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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:proline derivative
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Accession:CHEBI:26273 term browser browse the term
Definition:An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues.
Synonyms:related_synonym: proline derivatives

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5-oxo-L-proline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dek DEK proto-oncogene multiple interactions ISO DEK protein results in decreased chemical synthesis of and results in increased uptake of Pyrrolidonecarboxylic Acid CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Pyrrolidonecarboxylic Acid analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
captopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein] CTD PMID:31629013 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases response to substance
multiple interactions		 ISO
EXP		 ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]		 CTD PMID:17473847 PMID:31629013 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]		 CTD PMID:28130181 PMID:31181250 PMID:31629013 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]		 CTD PMID:28130181 PMID:31629013 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] CTD PMID:28130181 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] CTD PMID:28130181 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] CTD PMID:28130181 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036 		JBrowse link
G Lepr leptin receptor multiple interactions
affects response to substance		 ISO Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril		 CTD PMID:28130181 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein] CTD PMID:31629013 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] CTD PMID:28130181 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] CTD PMID:31629013 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873 		JBrowse link
G Pth parathyroid hormone multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] CTD PMID:28130181 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] CTD PMID:28130181 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] CTD PMID:28130181 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] CTD PMID:28130181 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
clindamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions		 ISO Clindamycin results in increased expression of CYP3A4 mRNA
Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein		 CTD PMID:18505790 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Clindamycin results in increased expression of MMP13 mRNA CTD PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Clindamycin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Clindamycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
clindamycin phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity ISO clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
domoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
increases localization
multiple interactions		 ISO domoic acid results in increased expression of BAX mRNA
domoic acid results in increased localization of BAX protein
Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]		 CTD PMID:18293405 PMID:19200344 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO domoic acid affects the expression of BCL2 mRNA CTD PMID:18293405 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein] CTD PMID:19200344 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO domoic acid results in increased expression of GCLC mRNA; domoic acid results in increased expression of GCLC protein CTD PMID:23315585 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
decreases response to substance
affects response to substance		 ISO domoic acid results in increased expression of GCLM mRNA; domoic acid results in increased expression of GCLM protein
[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone; [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide; GCLM protein results in decreased susceptibility to domoic acid; GCLM results in decreased susceptibility to domoic acid
GCLM affects the susceptibility to domoic acid		 CTD PMID:17804861 PMID:19200344 PMID:23315585 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation EXP domoic acid results in increased phosphorylation of GRIA1 protein CTD PMID:19564213 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Pvalb parvalbumin increases expression ISO domoic acid results in increased expression of PVALB protein CTD PMID:26797589 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487 		JBrowse link
G Wdr35 WD repeat domain 35 increases expression
multiple interactions		 EXP domoic acid results in increased expression of WDR35 mRNA; domoic acid results in increased expression of WDR35 protein
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [domoic acid results in increased expression of WDR35 protein]; Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein]		 CTD PMID:23289926 NCBI chr 6:34,094,291...34,152,048
Ensembl chr 6:34,094,306...34,151,622 		JBrowse link
fosinopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Fosinopril CTD PMID:22095822 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions
increases export		 ISO ABCC2 protein results in decreased susceptibility to Fosinopril
ABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]
desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]		 CTD PMID:22095822 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP fosinopril increases expression of adipor2 mRNA in rat liver RGD PMID:19076162 RGD:2307264 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Agt angiotensinogen decreases expression EXP Fosinopril results in decreased expression of AGT protein CTD PMID:12411096 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 multiple interactions EXP Fosinopril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of BMPR2 mRNA] CTD PMID:17803470 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein] CTD PMID:29859236 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Kl Klotho increases expression EXP Fosinopril results in increased expression of KL mRNA; Fosinopril results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] CTD PMID:29859236 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of MMP9 mRNA; Fosinopril results in decreased expression of MMP9 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein		 CTD PMID:21051829 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein] CTD PMID:29859236 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression EXP Fosinopril affects the expression of NOS3 mRNA; Fosinopril affects the expression of NOS3 protein CTD PMID:18209565 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Pde1a phosphodiesterase 1A affects expression EXP Fosinopril affects the expression of PDE1A mRNA; Fosinopril affects the expression of PDE1A protein CTD PMID:18209565 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094 		JBrowse link
G Pde1c phosphodiesterase 1C affects expression EXP Fosinopril affects the expression of PDE1C mRNA; Fosinopril affects the expression of PDE1C protein CTD PMID:18209565 NCBI chr 4:86,359,762...86,925,044
Ensembl chr 4:86,359,820...86,630,543 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein] CTD PMID:29859236 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of SERPINE1 mRNA; Fosinopril results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein		 CTD PMID:21051829 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions EXP Fosinopril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein] CTD PMID:29859236 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions		 EXP Fosinopril results in decreased expression of TIMP1 mRNA; Fosinopril results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein		 CTD PMID:21051829 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein] CTD PMID:29859236 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein] CTD PMID:29859236 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
kainic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Kainic Acid results in increased expression of ABCB1A mRNA; Kainic Acid results in increased expression of ABCB1A protein CTD PMID:14706787 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Kainic Acid results in increased expression of ABCB1B mRNA; Kainic Acid results in increased expression of ABCB1B protein CTD PMID:14706787 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Kainic Acid results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity		 EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein] CTD PMID:11520895 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Kainic Acid results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714 		JBrowse link
G Adk adenosine kinase increases expression ISO Kainic Acid results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888 		JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions
decreases expression		 EXP Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein]
Kainic Acid results in decreased expression of ADNP mRNA; Kainic Acid results in decreased expression of ADNP protein		 CTD PMID:18375135 NCBI chr 3:164,937,188...164,964,819
Ensembl chr 3:164,937,198...164,964,702 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Kainic Acid CTD PMID:19125850 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions		 EXP Kainic Acid results in increased expression of AIF1 protein
NADP inhibits the reaction [Kainic Acid results in increased expression of AIF1 protein]		 CTD PMID:32057834 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization
multiple interactions		 ISO Kainic Acid results in increased localization of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]		 CTD PMID:16469440 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Kainic Acid results in increased expression of ALOX5AP mRNA CTD PMID:19700661 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Apoe apolipoprotein E decreases expression ISO Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
ISO		 Kainic Acid results in increased expression of ARC mRNA; Kainic Acid results in increased expression of ARC protein CTD PMID:17632064 PMID:30557575 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Atf7ip activating transcription factor 7 interacting protein decreases expression EXP Kainic Acid results in decreased expression of ATF7IP mRNA CTD PMID:19700661 NCBI chr 4:170,476,998...170,563,063
Ensembl chr 4:170,518,673...170,559,532 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of ATG5 protein] CTD PMID:32057834 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140 		JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Kainic Acid results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,707,510...136,717,345
Ensembl chr 5:136,707,510...136,715,981 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Kainic Acid results in increased expression of BAG3 mRNA CTD PMID:19700661 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]
Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]		 CTD PMID:18711747 PMID:19700661 PMID:25453207 PMID:31430510 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]
Kainic Acid results in decreased expression of BCL2 mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]		 CTD PMID:25453207 PMID:31430510 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]
Kainic Acid results in increased expression of BDNF mRNA; Kainic Acid results in increased expression of BDNF protein		 CTD PMID:1641125 PMID:9073163 PMID:11279263 PMID:16166269 PMID:17827730 PMID:19700661 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of BECN1 protein] CTD PMID:32057834 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G C1qb complement C1q B chain increases expression ISO Kainic Acid results in increased expression of C1QB mRNA CTD PMID:17997037 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003 		JBrowse link
G C4b complement C4B (Chido blood group) increases expression ISO Kainic Acid results in increased expression of C4B mRNA CTD PMID:17997037 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715 		JBrowse link
G Calb1 calbindin 1 decreases expression ISO Kainic Acid results in decreased expression of CALB1 mRNA CTD PMID:17997037 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Kainic Acid results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957 		JBrowse link
G Capns1 calpain, small subunit 1 increases expression EXP Kainic Acid results in increased expression of CAPNS1 mRNA CTD PMID:19700661 NCBI chr 1:91,058,528...91,064,880 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 ISO
EXP		 Kainic Acid results in increased activity of CASP3 protein
oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]
Kainic Acid results in increased cleavage of CASP3 protein
Kainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:16469440 PMID:18711747 PMID:19700661 PMID:25453207 PMID:31430510 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Kainic Acid results in decreased expression of CAT mRNA; Kainic Acid results in decreased expression of CAT protein
Kainic Acid results in decreased activity of CAT protein
oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein]		 CTD PMID:29208536 PMID:31430510 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cck cholecystokinin decreases expression EXP Kainic Acid results in decreased expression of CCK protein CTD PMID:7774662 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Kainic Acid results in increased expression of CCL2 mRNA CTD PMID:19700661 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cd68 Cd68 molecule increases expression EXP Kainic Acid results in increased expression of CD68 mRNA CTD PMID:19700661 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Cdc42 cell division cycle 42 increases expression EXP Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300 		JBrowse link
G Cdh13 cadherin 13 increases expression ISO Kainic Acid results in increased expression of CDH13 mRNA CTD PMID:17997037 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Kainic Acid results in increased expression of CDK2 protein CTD PMID:12941380 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Kainic Acid results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345 		JBrowse link
G Chgb chromogranin B increases expression EXP Kainic Acid results in increased expression of CHGB mRNA CTD PMID:9427505 NCBI chr 3:125,428,050...125,441,601
Ensembl chr 3:125,428,260...125,441,594 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression EXP Kainic Acid results in increased expression of CITED2 mRNA CTD PMID:19700661 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression EXP Kainic Acid results in increased expression of CNR1 mRNA CTD PMID:22079489 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression EXP Kainic Acid results in increased expression of CNRIP1 mRNA CTD PMID:22079489 NCBI chr14:100,217,547...100,247,235
Ensembl chr14:100,217,289...100,247,235 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Kainic Acid results in increased expression of COL1A1 mRNA CTD PMID:17997037 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Kainic Acid results in increased expression of CRHR1 mRNA CTD PMID:12093084 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645 		JBrowse link
G Ctsb cathepsin B multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSB protein] CTD PMID:32057834 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSD protein] CTD PMID:32057834 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Ctss cathepsin S increases expression ISO Kainic Acid results in increased expression of CTSS mRNA; Kainic Acid results in increased expression of CTSS protein CTD PMID:17997037 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Ctsz cathepsin Z increases expression ISO Kainic Acid results in increased expression of CTSZ mRNA CTD PMID:17997037 NCBI chr 3:172,527,107...172,537,877
Ensembl chr 3:172,527,107...172,537,877 		JBrowse link
G Cycs cytochrome c, somatic increases localization
multiple interactions
increases expression		 ISO
EXP		 Kainic Acid results in increased localization of CYCS protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Kainic Acid results in increased expression of CYCS mRNA		 CTD PMID:16469440 PMID:19700661 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Kainic Acid results in decreased expression of DGCR6 mRNA CTD PMID:17997037 NCBI chr11:87,076,205...87,081,306
Ensembl chr11:87,076,381...87,081,950 		JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Kainic Acid results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression EXP Kainic Acid results in increased expression of DIABLO mRNA CTD PMID:19700661 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330 		JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance ISO DRD2 protein results in decreased susceptibility to Kainic Acid CTD PMID:11860278 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Egr1 early growth response 1 decreases expression
affects expression		 ISO
EXP		 Kainic Acid results in decreased expression of EGR1 mRNA
Kainic Acid affects the expression of EGR1 mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 increases expression EXP Kainic Acid results in increased expression of EIF4A3 protein CTD PMID:17632064 NCBI chr10:108,415,201...108,425,195
Ensembl chr10:108,415,202...108,425,206 		JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Kainic Acid results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426 		JBrowse link
G En2 engrailed homeobox 2 affects response to substance
decreases expression		 ISO EN2 protein affects the susceptibility to Kainic Acid
Kainic Acid results in decreased expression of EN2 mRNA		 CTD PMID:19186208 NCBI chr 4:438,668...444,508
Ensembl chr 4:438,668...444,501 		JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Kainic Acid results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029 		JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Epor erythropoietin receptor multiple interactions
decreases expression		 ISO
EXP		 EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Kainic Acid results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976 		JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Kainic Acid results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:2,726,705...2,731,213
Ensembl chr 3:2,727,254...2,731,212 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Kainic Acid results in increased expression of FGF2 mRNA CTD PMID:7649223 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Kainic Acid results in increased expression of FGF5 mRNA CTD PMID:7649223 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Kainic Acid results in increased expression of FGFR1 mRNA CTD PMID:7649223 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in increased expression of FOS mRNA; Kainic Acid results in increased expression of FOS protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in decreased expression of FOS mRNA		 CTD PMID:7655348 PMID:7887109 PMID:8417141 PMID:8758711 PMID:15723099 PMID:16686654 PMID:17827730 PMID:17997037 PMID:26348896 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Kainic Acid results in increased expression of FOSL2 mRNA CTD PMID:19700661 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995 		JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 decreases expression ISO Kainic Acid results in decreased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:89,484,197...89,488,279
Ensembl chr 1:89,484,199...89,488,223 		JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of GABRB1 mRNA
Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB1 mRNA]		 CTD PMID:27386150 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
increases expression		 ISO Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA] CTD PMID:27386150 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Kainic Acid results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression EXP Kainic Acid results in increased expression of GAD2 mRNA CTD PMID:16797850 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Kainic Acid results in increased expression of GADD45A mRNA; Kainic Acid results in increased expression of GADD45A protein CTD PMID:20955365 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Kainic Acid results in decreased expression of GADD45B mRNA CTD PMID:17997037 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression ISO Kainic Acid results in decreased expression of GADD45G mRNA CTD PMID:17997037 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions
increases expression		 EXP Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Kainic Acid results in increased expression of GCNT2 mRNA CTD PMID:17997037 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased expression of GFAP mRNA; Kainic Acid results in increased expression of GFAP protein
NADP inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]		 CTD PMID:17997037 PMID:18711747 PMID:19700661 PMID:21589914 PMID:22790971 PMID:32057834 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions
decreases expression		 EXP oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA] CTD PMID:31430510 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Kainic Acid results in decreased expression of GPX1 protein CTD PMID:29208536 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
decreases expression		 EXP
ISO		 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]; Kainic Acid binds to and results in increased activity of GRIA1 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]
Kainic Acid results in decreased expression of GRIA1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]
Kainic Acid results in decreased expression of GRIA1 mRNA; Kainic Acid results in decreased expression of GRIA1 protein		 CTD PMID:7529610 PMID:11812690 PMID:17585341 PMID:21589914 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
increases methylation
decreases expression
affects response to substance		 EXP
ISO		 Kainic Acid binds to and results in increased activity of GRIA2 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]
Kainic Acid results in increased methylation of GRIA2 gene
Kainic Acid results in decreased expression of GRIA2 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA]; RG108 inhibits the reaction [Kainic Acid results in increased methylation of GRIA2 gene]
GRIA2 protein affects the susceptibility to Kainic Acid		 CTD PMID:7529610 PMID:10551584 PMID:11812690 PMID:21589914 PMID:24098468 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Kainic Acid results in decreased expression of GRIA3 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]
Kainic Acid results in increased expression of GRIA3 mRNA		 CTD PMID:7529610 PMID:21589914 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIA4 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]		 CTD PMID:21589914 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression
increases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIK1 mRNA
Kainic Acid results in increased expression of GRIK1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]		 CTD PMID:21589914 PMID:29208536 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359 		JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of GRIK2 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA		 CTD PMID:17997037 PMID:21589914 PMID:29208536 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIK3 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA		 CTD PMID:21589914 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546 		JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions
decreases expression		 ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA
Kainic Acid results in decreased expression of GRIK4 mRNA		 CTD PMID:21589914 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352 		JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions
decreases expression		 ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects expression
decreases expression		 ISO
EXP		 celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]
Kainic Acid affects the expression of GRIN1		 CTD PMID:21589914 PMID:23159308 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2A mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]		 CTD PMID:21589914 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression		 ISO celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2C mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]		 CTD PMID:21589914 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN2D mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]		 CTD PMID:21589914 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881 		JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions
decreases expression		 ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012 		JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B decreases expression
multiple interactions		 ISO Kainic Acid results in decreased expression of GRIN3B mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]		 CTD PMID:21589914 NCBI chr 7:12,764,993...12,771,310
Ensembl chr 7:12,764,993...12,771,310 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
decreases phosphorylation
multiple interactions		 ISO Kainic Acid results in decreased activity of GSK3B protein
Kainic Acid results in decreased phosphorylation of GSK3B protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]		 CTD PMID:18619545 PMID:25453207 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression		 EXP Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
Kainic Acid results in decreased expression of HCN1 mRNA; Kainic Acid results in decreased expression of HCN1 protein		 CTD PMID:21905079 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Kainic Acid results in increased expression of HMOX1 mRNA CTD PMID:7655348 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Kainic Acid results in increased expression of HOMER1 mRNA CTD PMID:19700661 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hpca hippocalcin decreases response to substance ISO HPCA protein results in decreased susceptibility to Kainic Acid CTD PMID:15607944 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Kainic Acid results in decreased expression of HSD11B1 mRNA CTD PMID:17997037 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]; GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Kainic Acid results in decreased expression of IDI1 mRNA CTD PMID:17997037 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Il10 interleukin 10 decreases expression EXP Kainic Acid results in decreased expression of IL10 protein CTD PMID:15591643 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12a interleukin 12A affects response to substance ISO IL12A protein affects the susceptibility to Kainic Acid CTD PMID:15474355 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in increased secretion of IL1B protein
Kainic Acid results in increased expression of IL1B mRNA; Kainic Acid results in increased expression of IL1B protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]		 CTD PMID:7655348 PMID:11306611 PMID:21589914 PMID:31430510 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases response to substance
multiple interactions
increases expression		 ISO
EXP		 IL6 protein results in increased susceptibility to Kainic Acid
oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
Kainic Acid results in increased expression of IL6 mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]		 CTD PMID:12836160 PMID:21589914 PMID:31430510 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions		 ISO Kainic Acid results in increased expression of ITGAM mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]		 CTD PMID:21589914 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Kainic Acid results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:145,399,885...145,404,605
Ensembl chr 4:145,399,913...145,404,617 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression		 ISO
EXP		 EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]] CTD PMID:18711747 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of JUN protein]
Kainic Acid results in increased expression of JUN mRNA; Kainic Acid results in increased expression of JUN protein		 CTD PMID:8417141 PMID:15723099 PMID:17827730 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of JUNB mRNA
Kainic Acid results in increased expression of JUNB mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Kalrn kalirin, RhoGEF kinase increases expression EXP Kainic Acid results in increased expression of KALRN mRNA CTD PMID:19700661 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633 		JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 increases expression EXP Kainic Acid results in increased expression of KCNC2 protein CTD PMID:7643197 NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351 		JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Kainic Acid results in decreased expression of KCNC4 protein CTD PMID:21905079 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Kainic Acid results in decreased expression of KIF20A mRNA CTD PMID:17997037 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814 		JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression ISO Kainic Acid results in decreased expression of KLF10 mRNA CTD PMID:17997037 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148 		JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Lep leptin decreases response to substance ISO LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lmo1 LIM domain only 1 decreases expression ISO Kainic Acid results in decreased expression of LMO1 mRNA CTD PMID:17997037 NCBI chr 1:173,728,183...173,764,288
Ensembl chr 1:173,728,184...173,764,250 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP NADP inhibits the reaction [Kainic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:32057834 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression		 ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA] CTD PMID:21589914 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Kainic Acid results in decreased expression of MAP3K5 mRNA CTD PMID:17997037 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO Kainic Acid results in increased expression of MAPK3 mRNA CTD PMID:17997037 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mast3 microtubule associated serine/threonine kinase 3 decreases expression ISO Kainic Acid results in decreased expression of MAST3 mRNA CTD PMID:17997037 NCBI chr16:20,387,330...20,414,767
Ensembl chr16:20,395,845...20,414,767 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions		 ISO Kainic Acid results in increased activity of MMP9 protein
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]		 CTD PMID:30772382 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Kainic Acid CTD PMID:14960011 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318 		JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Kainic Acid results in increased expression of MPEG1 mRNA CTD PMID:17997037 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Kainic Acid results in decreased expression of MSMO1 mRNA CTD PMID:17997037 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Mt1 metallothionein 1 decreases response to substance
increases expression		 ISO
EXP		 MT1 protein results in decreased susceptibility to Kainic Acid
Kainic Acid results in increased expression of MT1A mRNA		 CTD PMID:7655348 PMID:10947810 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A decreases response to substance ISO MT2 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Myo5b myosin Vb decreases expression ISO Kainic Acid results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,426,865...70,729,985
Ensembl chr18:70,427,007...70,729,030 		JBrowse link
G Myo9a myosin IXA increases expression ISO Kainic Acid results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:64,573,248...64,777,607
Ensembl chr 8:64,573,358...64,777,543 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP
ISO		 Kainic Acid results in increased expression of NAIP mRNA; Kainic Acid results in increased expression of NAIP protein CTD PMID:12547647 PMID:15046874 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression
multiple interactions		 EXP
ISO		 Kainic Acid results in decreased expression of NCAM1 mRNA
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]		 CTD PMID:19700661 PMID:30772382 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Kainic Acid affects the localization of NFE2L2 protein CTD PMID:18619545 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
decreases expression		 EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]
Kainic Acid results in increased expression of NOS1 mRNA; Kainic Acid results in increased expression of NOS1 protein		 CTD PMID:17585341 PMID:18375135 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Kainic Acid results in increased expression of NOS2 mRNA
Kainic Acid results in increased expression of NOS2 mRNA; Kainic Acid results in increased expression of NOS2 protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]		 CTD PMID:17827730 PMID:18375135 PMID:21589914 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Npy neuropeptide Y decreases response to substance
multiple interactions
increases expression		 ISO
EXP		 NPY protein results in decreased susceptibility to Kainic Acid
Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]		 CTD PMID:9427505 PMID:15451008 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of NR4A1 mRNA
Kainic Acid results in increased expression of NR4A1 mRNA		 CTD PMID:17997037 PMID:19700661 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression EXP
ISO		 Kainic Acid results in increased expression of NR4A2 mRNA
Kainic Acid results in increased expression of NR4A2 protein		 CTD PMID:19700661 PMID:24813937 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Kainic Acid results in increased expression of NR4A3 mRNA CTD PMID:19700661 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637 		JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Kainic Acid CTD PMID:18657176 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087 		JBrowse link
G Ntn1 netrin 1 increases expression EXP Kainic Acid results in increased expression of NTN1 mRNA CTD PMID:19700661 NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676 		JBrowse link
G Nudcd2 NudC domain containing 2 increases expression ISO Kainic Acid results in increased expression of NUDCD2 mRNA CTD PMID:17997037 NCBI chr10:25,890,943...25,896,432
Ensembl chr10:25,890,943...25,896,432 		JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Kainic Acid results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:36,643,916...36,660,334
Ensembl chr 7:36,643,916...36,660,141 		JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression EXP Kainic Acid results in decreased expression of OTX2 mRNA CTD PMID:19700661 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression EXP Kainic Acid results in decreased expression of PAK3 mRNA CTD PMID:19700661 NCBI chr  X:114,784,452...115,042,683
Ensembl chr  X:114,929,029...115,036,669 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity EXP Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdyn prodynorphin multiple interactions
increases expression		 EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671 		JBrowse link
G Penk proenkephalin multiple interactions
increases expression		 EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141 PMID:9427505 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837 		JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Kainic Acid results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840 		JBrowse link
G Pkp2 plakophilin 2 decreases expression ISO Kainic Acid results in decreased expression of PKP2 mRNA CTD PMID:17997037 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Kainic Acid results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982 		JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Kainic Acid CTD PMID:21378209 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Kainic Acid results in increased expression of PPP1R9B protein CTD PMID:17443789 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
increases expression		 EXP
ISO		 [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein]
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]
Kainic Acid results in increased expression of PTGS2; Kainic Acid results in increased expression of PTGS2 mRNA; Kainic Acid results in increased expression of PTGS2 protein		 CTD PMID:11168565 PMID:12618123 PMID:17827730 PMID:18834901 PMID:19700661 PMID:21589914 PMID:31430510 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Qk quaking increases expression ISO Kainic Acid results in increased expression of QK mRNA CTD PMID:17997037 NCBI chr 1:50,983,647...51,050,692 JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP Kainic Acid results in increased expression of RAC1 mRNA CTD PMID:19700661 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression EXP Kainic Acid results in increased expression of RAD23A mRNA CTD PMID:19700661 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391 		JBrowse link
G Rasd1 ras related dexamethasone induced 1 decreases expression ISO Kainic Acid results in decreased expression of RASD1 mRNA CTD PMID:17997037 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172 		JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases response to substance ISO RBFOX1 gene mutant form results in increased susceptibility to Kainic Acid CTD PMID:21623373 NCBI chr10:8,312,961...10,437,778
Ensembl chr10:8,312,961...8,654,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA] CTD PMID:21589914 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rest RE1-silencing transcription factor increases expression
multiple interactions		 EXP Kainic Acid results in increased expression of REST protein
Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]		 CTD PMID:21905079 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Kainic Acid results in decreased expression of RGS16 mRNA CTD PMID:17997037 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216 		JBrowse link
G Rhoa ras homolog family member A increases expression EXP Kainic Acid results in increased expression of RHOA mRNA CTD PMID:19700661 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Kainic Acid results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761 		JBrowse link
G Sap30l SAP30-like decreases expression ISO Kainic Acid results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:43,224,151...43,231,864
Ensembl chr10:43,224,269...43,231,611 		JBrowse link
G Sema4d semaphorin 4D increases expression EXP Kainic Acid results in increased expression of SEMA4D mRNA CTD PMID:19700661 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression		 ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Kainic Acid results in increased expression of SFPQ mRNA CTD PMID:17997037 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] CTD PMID:15723099 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
increases expression		 ISO
EXP		 Kainic Acid results in decreased expression of SIRT1 protein
Kainic Acid results in increased expression of SIRT1 protein		 CTD PMID:18538940 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP Kainic Acid results in increased expression of SLC11A2 CTD PMID:16552559 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression ISO Kainic Acid results in decreased expression of SLC1A1 mRNA CTD PMID:17997037 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression		 ISO
EXP		 [Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein
Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]		 CTD PMID:19061913 PMID:28257918 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Kainic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Kainic Acid CTD PMID:15911120 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Slc8a3 solute carrier family 8 member A3 multiple interactions
increases expression
increases cleavage		 EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]
Kainic Acid results in increased expression of SLC8A3 protein		 CTD PMID:17585341 PMID:20928830 NCBI chr 6:104,889,500...105,099,408
Ensembl chr 6:104,891,376...105,097,054 		JBrowse link
G Snrk SNF related kinase decreases expression ISO Kainic Acid results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Kainic Acid results in decreased expression of SOD1 protein CTD PMID:29208536 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression		 EXP
ISO		 Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in decreased expression of SOD2 mRNA; Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in increased expression of SOD2 protein		 CTD PMID:10686417 PMID:29208536 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases expression EXP Kainic Acid results in increased expression of SPTAN1 protein modified form CTD PMID:22790971 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 EXP Kainic Acid results in decreased expression of SQSTM1 protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of SQSTM1 protein]		 CTD PMID:32057834 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Sst somatostatin decreases expression ISO Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444 		JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Kainic Acid results in decreased expression of TAC1 protein CTD PMID:6205719 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase decreases expression
multiple interactions		 EXP Kainic Acid results in decreased expression of TIGAR protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of TIGAR protein]		 CTD PMID:32057834 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Kainic Acid results in increased uptake of Cobalt]
oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein]
Kainic Acid results in increased expression of TNF mRNA; Kainic Acid results in increased expression of TNF protein		 CTD PMID:15869941 PMID:19700661 PMID:21589914 PMID:31430510 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Kainic Acid results in increased expression of TP53 protein CTD PMID:20955365 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trh thyrotropin releasing hormone decreases expression
increases expression		 EXP Kainic Acid results in decreased expression of TRH mRNA
Kainic Acid results in increased expression of TRH mRNA		 CTD PMID:10443546 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242 		JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression EXP Kainic Acid results in decreased expression of TRHR protein CTD PMID:10443546 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp increases expression ISO Kainic Acid results in increased expression of TYROBP mRNA CTD PMID:17997037 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression EXP Kainic Acid results in increased expression of UCHL1 protein CTD PMID:22790971 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973 		JBrowse link
G Uhmk1 U2AF homology motif kinase 1 decreases expression ISO Kainic Acid results in decreased expression of UHMK1 mRNA CTD PMID:17997037 NCBI chr13:88,521,625...88,536,728
Ensembl chr13:88,521,625...88,536,728 		JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Kainic Acid results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:94,346,513...94,404,362
Ensembl chr 1:94,346,514...94,404,211 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Kainic Acid results in decreased expression of UTP3 mRNA CTD PMID:17997037 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652 		JBrowse link
G Vamp7 vesicle-associated membrane protein 7 decreases expression EXP Kainic Acid results in decreased expression of VAMP7 mRNA CTD PMID:19700661 NCBI chr12:18,996,566...19,033,714
Ensembl chr12:18,996,591...19,030,381 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Kainic Acid results in decreased expression of VEGFA mRNA CTD PMID:17997037 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein increases expression ISO Kainic Acid results in increased expression of WFS1 mRNA CTD PMID:17997037 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966 		JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Kainic Acid results in increased expression of XPA mRNA CTD PMID:19700661 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928 		JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Kainic Acid results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:60,250,546...60,430,119
Ensembl chr 5:60,250,546...60,429,708 		JBrowse link
lincomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related affects expression ISO Lincomycin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Lincomycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              organonitrogen compound 18386
                amino acid derivative 10957
                  proline derivative 255
                    (2S)-1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indol-2-yl]-oxomethyl]-2-pyrrolidinecarboxamide 0
                    (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide 0
                    (2S)-N1-[5-(2-tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide 0
                    (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                    (2S,4R)-N-[(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                    (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-(1-oxopropoxy)propoxy]-(4-phenylbutyl)phosphoryl]-1-oxoethyl]-2-pyrrolidinecarboxylic acid 0
                    1-(4-methylphenyl)sulfonyl-5-oxo-2-pyrrolidinecarboxylic acid [[amino-(4-nitrophenyl)methylidene]amino] ester 0
                    1-(7-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-N-(4-methylphenyl)-2-pyrrolidinecarboxamide 0
                    1-[(2-chlorophenyl)methyl]-N-[3-(N-ethyl-3-methylanilino)propyl]-5-oxo-2-pyrrolidinecarboxamide 0
                    2-[[(4-methyl-2-thiazolyl)amino]-oxomethyl]-1-pyrrolidinecarboxylic acid 2-methylpropyl ester 0
                    Anatibant 0
                    D-proline derivative + 0
                    L-Proline, N-propargyloxycarbonyl-, propargyl ester 0
                    L-proline derivative + 255
                    LSM-10524 0
                    LSM-10687 0
                    LSM-10844 0
                    LSM-11040 0
                    LSM-11145 0
                    LSM-11580 0
                    LSM-11817 0
                    LSM-11971 0
                    LSM-12294 0
                    LSM-12476 0
                    LSM-12721 0
                    LSM-12803 0
                    LSM-13114 0
                    LSM-13399 0
                    LSM-13708 0
                    LSM-14052 0
                    LSM-14159 0
                    LSM-14375 0
                    LSM-14463 0
                    LSM-8454 0
                    LSM-8512 0
                    LSM-8728 0
                    LSM-9094 0
                    LSM-9150 0
                    LSM-9359 0
                    LSM-9560 0
                    LSM-9609 0
                    N-(1-Deoxy-1-fructosyl)proline 0
                    N-(2,4-dinitrophenyl)proline 0
                    N-Oleoyl proline 0
                    N-Palmitoyl proline 0
                    N-Stearoyl proline 0
                    N-[(4-fluorophenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-2-pyrrolidinecarboxamide 0
                    N-[2-chloro-1-[3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                    N1-cyclohexyl-N2-cyclopropylpyrrolidine-1,2-dicarboxamide 0
                    N2-(3-chloro-4-methylphenyl)-N1-(4-methoxyphenyl)pyrrolidine-1,2-dicarboxamide 0
                    hydroxyproline + 0
                    monohydroxyproline + 0
                    oxoproline + 2
                    peptidyl-proline + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        amino acid 14108
                                          alpha-amino acid 11593
                                            proline 270
                                              proline derivative 255
                                                (2S)-1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indol-2-yl]-oxomethyl]-2-pyrrolidinecarboxamide 0
                                                (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide 0
                                                (2S)-N1-[5-(2-tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide 0
                                                (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                                                (2S,4R)-N-[(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                                                (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-(1-oxopropoxy)propoxy]-(4-phenylbutyl)phosphoryl]-1-oxoethyl]-2-pyrrolidinecarboxylic acid 0
                                                1-(4-methylphenyl)sulfonyl-5-oxo-2-pyrrolidinecarboxylic acid [[amino-(4-nitrophenyl)methylidene]amino] ester 0
                                                1-(7-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)-N-(4-methylphenyl)-2-pyrrolidinecarboxamide 0
                                                1-[(2-chlorophenyl)methyl]-N-[3-(N-ethyl-3-methylanilino)propyl]-5-oxo-2-pyrrolidinecarboxamide 0
                                                2-[[(4-methyl-2-thiazolyl)amino]-oxomethyl]-1-pyrrolidinecarboxylic acid 2-methylpropyl ester 0
                                                Anatibant 0
                                                D-proline derivative + 0
                                                L-Proline, N-propargyloxycarbonyl-, propargyl ester 0
                                                L-proline derivative + 255
                                                LSM-10524 0
                                                LSM-10687 0
                                                LSM-10844 0
                                                LSM-11040 0
                                                LSM-11145 0
                                                LSM-11580 0
                                                LSM-11817 0
                                                LSM-11971 0
                                                LSM-12294 0
                                                LSM-12476 0
                                                LSM-12721 0
                                                LSM-12803 0
                                                LSM-13114 0
                                                LSM-13399 0
                                                LSM-13708 0
                                                LSM-14052 0
                                                LSM-14159 0
                                                LSM-14375 0
                                                LSM-14463 0
                                                LSM-8454 0
                                                LSM-8512 0
                                                LSM-8728 0
                                                LSM-9094 0
                                                LSM-9150 0
                                                LSM-9359 0
                                                LSM-9560 0
                                                LSM-9609 0
                                                N-(1-Deoxy-1-fructosyl)proline 0
                                                N-(2,4-dinitrophenyl)proline 0
                                                N-Oleoyl proline 0
                                                N-Palmitoyl proline 0
                                                N-Stearoyl proline 0
                                                N-[(4-fluorophenyl)methyl]-1-[(4-methylphenyl)methyl]-5-oxo-2-pyrrolidinecarboxamide 0
                                                N-[2-chloro-1-[3,4,5-trihydroxy-6-(methylthio)-2-oxanyl]propyl]-1-methyl-4-propyl-2-pyrrolidinecarboxamide 0
                                                N1-cyclohexyl-N2-cyclopropylpyrrolidine-1,2-dicarboxamide 0
                                                N2-(3-chloro-4-methylphenyl)-N1-(4-methoxyphenyl)pyrrolidine-1,2-dicarboxamide 0
                                                hydroxyproline + 0
                                                monohydroxyproline + 0
                                                oxoproline + 2
                                                peptidyl-proline + 0
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