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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandins F
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Accession:CHEBI:26340 term browser browse the term
Synonyms:related_synonym: Formula=C5H8O2R2;   PGF;   SMILES=OC1C[C@@H](O)[C@H]([*])[C@H]1[*]
 xref_mesh: MESH:D011460


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prostaglandins F term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghrl ghrelin increases secretion ISO GHRL protein results in increased secretion of Prostaglandins F CTD PMID:18703674 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
15-oxoprostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases metabolic processing
multiple interactions
ISO PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
6-oxoprostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) increases abundance
multiple interactions
ISO AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions EXP [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:21193584 NCBI chr11:70,344,147...70,390,538
Ensembl chr11:70,344,152...70,352,031
JBrowse link
G Apoe apolipoprotein E increases abundance
multiple interactions
EXP APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha
nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:14966570 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions
ISO AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 affects abundance
multiple interactions
EXP
ISO
BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha
[kallidin, des-Arg(10)- binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; [KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha
PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:16514058 PMID:29775649 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha decreases abundance
increases abundance
ISO CALCA protein alternative form results in decreased abundance of 6-Ketoprostaglandin F1 alpha
CALCA protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
CTD PMID:12024109 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Klkb1 kallikrein B, plasma 1 multiple interactions
increases abundance
EXP 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:25339356 NCBI chr 8:45,266,688...45,294,835
Ensembl chr 8:45,266,689...45,294,859
JBrowse link
G Kng2 kininogen 2 increases abundance
multiple interactions
ISO KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 PMID:29775649 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase multiple interactions
increases chemical synthesis
ISO [Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
PTGIS protein results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr 2:167,203,194...167,252,150
Ensembl chr 2:167,191,805...167,240,604
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; PTGS2 gene mutant form inhibits the reaction [[Nanotubes, Carbon co-treated with OVAL protein] results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209 PMID:23642096 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Tnf tumor necrosis factor increases abundance ISO TNF protein results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:1993070 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions EXP [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
increases abundance
ISO [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha
CTD PMID:22610977 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis
ISO 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:11530235 PMID:16529823 PMID:19751497 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions
EXP PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:18024956 NCBI chr 4:134,396,320...134,427,412
Ensembl chr 4:134,396,320...134,427,413
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 increases transport
multiple interactions
EXP REN2 protein results in increased transport of 8-epi-prostaglandin F2alpha
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased transport of 8-epi-prostaglandin F2alpha]; trandolapril inhibits the reaction [REN2 protein results in increased transport of 8-epi-prostaglandin F2alpha]
CTD PMID:27428043
G Tbxa2r thromboxane A2 receptor multiple interactions
affects response to substance
ISO
EXP
8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha
CTD PMID:18158556 PMID:22565502 NCBI chr10:81,328,268...81,335,174
Ensembl chr10:81,328,731...81,335,172
JBrowse link
fluprostenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP fluprostenol inhibits the reaction [Niacin results in increased expression of FABP4 mRNA] CTD PMID:21236357 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO fluprostenol results in decreased expression of FGFR2 mRNA CTD PMID:15654655 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]] CTD PMID:33486071 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]] CTD PMID:33486071 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO fluprostenol results in increased phosphorylation of MAPK1 protein
fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
CTD PMID:33486071 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO fluprostenol results in increased phosphorylation of MAPK3 protein
fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
CTD PMID:33486071 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]] CTD PMID:33486071 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP fluprostenol inhibits the reaction [Niacin results in increased expression of PPARG mRNA] CTD PMID:21236357 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgfr prostaglandin F receptor multiple interactions ISO PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr 3:151,798,610...151,837,528
Ensembl chr 3:151,796,502...151,837,630
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712
JBrowse link
latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
prostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases metabolic processing ISO PTGR1 protein results in increased metabolism of prostaglandin F1 analog CTD PMID:25619643 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased secretion of prostaglandin F1 CTD PMID:21913898 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost] CTD PMID:19997560 PMID:20036328 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases metabolic processing ISO AKR1C2 protein results in increased metabolism of Dinoprost CTD PMID:8573067 NCBI chr13:4,574,075...4,586,543
Ensembl chr13:4,574,075...4,586,541
JBrowse link
G Anxa4 annexin A4 increases expression ISO Dinoprost results in increased expression of ANXA4 mRNA CTD PMID:11517196 NCBI chr 6:86,736,840...86,793,634
Ensembl chr 6:86,736,840...86,793,584
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide increases expression ISO Dinoprost results in increased expression of ATP1A1 mRNA CTD PMID:11517196 NCBI chr 3:101,576,219...101,604,707
Ensembl chr 3:101,576,219...101,604,684
JBrowse link
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 increases response to substance ISO ATP2B4 protein results in increased susceptibility to Dinoprost CTD PMID:12933703 NCBI chr 1:133,702,674...133,801,059
Ensembl chr 1:133,699,457...133,801,041
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein] CTD PMID:20826536 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Dinoprost results in decreased expression of CCND2 mRNA CTD PMID:11517196 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Ces1d carboxylesterase 1D increases hydrolysis ISO CES1 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr 8:105,000,830...105,020,410
Ensembl chr 8:105,000,853...105,021,178
JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression EXP Dinoprost results in increased expression of COL10A1 mRNA; Dinoprost results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr10:34,389,981...34,397,085
Ensembl chr10:34,389,981...34,397,085
JBrowse link
G Col2a1 collagen, type II, alpha 1 increases expression EXP Dinoprost results in increased expression of COL2A1 mRNA; Dinoprost results in increased expression of COL2A1 protein CTD PMID:27050768 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP
ISO
Dinoprost results in decreased expression of CYP19A1 mRNA
Dinoprost results in decreased expression of CYP19A1 mRNA; Dinoprost results in decreased expression of CYP19A1 protein
Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
CTD PMID:11517196 PMID:15271885 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Dll4 delta like canonical Notch ligand 4 decreases expression ISO Dinoprost results in decreased expression of DLL4 mRNA CTD PMID:21209419 NCBI chr 2:119,325,784...119,335,666
Ensembl chr 2:119,325,784...119,335,962
JBrowse link
G Ereg epiregulin multiple interactions
increases expression
EXP [AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG; [trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG
Dinoprost results in increased expression of EREG
CTD PMID:22583689 NCBI chr 5:91,074,617...91,093,649
Ensembl chr 5:91,074,622...91,093,646
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression ISO Dinoprost results in increased expression of ESR1 mRNA CTD PMID:21654155 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 protein CTD PMID:21236357 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
affects localization
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Cycloheximide inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGF2 protein] CTD PMID:15654655 PMID:16365892 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions
affects localization
decreases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]
Dinoprost results in decreased expression of FGFR2 mRNA
CTD PMID:15654655 PMID:16365892 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Fosl2 fos-like antigen 2 increases expression ISO Dinoprost results in increased expression of FOSL2 mRNA CTD PMID:11517196 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases activity
ISO Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
Dinoprost results in increased activity of GATA4 protein
CTD PMID:15271885 NCBI chr14:63,198,914...63,271,712
Ensembl chr14:63,198,922...63,271,692
JBrowse link
G Gpx1 glutathione peroxidase 1 increases response to substance EXP GPX1 gene mutant form results in increased susceptibility to Dinoprost CTD PMID:24296279 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 decreases expression ISO Dinoprost results in decreased expression of HMGCS2 mRNA CTD PMID:11517196 NCBI chr 3:98,280,431...98,310,738
Ensembl chr 3:98,280,435...98,310,738
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
decreases expression
ISO Dinoprost results in decreased activity of HSD11B2 protein
Dinoprost results in decreased expression of HSD11B2 mRNA
CTD PMID:10377029 PMID:11517196 NCBI chr 8:105,518,746...105,523,988
Ensembl chr 8:105,518,755...105,523,988
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Dinoprost results in decreased expression of ID1 mRNA CTD PMID:11517196 NCBI chr 2:152,736,251...152,737,410
Ensembl chr 2:152,736,251...152,737,410
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Dinoprost results in decreased expression of ID2 mRNA CTD PMID:11517196 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Dinoprost results in decreased expression of ID3 mRNA CTD PMID:11517196 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance
ISO IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
IL10 protein results in increased abundance of Dinoprost
CTD PMID:12548226 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1a interleukin 1 alpha increases abundance ISO IL1A protein results in increased abundance of Dinoprost CTD PMID:21513769 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta increases abundance
multiple interactions
ISO IL1B protein results in increased abundance of Dinoprost
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
CTD PMID:12548226 PMID:16354411 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2ra interleukin 2 receptor, alpha chain increases expression ISO Dinoprost results in increased expression of IL2RA mRNA CTD PMID:11517196 NCBI chr 2:11,642,792...11,693,194
Ensembl chr 2:11,642,807...11,693,193
JBrowse link
G Il4 interleukin 4 increases secretion
multiple interactions
ISO IL4 protein results in increased secretion of Dinoprost
[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost
CTD PMID:23688403 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Kpnb1 karyopherin (importin) beta 1 increases expression ISO Dinoprost results in increased expression of KPNB1 protein CTD PMID:16365892 NCBI chr11:97,159,710...97,187,892
Ensembl chr11:97,159,714...97,187,881
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression ISO Dinoprost results in decreased expression of LHCGR mRNA CTD PMID:11517196 NCBI chr17:88,716,384...88,792,059
Ensembl chr17:88,716,481...88,791,990
JBrowse link
G Lypla2 lysophospholipase 2 increases hydrolysis ISO LYPLA2 protein results in increased hydrolysis of Dinoprost analog CTD PMID:25301951 NCBI chr 4:135,968,224...135,972,612
Ensembl chr 4:135,968,224...135,972,626
JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 increases phosphorylation
multiple interactions
EXP Dinoprost results in increased phosphorylation of MAP2K1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]
CTD PMID:24333336 NCBI chr 9:64,185,769...64,253,605
Ensembl chr 9:64,185,770...64,253,631
JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 increases phosphorylation
multiple interactions
EXP Dinoprost results in increased phosphorylation of MAP2K2 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]
CTD PMID:24333336 NCBI chr10:81,105,913...81,124,697
Ensembl chr10:81,105,915...81,133,975
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects localization
multiple interactions
increases phosphorylation
ISO
EXP
Dinoprost affects the localization of MAPK1 protein
Resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 affects localization
increases phosphorylation
multiple interactions
ISO
EXP
Dinoprost affects the localization of MAPK3 protein
Dinoprost results in increased phosphorylation of MAPK3 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO Dinoprost results in increased expression of MAPK6 mRNA CTD PMID:11517196 NCBI chr 9:75,386,782...75,410,016
Ensembl chr 9:75,369,062...75,410,005
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP Dinoprost results in increased phosphorylation of MAPK8 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]
CTD PMID:24333336 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
EXP Dinoprost results in increased phosphorylation of MAPK9 protein
Resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]
CTD PMID:24333336 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Dinoprost results in increased expression of and results in increased activity of MMP2 protein CTD PMID:11719597 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Dinoprost results in increased expression of and results in increased activity of MMP9 protein CTD PMID:11719597 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Notch1 notch 1 decreases cleavage
decreases expression
ISO Dinoprost results in decreased cleavage of NOTCH1 protein
Dinoprost results in decreased expression of NOTCH1 mRNA
CTD PMID:21209419 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Notch4 notch 4 decreases expression
decreases cleavage
ISO Dinoprost results in decreased expression of NOTCH4 mRNA
Dinoprost results in decreased cleavage of NOTCH4 protein
CTD PMID:21209419 NCBI chr17:34,564,286...34,588,543
Ensembl chr17:34,564,268...34,588,503
JBrowse link
G Pdia4 protein disulfide isomerase associated 4 decreases expression ISO Dinoprost results in decreased expression of PDIA4 mRNA CTD PMID:11517196 NCBI chr 6:47,796,141...47,813,512
Ensembl chr 6:47,796,141...47,813,430
JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression ISO Dinoprost results in increased expression of PLCD1 mRNA CTD PMID:11517196 NCBI chr 9:119,071,527...119,093,502
Ensembl chr 9:119,071,527...119,093,502
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO Dinoprost results in increased expression of POR mRNA CTD PMID:11517196 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG protein CTD PMID:21236357 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prl prolactin multiple interactions ISO [Dinoprost results in decreased abundance of Progesterone] which results in increased expression of PRL protein CTD PMID:21654155 NCBI chr13:27,057,570...27,065,204
Ensembl chr13:27,057,570...27,065,205
JBrowse link
G Prlr prolactin receptor increases expression ISO Dinoprost results in increased expression of PRLR mRNA CTD PMID:21654155 NCBI chr15:10,177,238...10,349,190
Ensembl chr15:10,177,238...10,349,180
JBrowse link
G Ptgdr prostaglandin D receptor multiple interactions ISO Dinoprost binds to and results in increased activity of PTGDR protein; Dinoprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:27636113 NCBI chr14:44,851,235...44,859,375
Ensembl chr14:44,851,235...44,859,375
JBrowse link
G Ptger2 prostaglandin E receptor 2 (subtype EP2) multiple interactions ISO Dinoprost binds to and results in increased activity of PTGER2 protein CTD PMID:27636113 NCBI chr14:44,988,111...45,003,820
Ensembl chr14:44,988,195...45,003,820
JBrowse link
G Ptgfr prostaglandin F receptor increases expression
multiple interactions
ISO
EXP
Dinoprost results in increased expression of PTGFR mRNA
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]
CTD PMID:11517196 PMID:22583689 NCBI chr 3:151,798,610...151,837,528
Ensembl chr 3:151,796,502...151,837,630
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases abundance
increases expression
EXP
ISO
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Niacin results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG
PTGS2 protein results in increased abundance of Dinoprost
Dinoprost results in increased expression of PTGS2 mRNA
[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; resveratrol inhibits the reaction [[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost]; resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]; SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]]
[Dinoprost results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprost; CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PTGS2 protein results in increased abundance of Dinoprost]
CTD PMID:18555068 PMID:18776171 PMID:18834901 PMID:20826536 PMID:20844277 PMID:21236357 PMID:22306367 PMID:22583689 PMID:27050768 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta increases expression ISO Dinoprost results in increased expression of PTK2B mRNA CTD PMID:11517196 NCBI chr14:66,153,257...66,281,100
Ensembl chr14:66,153,257...66,281,052
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 increases expression
multiple interactions
EXP Dinoprost results in increased expression of RAF1 protein modified form
resveratrol inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]
CTD PMID:24333336 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO Dinoprost results in decreased expression of RBL2 mRNA CTD PMID:11517196 NCBI chr 8:91,070,057...91,123,844
Ensembl chr 8:91,070,057...91,123,844
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein]; Dinoprost results in increased localization of and results in increased activity of RELA protein CTD PMID:20826536 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Runx2 runt related transcription factor 2 increases expression EXP Dinoprost results in increased expression of RUNX2 mRNA; Dinoprost results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Scn1b sodium channel, voltage-gated, type I, beta increases expression ISO Dinoprost results in increased expression of SCN1B mRNA CTD PMID:11517196 NCBI chr 7:31,116,524...31,127,023
Ensembl chr 7:31,116,524...31,127,003
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 increases phosphorylation ISO Dinoprost results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 NCBI chr 3:89,418,551...89,430,029
Ensembl chr 3:89,418,443...89,430,027
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc22a22 solute carrier family 22 (organic cation transporter), member 22 affects binding EXP Dinoprost binds to SLC22A22 protein CTD PMID:20448048 NCBI chr15:57,243,767...57,477,625
Ensembl chr15:57,243,767...57,477,625
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 increases uptake ISO SLC22A7 protein results in increased uptake of Dinoprost CTD PMID:15901346 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases transport EXP SLC22A8 protein results in increased transport of Dinoprost CTD PMID:15100168 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression ISO Dinoprost results in increased expression of SOCS1 mRNA CTD PMID:21654155 NCBI chr16:10,783,808...10,785,536
Ensembl chr16:10,782,240...10,785,536
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Dinoprost results in increased expression of SOCS3 mRNA CTD PMID:21654155 NCBI chr11:117,966,079...117,970,336
Ensembl chr11:117,966,079...117,970,047
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 increases expression EXP Dinoprost results in increased expression of SOX9 mRNA; Dinoprost results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Stat5a signal transducer and activator of transcription 5A increases expression ISO Dinoprost results in increased expression of STAT5A mRNA CTD PMID:21654155 NCBI chr11:100,859,351...100,885,169
Ensembl chr11:100,859,351...100,885,169
JBrowse link
G Syn2 synapsin II decreases expression ISO Dinoprost results in decreased expression of SYN2 mRNA CTD PMID:11517196 NCBI chr 6:115,134,902...115,282,626
Ensembl chr 6:115,134,902...115,282,006
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Dinoprost results in increased expression of TGFB1 mRNA CTD PMID:11517196 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Dinoprost results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 decreases expression ISO Dinoprost results in decreased expression of TIMP1 protein CTD PMID:11719597 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Timp3 tissue inhibitor of metalloproteinase 3 decreases expression ISO Dinoprost results in decreased expression of TIMP3 mRNA CTD PMID:11517196 NCBI chr10:86,300,412...86,349,505
Ensembl chr10:86,300,372...86,349,506
JBrowse link
G Tnf tumor necrosis factor increases abundance ISO TNF protein results in increased abundance of Dinoprost CTD PMID:1993070 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of TNFRSF11B mRNA]; SB 203580 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases chemical synthesis ISO UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprost CTD PMID:3864191 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Dinoprost results in decreased expression of VEGFA mRNA CTD PMID:11517196 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide increases expression ISO Dinoprost results in increased expression of YWHAE mRNA CTD PMID:11517196 NCBI chr11:75,732,887...75,765,841
Ensembl chr11:75,732,869...75,765,845
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide increases expression ISO Dinoprost results in increased expression of YWHAG mRNA CTD PMID:11517196 NCBI chr 5:135,908,379...135,934,641
Ensembl chr 5:135,908,409...135,934,616
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide increases expression ISO Dinoprost results in increased expression of YWHAZ mRNA CTD PMID:11517196 NCBI chr15:36,770,261...36,802,984
Ensembl chr15:36,770,770...36,796,929
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21746
    chemical entity 21744
      atom 21732
        nonmetal atom 21625
          carbon atom 21353
            organic molecular entity 21353
              fatty acid derivative 1033
                icosanoid 460
                  prostanoid 399
                    prostaglandin 394
                      prostaglandins F 103
                        11-epi-prostaglandin F2alpha + 0
                        prostaglandins Falpha + 102
                        prostaglandins Fbeta + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21746
    subatomic particle 21732
      composite particle 21732
        hadron 21732
          baryon 21732
            nucleon 21732
              atomic nucleus 21732
                atom 21732
                  main group element atom 21647
                    p-block element atom 21647
                      carbon group element atom 21454
                        carbon atom 21353
                          organic molecular entity 21353
                            organic group 19931
                              organic divalent group 19918
                                organodiyl group 19918
                                  carbonyl group 19903
                                    carbonyl compound 19903
                                      carboxylic acid 19223
                                        monocarboxylic acid 18556
                                          fatty acid 16599
                                            fatty acid derivative 1033
                                              icosanoid 460
                                                prostanoid 399
                                                  prostaglandin 394
                                                    prostaglandins F 103
                                                      11-epi-prostaglandin F2alpha + 0
                                                      prostaglandins Falpha + 102
                                                      prostaglandins Fbeta + 0
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