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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of and results in increased cleavage of CASP3 protein] |
CTD |
PMID:34732784 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] |
CTD |
PMID:37307957 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein] |
CTD |
PMID:37307957 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein] |
CTD |
PMID:37307957 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Dlg1 |
discs large MAGUK scaffold protein 1 |
increases expression multiple interactions |
ISO |
geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA] |
CTD |
PMID:21232033 |
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NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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G |
Edn1 |
endothelin 1 |
decreases expression |
EXP |
geranylgeranylacetone results in decreased expression of EDN1 protein |
CTD |
PMID:16324314 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein] |
CTD |
PMID:37307957 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions increases expression affects response to substance |
ISO |
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] geranylgeranylacetone results in increased expression of HSF1 protein HSF1 protein affects the susceptibility to geranylgeranylacetone |
CTD |
PMID:17189318 PMID:21232033 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein] |
CTD |
PMID:17189318 PMID:37307957 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
multiple interactions |
ISO |
[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein; geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] |
CTD |
PMID:15340226 PMID:37307957 |
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NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
increases expression |
ISO |
geranylgeranylacetone results in increased expression of KCNA5 protein |
CTD |
PMID:21232033 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MAP3K5 protein] |
CTD |
PMID:34732784 |
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NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA] |
CTD |
PMID:37307957 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] |
CTD |
PMID:34732784 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA] |
CTD |
PMID:34732784 PMID:37307957 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] |
CTD |
PMID:37307957 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN mRNA]; geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein] |
CTD |
PMID:34732784 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Vim |
vimentin |
multiple interactions |
ISO |
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:37307957 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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