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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandins I
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Accession:CHEBI:26345 term browser browse the term
Synonyms:related_synonym: Formula=C7H10O2R2;   PGI;   SMILES=[H][C@]12C[C@@H](O)[C@H]([*])[C@@]1([H])CC([*])O2


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prostaglandin I2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] CTD PMID:14738173 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen multiple interactions
increases abundance
EXP 1-Butanol inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; arachidonyltrifluoromethane inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol]; PTGS2 protein affects the reaction [AGT protein results in increased abundance of Epoprostenol]
AGT protein results in increased abundance of Epoprostenol; AGT results in increased abundance of Epoprostenol
CTD PMID:3888613 PMID:14613874 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Epoprostenol results in increased expression of CCL2 protein CTD PMID:15302794 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Fbn1 fibrillin 1 multiple interactions ISO FBN1 protein affects the reaction [Phenylephrine results in increased secretion of Epoprostenol metabolite] CTD PMID:17641673 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Il10 interleukin 10 multiple interactions EXP IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased abundance of Epoprostenol] CTD PMID:12632514 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha increases abundance ISO IL1A protein results in increased abundance of Epoprostenol CTD PMID:21513769 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion EXP IL1B protein results in increased secretion of Epoprostenol CTD PMID:11882577 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Kng2 kininogen 2 increases abundance EXP KNG1 results in increased abundance of Epoprostenol CTD PMID:3888613 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Epoprostenol results in increased activity of MAPK1 protein CTD PMID:19201774 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Epoprostenol results in increased activity of MAPK3 protein CTD PMID:19201774 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions
increases abundance
ISO 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; celecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Epoprostenol] CTD PMID:19201774 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Epoprostenol results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP PTGS2 protein affects the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      atom 19766
        nonmetal atom 19645
          oxygen atom 19349
            oxygen molecular entity 19349
              organooxygen compound 18872
                oxacycle 17548
                  cyclopentafuran 13
                    prostaglandins I 13
                      15-dehydro-prostaglandin I2 0
                      19-hydroxyprostaglandin I2 0
                      6alpha-Prostaglandin I1 0
                      prostaglandin I2 + 13
                      prostaglandin I2 2-glyceryl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18156
                                        monocarboxylic acid 17530
                                          fatty acid 16012
                                            fatty acid derivative 1043
                                              icosanoid 458
                                                prostanoid 398
                                                  prostaglandin 393
                                                    prostaglandins I 13
                                                      15-dehydro-prostaglandin I2 0
                                                      19-hydroxyprostaglandin I2 0
                                                      6alpha-Prostaglandin I1 0
                                                      prostaglandin I2 + 13
                                                      prostaglandin I2 2-glyceryl ester 0
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