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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amantadine
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Accession:CHEBI:2618 term browser browse the term
Definition:A member of the class of adamantanes that is used as an antiviral and antiparkinson drug.
Synonyms:exact_synonym: adamantan-1-ylamine
 related_synonym: 1-adamantanamine;   1-adamantylamine;   1-aminoadamantane;   Amantidine;   Aminoadamantane;   Formula=C10H17N;   InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2;   InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N;   SMILES=NC12CC3CC(CC(C3)C1)C2;   Viregyt;   Virosol;   amantadina;   amantadinum;   tricyclo[3.3.1.1(3,7)]decan-1-amine;   tricyclo[3.3.1.1(3,7)]decan-1-ylamine;   tricyclo[3.3.1.1(3,7)]decane-1-amine
 xref: Beilstein:2204333;   CAS:768-94-5;   DrugBank:DB00915;   Drug_Central:144;   Gmelin:27066;   KEGG:C06818;   KEGG:D07441
 xref_mesh: MESH:D000547
 xref: PMID:23011311;   PMID:24371305;   PMID:24427376;   Reaxys:2204333;   VSDB:2961;   Wikipedia:Amantadine
 cyclic_relationship: is_conjugate_base_of CHEBI:48320


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amantadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Fluoxetine co-treated with Amantadine] results in increased expression of BDNF mRNA CTD PMID:19211973 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO Amantadine results in increased expression of IFI27 mRNA CTD PMID:16756086 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 affects expression ISO Amantadine affects the expression of IFNAR1 mRNA CTD PMID:16756086 NCBI chr11:31,640,407...31,666,839
Ensembl chr11:31,640,407...31,664,061
JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Amantadine results in increased expression of JAK1 protein CTD PMID:16756086 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Amantadine results in decreased activity of KCNH2 protein CTD PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 increases expression ISO Amantadine results in increased expression of OAS2 mRNA CTD PMID:16756086 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Amantadine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amantadine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1 CTD PMID:15918519 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 decreases activity ISO Amantadine analog results in decreased activity of TDP1 protein CTD PMID:29248742 NCBI chr 6:123,895,860...123,963,688
Ensembl chr 6:123,897,956...123,963,675
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        pharmacological role 18831
          analgesic 13095
            amantadine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19426
                        hydrogen molecular entity 19420
                          hydrides 18753
                            inorganic hydride 17457
                              pnictogen hydride 17433
                                nitrogen hydride 17280
                                  azane 17015
                                    ammonia 17014
                                      organic amino compound 17013
                                        primary amino compound 7950
                                          primary amine 5720
                                            primary aliphatic amine 138
                                              amantadine 10
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