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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amiloride
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Accession:CHEBI:2639 term browser browse the term
Definition:A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Synonyms:exact_synonym: 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
 related_synonym: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide;   Formula=C6H8ClN7O;   InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15);   InChIKey=XSDQTOBWRPYKKA-UHFFFAOYSA-N;   N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide;   SMILES=NC(=N)NC(=O)c1nc(Cl)c(N)nc1N;   amilorida;   amiloridum
 alt_id: CHEBI:47210
 xref: Beilstein:616612;   CAS:2609-46-3;   DrugBank:DB00594;   Drug_Central:158;   HMDB:HMDB0014732;   KEGG:C06821;   KEGG:D07447;   LINCS:LSM-4194
 xref_mesh: MESH:D000584
 xref: MetaCyc:CPD-10324;   PDBeChem:AMR;   PMID:16020936;   PMID:24410943;   PMID:24419567;   PMID:9124403;   Patent:BE639386;   Patent:US3313813;   Reaxys:657410;   Wikipedia:Amiloride
 cyclic_relationship: is_conjugate_base_of CHEBI:84745


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amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan affects expression EXP Amiloride affects the expression of ACAN mRNA CTD PMID:20454829 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
EXP
ISO
Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]
Amiloride results in increased expression of AGT protein modified form
CTD PMID:7357812, PMID:14630723 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Amiloride results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of AKT1 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions EXP Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein] CTD PMID:11340305 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aoc1 amine oxidase, copper containing 1 affects binding
multiple interactions
decreases activity
ISO Amiloride binds to AOC1 protein
Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
Amiloride results in decreased activity of AOC1 protein
CTD PMID:2217167, PMID:8144586 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Asic3 acid sensing ion channel subunit 3 affects response to substance ISO ASIC3 protein affects the susceptibility to Amiloride CTD PMID:12037186 NCBI chr 4:7,287,868...7,293,295
Ensembl chr 4:7,288,855...7,292,901
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 multiple interactions EXP [Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 4:115,417,100...115,435,754
Ensembl chr 4:115,416,580...115,437,206
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions ISO Amiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium] CTD PMID:9930755, PMID:11897840 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO Amiloride inhibits the reaction [Acids results in increased secretion of CALCA protein] CTD PMID:20100279 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15607733, PMID:16059913 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:16059913 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
Amiloride results in decreased expression of CCL2 mRNA; Amiloride results in decreased expression of CCL2 protein
Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 protein]
CTD PMID:11340305, PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:11420121 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Amiloride results in decreased expression of CCNB1 protein CTD PMID:9458082 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cftr CF transmembrane conductance regulator increases activity ISO Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression EXP Amiloride affects the expression of COL2A1 mRNA CTD PMID:20454829 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL2 protein] CTD PMID:11420121 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein] CTD PMID:15607733 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased expression of DDIT3] CTD PMID:20015086 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dysf dysferlin decreases expression ISO Amiloride results in decreased expression of DYSF mRNA CTD PMID:15535137 NCBI chr 4:115,700,942...115,901,873
Ensembl chr 4:115,712,850...115,901,873
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Amiloride results in increased phosphorylation of EIF2A protein CTD PMID:20015086 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation ISO Amiloride results in decreased phosphorylation of ERBB2 protein CTD PMID:16059913 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein] CTD PMID:20015086 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Amiloride results in increased expression of FOS mRNA
Amiloride inhibits the reaction [Acids results in increased expression of and results in increased localization of FOS protein]
CTD PMID:12730611, PMID:16769263 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Grip1 glutamate receptor interacting protein 1 affects response to substance ISO GRIP1 gene SNP affects the susceptibility to Amiloride CTD PMID:25622337 NCBI chr 7:64,672,723...64,854,939
Ensembl chr 7:64,672,722...64,864,404
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] CTD PMID:20015086 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]
Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein]
CTD PMID:11420121, PMID:12070711 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Amiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Klk1 kallikrein 1 multiple interactions
increases response to substance
ISO KLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]
KLK1 protein results in increased susceptibility to Amiloride
CTD PMID:18086683 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] CTD PMID:12065299 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12065299 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK8 protein] CTD PMID:19815690 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK9 protein] CTD PMID:19815690 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Myf5 myogenic factor 5 increases expression ISO Amiloride results in increased expression of MYF5 mRNA CTD PMID:15535137 NCBI chr 7:49,729,533...49,732,974
Ensembl chr 7:49,729,533...49,732,764
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:12107048 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of NOS2] CTD PMID:21356098 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases phosphorylation ISO Amiloride results in decreased phosphorylation of PDPK1 protein CTD PMID:16059913 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Amiloride results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel multiple interactions ISO Amiloride results in decreased activity of [PKD2 protein binds to PKD2 protein]; Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases activity
ISO Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]
Amiloride results in decreased activity of PLAU protein
CTD PMID:8921802, PMID:11454671, PMID:14644129 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]; Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA] CTD PMID:12070711 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plg plasminogen multiple interactions ISO Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein] CTD PMID:14644129 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases phosphorylation
multiple interactions
ISO Amiloride results in decreased phosphorylation of PPP1CA protein
Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]
CTD PMID:16059913 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299, PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions
affects activity
ISO
EXP
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
[farglitazar co-treated with Amiloride] results in increased expression of SCNN1A mRNA
Amiloride affects the activity of SCNN1A protein
CTD PMID:8617496, PMID:15475592, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions
affects activity
ISO Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
Amiloride affects the activity of SCNN1B protein
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma affects activity
multiple interactions
ISO Amiloride affects the activity of SCNN1G protein
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sele selectin E multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:12107048 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Slc12a4 solute carrier family 12 member 4 multiple interactions ISO Amiloride inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] CTD PMID:11703599 NCBI chr19:37,917,003...37,938,952
Ensembl chr19:37,917,014...37,938,857
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Amiloride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc26a4 solute carrier family 26 member 4 multiple interactions EXP [Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein CTD PMID:17311909 NCBI chr 6:50,809,103...50,848,443
Ensembl chr 6:50,808,923...50,846,965
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Amiloride inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases activity
multiple interactions
ISO Amiloride results in decreased activity of SLC47A1 protein
Amiloride inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787, PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amiloride inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc52a3 solute carrier family 52 member 3 multiple interactions EXP Amiloride inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 3:147,503,266...147,517,935
Ensembl chr 3:147,511,406...147,516,455
JBrowse link
G Slc9a2 solute carrier family 9 member A2 multiple interactions EXP [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides; [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium CTD PMID:10958346 NCBI chr 9:47,386,581...47,491,813
Ensembl chr 9:47,386,626...47,491,907
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein]; Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of TNF] CTD PMID:10198263, PMID:21356098 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:15843607 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr 8:103,503,982...103,554,905
Ensembl chr 8:103,503,985...103,554,468
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity ISO Amiloride results in decreased activity of TRPC6 protein CTD PMID:11179201 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Amiloride results in decreased expression of VEGFA mRNA; Amiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:20015086 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
5-(N,N-hexamethylene)amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of DDIT3 mRNA CTD PMID:19302589 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSP90B1 mRNA CTD PMID:19302589 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSPA5 mRNA CTD PMID:19302589 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PPP1R15A mRNA CTD PMID:19302589 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PTGS2 mRNA CTD PMID:19302589 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions ISO 5-(N,N-hexamethylene)amiloride results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form CTD PMID:25447644 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
ethylisopropylamiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases uptake ISO ethylisopropylamiloride results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aoc1 amine oxidase, copper containing 1 affects binding
decreases activity
multiple interactions
ISO ethylisopropylamiloride binds to AOC1 protein
ethylisopropylamiloride results in decreased activity of AOC1 protein
ethylisopropylamiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
CTD PMID:2217167, PMID:8144586 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]; ethylisopropylamiloride inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of COL1A1 protein] CTD PMID:11159895 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A1 protein CTD PMID:15081870 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1A2 protein CTD PMID:15081870 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO ethylisopropylamiloride results in decreased activity of CYP1B1 protein CTD PMID:15081870 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Fah fumarylacetoacetate hydrolase affects splicing ISO ethylisopropylamiloride affects the splicing of FAH mutant form CTD PMID:23895425 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Ifng interferon gamma multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO ethylisopropylamiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ethylisopropylamiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ethylisopropylamiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO ethylisopropylamiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc9a1 solute carrier family 9 member A1 decreases activity
multiple interactions
ISO
EXP
ethylisopropylamiloride results in decreased activity of SLC9A1 protein
[ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin
CTD PMID:12562776, PMID:15729714, PMID:17552965 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 increases expression ISO ethylisopropylamiloride results in increased expression of SRSF3 protein CTD PMID:17924536 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ethylisopropylamiloride results in decreased expression of VEGFA mRNA; ethylisopropylamiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            diuretic 1120
              amiloride 80
                5-(N,N-hexamethylene)amiloride 6
                5-(N-methyl-N-propyl)amiloride 0
                ethylisopropylamiloride 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        aromatic amine 13616
                                          amiloride 80
                                            5-(N,N-hexamethylene)amiloride 6
                                            5-(N-methyl-N-propyl)amiloride 0
                                            ethylisopropylamiloride 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.