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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propan-1-ols
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Accession:CHEBI:26279 term browser browse the term
Definition:A primary alcohol based on a propan-1-olskeleton and its substituted derivatives.



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etofenprox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA CTD PMID:22467020 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP ethofenprox results in increased activity of CYP1A1 protein CTD PMID:20009351 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:22467020 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP ethofenprox results in decreased activity of ESR1 protein CTD PMID:20410157 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:22467020 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:22467020 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethofenprox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
EXP
ISO
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein
ethofenprox results in increased activity of NR1I3 protein
CTD PMID:22467020 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA CTD PMID:22467020 NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA CTD PMID:22467020 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
propamocarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases expression ISO propamocarb results in decreased expression of ACACA mRNA CTD PMID:29137890 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ache acetylcholinesterase decreases expression ISO propamocarb results in decreased expression of ACHE protein CTD PMID:30251769 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase decreases expression ISO propamocarb results in decreased expression of ACLY mRNA CTD PMID:29137890 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO propamocarb results in decreased expression of ACOX1 mRNA CTD PMID:29137890 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO propamocarb results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression ISO propamocarb results in decreased expression of DGAT2 mRNA CTD PMID:29137890 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO propamocarb results in decreased expression of DRD2 mRNA CTD PMID:30251769 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR1 protein
propamocarb results in increased activity of ESR1 protein
CTD PMID:26812056 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO [fludioxonil co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with propamocarb] results in increased activity of ESR2 protein
propamocarb results in increased activity of ESR2 protein
CTD PMID:26812056 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression ISO propamocarb results in decreased expression of FABP2 mRNA CTD PMID:29137890 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fasn fatty acid synthase decreases expression ISO propamocarb results in decreased expression of FASN mRNA CTD PMID:29137890 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Ffar3 free fatty acid receptor 3 decreases expression ISO propamocarb results in decreased expression of FFAR3 mRNA CTD PMID:29137890 NCBI chr 1:86,105,388...86,106,728
Ensembl chr 1:86,104,920...86,106,849
JBrowse link
G Gk glycerol kinase decreases expression ISO propamocarb results in decreased expression of GK mRNA CTD PMID:29137890 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression ISO propamocarb results in decreased expression of GPAM mRNA CTD PMID:29137890 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Lpl lipoprotein lipase increases expression ISO propamocarb results in increased expression of LPL mRNA CTD PMID:29137890 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mlxipl MLX interacting protein-like decreases expression ISO propamocarb results in decreased expression of MLXIPL mRNA CTD PMID:29137890 NCBI chr12:21,542,964...21,577,120
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Pklr pyruvate kinase L/R decreases expression ISO propamocarb results in decreased expression of PKLR mRNA CTD PMID:29137890 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO propamocarb results in decreased expression of PPARG mRNA CTD PMID:29137890 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO propamocarb results in decreased expression of SCD1 mRNA CTD PMID:29137890 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO propamocarb results in decreased expression of SLC27A2 mRNA CTD PMID:29137890 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO propamocarb results in decreased expression of SREBF1 mRNA CTD PMID:29137890 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tph2 tryptophan hydroxylase 2 decreases expression ISO propamocarb results in decreased expression of TPH2 mRNA CTD PMID:30251769 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
propan-1-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] CTD PMID:11821649 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO 1-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]] CTD PMID:11821649 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Gh1 growth hormone 1 affects folding ISO 1-Propanol affects the folding of GH1 protein CTD PMID:11064379 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]; 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] CTD PMID:17360702 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B multiple interactions ISO 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] CTD PMID:17360702 NCBI chr 8:49,279,291...49,308,444
Ensembl chr 8:49,279,173...49,308,444
JBrowse link
propylparaben term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO propylparaben results in increased expression of ADIPOQ mRNA CTD PMID:22956630 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO propylparaben results in increased expression of APAF1 mRNA CTD PMID:24481588 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
propylparaben binds to AR protein
propylparaben inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:14565775 PMID:20371976 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin increases expression ISO propylparaben results in increased expression of AREG mRNA CTD PMID:31939680 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Atm ATM serine/threonine kinase affects expression ISO propylparaben affects the expression of ATM mRNA CTD PMID:24481588 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase increases expression ISO propylparaben results in increased expression of ATR mRNA CTD PMID:24481588 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
decreases expression
ISO propylparaben results in increased expression of BAD mRNA
propylparaben results in decreased expression of BAD mRNA
CTD PMID:24481588 PMID:33358972 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO propylparaben results in increased expression of BAK1 mRNA CTD PMID:24481588 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO propylparaben results in increased expression of BAX mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO propylparaben results in increased expression of BBC3 mRNA CTD PMID:24481588 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
ISO propylparaben results in increased expression of BCL2 mRNA
propylparaben results in decreased expression of BCL2 mRNA
CTD PMID:24481588 PMID:33358972 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO propylparaben results in increased expression of BCL2L1 mRNA; propylparaben results in increased expression of BCL2L1 protein CTD PMID:24481588 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO propylparaben results in increased expression of BCL2L11 mRNA CTD PMID:24481588 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO propylparaben results in increased expression of BCL2L2 mRNA CTD PMID:24481588 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO propylparaben results in increased expression of BID mRNA CTD PMID:24481588 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bik BCL2-interacting killer increases expression ISO propylparaben results in increased expression of BIK mRNA CTD PMID:24481588 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO propylparaben results in increased expression of BIRC5 mRNA CTD PMID:24481588 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 increases expression ISO propylparaben results in increased expression of BIRC6 mRNA CTD PMID:24481588 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Bok BCL2 family apoptosis regulator BOK increases expression ISO propylparaben results in increased expression of BOK mRNA CTD PMID:24481588 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Casp1 caspase 1 increases expression ISO propylparaben results in increased expression of CASP1 mRNA CTD PMID:24481588 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp2 caspase 2 increases expression ISO propylparaben results in increased expression of CASP2 mRNA CTD PMID:24481588 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 increases expression ISO propylparaben results in increased expression of CASP3 mRNA CTD PMID:24481588 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases expression ISO propylparaben results in increased expression of CASP4 mRNA CTD PMID:24481588 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp6 caspase 6 increases expression ISO propylparaben results in increased expression of CASP6 mRNA CTD PMID:24481588 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 increases expression ISO propylparaben results in increased expression of CASP7 mRNA CTD PMID:24481588 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases expression ISO propylparaben results in increased expression of CASP8 mRNA; propylparaben results in increased expression of CASP8 protein CTD PMID:24481588 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 increases expression ISO propylparaben results in increased expression of CASP8AP2 mRNA CTD PMID:24481588 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
JBrowse link
G Casp9 caspase 9 increases expression ISO propylparaben results in increased expression of CASP9 mRNA; propylparaben results in increased expression of CASP9 protein CTD PMID:24481588 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccna1 cyclin A1 increases expression ISO propylparaben results in increased expression of CCNA1 mRNA CTD PMID:24481588 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
ISO propylparaben results in increased expression of CCNA2 mRNA
propylparaben results in decreased expression of CCNA2 mRNA
CTD PMID:24481588 PMID:33358972 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO propylparaben results in decreased expression of CCNB1 mRNA CTD PMID:24481588 PMID:33358972 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO propylparaben results in increased expression of CCND1 mRNA CTD PMID:24481588 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression
decreases expression
ISO propylparaben results in increased expression of CCNE1 mRNA
propylparaben results in decreased expression of CCNE1 mRNA
CTD PMID:24481588 PMID:33358972 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO propylparaben results in increased expression of CDC25A mRNA CTD PMID:24481588 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression
decreases expression
ISO propylparaben results in increased expression of CDK2 mRNA
propylparaben results in decreased expression of CDK2 mRNA
CTD PMID:24481588 PMID:33358972 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO propylparaben results in increased expression of CDK4 mRNA CTD PMID:24481588 PMID:31306770 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO propylparaben results in decreased expression of CDK6 mRNA CTD PMID:24481588 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO propylparaben results in decreased expression of CDKN1A mRNA; propylparaben results in decreased expression of CDKN1A protein
propylparaben results in increased expression of CDKN1A mRNA
CTD PMID:24481588 PMID:31306770 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO propylparaben results in increased expression of CEBPA mRNA CTD PMID:22956630 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects expression ISO propylparaben affects the expression of CYP19A1 mRNA; propylparaben affects the expression of CYP19A1 protein CTD PMID:23744433 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP
ISO
propylparaben results in decreased activity of CYP1A1 protein CTD PMID:27432241 PMID:34181028 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP propylparaben results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP propylparaben results in decreased activity of CYP2C11 protein CTD PMID:27432241 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP propylparaben results in decreased activity of CYP2E1 protein CTD PMID:27432241 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP propylparaben results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO propylparaben results in increased expression of DIABLO mRNA CTD PMID:24481588 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO propylparaben results in increased expression of E2F1 mRNA CTD PMID:24481588 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f3 E2F transcription factor 3 affects expression ISO propylparaben affects the expression of E2F3 mRNA CTD PMID:24481588 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases expression
increases activity
multiple interactions
EXP
ISO
propylparaben binds to ESR1 protein
propylparaben results in increased expression of ESR1 mRNA; propylparaben results in increased expression of ESR1 protein
propylparaben results in increased activity of ESR1 protein
Fulvestrant inhibits the reaction [propylparaben results in increased activity of ESR1 protein]; propylparaben binds to and results in increased activity of ESR1 protein
CTD PMID:11193391 PMID:19063592 PMID:20132880 PMID:22562034 PMID:23567241 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects binding
increases expression
multiple interactions
EXP
ISO
propylparaben binds to ESR2 protein
propylparaben results in increased expression of ESR2 mRNA; propylparaben results in increased expression of ESR2 protein
propylparaben binds to and results in increased activity of ESR2 protein
CTD PMID:11193391 PMID:20132880 PMID:23567241 PMID:25128701 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO propylparaben results in decreased activity of FAAH protein CTD PMID:27659731 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO propylparaben results in increased expression of FABP4 mRNA CTD PMID:22956630 PMID:24155963 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fadd Fas associated via death domain increases expression ISO propylparaben results in increased expression of FADD mRNA CTD PMID:24481588 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fasn fatty acid synthase increases expression ISO propylparaben results in increased expression of FASN mRNA CTD PMID:22956630 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Flg filaggrin multiple interactions ISO FLG gene mutant form affects the abundance of and affects the susceptibility to propylparaben CTD PMID:28525834 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [Parabens results in increased abundance of propylparaben] which results in decreased secretion of FSHB protein CTD PMID:32122340 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression ISO propylparaben results in increased expression of GPER1 mRNA; propylparaben results in increased expression of GPER1 protein CTD PMID:26253279 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO propylparaben results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form]
CTD PMID:31939680 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Lep leptin decreases expression
increases expression
ISO propylparaben results in decreased expression of LEP mRNA
propylparaben results in increased expression of LEP mRNA
CTD PMID:22956630 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK1 protein CTD PMID:26253279 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO propylparaben affects the phosphorylation of MAPK3 protein CTD PMID:26253279 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO propylparaben results in increased expression of MCL1 mRNA CTD PMID:24481588 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO propylparaben inhibits the reaction [afimoxifene inhibits the reaction [ESRRG protein binds to NCOA2 protein]] CTD PMID:23583298 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
EXP
ISO
propylparaben results in increased expression of NR1I2 mRNA
propylparaben binds to and results in increased activity of NR1I2 protein
CTD PMID:31472229 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO propylparaben results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
ISO [butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with butylparaben co-treated with tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein; [Diethylhexyl Phthalate co-treated with propylparaben] results in increased activity of NR3C1 protein; [tetramethrin co-treated with propylparaben] results in increased activity of NR3C1 protein
propylparaben results in increased activity of NR3C1 protein
CTD PMID:25448277 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO NRG1 protein promotes the reaction [propylparaben results in increased expression of MYC mRNA]; propylparaben promotes the reaction [NRG1 protein results in increased expression of MYC mRNA] CTD PMID:26502914 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Pgr progesterone receptor increases expression ISO propylparaben results in increased expression of PGR mRNA CTD PMID:25128701 PMID:31939680 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects expression EXP propylparaben affects the expression of PPARA mRNA CTD PMID:31472229 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO propylparaben results in increased expression of PPARG mRNA
PPARG protein promotes the reaction [propylparaben binds to and results in increased activity of PPARG protein]; propylparaben binds to and results in increased activity of PPARG protein
CTD PMID:22956630 PMID:24155963 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO propylparaben results in increased expression of RIPK1 mRNA CTD PMID:24481588 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 increases expression ISO propylparaben results in increased expression of RIPK2 mRNA CTD PMID:24481588 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G S100g S100 calcium binding protein G increases expression EXP propylparaben results in increased expression of S100G protein CTD PMID:19654335 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO propylparaben binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO propylparaben results in increased expression of STAR mRNA CTD PMID:31306770 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [propylparaben results in increased expression of TFF1 mRNA] CTD PMID:16797915 PMID:22562034 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO propylparaben binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO propylparaben binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tnf tumor necrosis factor increases expression ISO propylparaben results in increased expression of TNF mRNA CTD PMID:24481588 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO propylparaben results in increased expression of TNFRSF10A mRNA CTD PMID:24481588 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO propylparaben results in increased expression of TNFRSF1A mRNA CTD PMID:24481588 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO propylparaben results in increased expression of TNFRSF25 mRNA CTD PMID:24481588 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO propylparaben results in increased expression of TNFSF10 mRNA CTD PMID:24481588 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 increases expression ISO propylparaben results in increased expression of TP53 mRNA; propylparaben results in increased expression of TP53 protein CTD PMID:24481588 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO propylparaben results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO propylparaben results in increased expression of TRADD mRNA CTD PMID:24481588 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      molecular entity 20055
        polyatomic entity 19983
          heteroatomic molecular entity 19923
            hydroxides 19380
              organic hydroxy compound 18898
                alcohol 15184
                  primary alcohol 14059
                    propan-1-ols 117
                      (R)-2-methylimino-1-phenylpropan-1-ol 0
                      2,2-bis(4-hydroxyphenyl)propan-1-ol 0
                      2,3-dibromo-1-propanol 0
                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
                      2-methyl-2-hydroxy-1-propanol 0
                      3-[3-(trifluoromethyl)phenyl]propan-1-ol + 0
                      3-ethoxy-1-propanol 0
                      propan-1-ol + 111
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      p-block molecular entity 19956
                        chalcogen molecular entity 19683
                          oxygen molecular entity 19655
                            hydroxides 19380
                              organic hydroxy compound 18898
                                alcohol 15184
                                  primary alcohol 14059
                                    propan-1-ols 117
                                      (R)-2-methylimino-1-phenylpropan-1-ol 0
                                      2,2-bis(4-hydroxyphenyl)propan-1-ol 0
                                      2,3-dibromo-1-propanol 0
                                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
                                      2-methyl-2-hydroxy-1-propanol 0
                                      3-[3-(trifluoromethyl)phenyl]propan-1-ol + 0
                                      3-ethoxy-1-propanol 0
                                      propan-1-ol + 111
paths to the root