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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prostaglandins F
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Accession:CHEBI:26340 term browser browse the term
Synonyms:related_synonym: Formula=C5H8O2R2;   PGF;   SMILES=OC1C[C@@H](O)[C@H]([*])[C@H]1[*]
 xref_mesh: MESH:D011460


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prostaglandins F term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide increases secretion EXP GHRL protein results in increased secretion of Prostaglandins F CTD PMID:18703674 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
JBrowse link
13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases abundance
multiple interactions
EXP PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
15-oxoprostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases metabolic processing
multiple interactions
EXP PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
6-oxoprostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance
multiple interactions
ISO AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AGT protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G ALOX15 arachidonate 15-lipoxygenase multiple interactions ISO [ALOX15 protein affects the metabolism of Arachidonic Acid] which results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:21193584 NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
JBrowse link
G APOE apolipoprotein E increases abundance
multiple interactions
ISO APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha
nimesulide inhibits the reaction [APOE results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:14966570 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G AVP arginine vasopressin increases abundance
multiple interactions
ISO AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
Dexamethasone inhibits the reaction [AVP protein results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 NCBI chr20:3,082,556...3,093,521
Ensembl chr20:3,082,556...3,084,724
JBrowse link
G BDKRB2 bradykinin receptor B2 affects abundance
multiple interactions
ISO BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha
[kallidin, des-Arg(10)- binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; [KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha
PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:16514058 PMID:29775649 NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
JBrowse link
G CALCA calcitonin related polypeptide alpha decreases abundance
increases abundance
EXP
ISO
CALCA protein alternative form results in decreased abundance of 6-Ketoprostaglandin F1 alpha
CALCA protein results in increased abundance of 6-Ketoprostaglandin F1 alpha
CTD PMID:12024109 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,351
JBrowse link
G KLKB1 kallikrein B1 multiple interactions
increases abundance
ISO 7-Ala-angiotensin (1-7) inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha]; nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:25339356 NCBI chr 4:186,215,714...186,258,477
Ensembl chr 4:186,208,979...186,258,471
JBrowse link
G KNG1 kininogen 1 increases abundance
multiple interactions
ISO KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha
[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased secretion of 6-Ketoprostaglandin F1 alpha; Dexamethasone inhibits the reaction [KNG1 protein alternative form results in increased abundance of 6-Ketoprostaglandin F1 alpha]
CTD PMID:4030047 PMID:29775649 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PTGIS prostaglandin I2 synthase multiple interactions
increases chemical synthesis
ISO [Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
PTGIS protein results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha
CTD PMID:19491382 NCBI chr20:49,503,874...49,568,137
Ensembl chr20:49,503,874...49,568,137
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; PTGS2 gene mutant form inhibits the reaction [[Nanotubes, Carbon co-treated with OVAL protein] results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16325209 PMID:23642096 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G TNF tumor necrosis factor increases abundance EXP TNF protein results in increased abundance of 6-Ketoprostaglandin F1 alpha CTD PMID:1993070 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E multiple interactions ISO [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APP amyloid beta precursor protein multiple interactions
increases abundance
EXP [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha
CTD PMID:22610977 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis
EXP
ISO
1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:11530235 PMID:16529823 PMID:19751497 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G PAFAH2 platelet activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions
ISO PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]
CTD PMID:18024956 NCBI chr 1:25,959,764...25,998,164
Ensembl chr 1:25,959,767...25,998,117
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G TBXA2R thromboxane A2 receptor multiple interactions
affects response to substance
EXP
ISO
8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha
CTD PMID:18158556 PMID:22565502 NCBI chr19:3,594,507...3,608,749
Ensembl chr19:3,594,507...3,606,875
JBrowse link
fluprostenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4 multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of FABP4 mRNA] CTD PMID:21236357 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression ISO fluprostenol results in decreased expression of FGFR2 mRNA CTD PMID:15654655 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions EXP AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]] CTD PMID:33486071 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]] CTD PMID:33486071 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
fluprostenol results in increased phosphorylation of MAPK1 protein
CTD PMID:33486071 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
fluprostenol results in increased phosphorylation of MAPK3 protein
CTD PMID:33486071 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]] CTD PMID:33486071 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of PPARG mRNA] CTD PMID:21236357 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PTGFR prostaglandin F receptor multiple interactions EXP PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr 1:78,490,974...78,540,701
Ensembl chr 1:78,303,884...78,540,701
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions EXP fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity EXP latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
prostaglandin F1alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases metabolic processing EXP PTGR1 protein results in increased metabolism of prostaglandin F1 analog CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased secretion of prostaglandin F1 CTD PMID:21913898 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C2 aldo-keto reductase family 1 member C2 increases metabolic processing EXP AKR1C2 protein results in increased metabolism of Dinoprost CTD PMID:8573067 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,400...5,018,031
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost] CTD PMID:19997560 PMID:20036328 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G ANXA4 annexin A4 increases expression ISO Dinoprost results in increased expression of ANXA4 mRNA CTD PMID:11517196 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression ISO Dinoprost results in increased expression of ATP1A1 mRNA CTD PMID:11517196 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance EXP ATP2B4 protein results in increased susceptibility to Dinoprost CTD PMID:12933703 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,787...203,744,081
JBrowse link
G CAT catalase multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein] CTD PMID:20826536 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCND2 cyclin D2 decreases expression ISO Dinoprost results in decreased expression of CCND2 mRNA CTD PMID:11517196 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CES1 carboxylesterase 1 increases hydrolysis EXP CES1 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CES2 carboxylesterase 2 increases hydrolysis EXP CES2 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CGB3 chorionic gonadotropin subunit beta 3 multiple interactions
increases chemical synthesis
EXP [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; Indomethacin inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost] CTD PMID:18555068 NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333
JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL10A1 mRNA; Dinoprost results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr 6:116,118,909...116,219,937
Ensembl chr 6:116,118,909...116,158,747
JBrowse link
G COL2A1 collagen type II alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL2A1 mRNA; Dinoprost results in increased expression of COL2A1 protein CTD PMID:27050768 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression
multiple interactions
ISO Dinoprost results in decreased expression of CYP19A1 mRNA
Dinoprost results in decreased expression of CYP19A1 mRNA; Dinoprost results in decreased expression of CYP19A1 protein
Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
CTD PMID:11517196 PMID:15271885 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G DLL4 delta like canonical Notch ligand 4 decreases expression ISO Dinoprost results in decreased expression of DLL4 mRNA CTD PMID:21209419 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073
JBrowse link
G EREG epiregulin multiple interactions
increases expression
ISO [AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG; [trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG
Dinoprost results in increased expression of EREG
CTD PMID:22583689 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G ESR1 estrogen receptor 1 increases expression ISO Dinoprost results in increased expression of ESR1 mRNA CTD PMID:21654155 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 protein CTD PMID:21236357 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions
affects localization
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Cycloheximide inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGF2 protein] CTD PMID:15654655 PMID:16365892 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 multiple interactions
affects localization
decreases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]
Dinoprost results in decreased expression of FGFR2 mRNA
CTD PMID:15654655 PMID:16365892 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Dinoprost results in increased expression of FOSL2 mRNA CTD PMID:11517196 NCBI chr 2:28,392,855...28,417,317
Ensembl chr 2:28,392,448...28,417,317
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions
increases activity
ISO Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
Dinoprost results in increased activity of GATA4 protein
CTD PMID:15271885 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G GPX1 glutathione peroxidase 1 increases response to substance ISO GPX1 gene mutant form results in increased susceptibility to Dinoprost CTD PMID:24296279 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Dinoprost results in decreased expression of HMGCS2 mRNA CTD PMID:11517196 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
decreases expression
EXP
ISO
Dinoprost results in decreased activity of HSD11B2 protein
Dinoprost results in decreased expression of HSD11B2 mRNA
CTD PMID:10377029 PMID:11517196 NCBI chr16:67,431,121...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein decreases expression ISO Dinoprost results in decreased expression of ID1 mRNA CTD PMID:11517196 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515
JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression ISO Dinoprost results in decreased expression of ID2 mRNA CTD PMID:11517196 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Dinoprost results in decreased expression of ID3 mRNA CTD PMID:11517196 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IL10 interleukin 10 multiple interactions
increases abundance
EXP IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
IL10 protein results in increased abundance of Dinoprost
CTD PMID:12548226 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha increases abundance EXP IL1A protein results in increased abundance of Dinoprost CTD PMID:21513769 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta increases abundance
multiple interactions
EXP IL1B protein results in increased abundance of Dinoprost
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
CTD PMID:12548226 PMID:16354411 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha increases expression ISO Dinoprost results in increased expression of IL2RA mRNA CTD PMID:11517196 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL4 interleukin 4 increases secretion
multiple interactions
EXP IL4 protein results in increased secretion of Dinoprost
[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost
CTD PMID:23688403 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G KPNB1 karyopherin subunit beta 1 increases expression ISO Dinoprost results in increased expression of KPNB1 protein CTD PMID:16365892 NCBI chr17:47,649,919...47,685,505
Ensembl chr17:47,649,476...47,685,505
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor decreases expression ISO Dinoprost results in decreased expression of LHCGR mRNA CTD PMID:11517196 NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730
JBrowse link
G LYPLA2 lysophospholipase 2 increases hydrolysis EXP LYPLA2 protein results in increased hydrolysis of Dinoprost analog CTD PMID:25301951 NCBI chr 1:23,790,789...23,795,539
Ensembl chr 1:23,791,145...23,795,539
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAP2K1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]
CTD PMID:24333336 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,544
JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAP2K2 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]
CTD PMID:24333336 NCBI chr19:4,090,321...4,124,184
Ensembl chr19:4,090,321...4,124,122
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects localization
multiple interactions
increases phosphorylation
ISO Dinoprost affects the localization of MAPK1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects localization
increases phosphorylation
multiple interactions
ISO Dinoprost affects the localization of MAPK3 protein
Dinoprost results in increased phosphorylation of MAPK3 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK6 mitogen-activated protein kinase 6 increases expression ISO Dinoprost results in increased expression of MAPK6 mRNA CTD PMID:11517196 NCBI chr15:52,019,219...52,067,375
Ensembl chr15:51,952,106...52,067,375
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAPK8 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]
CTD PMID:24333336 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions
ISO Dinoprost results in increased phosphorylation of MAPK9 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]
CTD PMID:24333336 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP Dinoprost results in increased expression of and results in increased activity of MMP2 protein CTD PMID:11719597 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP Dinoprost results in increased expression of and results in increased activity of MMP9 protein CTD PMID:11719597 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G NOTCH1 notch receptor 1 decreases cleavage
decreases expression
ISO Dinoprost results in decreased cleavage of NOTCH1 protein
Dinoprost results in decreased expression of NOTCH1 mRNA
CTD PMID:21209419 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048
JBrowse link
G NOTCH4 notch receptor 4 decreases expression
decreases cleavage
ISO Dinoprost results in decreased expression of NOTCH4 mRNA
Dinoprost results in decreased cleavage of NOTCH4 protein
CTD PMID:21209419 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067
JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 decreases expression ISO Dinoprost results in decreased expression of PDIA4 mRNA CTD PMID:11517196 NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662
JBrowse link
G PLCD1 phospholipase C delta 1 increases expression ISO Dinoprost results in increased expression of PLCD1 mRNA CTD PMID:11517196 NCBI chr 3:38,007,496...38,029,642
Ensembl chr 3:38,007,496...38,029,642
JBrowse link
G POR cytochrome p450 oxidoreductase increases expression ISO Dinoprost results in increased expression of POR mRNA CTD PMID:11517196 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG protein CTD PMID:21236357 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRL prolactin multiple interactions ISO [Dinoprost results in decreased abundance of Progesterone] which results in increased expression of PRL protein CTD PMID:21654155 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PRLR prolactin receptor increases expression ISO Dinoprost results in increased expression of PRLR mRNA CTD PMID:21654155 NCBI chr 5:35,048,756...35,230,724
Ensembl chr 5:35,048,756...35,230,487
JBrowse link
G PTGDR prostaglandin D2 receptor multiple interactions EXP Dinoprost binds to and results in increased activity of PTGDR protein; Dinoprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:27636113 NCBI chr14:52,267,256...52,276,724
Ensembl chr14:52,267,698...52,276,724
JBrowse link
G PTGER2 prostaglandin E receptor 2 multiple interactions EXP Dinoprost binds to and results in increased activity of PTGER2 protein CTD PMID:27636113 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598
JBrowse link
G PTGFR prostaglandin F receptor increases expression
multiple interactions
ISO Dinoprost results in increased expression of PTGFR mRNA
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]
CTD PMID:11517196 PMID:22583689 NCBI chr 1:78,490,974...78,540,701
Ensembl chr 1:78,303,884...78,540,701
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases abundance
increases expression
ISO
EXP
[Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Niacin results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG
PTGS2 protein results in increased abundance of Dinoprost
Dinoprost results in increased expression of PTGS2 mRNA
[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; Resveratrol inhibits the reaction [[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]]
[Dinoprost results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprost; CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PTGS2 protein results in increased abundance of Dinoprost]
CTD PMID:18555068 PMID:18776171 PMID:18834901 PMID:20826536 PMID:20844277 PMID:21236357 PMID:22306367 PMID:22583689 PMID:27050768 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTK2B protein tyrosine kinase 2 beta increases expression ISO Dinoprost results in increased expression of PTK2B mRNA CTD PMID:11517196 NCBI chr 8:27,311,478...27,459,391
Ensembl chr 8:27,311,482...27,459,391
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
multiple interactions
ISO Dinoprost results in increased expression of RAF1 protein modified form
resveratrol inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]
CTD PMID:24333336 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,125
JBrowse link
G RBL2 RB transcriptional corepressor like 2 decreases expression ISO Dinoprost results in decreased expression of RBL2 mRNA CTD PMID:11517196 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein]; Dinoprost results in increased localization of and results in increased activity of RELA protein CTD PMID:20826536 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO Dinoprost results in increased expression of RUNX2 mRNA; Dinoprost results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 increases expression ISO Dinoprost results in increased expression of SCN1B mRNA CTD PMID:11517196 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449
JBrowse link
G SHC1 SHC adaptor protein 1 increases phosphorylation ISO Dinoprost results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 NCBI chr 1:154,962,298...154,974,492
Ensembl chr 1:154,962,298...154,974,395
JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases uptake EXP SLC22A7 protein results in increased uptake of Dinoprost CTD PMID:15901346 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC22A8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Dinoprost CTD PMID:15100168 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 increases expression ISO Dinoprost results in increased expression of SOCS1 mRNA CTD PMID:21654155 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression ISO Dinoprost results in increased expression of SOCS3 mRNA CTD PMID:21654155 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077
JBrowse link
G SOX9 SRY-box transcription factor 9 increases expression ISO Dinoprost results in increased expression of SOX9 mRNA; Dinoprost results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G STAT5A signal transducer and activator of transcription 5A increases expression ISO Dinoprost results in increased expression of STAT5A mRNA CTD PMID:21654155 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943
JBrowse link
G SYN2 synapsin II decreases expression ISO Dinoprost results in decreased expression of SYN2 mRNA CTD PMID:11517196 NCBI chr 3:12,004,366...12,192,032
Ensembl chr 3:12,004,388...12,192,032
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression ISO Dinoprost results in increased expression of TGFB1 mRNA CTD PMID:11517196 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THRSP thyroid hormone responsive decreases expression ISO Dinoprost results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Dinoprost results in decreased expression of TIMP1 protein CTD PMID:11719597 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 decreases expression ISO Dinoprost results in decreased expression of TIMP3 mRNA CTD PMID:11517196 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
JBrowse link
G TNF tumor necrosis factor increases abundance EXP TNF protein results in increased abundance of Dinoprost CTD PMID:1993070 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of TNFRSF11B mRNA]; SB 203580 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases chemical synthesis ISO UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprost CTD PMID:3864191 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Dinoprost results in decreased expression of VEGFA mRNA CTD PMID:11517196 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon increases expression ISO Dinoprost results in increased expression of YWHAE mRNA CTD PMID:11517196 NCBI chr17:1,344,275...1,400,229
Ensembl chr17:1,344,275...1,400,222
JBrowse link
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma increases expression ISO Dinoprost results in increased expression of YWHAG mRNA CTD PMID:11517196 NCBI chr 7:76,326,799...76,358,991
Ensembl chr 7:76,326,799...76,358,991
JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta increases expression ISO Dinoprost results in increased expression of YWHAZ mRNA CTD PMID:11517196 NCBI chr 8:100,916,523...100,954,068
Ensembl chr 8:100,916,523...100,953,388
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24779
    chemical entity 24749
      atom 24738
        nonmetal atom 24470
          carbon atom 24360
            organic molecular entity 24360
              fatty acid derivative 1054
                icosanoid 464
                  prostanoid 402
                    prostaglandin 397
                      prostaglandins F 102
                        11-epi-prostaglandin F2alpha + 0
                        prostaglandins Falpha + 101
                        prostaglandins Fbeta + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24779
    subatomic particle 24738
      composite particle 24738
        hadron 24738
          baryon 24738
            nucleon 24738
              atomic nucleus 24738
                atom 24738
                  main group element atom 24603
                    p-block element atom 24603
                      carbon group element atom 24396
                        carbon atom 24360
                          organic molecular entity 24360
                            organic group 22765
                              organic divalent group 22744
                                organodiyl group 22744
                                  carbonyl group 22731
                                    carbonyl compound 22731
                                      carboxylic acid 21802
                                        monocarboxylic acid 20858
                                          fatty acid 18323
                                            fatty acid derivative 1054
                                              icosanoid 464
                                                prostanoid 402
                                                  prostaglandin 397
                                                    prostaglandins F 102
                                                      11-epi-prostaglandin F2alpha + 0
                                                      prostaglandins Falpha + 101
                                                      prostaglandins Fbeta + 0
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