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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyridazinone
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Accession:CHEBI:26414 term browser browse the term
Synonyms:related_synonym: pyridazinones



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Maleic hydrazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity ISO Maleic Hydrazide results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases activity ISO Maleic Hydrazide results in decreased activity of IMPDH2 protein CTD PMID:11370715 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Maleic Hydrazide co-treated with Chlorpropham] results in increased activity of NR1I2 protein CTD PMID:25028461 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone; CYP2B6 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:15853388 PMID:16608219 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to [norflurazone co-treated with metolachlor co-treated with Atrazine]; [CYP1A1 protein co-treated with CYP2B6 protein co-treated with CYP2C19 protein] results in decreased susceptibility to norflurazone CTD PMID:16608219 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
pimobendan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation ISO CYP3A4 protein results in decreased methylation of pimobendan CTD PMID:10611143 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO pimobendan promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
pimobendan results in decreased expression of IL1B protein
CTD PMID:9004165 PMID:10193745 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of IL6 protein
pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:9004165 PMID:10193745 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO pimobendan results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO pimobendan results in decreased expression of NOS2 mRNA
[pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide
CTD PMID:10193745 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO pimobendan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
pimobendan results in decreased expression of TNF protein
CTD PMID:9004165 PMID:10193745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
pyridaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco2 aconitase 2 decreases activity EXP pyridaben results in decreased activity of ACO2 protein CTD PMID:26141520 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 increases expression ISO pyridaben results in increased expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases expression ISO pyridaben results in increased expression of ADCYAP1 mRNA CTD PMID:22563483 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Ago3 argonaute RISC catalytic component 3 increases expression ISO pyridaben results in increased expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
JBrowse link
G Amn amnion associated transmembrane protein decreases expression ISO pyridaben results in decreased expression of AMN mRNA CTD PMID:22563483 NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815
JBrowse link
G Ar androgen receptor multiple interactions ISO pyridaben inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atoh7 atonal bHLH transcription factor 7 decreases expression ISO pyridaben results in decreased expression of ATOH7 mRNA CTD PMID:22563483 NCBI chr20:25,530,826...25,531,275
Ensembl chr20:25,530,826...25,531,275
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases response to substance
multiple interactions
ISO BCL2 protein results in decreased susceptibility to pyridaben
PK 11195 inhibits the reaction [BCL2 protein results in decreased susceptibility to pyridaben]
CTD PMID:12730627 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO pyridaben results in increased expression of BCL2A1 mRNA CTD PMID:22563483 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bicd1 BICD cargo adaptor 1 increases expression ISO pyridaben results in increased expression of BICD1 mRNA CTD PMID:22563483 NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
JBrowse link
G C2cd4d C2 calcium-dependent domain containing 4D decreases expression ISO pyridaben results in decreased expression of C2CD4D mRNA CTD PMID:22563483 NCBI chr 2:181,997,393...182,001,938
Ensembl chr 2:181,997,078...182,002,087
JBrowse link
G Cabyr calcium binding tyrosine phosphorylation regulated increases expression ISO pyridaben results in increased expression of CABYR mRNA CTD PMID:22563483 NCBI chr18:3,892,062...3,904,391
Ensembl chr18:3,892,132...3,903,840
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E increases expression ISO pyridaben results in increased expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO pyridaben results in increased expression of CAMP mRNA CTD PMID:22563483 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Capn11 calpain 11 decreases expression ISO pyridaben results in decreased expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO pyridaben results in increased expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO pyridaben results in increased expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 increases expression ISO pyridaben results in increased expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Cdhr4 cadherin-related family member 4 decreases expression ISO pyridaben results in decreased expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 8:108,682,594...108,690,358 JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO pyridaben results in decreased expression of CEBPD mRNA CTD PMID:22563483 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO pyridaben results in increased expression of CEP290 mRNA CTD PMID:22563483 NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392
JBrowse link
G Cldn3 claudin 3 decreases expression ISO pyridaben results in decreased expression of CLDN3 mRNA CTD PMID:22563483 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Crlf2 cytokine receptor-like factor 2 decreases expression ISO pyridaben results in decreased expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642
JBrowse link
G Dgki diacylglycerol kinase, iota increases expression ISO pyridaben results in increased expression of DGKI mRNA CTD PMID:22563483 NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733
JBrowse link
G Dip2b disco-interacting protein 2 homolog B increases expression ISO pyridaben results in increased expression of DIP2B mRNA CTD PMID:22563483 NCBI chr 7:131,174,575...131,350,417
Ensembl chr 7:131,174,567...131,349,092
JBrowse link
G Dmrta2 DMRT-like family A2 decreases expression ISO pyridaben results in decreased expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630
JBrowse link
G Drd4 dopamine receptor D4 decreases expression ISO pyridaben results in decreased expression of DRD4 mRNA CTD PMID:22563483 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Egr4 early growth response 4 decreases expression ISO pyridaben results in decreased expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Elane elastase, neutrophil expressed increases expression ISO pyridaben results in increased expression of ELANE mRNA CTD PMID:22563483 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
ISO pyridaben results in increased activity of ESR1 protein
pyridaben binds to and results in increased activity of ESR1 protein; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]
CTD PMID:20143881 PMID:30818834 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; pyridaben inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Etl4 enhancer trap locus 4 increases expression ISO pyridaben results in increased expression of ETL4 mRNA CTD PMID:22563483 NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715
JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO pyridaben results in decreased expression of H2BC9 mRNA CTD PMID:22563483 NCBI chr17:42,470,593...42,478,605 JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO pyridaben results in decreased expression of H3C1 mRNA CTD PMID:22563483 NCBI chr17:41,367,824...41,368,902 JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [pyridaben results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hmx3 H6 family homeobox 3 decreases expression ISO pyridaben results in decreased expression of HMX3 mRNA CTD PMID:22563483 NCBI chr 1:186,313,237...186,315,201
Ensembl chr 1:186,313,063...186,315,201
JBrowse link
G Hs3st6 heparan sulfate-glucosamine 3-sulfotransferase 6 decreases expression ISO pyridaben results in decreased expression of HS3ST6 mRNA CTD PMID:22563483 NCBI chr10:13,781,999...13,788,133
Ensembl chr10:13,781,993...13,788,133
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO pyridaben results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO pyridaben results in increased expression of INHBA mRNA CTD PMID:22563483 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Insl3 insulin-like 3 decreases expression ISO pyridaben results in decreased expression of INSL3 mRNA CTD PMID:22563483 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression ISO pyridaben results in increased expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr 6:140,124,997...140,208,254
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Kcna2 potassium voltage-gated channel subfamily A member 2 increases expression ISO pyridaben results in increased expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 increases expression ISO pyridaben results in increased expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kif1b kinesin family member 1B increases expression ISO pyridaben results in increased expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression ISO pyridaben results in decreased expression of KLF2 mRNA CTD PMID:22563483 NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klhl15 kelch-like family member 15 increases expression ISO pyridaben results in increased expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:58,994,726...59,050,207
Ensembl chr  X:58,995,461...59,046,069
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO pyridaben results in increased expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lifr LIF receptor subunit alpha increases expression ISO pyridaben results in increased expression of LIFR mRNA CTD PMID:22563483 NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
JBrowse link
G Lrp4 LDL receptor related protein 4 increases expression ISO pyridaben results in increased expression of LRP4 mRNA CTD PMID:22563483 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
JBrowse link
G Lrrc63 leucine rich repeat containing 63 decreases expression ISO pyridaben results in decreased expression of LRRC63 mRNA CTD PMID:22563483 NCBI chr15:50,400,199...50,437,321
Ensembl chr15:50,400,200...50,437,321
JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 decreases expression ISO pyridaben results in decreased expression of LTB4R2 mRNA CTD PMID:22563483 NCBI chr15:29,258,427...29,260,340
Ensembl chr15:29,259,240...29,260,316
JBrowse link
G Ltf lactotransferrin increases expression ISO pyridaben results in increased expression of LTF mRNA CTD PMID:22563483 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 decreases expression ISO pyridaben results in decreased expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645
JBrowse link
G Marchf9 membrane associated ring-CH-type finger 9 decreases expression ISO pyridaben results in decreased expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr 7:62,879,017...62,882,495 JBrowse link
G Mboat2 membrane bound O-acyltransferase domain containing 2 increases expression ISO pyridaben results in increased expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485
JBrowse link
G Mdfi MyoD family inhibitor decreases expression ISO pyridaben results in decreased expression of MDFI mRNA CTD PMID:22563483 NCBI chr 9:13,156,806...13,175,218
Ensembl chr 9:13,156,866...13,175,217
JBrowse link
G Mpo myeloperoxidase increases expression ISO pyridaben results in increased expression of MPO mRNA CTD PMID:22563483 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrtfb myocardin related transcription factor B increases expression ISO pyridaben results in increased expression of MRTFB mRNA CTD PMID:22563483 NCBI chr10:1,116,315...1,278,106 JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming increases expression ISO pyridaben results in increased expression of MUC6 mRNA CTD PMID:22563483 NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842
JBrowse link
G Myoc myocilin increases expression ISO pyridaben results in increased expression of MYOC mRNA CTD PMID:22563483 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression ISO pyridaben results in increased expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO pyridaben results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfib nuclear factor I/B increases expression ISO pyridaben results in increased expression of NFIB mRNA CTD PMID:22563483 NCBI chr 5:96,759,208...96,973,092
Ensembl chr 5:96,764,653...96,975,479
JBrowse link
G Nipbl NIPBL, cohesin loading factor increases expression ISO pyridaben results in increased expression of NIPBL mRNA CTD PMID:22563483 NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899
JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 decreases response to substance ISO NMNAT3 protein results in decreased susceptibility to pyridaben CTD PMID:18463239 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645
JBrowse link
G Nps neuropeptide S increases expression ISO pyridaben results in increased expression of NPS mRNA CTD PMID:22563483 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyridaben binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO pyridaben results in decreased expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
ISO pyridaben inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
pyridaben results in increased activity of ODC1 protein
CTD PMID:9834970 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide decreases expression ISO pyridaben results in decreased expression of OXT mRNA CTD PMID:22563483 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Park7 Parkinsonism associated deglycase decreases response to substance ISO PARK7 protein results in decreased susceptibility to pyridaben CTD PMID:21219333 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO pyridaben results in increased cleavage of PARP1 protein
[pyridaben co-treated with Paraquat] results in increased cleavage of PARP1 protein
CTD PMID:16237197 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phox2a paired-like homeobox 2a decreases expression ISO pyridaben results in decreased expression of PHOX2A mRNA CTD PMID:22563483 NCBI chr 1:156,178,754...156,183,118
Ensembl chr 1:156,178,754...156,183,118
JBrowse link
G Plce1 phospholipase C, epsilon 1 increases expression ISO pyridaben results in increased expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO pyridaben binds to and results in increased activity of PPARG protein; pyridaben inhibits the reaction [Rosiglitazone results in increased activity of PPARG protein] CTD PMID:30818834 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO pyridaben results in increased expression of PPARGC1A mRNA
pyridaben inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD PMID:22563483 PMID:30818834 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prr7 proline rich 7 (synaptic) decreases expression ISO pyridaben results in decreased expression of PRR7 mRNA CTD PMID:22563483 NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536
JBrowse link
G Retnlb resistin like beta increases expression ISO pyridaben results in increased expression of RETNLB mRNA CTD PMID:22563483 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression ISO pyridaben results in increased expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO pyridaben results in increased expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO pyridaben results in increased expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Shox2 short stature homeobox 2 decreases expression ISO pyridaben results in decreased expression of SHOX2 mRNA CTD PMID:22563483 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression ISO pyridaben results in increased expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Smoc2 SPARC related modular calcium binding 2 increases expression ISO pyridaben results in increased expression of SMOC2 mRNA CTD PMID:22563483 NCBI chr 1:55,262,472...55,391,804
Ensembl chr 1:55,262,530...55,391,693
JBrowse link
G Snca synuclein alpha increases response to substance ISO SNCA protein results in increased susceptibility to pyridaben CTD PMID:16239214 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO pyridaben results in decreased expression of SOCS1 mRNA CTD PMID:22563483 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Ston2 stonin 2 increases expression ISO pyridaben results in increased expression of STON2 mRNA CTD PMID:22563483 NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO pyridaben results in increased expression of STRBP mRNA CTD PMID:22563483 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
JBrowse link
G Tbck TBC1 domain containing kinase increases expression ISO pyridaben results in increased expression of TBCK mRNA CTD PMID:22563483 NCBI chr 2:221,175,749...221,348,126
Ensembl chr 2:221,175,785...221,348,126
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO pyridaben results in decreased expression of TCF15 mRNA CTD PMID:22563483 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO pyridaben binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tmem42 transmembrane protein 42 decreases expression ISO pyridaben results in decreased expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO pyridaben results in increased expression of TNNT2 mRNA CTD PMID:22563483 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Trpm3 transient receptor potential cation channel, subfamily M, member 3 increases expression ISO pyridaben results in increased expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717
JBrowse link
G Tusc1 tumor suppressor candidate 1 decreases expression ISO pyridaben results in decreased expression of TUSC1 mRNA CTD PMID:22563483 NCBI chr 5:108,089,952...108,091,636 JBrowse link
G Ubxn7 UBX domain protein 7 increases expression ISO pyridaben results in increased expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr11:68,427,896...68,460,100 JBrowse link
G Ucn urocortin decreases expression ISO pyridaben results in decreased expression of UCN mRNA CTD PMID:22563483 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
G Unc13c unc-13 homolog C increases expression ISO pyridaben results in increased expression of UNC13C mRNA CTD PMID:22563483 NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223
JBrowse link
G Vdr vitamin D receptor increases activity ISO pyridaben results in increased activity of VDR protein CTD PMID:20143881 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 increases expression ISO pyridaben results in increased expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163
JBrowse link
G Zfp580 zinc finger protein 580 decreases expression ISO pyridaben results in decreased expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr 1:68,787,118...68,789,286
Ensembl chr 1:68,787,118...68,789,286
JBrowse link
G Zhx3 zinc fingers and homeoboxes 3 increases expression ISO pyridaben results in increased expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr 3:149,417,843...149,548,671
Ensembl chr 3:149,417,818...149,527,079
JBrowse link
pyridaphenthion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO pyridafenthion binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
zardaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh2 cadherin 2 decreases localization EXP zardaverine results in decreased localization of CDH2 protein CTD PMID:15082077 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases localization EXP zardaverine results in decreased localization of GJA1 protein CTD PMID:15082077 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Tjp1 tight junction protein 1 decreases localization EXP zardaverine results in decreased localization of TJP1 protein CTD PMID:15082077 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  diazines 12333
                    pyridazines 122
                      pyridazinone 119
                        (5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 0
                        1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine 0
                        3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester 0
                        4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone 0
                        4-phenyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                        5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one 0
                        5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                        5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one 0
                        6-hydroxy-2-phenylpyridazin-3-one + 1
                        6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one 0
                        Maleic hydrazide 4
                        Y 23684 0
                        chloridazon 0
                        chloridazone-methyl-desphenyl 0
                        clofencet 0
                        diclomezine 0
                        flufenpyr + 0
                        flufenpyr-ethyl 0
                        levosimendan 0
                        norflurazon 3
                        pimobendan 7
                        pyridaben 104
                        pyridaphenthion 1
                        zardaverine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    diazines 12333
                                      pyridazines 122
                                        pyridazinone 119
                                          (5R)-6-(4-\{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino\}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one 0
                                          1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine 0
                                          3-oxo-2-[(6-oxo-1-phenyl-3-pyridazinyl)oxy]butanoic acid ethyl ester 0
                                          4-chloro-5-[2-[(4-chlorophenyl)methylidene]hydrazinyl]-2-phenyl-3-pyridazinone 0
                                          4-phenyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-one 0
                                          5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one 0
                                          5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one 0
                                          5-chloro-4-[2-[(3-methyl-2-thiophenyl)methylidene]hydrazinyl]-1H-pyridazin-6-one 0
                                          6-hydroxy-2-phenylpyridazin-3-one + 1
                                          6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one 0
                                          Maleic hydrazide 4
                                          Y 23684 0
                                          chloridazon 0
                                          chloridazone-methyl-desphenyl 0
                                          clofencet 0
                                          diclomezine 0
                                          flufenpyr + 0
                                          flufenpyr-ethyl 0
                                          levosimendan 0
                                          norflurazon 3
                                          pimobendan 7
                                          pyridaben 104
                                          pyridaphenthion 1
                                          zardaverine 3
paths to the root