reactive oxygen species - Ontology Report

Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]

PMID:8021468

NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880

TNF

tumor necrosis factor

multiple interactions
increases abundance

manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Vitamin E inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]

PMID:14973143

NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425

hydrogen peroxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CLDN4

claudin 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]

NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145

MAPK1

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]

NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998

MAPK3

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425

MAPK8

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]

NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401

MAPK9

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]

NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119

SOD2

superoxide dismutase 2

multiple interactions
decreases activity

Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein]