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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amifostine
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Accession:CHEBI:2636 term browser browse the term
Definition:An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Synonyms:exact_synonym: S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate
 related_synonym: Ethyol;   Formula=C5H15N2O3PS;   InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10);   InChIKey=JKOQGQFVAUAYPM-UHFFFAOYSA-N;   SMILES=NCCCNCCSP(O)(O)=O;   amifostina;   amifostinum
 xref: Beilstein:2088122;   CAS:20537-88-6;   DrugBank:DB01143;   Drug_Central:156;   HMDB:HMDB0015274;   KEGG:C06819;   LINCS:LSM-4721
 xref_mesh: MESH:D004999
 xref: PMID:10553165;   PMID:10942928;   PMID:11013273;   PMID:11201306;   PMID:11984063;   PMID:12005544;   PMID:12433814;   PMID:12499421;   PMID:12561384;   PMID:12751907;   PMID:14980067;   PMID:15380592;   PMID:15698860;   PMID:15875769;   PMID:16465691;   PMID:17602063;   PMID:18072151;   PMID:18549666;   PMID:19712749;   PMID:20334641;   PMID:21347716;   PMID:21646919;   PMID:22267539;   PMID:22402174;   PMID:22440042;   PMID:22456378;   PMID:22496587;   PMID:22643562;   PMID:22844290;   PMID:22878481;   PMID:22885239;   PMID:22989457;   PMID:23040218;   PMID:23052919;   PMID:23092832;   PMID:23401928;   PMID:8612469;   PMID:8683243;   Patent:US3892824;   Reaxys:2088122;   Wikipedia:Amifostine



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amifostine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in increased expression of BAX mRNA CTD PMID:15985719 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in decreased expression of BCL2 mRNA CTD PMID:15985719 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Amifostine co-treated with Doxorubicin] results in increased activity of CASP3 protein; Amifostine inhibits the reaction [Idarubicin results in increased activity of CASP3 protein]; Amifostine promotes the reaction [Idarubicin results in increased activity of CASP3 protein] CTD PMID:15985719 PMID:18438337 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation
multiple interactions
ISO Amifostine results in decreased phosphorylation of CDK1 protein
olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]
CTD PMID:16628227 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO Amifostine results in decreased expression of CDKN1A mRNA
Amifostine results in increased expression of CDKN1A protein
CTD PMID:12618886 PMID:14555708 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein decreases expression ISO Amifostine results in decreased expression of EI24 mRNA CTD PMID:14555708 NCBI chr 8:36,494,289...36,510,653
Ensembl chr 8:36,494,289...36,510,571
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein] CTD PMID:19010997 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased phosphorylation of MAPK14 protein] CTD PMID:19010997 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO Amifostine results in decreased expression of MDM2 mRNA CTD PMID:14555708 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] CTD PMID:19010997 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Amifostine co-treated with TP53] results in increased expression of MYC mRNA CTD PMID:14555708 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MYL2 protein]
Amifostine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MYL2 protein]; Amifostine inhibits the reaction [IL6 protein results in increased phosphorylation of MYL2 protein]
CTD PMID:19010997 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression
multiple interactions
ISO Amifostine results in decreased expression of NFKBIA protein
Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:10590050 PMID:19010997 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Amifostine inhibits the reaction [Benzene results in decreased expression of PCNA protein] CTD PMID:17661222 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases localization
ISO Amifostine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
Amifostine results in increased localization of RELA protein
CTD PMID:10590050 PMID:19010997 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
affects response to substance
increases activity
ISO [Amifostine co-treated with TP53] results in increased expression of MYC mRNA; olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]
Amifostine results in increased expression of TP53 protein
TP53 affects the susceptibility to Amifostine
Amifostine results in increased activity of TP53 protein
CTD PMID:12618886 PMID:14555708 PMID:16628227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 decreases expression ISO Amifostine results in decreased expression of TP53I3 mRNA CTD PMID:14555708 NCBI chr13:69,612,605...69,655,018
Ensembl chr13:69,620,792...69,652,475
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 20050
    role 20001
      chemical role 19530
        antioxidant 14499
          amifostine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    main group molecular entity 19948
                      s-block molecular entity 19735
                        hydrogen molecular entity 19727
                          hydrides 19093
                            inorganic hydride 17893
                              pnictogen hydride 17876
                                nitrogen hydride 17767
                                  azane 17517
                                    ammonia 17516
                                      organic amino compound 17516
                                        primary amino compound 8271
                                          primary amine 5836
                                            primary aliphatic amine 145
                                              ethylamine 45
                                                cysteamine 44
                                                  amifostine 17
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