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ONTOLOGY REPORT - ANNOTATIONS


Term:amifostine
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Accession:CHEBI:2636 term browser browse the term
Definition:An organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
Synonyms:exact_synonym: S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate
 related_synonym: Ethyol;   Formula=C5H15N2O3PS;   InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10);   InChIKey=JKOQGQFVAUAYPM-UHFFFAOYSA-N;   SMILES=NCCCNCCSP(O)(O)=O;   amifostina;   amifostinum
 xref: Beilstein:2088122;   CAS:20537-88-6;   DrugBank:DB01143;   Drug_Central:156;   HMDB:HMDB0015274;   KEGG:C06819;   LINCS:LSM-4721
 xref_mesh: MESH:D004999
 xref: PMID:10553165;   PMID:10942928;   PMID:11013273;   PMID:11201306;   PMID:11984063;   PMID:12005544;   PMID:12433814;   PMID:12499421;   PMID:12561384;   PMID:12751907;   PMID:14980067;   PMID:15380592;   PMID:15698860;   PMID:15875769;   PMID:16465691;   PMID:17602063;   PMID:18072151;   PMID:18549666;   PMID:19712749;   PMID:20334641;   PMID:21347716;   PMID:21646919;   PMID:22267539;   PMID:22402174;   PMID:22440042;   PMID:22456378;   PMID:22496587;   PMID:22643562;   PMID:22844290;   PMID:22878481;   PMID:22885239;   PMID:22989457;   PMID:23040218;   PMID:23052919;   PMID:23092832;   PMID:23401928;   PMID:8612469;   PMID:8683243;   Patent:US3892824;   Reaxys:2088122;   Wikipedia:Amifostine


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amifostine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Ei24 EI24, autophagy associated transmembrane protein JBrowse link 8 39,254,883 39,271,238 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Myl2 myosin light chain 2 JBrowse link 12 39,951,863 39,959,065 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tp53i3 tumor protein p53 inducible protein 3 JBrowse link 13 75,101,759 75,145,967 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      chemical role 19258
        antioxidant 14222
          amifostine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    main group molecular entity 19664
                      s-block molecular entity 19406
                        hydrogen molecular entity 19397
                          hydrides 18386
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17020
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        primary amino compound 7861
                                          primary amine 5659
                                            primary aliphatic amine 136
                                              ethylamine 45
                                                cysteamine 44
                                                  amifostine 17
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