPP1CA protein
CTD
PMID:26102013
NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419
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Prdx3
peroxiredoxin 3
increases expression
ISO
Aminoglutethimide results in increased expression of PRDX3 protein
CTD
PMID:26102013
NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
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Psmb4
proteasome (prosome, macropain) subunit, beta type 4
decreases expression
ISO
Aminoglutethimide results in decreased expression of PSMB4 protein
CTD
PMID:26102013
NCBI chr 3:94,791,635...94,794,269
Ensembl chr 3:94,791,404...94,794,272
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Rtraf
RNA transcription, translation and transport factor
decreases expression
ISO
Aminoglutethimide results in decreased expression of RTRAF protein
CTD
PMID:26102013
NCBI chr14:19,861,470...19,873,891
Ensembl chr14:19,861,419...19,873,892
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Spp1
secreted phosphoprotein 1
decreases expression
ISO
Aminoglutethimide results in decreased expression of SPP1 mRNA
CTD
PMID:23558518
NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
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Ssb
small RNA binding exonuclease protection factor La
decreases expression
ISO
Aminoglutethimide results in decreased expression of SSB protein
CTD
PMID:26102013
NCBI chr 2:69,691,963...69,702,185
Ensembl chr 2:69,691,906...69,702,190
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Star
steroidogenic acute regulatory protein
decreases expression increases expression
ISO EXP
Aminoglutethimide results in decreased expression of STAR mRNA Aminoglutethimide results in increased expression of STAR mRNA
CTD
PMID:10960482 PMID:16935330
NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
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Tpt1
tumor protein, translationally-controlled 1
decreases expression
ISO
Aminoglutethimide results in decreased expression of TPT1 protein
CTD
PMID:26102013
NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965
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Ubc
ubiquitin C
increases expression
ISO
Aminoglutethimide results in increased expression of UBC protein
CTD
PMID:26102013
NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
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Ube2k
ubiquitin-conjugating enzyme E2K
decreases expression
ISO
Aminoglutethimide results in decreased expression of UBE2K protein
CTD
PMID:26102013
NCBI chr 5:65,694,588...65,756,332
Ensembl chr 5:65,694,576...65,756,331
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Wdr1
WD repeat domain 1
increases expression
ISO
Aminoglutethimide results in increased expression of WDR1 protein
CTD
PMID:26102013
NCBI chr 5:38,684,149...38,720,265
Ensembl chr 5:38,684,156...38,720,564
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
increases expression
ISO
Aminoglutethimide results in increased expression of YWHAQ protein
CTD
PMID:26102013
NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638
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