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ONTOLOGY REPORT - ANNOTATIONS


Term:prostaglandins D
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Accession:CHEBI:26337 term browser browse the term
Synonyms:related_synonym: Formula=C5H6O2R2;   PGD;   SMILES=O[C@H]1CC(=O)[C@H]([*])[C@H]1[*]


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13,14-dihydro-15-ketoprostaglandin D2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl2 chemokine (C-X-C motif) ligand 2 JBrowse link 5 90,903,899 90,905,938 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 2 9,857,078 9,887,953 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Ptgdr prostaglandin D receptor JBrowse link 14 44,851,235 44,859,375 RGD:6480464
G Ptgdr2 prostaglandin D2 receptor 2 JBrowse link 19 10,924,519 10,942,511 RGD:6480464
13,14-dihydro-Delta(12)-prostaglandin J2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:6480464
G Gdnf glial cell line derived neurotrophic factor JBrowse link 15 7,810,048 7,837,580 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Ngf nerve growth factor JBrowse link 3 102,469,919 102,521,013 RGD:6480464
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 JBrowse link 16 14,361,453 14,474,878 RGD:6480464
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 JBrowse link 11 94,343,295 94,393,017 RGD:6480464
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,706 RGD:6480464
G Akr1c18 aldo-keto reductase family 1, member C18 JBrowse link 13 4,132,615 4,150,646 RGD:6480464
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6480464
G Bglap bone gamma carboxyglutamate protein JBrowse link 3 88,383,495 88,384,466 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 9 7,818,226 7,837,131 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 9 7,847,468 7,873,205 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:6480464
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:6480464
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 10 24,595,442 24,598,683 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 3 36,564,865 36,573,038 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 13 100,778,739 100,786,486 RGD:6480464
G Ccnd3 cyclin D3 JBrowse link 17 47,505,051 47,599,689 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 7 38,097,984 38,107,490 RGD:6480464
G Cdk2 cyclin-dependent kinase 2 JBrowse link 10 128,697,938 128,705,051 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha JBrowse link 7 35,119,293 35,121,928 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 1 58,711,311 58,758,884 RGD:6480464
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 19 44,073,334 44,107,505 RGD:6480464
G Col1a1 collagen, type I, alpha 1 JBrowse link 11 94,936,224 94,953,042 RGD:6480464
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 JBrowse link 4 115,563,627 115,579,015 RGD:6480464
G Ddx58 DEAD/H box helicase 58 JBrowse link 4 40,203,777 40,239,825 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 34,861,207 34,864,956 RGD:6480464
G Fabp4 fatty acid binding protein 4, adipocyte JBrowse link 3 10,204,342 10,208,616 RGD:6480464
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:6480464
G Fos FBJ osteosarcoma oncogene JBrowse link 12 85,473,890 85,477,274 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 11 102,887,336 102,897,200 RGD:6480464
G Gsta3 glutathione S-transferase, alpha 3 JBrowse link 1 21,240,565 21,265,575 RGD:6480464
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,973 RGD:6480464
G Gstp1 glutathione S-transferase, pi 1 JBrowse link 19 4,035,411 4,037,912 RGD:6480464
G Hdac1 histone deacetylase 1 JBrowse link 4 129,516,104 129,542,646 RGD:6480464
G Hdac2 histone deacetylase 2 JBrowse link 10 36,974,297 37,001,889 RGD:6480464
G Hdac3 histone deacetylase 3 JBrowse link 18 37,936,971 37,955,015 RGD:6480464
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hsf1 heat shock factor 1 JBrowse link 15 76,477,362 76,501,155 RGD:6480464
G Hspb1 heat shock protein 1 JBrowse link 5 135,887,919 135,889,563 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il1rn interleukin 1 receptor antagonist JBrowse link 2 24,336,860 24,351,491 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Ins2 insulin II JBrowse link 7 142,678,656 142,679,726 RGD:6480464
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,770,014 53,778,374 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 19 29,251,803 29,313,095 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 13 5,861,489 5,870,393 RGD:6480464
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:6480464
G Lif leukemia inhibitory factor JBrowse link 11 4,257,568 4,272,514 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 8 68,880,555 68,906,932 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Med1 mediator complex subunit 1 JBrowse link 11 98,152,154 98,193,313 RGD:6480464
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) JBrowse link 9 7,464,141 7,476,869 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 4 148,448,582 148,557,685 RGD:6480464
G Nes nestin JBrowse link 3 87,971,093 87,980,451 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:6480464
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 39,410,545 39,519,421 RGD:6480464
G Park7 Parkinson disease (autosomal recessive, early onset) 7 JBrowse link 4 150,897,133 150,909,921 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic JBrowse link 2 173,153,073 173,159,274 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Ppard peroxisome proliferator activator receptor delta JBrowse link 17 28,232,754 28,301,469 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:6480464
G Ptgdr prostaglandin D receptor JBrowse link 14 44,851,235 44,859,375 RGD:6480464
G Ptgdr2 prostaglandin D2 receptor 2 JBrowse link 19 10,924,519 10,942,511 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 2 36,216,742 36,258,593 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 5 121,130,533 121,191,397 RGD:6480464
G Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:6480464
G Rarb retinoic acid receptor, beta JBrowse link 14 16,430,839 17,082,331 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 14 73,192,858 73,325,951 RGD:6480464
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) JBrowse link 19 5,637,442 5,648,134 RGD:6480464
G Rps6ka1 ribosomal protein S6 kinase polypeptide 1 JBrowse link 4 133,847,290 133,887,797 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 JBrowse link 11 86,498,869 86,544,885 RGD:6480464
G Runx2 runt related transcription factor 2 JBrowse link 17 44,495,987 44,814,797 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 2 27,676,445 27,763,319 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 76,241,090 76,311,748 RGD:6480464
G Socs1 suppressor of cytokine signaling 1 JBrowse link 16 10,783,808 10,785,536 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 11 117,966,079 117,970,336 RGD:6480464
G Spp1 secreted phosphoprotein 1 JBrowse link 5 104,435,111 104,441,053 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 1 52,119,438 52,161,865 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 11 100,886,806 100,939,594 RGD:6480464
G Tbxa2r thromboxane A2 receptor JBrowse link 10 81,328,268 81,335,174 RGD:6480464
G Tg thyroglobulin JBrowse link 15 66,670,754 66,850,721 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 7 142,892,779 142,899,995 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 3 83,836,272 83,841,824 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tshb thyroid stimulating hormone, beta subunit JBrowse link 3 102,777,398 102,789,082 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 32,815,383 32,819,799 RGD:6480464
G Vim vimentin JBrowse link 2 13,574,311 13,582,826 RGD:6480464
G Wnt10b wingless-type MMTV integration site family, member 10B JBrowse link 15 98,770,712 98,778,206 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 42,059,613 42,109,664 RGD:6480464
prostaglandin D2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c18 aldo-keto reductase family 1, member C18 JBrowse link 13 4,132,615 4,150,646 RGD:6480464
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta JBrowse link 6 136,923,655 136,941,899 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Cryab crystallin, alpha B JBrowse link 9 50,745,951 50,756,636 RGD:6480464
G Cxcl2 chemokine (C-X-C motif) ligand 2 JBrowse link 5 90,903,899 90,905,938 RGD:6480464
G Egf epidermal growth factor JBrowse link 3 129,677,574 129,755,322 RGD:6480464
G Ephx2 epoxide hydrolase 2, cytoplasmic JBrowse link 14 66,084,372 66,124,522 RGD:6480464
G Fabp4 fatty acid binding protein 4, adipocyte JBrowse link 3 10,204,342 10,208,616 RGD:6480464
G Hcar2 hydroxycarboxylic acid receptor 2 JBrowse link 5 123,863,570 123,865,516 RGD:6480464
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 6 65,117,293 65,144,981 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:6480464
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6480464
G Lypla2 lysophospholipase 2 JBrowse link 4 135,968,224 135,972,612 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Myc myelocytomatosis oncogene JBrowse link 15 61,985,341 61,990,361 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha JBrowse link 5 51,454,249 52,115,853 RGD:6480464
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A JBrowse link 10 108,162,092 108,279,985 RGD:6480464
G Ptgdr prostaglandin D receptor JBrowse link 14 44,851,235 44,859,375 RGD:6480464
G Ptgdr2 prostaglandin D2 receptor 2 JBrowse link 19 10,924,519 10,942,511 RGD:6480464
G Ptger2 prostaglandin E receptor 2 (subtype EP2) JBrowse link 14 44,988,111 45,003,820 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Rorc RAR-related orphan receptor gamma JBrowse link 3 94,372,794 94,398,276 RGD:6480464
G Slc22a22 solute carrier family 22 (organic cation transporter), member 22 JBrowse link 15 57,243,767 57,477,625 RGD:6480464
G Tac1 tachykinin 1 JBrowse link 6 7,555,061 7,562,978 RGD:6480464
G Tg thyroglobulin JBrowse link 15 66,670,754 66,850,721 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) JBrowse link 15 54,250,619 54,278,484 RGD:6480464
G Tshb thyroid stimulating hormone, beta subunit JBrowse link 3 102,777,398 102,789,082 RGD:6480464
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) JBrowse link 7 100,493,337 100,499,629 RGD:6480464
prostaglandin D3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
prostaglandin J2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 JBrowse link 4 53,030,789 53,159,988 RGD:6480464
G Akr1c18 aldo-keto reductase family 1, member C18 JBrowse link 13 4,132,615 4,150,646 RGD:6480464
G Apoa1 apolipoprotein A-I JBrowse link 9 46,228,630 46,230,469 RGD:6480464
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta JBrowse link 6 136,923,655 136,941,899 RGD:6480464
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:6480464
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta JBrowse link 2 167,688,915 167,690,432 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 8 93,166,072 93,197,804 RGD:6480464
G Cryab crystallin, alpha B JBrowse link 9 50,745,951 50,756,636 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 15 81,586,209 81,652,077 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 9 77,754,535 77,794,489 RGD:6480464
G Gclm glutamate-cysteine ligase, modifier subunit JBrowse link 3 122,245,487 122,267,215 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 8 70,629,393 70,632,470 RGD:6480464
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) JBrowse link 9 78,331,018 78,347,192 RGD:6480464
G Gstm1 glutathione S-transferase, mu 1 JBrowse link 3 108,012,250 108,017,973 RGD:6480464
G Jun jun proto-oncogene JBrowse link 4 95,049,036 95,052,222 RGD:6480464
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 JBrowse link 2 75,675,513 75,704,663 RGD:6480464
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 JBrowse link 2 91,184,061 91,202,829 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Ptgdr prostaglandin D receptor JBrowse link 14 44,851,235 44,859,375 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 2 27,676,445 27,763,319 RGD:6480464
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 JBrowse link 11 69,942,286 69,948,216 RGD:6480464
G Tg thyroglobulin JBrowse link 15 66,670,754 66,850,721 RGD:6480464
G Tshb thyroid stimulating hormone, beta subunit JBrowse link 3 102,777,398 102,789,082 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    chemical entity 21258
      molecular entity 21251
        polyatomic entity 21130
          heteroatomic molecular entity 21037
            hydroxides 19767
              organic hydroxy compound 18879
                alcohol 15210
                  secondary alcohol 7363
                    prostaglandins D 142
                      13,14-dihydro-15-ketoprostaglandin D2 5
                      15-dehydro-prostaglandin D2 0
                      15-deoxy-Delta(12,14)-prostaglandin D2 0
                      prostaglandin D1 0
                      prostaglandin D2 + 142
                      prostaglandin D2 1-glyceryl ester 0
                      prostaglandin D2 2-glyceryl ester 0
                      prostaglandin D3 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21125
                    p-block element atom 21125
                      carbon group element atom 20894
                        carbon atom 20785
                          organic molecular entity 20785
                            organic group 19179
                              organic divalent group 19169
                                organodiyl group 19169
                                  carbonyl group 19143
                                    carbonyl compound 19143
                                      carboxylic acid 18827
                                        monocarboxylic acid 18003
                                          fatty acid 16404
                                            fatty acid derivative 1018
                                              icosanoid 456
                                                prostanoid 397
                                                  prostaglandin 392
                                                    prostaglandins D 142
                                                      13,14-dihydro-15-ketoprostaglandin D2 5
                                                      15-dehydro-prostaglandin D2 0
                                                      15-deoxy-Delta(12,14)-prostaglandin D2 0
                                                      prostaglandin D1 0
                                                      prostaglandin D2 + 142
                                                      prostaglandin D2 1-glyceryl ester 0
                                                      prostaglandin D2 2-glyceryl ester 0
                                                      prostaglandin D3 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.