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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:radical
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Accession:CHEBI:26519 term browser browse the term
Definition:A molecular entity possessing an unpaired electron.
Synonyms:related_synonym: Radikal;   Radikale;   free radical;   freies Radikal;   radical libre;   radicales libres;   radicals


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4-hydroxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
hydroxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MT3 metallothionein 3 multiple interactions EXP MT3 protein binds to and affects the metabolism of Hydroxyl Radical CTD PMID:12680700 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131 		JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 multiple interactions EXP ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide] CTD PMID:12672649 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G AGT angiotensinogen affects activity EXP Nitric Oxide affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Nitric Oxide results in increased phosphorylation of and results in decreased activity of BCL2 protein CTD PMID:16039061 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G CAPN1 calpain 1 decreases expression EXP Nitric Oxide results in decreased expression of CAPN1 mRNA CTD PMID:9728040 NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684 		JBrowse link
G EDN1 endothelin 1 increases abundance
multiple interactions		 EXP EDN1 protein results in increased abundance of Nitric Oxide
Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]		 CTD PMID:12672649 PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G KNG1 kininogen 1 multiple interactions
increases abundance		 EXP ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide] CTD PMID:12672649 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP Resveratrol inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:20825639 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
decreases activity		 EXP TXNRD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein] CTD PMID:8810647 PMID:10823391 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G TAC1 tachykinin precursor 1 increases abundance EXP TAC1 protein results in increased abundance of Nitric Oxide CTD PMID:12672649 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523 		JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions EXP TXNRD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein] CTD PMID:8810647 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219 		JBrowse link
superoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MT3 metallothionein 3 multiple interactions EXP MT3 protein binds to and affects the metabolism of Superoxides CTD PMID:12680700 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions EXP Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein] CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5177
    chemical entity 5177
      molecular entity 5176
        radical 14
          inorganic radical + 13
          organic radical + 2
          radical ion + 3
paths to the root