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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quinoline alkaloid
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Accession:CHEBI:26509 term browser browse the term
Synonyms:related_synonym: quinoline alkaloids

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3-hydroxyquinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects chemical synthesis ISO CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine CTD PMID:15896247 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
camptothecin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of ABCB1 mRNA; Camptothecin results in decreased expression of ABCB1 protein
Camptothecin inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]		 CTD PMID:10692111 PMID:29356861 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance
multiple interactions		 ISO ABCC1 protein results in decreased susceptibility to Camptothecin analog
Camptothecin inhibits the reaction [ABCC1 results in decreased susceptibility to Daunorubicin]		 CTD PMID:11778547 PMID:12115804 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Acvr1b activin A receptor type 1B increases methylation ISO Camptothecin results in increased methylation of ACVR1B gene CTD PMID:30720231 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 decreases response to substance ISO ADAM19 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582 		JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 increases methylation ISO Camptothecin results in increased methylation of AGAP1 gene CTD PMID:30720231 NCBI chr 9:96,718,901...97,034,400
Ensembl chr 9:96,621,586...97,030,163 		JBrowse link
G Agrn agrin increases expression ISO Camptothecin results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645 		JBrowse link
G Agrp agouti related neuropeptide decreases response to substance ISO AGRP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011 		JBrowse link
G Aifm3 apoptosis inducing factor, mitochondria associated 3 decreases response to substance ISO AIFM3 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr11:87,364,452...87,380,705
Ensembl chr11:87,366,621...87,380,704 		JBrowse link
G Akap13 A-kinase anchoring protein 13 decreases response to substance ISO AKAP13 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
increases phosphorylation
multiple interactions		 ISO Camptothecin affects the phosphorylation of AKT1 protein
Camptothecin results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]		 CTD PMID:24095863 PMID:30851366 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO Camptothecin analog binds to ALB protein; Camptothecin binds to ALB protein
CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein]		 CTD PMID:10803926 PMID:17378599 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases methylation ISO Camptothecin results in decreased methylation of ALMS1 gene CTD PMID:30720231 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198 		JBrowse link
G Anxa4 annexin A4 increases expression ISO Camptothecin results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases methylation ISO Camptothecin results in increased methylation of APC gene CTD PMID:30720231 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531 		JBrowse link
G Ar androgen receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Artn artemin decreases response to substance ISO ARTN mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:136,759,717...136,765,036
Ensembl chr 5:136,759,717...136,762,986 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein] CTD PMID:30266318 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of ATG7 protein] CTD PMID:30266318 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression
increases expression
multiple interactions		 ISO Camptothecin results in decreased expression of ATM mRNA
Camptothecin results in increased expression of ATM protein modified form
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]		 CTD PMID:24792648 PMID:30720231 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance
increases phosphorylation
multiple interactions		 ISO ATR mRNA results in decreased susceptibility to Camptothecin; ATR protein results in decreased susceptibility to Camptothecin
Camptothecin results in increased phosphorylation of ATR protein
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased phosphorylation of ATR protein]		 CTD PMID:25269479 PMID:30555576 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
decreases expression		 ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAK1 mRNA] CTD PMID:30581319 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
increases activity		 ISO
EXP		 [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in decreased expression of BAX protein; Camptothecin affects the cleavage of and results in decreased expression of BAX protein; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BAX mRNA]
Camptothecin results in decreased expression of BAX mRNA; Camptothecin results in decreased expression of BAX protein
pifithrin inhibits the reaction [Camptothecin results in increased expression of BAX protein]
Camptothecin results in increased activity of BAX protein		 CTD PMID:11279278 PMID:15665116 PMID:17555331 PMID:19481069 PMID:30581319 PMID:30885713 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 affects response to substance ISO BBC3 protein affects the susceptibility to Camptothecin CTD PMID:20477944 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
decreases response to substance		 ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in decreased expression of BCL2 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2 mRNA]
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]
Camptothecin results in increased expression of BCL2 mRNA
Camptothecin results in decreased expression of BCL2 mRNA; Camptothecin results in decreased expression of BCL2 protein
BCL2 results in decreased susceptibility to Camptothecin		 CTD PMID:9664115 PMID:10692111 PMID:10896673 PMID:19481069 PMID:24726431 PMID:25449198 PMID:30581319 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases response to substance
decreases expression
multiple interactions
increases expression		 EXP
ISO		 BCL2L1 gene mutant form results in decreased susceptibility to Camptothecin
Camptothecin results in decreased expression of BCL2L1 mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 mRNA]
BCL2L1 mRNA results in decreased susceptibility to Camptothecin
Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]; Mifepristone affects the reaction [Dexamethasone inhibits the reaction [Camptothecin results in decreased expression of BCL2L1 protein alternative form]]; Naphthoquinones analog promotes the reaction [Camptothecin results in increased expression of BCL2L1 protein]		 CTD PMID:10970895 PMID:19339209 PMID:19497415 PMID:25269479 PMID:30581319 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO Egtazic Acid inhibits the reaction [Camptothecin results in increased expression of BECN1 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; staurosporine aglycone inhibits the reaction [Camptothecin results in increased expression of BECN1 protein] CTD PMID:30266318 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Camptothecin co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased cleavage of and results in decreased expression of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; Camptothecin results in increased cleavage of and results in decreased expression of BID protein CTD PMID:19481069 PMID:19633536 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
increases expression		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of BIRC5 protein; [Folic Acid co-treated with Camptothecin] results in decreased expression of BIRC5 mRNA
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein]
Camptothecin results in decreased expression of BIRC5 mRNA
Camptothecin results in increased expression of BIRC5 mRNA		 CTD PMID:16061681 PMID:24726431 PMID:25449198 PMID:30581319 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of BRCA1 mRNA
BRCA1 mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:10344722 PMID:25269479 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO Camptothecin results in decreased expression of BRCA2 mRNA CTD PMID:10344722 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO Camptothecin results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040 		JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Camptothecin results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778 		JBrowse link
G Casp2 caspase 2 increases splicing
increases expression		 ISO Camptothecin results in increased splicing of CASP2 mRNA
Camptothecin results in increased expression of CASP2 mRNA alternative form		 CTD PMID:14757846 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP3 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Camptothecin promotes the reaction [15-deoxyprostaglandin J2 results in increased activity of CASP3 protein]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]
Cadmium Chloride inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Cadmium inhibits the reaction [Camptothecin results in increased cleavage of CASP3 protein]; Dexamethasone inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of CASP3 protein]		 CTD PMID:10896673 PMID:15862279 PMID:15958570 PMID:16263807 PMID:16273314 PMID:16756956 PMID:16962673 PMID:18506790 PMID:19339209 PMID:19481069 PMID:19497415 PMID:19633536 PMID:21683069 PMID:22302033 PMID:24726431 PMID:24792648 PMID:25412314 PMID:25592883 PMID:25843524 PMID:29384525 PMID:30720231 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions
decreases expression
increases activity		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Camptothecin results in increased activity of CASP7 protein]
Camptothecin results in decreased expression of CASP7 mRNA		 CTD PMID:22302033 PMID:24726431 PMID:30581319 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression
increases expression
increases activity
affects cleavage		 ISO
EXP		 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]
Camptothecin results in decreased expression of CASP8 mRNA
Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]
Camptothecin affects the cleavage of CASP8 protein		 CTD PMID:10896673 PMID:15475000 PMID:15958570 PMID:19497415 PMID:19633536 PMID:30581319 PMID:30885713 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity		 ISO
EXP		 [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]
Camptothecin results in decreased expression of CASP9 mRNA
Camptothecin results in increased cleavage of CASP9 protein
Camptothecin results in increased activity of CASP9 protein
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of CASP9 protein]; Cadmium Chloride inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Cadmium inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]; Naphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP9 protein]		 CTD PMID:10896673 PMID:15958570 PMID:16263807 PMID:19497415 PMID:19633536 PMID:24823293 PMID:30581319 PMID:30885713 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cav1 caveolin 1 decreases methylation ISO Camptothecin results in decreased methylation of CAV1 gene CTD PMID:30720231 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Camptothecin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Camptothecin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Camptothecin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression		 ISO [Folic Acid co-treated with Camptothecin] results in decreased expression of CCNA2 mRNA
Camptothecin results in decreased expression of CCNA2 mRNA		 CTD PMID:30581319 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
increases expression		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of CCNB1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]
Camptothecin results in decreased expression of CCNB1 protein		 CTD PMID:16061681 PMID:23376119 PMID:30851366 PMID:30885713 PMID:31255635 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 affects localization ISO Camptothecin affects the localization of CCND1 protein CTD PMID:14647467 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Camptothecin results in increased expression of CCNE1 protein CTD PMID:30851366 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein] CTD PMID:30885713 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Camptothecin results in increased expression of and results in increased activity of CDK1 protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein] CTD PMID:30885713 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Camptothecin results in increased phosphorylation of and results in decreased activity of CDK2 protein CTD PMID:15141020 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Camptothecin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A protein affects the reaction [Camptothecin results in increased activity of CDK1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of CDKN1A mRNA; Camptothecin results in increased expression of CDKN1A protein		 CTD PMID:9673414 PMID:17555331 PMID:19212664 PMID:24211769 PMID:30022047 PMID:30851366 PMID:30885713 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Camptothecin results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Camptothecin results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr 6:1,516,804...1,534,488
Ensembl chr 6:1,516,804...1,534,488 		JBrowse link
G Cep85l centrosomal protein 85-like increases methylation ISO Camptothecin results in increased methylation of CEP85L gene CTD PMID:30720231 NCBI chr20:34,574,043...34,743,142
Ensembl chr20:34,575,950...34,684,418 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] CTD PMID:25449198 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases response to substance
increases expression		 ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
CHEK1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in increased expression of CHEK1 protein modified form
3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK1 protein modified form]		 CTD PMID:21646468 PMID:22403396 PMID:25269479 PMID:30555576 PMID:30720231 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
increases phosphorylation		 ISO Camptothecin results in increased expression of CHEK2 protein modified form
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of CHEK2 protein modified form]
Camptothecin results in increased phosphorylation of CHEK2 protein		 CTD PMID:21646468 PMID:25269479 PMID:25977998 PMID:30720231 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Clptm1l CLPTM1-like increases response to substance ISO CLPTM1L mutant form results in increased susceptibility to Camptothecin CTD PMID:22675468 NCBI chr 1:32,281,207...32,297,196
Ensembl chr 1:32,281,207...32,297,190 		JBrowse link
G Crebbp CREB binding protein multiple interactions EXP Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]] CTD PMID:13679428 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Crx cone-rod homeobox decreases response to substance ISO CRX mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:77,744,593...77,758,913
Ensembl chr 1:77,745,288...77,750,960 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO CTSB protein results in increased cleavage of [Camptothecin analog binds to ALB protein] CTD PMID:17378599 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
affects localization		 ISO 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin affects the localization of CYCS protein] CTD PMID:19481069 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases response to substance ISO CYP26B1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of CYP2B6 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]		 CTD PMID:29356861 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of CYP2C8 mRNA
Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP2C8 mRNA]		 CTD PMID:29356861 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:29356861 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
increases expression		 ISO Folic Acid inhibits the reaction [Camptothecin results in decreased expression of DDIT3 mRNA]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein] CTD PMID:30266318 PMID:30581319 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Dgkz diacylglycerol kinase zeta decreases response to substance ISO DGKZ mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases activity
decreases expression		 ISO Camptothecin inhibits the reaction [Fluorouracil results in increased expression of DPYD mRNA]
Camptothecin results in decreased activity of DPYD protein
Camptothecin results in decreased expression of DPYD mRNA		 CTD PMID:16568373 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression		 ISO 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO Camptothecin results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:30266318 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 ISO
EXP		 Camptothecin results in increased phosphorylation of EIF2S1 protein
[Camptothecin co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein
EIF2S1 protein affects the reaction [Camptothecin results in increased expression of ATG7 protein]; EIF2S1 protein affects the reaction [Camptothecin results in increased expression of BECN1 protein]; Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:19046382 PMID:30266318 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO Camptothecin results in decreased expression of EP300 mRNA; Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Epm2aip1 EPM2A interacting protein 1 increases expression ISO Camptothecin results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 8:119,524,039...119,531,387
Ensembl chr 8:119,524,039...119,531,387 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression		 ISO ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
Camptothecin results in decreased expression of ERCC1 mRNA		 CTD PMID:21227924 PMID:24792648 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases response to substance		 ISO ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]
ERCC4 protein results in decreased susceptibility to Camptothecin		 CTD PMID:21227924 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR1 protein; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of ATM protein modified form]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]] CTD PMID:25752796 PMID:30720231 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Camptothecin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased activity of CASP9 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of BID protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP3 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP9 protein; Camptothecin results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 PMID:15958570 PMID:19633536 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Camptothecin results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448 		JBrowse link
G Fxn frataxin increases expression ISO Camptothecin results in increased expression of FXN protein CTD PMID:23418481 NCBI chr 1:242,123,975...242,152,834
Ensembl chr 1:242,123,975...242,152,834 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases methylation ISO Camptothecin results in decreased methylation of FZD1 gene CTD PMID:30720231 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262 		JBrowse link
G Fzd8 frizzled class receptor 8 decreases methylation ISO Camptothecin results in decreased methylation of FZD8 gene CTD PMID:30720231 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression
multiple interactions		 ISO Camptothecin results in decreased expression of GADD45A mRNA
Folic Acid inhibits the reaction [Camptothecin results in decreased expression of GADD45A mRNA]		 CTD PMID:24792648 PMID:30581319 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO Camptothecin results in increased expression of GADD45G mRNA CTD PMID:24792648 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Git2 GIT ArfGAP 2 decreases response to substance ISO GIT2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:47,590,110...47,630,991
Ensembl chr12:47,590,154...47,631,119 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
decreases response to substance		 ISO Camptothecin results in increased expression of GSTP1 protein
GSTP1 protein polymorphism results in decreased susceptibility to Camptothecin; GSTP1 protein results in decreased susceptibility to Camptothecin		 CTD PMID:14732228 PMID:15500952 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; ERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; ESR1 promotes the reaction [Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]]; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin]; palbociclib inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]; TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]]; veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]
Camptothecin results in increased phosphorylation of H2AX protein
Camptothecin results in increased expression of H2AX protein; Camptothecin results in increased expression of H2AX protein modified form		 CTD PMID:17875725 PMID:21227924 PMID:21646468 PMID:21693595 PMID:22302033 PMID:25269479 PMID:25772433 PMID:26928355 PMID:30720231 PMID:32482060 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Camptothecin results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hemk1 HemK methyltransferase family member 1 decreases response to substance ISO HEMK1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:116,081,858...116,092,872
Ensembl chr 8:116,082,005...116,092,763 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [HNRNPC protein binds to HNRNPC protein alternative form] which results in decreased susceptibility to Camptothecin CTD PMID:16960656 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353 		JBrowse link
G Hoxa1 homeobox A1 decreases response to substance
multiple interactions		 ISO HOXA1 mRNA results in decreased susceptibility to Camptothecin
Camptothecin inhibits the reaction [Vitamin A results in increased expression of HOXA1]		 CTD PMID:25269479 PMID:26820057 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066 		JBrowse link
G Ibsp integrin-binding sialoprotein decreases response to substance ISO IBSP mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945 		JBrowse link
G Il1b interleukin 1 beta decreases response to substance ISO IL1B protein results in decreased susceptibility to Camptothecin CTD PMID:16356833 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Camptothecin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
increases phosphorylation		 ISO
EXP		 Camptothecin results in increased expression of JUN protein
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:9751194 PMID:15585644 PMID:30266318 PMID:30885713 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 decreases response to substance ISO KCNK2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr13:107,690,111...107,886,476
Ensembl chr13:107,690,087...107,886,476 		JBrowse link
G Lgals1 galectin 1 decreases expression ISO Camptothecin results in decreased expression of LGALS1 mRNA; Camptothecin results in decreased expression of LGALS1 protein CTD PMID:19483324 NCBI chr 7:120,153,184...120,156,290
Ensembl chr 7:120,153,184...120,156,289 		JBrowse link
G Lrch4 leucine rich repeats and calponin homology domain containing 4 decreases response to substance ISO LRCH4 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:22,127,387...22,138,436
Ensembl chr12:22,127,393...22,138,382 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 multiple interactions
increases expression		 ISO Camptothecin promotes the reaction [MAD2L1 protein binds to CDC20 protein]; CDKN1A protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of and results in increased activity of CDK1 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP9 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]
Camptothecin results in increased expression of MAD2L1 mRNA; Camptothecin results in increased expression of MAD2L1 protein		 CTD PMID:30885713 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 increases expression ISO Camptothecin results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Camptothecin results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases response to substance ISO MAP3K7 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein CTD PMID:24095863 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein CTD PMID:24095863 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Camptothecin results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CCNB1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of CDK1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased expression of MAD2L1 protein]; MAPK8 protein affects the reaction [Camptothecin results in increased phosphorylation of JUN protein]		 CTD PMID:30885713 PMID:31255635 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Camptothecin results in increased phosphorylation of MAPK9 protein CTD PMID:15585644 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Camptothecin results in decreased expression of MAPT mRNA; Camptothecin results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Aminacrine inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]; Camptothecin results in increased activity of and affects the localization of MDC1 protein; Propyl Gallate inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Camptothecin results in increased expression of MDM2 protein CTD PMID:17555331 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Camptothecin results in decreased expression of MGMT mRNA CTD PMID:18492797 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions
increases response to substance		 ISO [MIR138-1 results in decreased expression of H2AX] which results in increased susceptibility to Camptothecin; H2AX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin] CTD PMID:21693595 NCBI chr 8:131,731,726...131,731,824
Ensembl chr 8:131,731,726...131,731,824 		JBrowse link
G Mir145 microRNA 145 increases expression
decreases expression		 ISO Camptothecin results in increased expression of MIR145 mRNA
Camptothecin results in decreased expression of MIR145 mRNA		 CTD PMID:24726431 NCBI chr18:56,969,907...56,969,994
Ensembl chr18:56,969,907...56,969,994 		JBrowse link
G Mir34a microRNA 34a increases expression ISO Camptothecin results in increased expression of MIR34A mRNA CTD PMID:24726431 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases response to substance
decreases methylation		 ISO MMP9 mRNA results in decreased susceptibility to Camptothecin
Camptothecin results in decreased methylation of MMP9 gene		 CTD PMID:25269479 PMID:30720231 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Camptothecin results in decreased expression of MRE11 mRNA CTD PMID:24792648 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Mtmr2 myotubularin related protein 2 decreases response to substance ISO MTMR2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Camptothecin results in decreased expression of MTOR protein CTD PMID:31255635 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
affects localization		 ISO Camptothecin results in increased expression of MYC mRNA
Camptothecin results in increased expression of and results in increased activity of MYC protein; MYC protein affects the reaction [Camptothecin results in increased expression of ATF4 protein]; MYC protein affects the reaction [Camptothecin results in increased expression of DDIT3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; MYC protein affects the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]
Camptothecin affects the localization of MYC protein		 CTD PMID:30266318 PMID:30851366 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases response to substance ISO NCAM1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358 		JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression ISO Camptothecin results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]] CTD PMID:29356861 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein] CTD PMID:29356861 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases activity		 ISO NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]
Camptothecin results in increased activity of NFE2L2 protein		 CTD PMID:30851366 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Camptothecin inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Camptothecin inhibits the reaction [Rifampin promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Camptothecin inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] CTD PMID:29356861 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Olr1086 olfactory receptor 1086 decreases response to substance ISO OR7C2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:13,698,647...13,699,609
Ensembl chr 7:13,698,647...13,699,609 		JBrowse link
G Olr1514 olfactory receptor 1514 decreases response to substance ISO OR1A2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr10:61,044,411...61,045,355
Ensembl chr10:61,044,411...61,045,355 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
affects response to substance
decreases response to substance
increases cleavage		 ISO
EXP		 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Camptothecin results in increased ADP-ribosylation of and results in increased degradation of PARP1 protein]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; PARP1 protein promotes the reaction [Camptothecin results in increased abundance of Poly Adenosine Diphosphate Ribose]; RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
PARP1 protein affects the susceptibility to Camptothecin
PARP1 results in decreased susceptibility to Camptothecin
Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein]
[Camptothecin co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased cleavage of PARP1 protein; [veliparib results in decreased activity of PARP1 protein] which results in increased susceptibility to Camptothecin		 CTD PMID:11741290 PMID:15585644 PMID:16962673 PMID:18506790 PMID:19559722 PMID:22158865 PMID:23376119 PMID:24095863 PMID:24726431 PMID:24792648 PMID:24823293 PMID:25412314 PMID:25449198 PMID:25843524 PMID:27694308 PMID:29384525 PMID:31255635 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camptothecin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Plk3 polo-like kinase 3 increases expression ISO Camptothecin results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900 		JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B decreases response to substance ISO PPP1R16B mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:155,160,474...155,267,002
Ensembl chr 3:155,160,481...155,262,941 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B decreases response to substance ISO PPP1R1B protein alternative form results in decreased susceptibility to Camptothecin; PPP1R1B protein results in decreased susceptibility to Camptothecin CTD PMID:16061638 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein] CTD PMID:25772433 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha affects localization
decreases response to substance		 ISO Camptothecin affects the localization of PPP2R1A protein
PPP2R1A mRNA results in decreased susceptibility to Camptothecin		 CTD PMID:25269479 PMID:25772433 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions
decreases response to substance		 ISO PPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R2A protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma multiple interactions
increases response to substance		 ISO PPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5C protein results in increased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358 		JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon multiple interactions
decreases response to substance		 ISO Camptothecin affects the localization of [PPP2R5E protein binds to PPP2CA protein]; PPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form]
PPP2R5E protein results in decreased susceptibility to Camptothecin		 CTD PMID:25772433 NCBI chr 6:98,417,974...98,567,016
Ensembl chr 6:98,417,974...98,566,966 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Camptothecin results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746 		JBrowse link
G Ptar1 protein prenyltransferase alpha subunit repeat containing 1 decreases response to substance ISO PTAR1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:241,501,679...241,557,651
Ensembl chr 1:241,501,679...241,557,651 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O decreases response to substance ISO PTPRO mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:171,250,766...171,461,571
Ensembl chr 4:171,250,818...171,461,677 		JBrowse link
G Rad50 RAD50 double strand break repair protein decreases expression ISO Camptothecin results in decreased expression of RAD50 mRNA CTD PMID:24792648 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO Camptothecin results in decreased expression of RAD51 mRNA; Camptothecin results in decreased expression of RAD51 protein CTD PMID:10344722 PMID:24792648 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917 		JBrowse link
G Rad51c RAD51 paralog C increases response to substance ISO RAD51C gene mutant form results in increased susceptibility to Camptothecin CTD PMID:20400963 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472 		JBrowse link
G Rara retinoic acid receptor, alpha increases methylation ISO Camptothecin results in increased methylation of RARA gene CTD PMID:30720231 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation
affects response to substance		 ISO Camptothecin results in increased phosphorylation of RB1 protein
RB1 protein affects the susceptibility to Camptothecin		 CTD PMID:14647467 PMID:14704340 PMID:15064736 PMID:15585644 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Camptothecin results in decreased expression of RBL1 protein CTD PMID:15585644 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions
decreases response to substance		 ISO RBL2 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]
RBL2 protein results in decreased susceptibility to Camptothecin		 CTD PMID:15585644 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases response to substance
multiple interactions		 ISO
EXP		 RELA results in increased susceptibility to Camptothecin
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] affects the localization of and results in increased phosphorylation of RELA protein]
Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin inhibits the reaction [RELA protein binds to CREBBP protein]]		 CTD PMID:13679428 PMID:21737676 PMID:25449198 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ret ret proto-oncogene decreases expression EXP Camptothecin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Rnf31 ring finger protein 31 decreases response to substance ISO RNF31 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr15:34,270,037...34,282,385
Ensembl chr15:34,270,648...34,282,495 		JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Camptothecin results in increased expression of RPS6 protein modified form CTD PMID:29384525 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
increases expression		 ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; 7-hydroxystaurosporine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein]; E2F1 protein promotes the reaction [Camptothecin results in increased expression of RRM2 protein]
Camptothecin results in increased expression of RRM2 mRNA; Camptothecin results in increased expression of RRM2 protein		 CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G Sdc1 syndecan 1 increases expression ISO Camptothecin results in increased expression of SDC1 mRNA CTD PMID:17374387 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016 		JBrowse link
G Sel1l SEL1L adaptor subunit of ERAD E3 ubiquitin ligase decreases response to substance ISO SEL1L mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 6:115,572,683...115,616,904
Ensembl chr 6:115,572,649...115,616,859 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]
Camptothecin results in decreased expression of SIRT1 protein		 CTD PMID:24726431 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases methylation ISO Camptothecin results in increased methylation of SLC2A12 gene CTD PMID:30720231 NCBI chr 1:24,003,625...24,056,373
Ensembl chr 1:24,003,625...24,056,373 		JBrowse link
G Smn1 survival of motor neuron 1, telomeric multiple interactions
increases response to substance		 ISO SMN1 mRNA affects the reaction [Camptothecin results in increased activity of CASP3 protein]
SMN1 protein results in increased susceptibility to Camptothecin		 CTD PMID:15862279 NCBI chr 2:30,360,101...30,371,147
Ensembl chr 2:30,360,100...30,371,147 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression ISO Camptothecin results in increased expression of SMPD3 mRNA CTD PMID:19698806 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO Camptothecin results in increased expression of SOD1 protein
Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD1 protein]		 CTD PMID:30720231 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression		 ISO Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of SOD2 protein] CTD PMID:30720231 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sox11 SRY-box transcription factor 11 increases methylation ISO Camptothecin results in increased methylation of SOX11 gene CTD PMID:30720231 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983 		JBrowse link
G Sox12 SRY-box transcription factor 12 increases methylation ISO Camptothecin results in increased methylation of SOX12 gene CTD PMID:30720231 NCBI chr 3:147,864,374...147,865,393
Ensembl chr 3:147,864,374...147,865,393 		JBrowse link
G Sox17 SRY-box transcription factor 17 increases methylation ISO Camptothecin results in increased methylation of SOX17 gene CTD PMID:30720231 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907 		JBrowse link
G Sox3 SRY-box transcription factor 3 increases methylation ISO Camptothecin results in increased methylation of SOX3 gene CTD PMID:30720231 NCBI chr  X:144,035,162...144,037,364
Ensembl chr  X:144,035,883...144,037,294 		JBrowse link
G Sox4 SRY-box transcription factor 4 increases methylation ISO Camptothecin results in increased methylation of SOX4 gene CTD PMID:30720231 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Sox8 SRY-box transcription factor 8 increases methylation ISO Camptothecin results in increased methylation of SOX8 gene CTD PMID:30720231 NCBI chr10:14,932,348...14,937,336
Ensembl chr10:14,932,348...14,937,336 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression
increases activity		 ISO Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA]; Camptothecin results in increased activity of and affects the localization of SP1 protein; Camptothecin results in increased expression of and results in increased activity of SP1 protein; MAPK8 protein affects the reaction [Camptothecin results in increased activity of SP1 protein]; mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP1 protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein] CTD PMID:11261509 PMID:30851366 PMID:30885713 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sp3 Sp3 transcription factor increases activity
multiple interactions		 ISO Camptothecin results in increased activity of SP3 protein
mithramycin A inhibits the reaction [Camptothecin results in increased activity of SP3 protein]		 CTD PMID:11261509 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases degradation		 ISO ATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Camptothecin results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801 		JBrowse link
G Stambpl1 STAM binding protein-like 1 increases methylation ISO Camptothecin results in increased methylation of STAMBPL1 gene CTD PMID:30720231 NCBI chr 1:252,490,125...252,536,113
Ensembl chr 1:252,497,452...252,536,104 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 decreases response to substance ISO STYXL1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases response to substance ISO TAB2 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:1,999,574...2,017,574
Ensembl chr 1:1,999,596...2,073,896 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Camptothecin results in increased expression of TAP1 mRNA CTD PMID:17374387 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669 		JBrowse link
G Tax1bp3 Tax1 binding protein 3 increases expression ISO Camptothecin results in increased expression of TAX1BP3 mRNA CTD PMID:17374387 NCBI chr10:59,743,356...59,748,063
Ensembl chr10:59,743,544...59,748,062 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 multiple interactions ISO TDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AX protein]; TDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 NCBI chr 6:123,895,860...123,963,688
Ensembl chr 6:123,897,956...123,963,675 		JBrowse link
G Tert telomerase reverse transcriptase increases expression
multiple interactions		 ISO Camptothecin results in increased expression of TERT mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TERT protein]; Camptothecin results in increased expression of and results in increased phosphorylation of TERT protein; Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]; NFE2L2 protein affects the reaction [Camptothecin results in increased expression of TERT mRNA]; TERT protein affects the reaction [Camptothecin results in increased expression of MYC protein]; TERT protein affects the reaction [Camptothecin results in increased expression of SP1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]		 CTD PMID:30851366 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476 		JBrowse link
G Thbs1 thrombospondin 1 decreases expression
decreases secretion
multiple interactions		 ISO Camptothecin results in decreased expression of THBS1 mRNA
Camptothecin results in decreased secretion of THBS1 protein
THBS1 protein inhibits the reaction [Camptothecin results in increased activity of CASP3 protein]; THBS1 protein inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]		 CTD PMID:16962673 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Camptothecin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Camptothecin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Camptothecin results in increased expression of TNFSF9 mRNA CTD PMID:17374387 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276 		JBrowse link
G Top1 DNA topoisomerase I multiple interactions
decreases activity
decreases response to substance		 ISO
EXP		 [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein; [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein
Camptothecin results in decreased activity of TOP1 protein
Camptothecin analog results in decreased activity of TOP1 protein; Camptothecin results in decreased activity of TOP1 protein
TOP1 protein mutant form results in decreased susceptibility to Camptothecin		 CTD PMID:12097280 PMID:18191106 PMID:20600288 PMID:21056033 PMID:21227924 PMID:23376119 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases response to substance
increases phosphorylation
affects response to substance
decreases acetylation
increases expression
increases response to substance
increases activity
increases glutathionylation		 ISO
EXP		 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole promotes the reaction [Camptothecin results in increased expression of TP53 protein]; [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein; Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]; Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased acetylation of TP53 protein]; Camptothecin results in increased stability of and results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; S-ethyl glutathione inhibits the reaction [Camptothecin results in increased expression of TP53 protein modified form]
TP53 mutant form results in decreased susceptibility to Camptothecin; TP53 protein mutant form results in decreased susceptibility to Camptothecin; TP53 protein results in decreased susceptibility to Camptothecin
Camptothecin results in increased phosphorylation of TP53 protein
TRP53 protein affects the susceptibility to Camptothecin
Camptothecin results in decreased acetylation of TP53 protein
TP53 protein results in increased susceptibility to Camptothecin
Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]; pifithrin inhibits the reaction [Camptothecin promotes the reaction [TP53 protein binds to CREBBP protein]]; pifithrin inhibits the reaction [Camptothecin results in increased activity of TP53 protein]
Camptothecin results in increased glutathionylation of TP53 protein		 CTD PMID:9673414 PMID:10692111 PMID:11279278 PMID:11741290 PMID:12082016 PMID:13679428 PMID:17555331 PMID:19481069 PMID:20477944 PMID:20978201 PMID:23285096 PMID:24726431 PMID:25269479 PMID:26657896 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Camptothecin results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Camptothecin results in decreased expression of TP63 protein alternative form CTD PMID:23376119 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases response to substance ISO TRAF6 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607 		JBrowse link
G Trim28 tripartite motif-containing 28 increases expression ISO Camptothecin results in increased expression of TRIM28 protein modified form CTD PMID:25977998 NCBI chr 1:65,544,369...65,551,043
Ensembl chr 1:65,544,373...65,551,043 		JBrowse link
G Tsg101 tumor susceptibility 101 decreases response to substance ISO TSG101 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 decreases response to substance ISO TWF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 7:135,838,647...135,850,542
Ensembl chr 7:135,838,648...135,850,542 		JBrowse link
G Tyms thymidylate synthetase increases expression ISO Camptothecin results in increased expression of TYMS mRNA CTD PMID:16568373 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases methylation ISO Camptothecin results in decreased methylation of UGT1A6 gene CTD PMID:30720231 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Upf1 UPF1, RNA helicase and ATPase decreases response to substance ISO UPF1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases response to substance ISO USP5 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
decreases response to substance		 ISO Camptothecin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to Camptothecin		 CTD PMID:16356833 PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases response to substance		 ISO [Butyrates co-treated with Camptothecin] results in decreased expression of XIAP protein; [Camptothecin co-treated with FAS protein] results in decreased expression of XIAP protein
Camptothecin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of XIAP protein]
XIAP protein results in decreased susceptibility to Camptothecin		 CTD PMID:16061681 PMID:16211302 PMID:19633536 PMID:25449198 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO Camptothecin results in decreased expression of XRCC3 mRNA CTD PMID:24792648 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance
increases methylation		 ISO XRCC4 results in decreased susceptibility to Camptothecin
Camptothecin results in increased methylation of XRCC4 gene		 CTD PMID:21785230 PMID:30720231 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365 		JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 decreases response to substance ISO ZAP70 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113 		JBrowse link
G Zc3hc1 zinc finger, C3HC-type containing 1 decreases response to substance ISO ZC3HC1 mRNA results in decreased susceptibility to Camptothecin CTD PMID:25269479 NCBI chr 4:57,684,678...57,706,613
Ensembl chr 4:57,684,678...57,706,613 		JBrowse link
cinchonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO cinchonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO cinchonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
cinchonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression		 ISO cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]
cinchonine analog results in decreased expression of ABCB1 protein; cinchonine results in decreased expression of ABCB1 protein		 CTD PMID:20196146 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO cinchonine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO cinchonine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO cinchonine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
quinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
affects response to substance
decreases expression
affects transport
affects binding
multiple interactions		 ISO ABCB1 protein results in increased transport of Quinidine
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
ABCB1 protein affects the transport of Quinidine
Quinidine binds to ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]		 CTD PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance
affects activity		 ISO
EXP		 ABCB1B protein affects the susceptibility to Quinidine
Quinidine affects the activity of ABCB1B protein		 CTD PMID:12626638 PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Quinidine results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions		 ISO Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1b adrenoceptor alpha 1B affects binding
multiple interactions		 ISO Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
multiple interactions		 ISO Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Quinidine results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Quinidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Cat catalase increases expression ISO Quinidine results in increased expression of CAT protein CTD PMID:12708743 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Quinidine results in increased expression of CDKN1A protein CTD PMID:12243503 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression EXP Quinidine results in increased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein		 CTD PMID:18420780 PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein		 CTD PMID:15916432 PMID:19053182 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity
multiple interactions		 EXP
ISO		 Quinidine results in decreased activity of CYP2C6V1 protein
Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]		 CTD PMID:12814958 PMID:19053182 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Quinidine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Quinidine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions		 ISO
EXP		 CYP2D6 protein results in increased metabolism of Quinidine
Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]		 CTD PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 PMID:12467917 PMID:12569440 PMID:12814958 PMID:14652237 PMID:15155557 PMID:15306208 PMID:15860655 PMID:16035375 PMID:16595712 PMID:17702393 PMID:18238857 PMID:18420780 PMID:19230594 PMID:19328226 PMID:20345925 PMID:20590588 PMID:20669986 PMID:21277363 PMID:21336516 PMID:21915887 PMID:23850985 PMID:24167220 PMID:26599973 PMID:28119166 PMID:28887089 PMID:31515991 PMID:32198085 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Quinidine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
affects metabolic processing		 ISO Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Quinidine		 CTD PMID:2271712 PMID:15784650 PMID:19230594 PMID:19299527 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Quinidine results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Quinidine results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Quinidine results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763 		JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Quinidine results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Quinidine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Quinidine results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity		 ISO Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein		 CTD PMID:11807801 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression EXP Quinidine results in increased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Quinidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance		 ISO [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine		 CTD PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18701618 PMID:18724381 PMID:19583963 PMID:21158687 PMID:21362439 PMID:22020101 PMID:24052561 PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 multiple interactions ISO Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium] CTD PMID:16847696 NCBI chr19:58,823,836...58,862,926
Ensembl chr19:58,823,814...58,862,926 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:280,383,579...280,397,784
Ensembl chr 1:280,383,579...280,397,784 		JBrowse link
G Kcnk9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 7:113,894,918...113,938,397
Ensembl chr 7:113,903,557...113,937,941 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Quinidine results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464 		JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Quinidine results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression EXP Quinidine results in decreased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Quinidine results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Quinidine results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Quinidine results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592 		JBrowse link
G Ptma prothymosin alpha decreases expression EXP Quinidine results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Quinidine results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A gene mutant form affects the susceptibility to Quinidine CTD PMID:17805561 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP
ISO		 [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]		 CTD PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16141367 PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Quinidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions		 ISO Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:16928787 PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Tagln transgelin decreases expression ISO Quinidine results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Quinidine results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Quinidine results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 decreases expression ISO Quinidine results in decreased expression of TNFRSF8 protein CTD PMID:12441127 NCBI chr 5:163,186,349...163,231,578
Ensembl chr 5:163,186,349...163,231,578 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Quinidine results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
quinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects uptake ISO ABCB1 protein affects the uptake of Quinine analog CTD PMID:11934808 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects uptake EXP ABCB1B protein affects the uptake of Quinine analog CTD PMID:11934808 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Quinine affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression		 ISO Quinine results in increased activity of CYP1A1 protein
Quinine results in increased expression of CYP1A1 mRNA		 CTD PMID:12451431 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Quinine results in increased expression of CYP1A2 mRNA CTD PMID:12451431 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions		 EXP
ISO		 Quinine results in decreased activity of CYP2C11 protein
Quinine inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]
Quinine results in decreased activity of CYP2C9 protein		 CTD PMID:11124226 PMID:12814958 PMID:15879494 PMID:16081671 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP
ISO		 Quinine results in decreased activity of CYP2C6V1 protein
Quinine results in decreased activity of CYP2C19 protein		 CTD PMID:11124226 PMID:12814958 PMID:15879494 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 decreases activity
multiple interactions		 EXP Quinine results in decreased activity of CYP2D2 protein
Quinine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]		 CTD PMID:12814958 PMID:19858067 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
affects metabolic processing		 ISO Quinine results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Quinine		 CTD PMID:11124226 PMID:12920490 PMID:15896247 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 affects response to substance EXP GRM1 protein affects the susceptibility to Quinine CTD PMID:19174448 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Quinine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity		 ISO Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinine results in decreased activity of GSTP1 protein		 CTD PMID:11807801 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects response to substance
decreases activity		 ISO KCNH2 gene SNP affects the susceptibility to Quinine
Quinine results in decreased activity of KCNH2 protein		 CTD PMID:12695533 PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Quinine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:280,383,579...280,397,784
Ensembl chr 1:280,383,579...280,397,784 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
decreases activity		 EXP
ISO		 Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Quinine
[Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir; Quinine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A1; Quinine results in decreased activity of SLC22A1 protein		 CTD PMID:16142924 PMID:16263091 PMID:19357179 PMID:25844889 PMID:27504015 PMID:31830554 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO Quinine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Quinine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]
Quinine results in decreased activity of SLC22A2 protein		 CTD PMID:16263091 PMID:19357179 PMID:21599003 PMID:27504015 PMID:31830554 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Quinine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Quinine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium] CTD PMID:16263091 PMID:19357179 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Quinine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Quinine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Slc9a7 solute carrier family 9 member A7 decreases activity ISO Quinine results in decreased activity of SLC9A7 protein CTD PMID:11279194 NCBI chr  X:2,434,918...2,615,936
Ensembl chr  X:2,435,305...2,614,770 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases activity
increases uptake
multiple interactions		 EXP
ISO		 Quinine results in decreased activity of SLCO1A4 protein
SLCO1A2 protein results in increased uptake of Quinine
naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]; Quinine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]		 CTD PMID:11883641 PMID:27504015 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Quinine
Quinine inhibits the reaction [TNF protein results in increased transport of Potassium]		 CTD PMID:10783394 PMID:19362101 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Strychnine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions		 ISO Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]		 CTD PMID:9495826 PMID:15647330 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP
ISO		 Strychnine binds to CHRM3 protein CTD PMID:12435818 PMID:15647330 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9495826 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Strychnine results in increased expression of and results in increased degradation of CYP2B1 protein CTD PMID:7906730 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Strychnine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Strychnine results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions
decreases activity		 ISO
EXP		 Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Strychnine results in decreased activity of GLRA1 protein
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]		 CTD PMID:7752562 PMID:15081878 PMID:16687139 PMID:20719748 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651 		JBrowse link
G Glra2 glycine receptor, alpha 2 decreases activity EXP Strychnine results in decreased activity of GLRA2 protein CTD PMID:7752562 NCBI chr  X:30,612,894...30,832,078
Ensembl chr  X:30,612,903...30,831,483 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO Strychnine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          metabolite 19319
            alkaloid 5366
              quinoline alkaloid 265
                (-)-tortuosamine 0
                acronidine 0
                acronycidine 0
                acrophylline 0
                benzastatin C 0
                beta-obscurine 0
                camptothecin 201
                cinchona alkaloid + 65
                jineol 0
                robustine 0
                strychnidine + 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      p-block molecular entity 19744
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            heteroorganic entity 19229
                              organonitrogen compound 18395
                                alkaloid 5366
                                  quinoline alkaloid 265
                                    (-)-tortuosamine 0
                                    acronidine 0
                                    acronycidine 0
                                    acrophylline 0
                                    benzastatin C 0
                                    beta-obscurine 0
                                    camptothecin 201
                                    cinchona alkaloid + 65
                                    jineol 0
                                    robustine 0
                                    strychnidine + 13
paths to the root