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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases activity |
ISO |
13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] 13-cis-retinal results in increased activity of CYP3A4 protein |
CTD |
PMID:16632523 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases reduction |
ISO |
AKR1B10 protein results in increased reduction of 9-cis-retinal |
CTD |
PMID:21851338 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases reduction |
ISO |
AKR1C1 protein results in increased reduction of 9-cis-retinal |
CTD |
PMID:21851338 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases reduction |
ISO |
AKR1C3 protein mutant form results in increased reduction of 9-cis-retinal; AKR1C3 protein results in increased reduction of 9-cis-retinal |
CTD |
PMID:21851338 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects oxidation multiple interactions |
EXP ISO |
ALDH1A1 protein affects the oxidation of 9-cis-retinal Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of 9-cis-retinal] ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of MITF mRNA]; ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of TYR mRNA] |
CTD |
PMID:17167544 PMID:23489423 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases activity multiple interactions |
ISO |
9-cis-retinal results in increased activity of CYP3A4 protein 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter] |
CTD |
PMID:16632523 PMID:19686701 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Mitf |
melanocyte inducing transcription factor |
increases expression multiple interactions |
ISO |
9-cis-retinal results in increased expression of MITF mRNA ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of MITF mRNA] |
CTD |
PMID:23489423 |
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NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter] |
CTD |
PMID:19686701 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Rdh9 |
retinol dehydrogenase 9 |
increases chemical synthesis |
ISO |
RDH9 protein results in increased chemical synthesis of 9-cis-retinal |
CTD |
PMID:17270348 |
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NCBI chr 7:63,642,305...63,645,149
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; 9-cis-retinal promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter] |
CTD |
PMID:16632523 PMID:19686701 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Tyr |
tyrosinase |
increases expression multiple interactions |
ISO |
9-cis-retinal results in increased expression of TYR mRNA ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of TYR mRNA] |
CTD |
PMID:23489423 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases reduction |
ISO |
AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde |
CTD |
PMID:19014918 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases reduction |
ISO |
AKR1B10 protein results in increased reduction of 4-oxoretinaldehyde |
CTD |
PMID:19014918 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases reduction |
ISO |
AKR1B1 protein results in increased reduction of dehydroretinal |
CTD |
PMID:19014918 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases reduction |
ISO |
AKR1B10 protein results in increased reduction of dehydroretinal |
CTD |
PMID:19014918 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Abca4 |
ATP binding cassette subfamily A member 4 |
affects transport |
ISO |
ABCA4 protein affects the transport of Retinaldehyde |
CTD |
PMID:16968212 |
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NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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G |
Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
increases metabolic processing |
EXP |
ADH4 protein results in increased metabolism of Retinaldehyde |
CTD |
PMID:17279314 |
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NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases reduction |
ISO |
AKR1B1 protein results in increased reduction of Retinaldehyde |
CTD |
PMID:19014918 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases reduction increases metabolic processing |
ISO |
AKR1B10 protein results in increased reduction of Retinaldehyde AKR1B10 protein results in increased metabolism of Retinaldehyde |
CTD |
PMID:19014918 PMID:21329680 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
increases metabolic processing |
ISO |
AKR1B7 protein results in increased metabolism of Retinaldehyde |
CTD |
PMID:21329680 |
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NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases reduction |
ISO |
AKR1C3 protein results in increased reduction of Retinaldehyde |
CTD |
PMID:23261716 |
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NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Alb |
albumin |
affects binding |
ISO |
Retinaldehyde binds to ALB protein |
CTD |
PMID:17217919 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions affects oxidation |
ISO EXP |
[ALDH1A1 protein co-treated with NAD] results in increased oxidation of Retinaldehyde; ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde]; ALDH1A1 protein binds to and results in increased oxidation of Retinaldehyde Magnesium Chloride inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde]; Magnesium inhibits the reaction [ALDH1A1 protein affects the oxidation of Retinaldehyde] |
CTD |
PMID:10559215 PMID:17167544 PMID:23220587 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
multiple interactions |
EXP |
ALDH1A2 protein binds to and results in increased oxidation of Retinaldehyde |
CTD |
PMID:23220587 |
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NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
increases oxidation |
ISO |
ALDH1A3 protein results in increased oxidation of Retinaldehyde |
CTD |
PMID:17526768 |
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NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions increases metabolic processing |
ISO |
[ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde ALDH2 protein results in increased metabolism of Retinaldehyde |
CTD |
PMID:10559215 PMID:11744614 |
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NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
increases activity |
EXP |
Retinaldehyde results in increased activity of ALDH3A1 protein |
CTD |
PMID:17126819 |
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NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Areg |
amphiregulin |
increases expression |
ISO |
Retinaldehyde results in increased expression of AREG mRNA |
CTD |
PMID:16470170 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
Retinaldehyde results in increased expression of ATF4 mRNA |
CTD |
PMID:25331497 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Btc |
betacellulin |
decreases expression |
ISO |
Retinaldehyde results in decreased expression of BTC mRNA |
CTD |
PMID:16470170 |
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NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
Retinaldehyde results in increased activity of CASP3 protein |
CTD |
PMID:25331497 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[Retinaldehyde co-treated with Dihydrotestosterone] results in increased expression of CYP26A1 mRNA Retinaldehyde results in increased expression of CYP26A1 mRNA |
CTD |
PMID:17526768 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Retinaldehyde results in increased expression of DDIT3 mRNA |
CTD |
PMID:25331497 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dhrs4 |
dehydrogenase/reductase 4 |
increases reduction |
ISO |
DHRS4 protein results in increased reduction of Retinaldehyde |
CTD |
PMID:12680773 |
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NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Retinaldehyde results in increased expression of GCLC mRNA |
CTD |
PMID:25331497 PMID:27751755 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Hbegf |
heparin-binding EGF-like growth factor |
increases expression |
ISO |
Retinaldehyde results in increased expression of HBEGF mRNA |
CTD |
PMID:16470170 |
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NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Retinaldehyde results in increased expression of HMOX1 mRNA |
CTD |
PMID:25331497 PMID:27751755 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Retinaldehyde results in increased expression of HSPA5 protein |
CTD |
PMID:25331497 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression |
ISO |
Retinaldehyde results in increased expression of NFE2L2 mRNA |
CTD |
PMID:25331497 PMID:27751755 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Retinaldehyde results in increased cleavage of PARP1 protein |
CTD |
PMID:25331497 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Retinaldehyde results in increased expression of PPARGC1A mRNA |
CTD |
PMID:23056435 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
Retinaldehyde results in increased expression of PPP1R15A mRNA |
CTD |
PMID:25331497 |
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NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Rbp1 |
retinol binding protein 1 |
multiple interactions |
ISO |
ALDH1A1 protein affects the metabolism of [RBP1 protein binds to Retinaldehyde] |
CTD |
PMID:10559215 |
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NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
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G |
Rdh10 |
retinol dehydrogenase 10 |
increases chemical synthesis |
ISO |
RDH10 protein results in increased chemical synthesis of Retinaldehyde |
CTD |
PMID:17473173 |
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NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
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G |
Rdh12 |
retinol dehydrogenase 12 |
increases metabolic processing |
ISO |
RDH12 protein results in increased metabolism of Retinaldehyde |
CTD |
PMID:16269441 |
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NCBI chr 6:98,015,465...98,028,388
Ensembl chr 6:98,015,465...98,028,388
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G |
Rdh5 |
retinol dehydrogenase 5 |
increases chemical synthesis |
ISO |
RDH5 protein results in increased chemical synthesis of Retinaldehyde |
CTD |
PMID:16968212 |
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NCBI chr 7:1,341,172...1,346,863
Ensembl chr 7:1,340,934...1,351,558
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G |
Rpe65 |
retinoid isomerohydrolase RPE65 |
increases chemical synthesis increases metabolic processing multiple interactions |
ISO EXP |
RPE65 protein results in increased chemical synthesis of Retinaldehyde RPE65 protein results in increased metabolism of Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde [13,17,21-trimethyldocosa-12,16,20-trien-11-one binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [3,7,11-trimethyldodeca-2,6,10-trienoic acid hexadecylamide binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; [Isotretinoin binds to and results in decreased activity of RPE65 protein] which results in decreased abundance of Retinaldehyde; Retinaldehyde inhibits the reaction [RPE65 exon mutant form results in decreased uptake of Manganese] |
CTD |
PMID:16026160 PMID:16411761 PMID:16828753 PMID:17251447 PMID:19060264 |
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NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403
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G |
Sdr16c5 |
short chain dehydrogenase/reductase family 16C, member 5 |
increases reduction increases chemical synthesis |
ISO |
SDR16C5 protein results in increased reduction of Retinaldehyde SDR16C5 protein results in increased chemical synthesis of Retinaldehyde |
CTD |
PMID:18926804 PMID:27793605 |
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NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970
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