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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminoglutethimide
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Accession:CHEBI:2654 term browser browse the term
Definition:A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Synonyms:exact_synonym: 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
 related_synonym: 2-(p-Aminophenyl)-2-ethylglutarimide;   3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine;   DL-Aminoglutethimide;   Formula=C13H16N2O2;   InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);   InChIKey=ROBVIMPUHSLWNV-UHFFFAOYSA-N;   SMILES=CCC1(CCC(=O)NC1=O)c1ccc(N)cc1;   alpha-(p-Aminophenyl)-alpha-ethylglutarimide;   aminoglutethimidum;   aminoglutetimida;   p-Aminoglutethimide
 xref: Beilstein:210656;   CAS:125-84-8;   DrugBank:DB00357;   Drug_Central:164;   HMDB:HMDB0014501;   KEGG:C07617;   KEGG:D00574;   LINCS:LSM-1409
 xref_mesh: MESH:D000616
 xref: PMID:11916226;   PMID:17602675;   PMID:24350727;   Patent:US2848455;   Reaxys:210656;   Wikipedia:Aminoglutethimide



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aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp1 acid phosphatase 1, soluble decreases expression ISO Aminoglutethimide results in decreased expression of ACP1 protein CTD PMID:26102013 NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588
JBrowse link
G Anp32b acidic nuclear phosphoprotein 32 family member B decreases expression ISO Aminoglutethimide results in decreased expression of ANP32B protein CTD PMID:26102013 NCBI chr 4:46,450,926...46,472,657
Ensembl chr 4:46,450,902...46,472,657
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO Aminoglutethimide results in decreased expression of BASP1 protein CTD PMID:26102013 NCBI chr15:25,363,363...25,413,850
Ensembl chr15:25,363,363...25,413,850
JBrowse link
G Bcap31 B cell receptor associated protein 31 decreases expression ISO Aminoglutethimide results in decreased expression of BCAP31 protein CTD PMID:26102013 NCBI chr  X:72,729,784...72,761,464
Ensembl chr  X:72,729,784...72,759,781
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Aminoglutethimide results in increased expression of CCT4 protein CTD PMID:26102013 NCBI chr11:22,940,593...22,953,336
Ensembl chr11:22,940,519...22,953,780
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Aminoglutethimide results in decreased expression of CCT6A protein CTD PMID:26102013 NCBI chr 5:129,864,420...129,875,284
Ensembl chr 5:129,864,062...129,875,212
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 decreases expression ISO Aminoglutethimide results in decreased expression of CCT7 protein CTD PMID:26102013 NCBI chr 6:85,428,487...85,445,459
Ensembl chr 6:85,428,496...85,445,457
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Aminoglutethimide results in increased expression of COMT protein CTD PMID:26102013 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Cuta cutA divalent cation tolerance homolog decreases expression ISO Aminoglutethimide results in decreased expression of CUTA protein CTD PMID:26102013 NCBI chr17:27,156,946...27,158,847
Ensembl chr17:27,152,793...27,158,543
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] CTD PMID:16935330 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Aminoglutethimide results in decreased expression of CYP17A1 mRNA CTD PMID:16935330 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity
ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the chemical synthesis of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine]; Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]
Aminoglutethimide results in decreased activity of CYP19A1 protein
Aminoglutethimide results in increased activity of CYP19A1 protein
CTD PMID:15242824 PMID:15968818 PMID:16935330 PMID:17910019 PMID:20087668 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Fshb follicle stimulating hormone beta decreases expression
multiple interactions
ISO
EXP
Aminoglutethimide results in decreased expression of FSHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD PMID:9208491 PMID:22285649 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
JBrowse link
G Gatd3a glutamine amidotransferase like class 1 domain containing 3A increases expression ISO Aminoglutethimide results in increased expression of GATD3 protein CTD PMID:26102013 NCBI chr10:77,997,900...78,005,589
Ensembl chr10:77,997,900...78,005,616
JBrowse link
G Gns glucosamine (N-acetyl)-6-sulfatase decreases expression ISO Aminoglutethimide results in decreased expression of GNS protein CTD PMID:26102013 NCBI chr10:121,200,995...121,233,159
Ensembl chr10:121,200,995...121,233,154
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Aminoglutethimide results in increased expression of GPX1 protein CTD PMID:26102013 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
JBrowse link
G Gsn gelsolin decreases expression ISO Aminoglutethimide results in decreased expression of GSN protein CTD PMID:26102013 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904
JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO Aminoglutethimide results in increased expression of H1-2 protein CTD PMID:26102013 NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350
JBrowse link
G H2ac12 H2A clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2AC12 protein CTD PMID:26102013 NCBI chr13:22,219,292...22,219,813
Ensembl chr13:22,219,334...22,219,738
JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression ISO Aminoglutethimide results in increased expression of H2AZ1 protein CTD PMID:26102013 NCBI chr 3:137,570,248...137,572,683
Ensembl chr 3:137,570,248...137,572,683
JBrowse link
G H2bc12 H2B clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H2BC12 protein CTD PMID:26102013 NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515
JBrowse link
G H3c11 H3 clustered histone 11 increases expression ISO Aminoglutethimide results in increased expression of H3C7 protein CTD PMID:26102013 NCBI chr13:21,967,085...21,967,567
Ensembl chr13:21,967,130...21,967,540
JBrowse link
G H3c3 H3 clustered histone 3 increases expression ISO Aminoglutethimide results in increased expression of H3C13 protein CTD PMID:26102013 NCBI chr13:23,929,025...23,929,504
Ensembl chr13:23,928,956...23,929,585
JBrowse link
G H4c12 H4 clustered histone 12 increases expression ISO Aminoglutethimide results in increased expression of H4C8 protein CTD PMID:26102013 NCBI chr13:21,934,315...21,934,723
Ensembl chr13:21,934,364...21,934,675
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Aminoglutethimide results in decreased expression of HMGB2 protein CTD PMID:26102013 NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Aminoglutethimide results in decreased expression of HNRNPH1 protein CTD PMID:26102013 NCBI chr11:50,266,084...50,277,355
Ensembl chr11:50,267,817...50,277,355
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO [Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA CTD PMID:16935330 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression ISO Aminoglutethimide results in decreased expression of HSD17B10 protein CTD PMID:26102013 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions
decreases expression
ISO Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Aminoglutethimide results in decreased expression of HSD17B4 mRNA
CTD PMID:16935330 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression ISO Aminoglutethimide results in decreased expression of HSD17B7 mRNA CTD PMID:9231770 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810
JBrowse link
G Hspa1a heat shock protein 1A increases expression ISO Aminoglutethimide results in increased expression of HSPA1A protein CTD PMID:26102013 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression ISO Aminoglutethimide results in increased expression of HYOU1 protein CTD PMID:26102013 NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Aminoglutethimide results in decreased expression of IMPDH2 protein CTD PMID:26102013 NCBI chr 9:108,437,635...108,442,776
Ensembl chr 9:108,437,485...108,442,783
JBrowse link
G Lhb luteinizing hormone beta decreases expression
multiple interactions
ISO
EXP
Aminoglutethimide results in decreased expression of LHB protein
Aminoglutethimide inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased abundance of Acetaldehyde]
CTD PMID:9208491 PMID:22285649 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Lmna lamin A decreases expression ISO Aminoglutethimide results in decreased expression of LMNA protein CTD PMID:26102013 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
JBrowse link
G Lmnb2 lamin B2 decreases expression ISO Aminoglutethimide results in decreased expression of LMNB2 protein CTD PMID:26102013 NCBI chr10:80,737,197...80,754,079
Ensembl chr10:80,737,037...80,754,079
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Aminoglutethimide results in decreased expression of MCM3 protein CTD PMID:26102013 NCBI chr 1:20,873,188...20,890,536
Ensembl chr 1:20,873,192...20,890,536
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [Aminoglutethimide co-treated with Hydrogen Peroxide] results in increased oxidation of MPO protein; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide CTD PMID:20199096 PMID:26102013 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Myo18a myosin XVIIIA decreases expression ISO Aminoglutethimide results in decreased expression of MYO18A protein CTD PMID:26102013 NCBI chr11:77,654,066...77,756,806
Ensembl chr11:77,654,072...77,756,806
JBrowse link
G Npm3 nucleoplasmin 3 decreases expression ISO Aminoglutethimide results in decreased expression of NPM3 protein CTD PMID:26102013 NCBI chr19:45,736,173...45,738,004
Ensembl chr19:45,736,173...45,738,030
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Aminoglutethimide results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186
JBrowse link
G Nup210 nucleoporin 210 decreases expression ISO Aminoglutethimide results in decreased expression of NUP210 protein CTD PMID:26102013 NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO [Aminoglutethimide co-treated with 17 alpha-Hydroxyprogesterone Caproate] results in decreased expression of PGR protein
Aminoglutethimide results in decreased expression of PGR protein
CTD PMID:8565696 PMID:9208491 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Pitpnb phosphatidylinositol transfer protein, beta increases expression ISO Aminoglutethimide results in increased expression of PITPNB protein CTD PMID:26102013 NCBI chr 5:111,478,563...111,536,225
Ensembl chr 5:111,478,629...111,536,225
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Aminoglutethimide results in decreased expression of PPP1CA protein CTD PMID:26102013 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Aminoglutethimide results in increased expression of PRDX3 protein CTD PMID:26102013 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Psmb4 proteasome (prosome, macropain) subunit, beta type 4 decreases expression ISO Aminoglutethimide results in decreased expression of PSMB4 protein CTD PMID:26102013 NCBI chr 3:94,791,635...94,794,269
Ensembl chr 3:94,791,404...94,794,272
JBrowse link
G Rtraf RNA transcription, translation and transport factor decreases expression ISO Aminoglutethimide results in decreased expression of RTRAF protein CTD PMID:26102013 NCBI chr14:19,861,470...19,873,891
Ensembl chr14:19,861,419...19,873,892
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Aminoglutethimide results in decreased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
JBrowse link
G Ssb small RNA binding exonuclease protection factor La decreases expression ISO Aminoglutethimide results in decreased expression of SSB protein CTD PMID:26102013 NCBI chr 2:69,691,963...69,702,185
Ensembl chr 2:69,691,906...69,702,190
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
increases expression
ISO
EXP
Aminoglutethimide results in decreased expression of STAR mRNA
Aminoglutethimide results in increased expression of STAR mRNA
CTD PMID:10960482 PMID:16935330 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO Aminoglutethimide results in decreased expression of TPT1 protein CTD PMID:26102013 NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965
JBrowse link
G Ubc ubiquitin C increases expression ISO Aminoglutethimide results in increased expression of UBC protein CTD PMID:26102013 NCBI chr 5:125,463,029...125,467,081
Ensembl chr 5:125,463,029...125,467,266
JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K decreases expression ISO Aminoglutethimide results in decreased expression of UBE2K protein CTD PMID:26102013 NCBI chr 5:65,694,588...65,756,332
Ensembl chr 5:65,694,576...65,756,331
JBrowse link
G Wdr1 WD repeat domain 1 increases expression ISO Aminoglutethimide results in increased expression of WDR1 protein CTD PMID:26102013 NCBI chr 5:38,684,149...38,720,265
Ensembl chr 5:38,684,156...38,720,564
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta increases expression ISO Aminoglutethimide results in increased expression of YWHAQ protein CTD PMID:26102013 NCBI chr12:21,440,330...21,467,437
Ensembl chr12:21,440,072...21,467,638
JBrowse link

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  CHEBI ontology 22188
    role 22173
      application 21755
        pharmaceutical 21163
          drug 21163
            antineoplastic agent 18840
              aminoglutethimide 56
                (R)-aminoglutethimide 0
                (S)-aminoglutethimide 0
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  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    main group molecular entity 22114
                      s-block molecular entity 21706
                        hydrogen molecular entity 21622
                          hydrides 20748
                            inorganic hydride 18678
                              pnictogen hydride 18658
                                nitrogen hydride 18537
                                  azane 18445
                                    ammonia 18444
                                      organic amino compound 18444
                                        aromatic amine 15740
                                          anilines 14581
                                            substituted aniline 14212
                                              aminoglutethimide 56
                                                (R)-aminoglutethimide 0
                                                (S)-aminoglutethimide 0
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