CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: polyene antibiotic
Accession: CHEBI:26177
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Definition: A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of Streptomyces.
Synonyms: related_synonym: polyene antibiotics
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Arhgef26
Rho guanine nucleotide exchange factor 26
increases expression
ISO
Amphotericin B results in increased expression of ARHGEF26 mRNA
CTD
PMID:20849824
NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]
CTD
PMID:16189267
NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
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Atg3
autophagy related 3
decreases expression
ISO
Amphotericin B results in decreased expression of ATG3 mRNA
CTD
PMID:20849824
NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
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Casp3
caspase 3
increases expression
ISO
Amphotericin B results in increased expression of CASP3 protein
CTD
PMID:23988732
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cat
catalase
decreases expression
EXP
Amphotericin B results in decreased expression of CAT mRNA
CTD
PMID:20623750
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccr2
C-C motif chemokine receptor 2
decreases expression
EXP
Amphotericin B results in decreased expression of CCR2 mRNA
CTD
PMID:20623750
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Clu
clusterin
affects expression
EXP
Amphotericin B affects the expression of CLU mRNA
CTD
PMID:20623750
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
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Ednrb
endothelin receptor type B
increases expression
ISO
Amphotericin B results in increased expression of EDNRB mRNA
CTD
PMID:20849824
NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
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Eno1
enolase 1
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]; Amphotericin B results in increased expression of and results in increased secretion of ENO1 protein
CTD
PMID:16189267 PMID:26259607
NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
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Ep300
E1A binding protein p300
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
CTD
PMID:16189267
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
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Epo
erythropoietin
multiple interactions decreases expression
ISO EXP
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] Amphotericin B results in decreased expression of EPO protein
CTD
PMID:697352 PMID:2299214 PMID:16189267
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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Glod4
glyoxalase domain containing 4
decreases expression
ISO
Amphotericin B results in decreased expression of GLOD4 mRNA
CTD
PMID:20849824
NCBI chr10:64,379,922...64,398,263
Ensembl chr10:64,379,921...64,398,294
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Gpr20
G protein-coupled receptor 20
increases expression
ISO
Amphotericin B results in increased expression of GPR20 mRNA
CTD
PMID:20849824
NCBI chr 7:114,943,675...114,953,977
Ensembl chr 7:114,944,282...114,945,344
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Gstp1
glutathione S-transferase pi 1
decreases expression multiple interactions
EXP ISO
Amphotericin B results in decreased expression of GSTP1 mRNA Amphotericin B inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:20623750 PMID:23769903
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Gstt1
glutathione S-transferase theta 1
decreases expression
EXP
Amphotericin B results in decreased expression of GSTT1 mRNA
CTD
PMID:20623750
NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions decreases activity
ISO
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein] Amphotericin B results in decreased activity of HIF1A protein
CTD
PMID:16189267
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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Hif1an
hypoxia inducible factor 1 subunit alpha inhibitor
multiple interactions
ISO
Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]
CTD
PMID:16189267
NCBI chr 1:264,309,214...264,319,269
Ensembl chr 1:264,309,214...264,319,267
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Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
Amphotericin B results in increased expression of and results in increased secretion of HSPA8 protein
CTD
PMID:26259607
NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
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Ifng
interferon gamma
multiple interactions
ISO
[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein
CTD
PMID:17911647 PMID:29594315
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Amphotericin B results in increased expression of IFNGR1
CTD
PMID:12803856
NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
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Igfbp5
insulin-like growth factor binding protein 5
decreases expression
ISO
Amphotericin B results in decreased expression of IGFBP5 mRNA
CTD
PMID:20849824
NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
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Il10
interleukin 10
multiple interactions
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein
CTD
PMID:17911647
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il1b
interleukin 1 beta
increases expression
ISO
Amphotericin B results in increased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il2
interleukin 2
multiple interactions
ISO
[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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Kcnq4
potassium voltage-gated channel subfamily Q member 4
decreases expression
ISO
Amphotericin B results in decreased expression of KCNQ4 mRNA
CTD
PMID:20849824
NCBI chr 5:139,625,783...139,677,300
Ensembl chr 5:139,627,576...139,677,300
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Lsg1
large 60S subunit nuclear export GTPase 1
decreases expression
ISO
Amphotericin B results in decreased expression of LSG1 mRNA
CTD
PMID:20849824
NCBI chr11:73,693,862...73,723,457
Ensembl chr11:73,693,814...73,723,501
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
Amphotericin B results in increased expression of MAP1LC3B protein
CTD
PMID:23988732
NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
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Nprl2
NPR2-like, GATOR1 complex subunit
decreases expression
ISO
Amphotericin B results in decreased expression of NPRL2 mRNA
CTD
PMID:20849824
NCBI chr 8:116,297,950...116,301,123
Ensembl chr 8:116,297,950...116,301,122
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Nt5c2
5'-nucleotidase, cytosolic II
increases expression
ISO
Amphotericin B results in increased expression of NT5C2 mRNA
CTD
PMID:20849824
NCBI chr 1:266,652,966...266,782,935
Ensembl chr 1:266,659,519...266,782,910
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Paip1
poly(A) binding protein interacting protein 1
decreases expression
ISO
Amphotericin B results in decreased expression of PAIP1 mRNA
CTD
PMID:20849824
NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205
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Pard3
par-3 family cell polarity regulator
decreases expression
ISO
Amphotericin B results in decreased expression of PARD3 mRNA
CTD
PMID:20849824
NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
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Pgk1
phosphoglycerate kinase 1
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]
CTD
PMID:16189267
NCBI chr X:77,263,399...77,279,373
Ensembl chr X:77,263,359...77,279,367
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Polm
DNA polymerase mu
increases expression
ISO
Amphotericin B results in increased expression of POLM mRNA
CTD
PMID:20849824
NCBI chr14:86,069,378...86,079,327
Ensembl chr14:86,069,016...86,078,954
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RT1-CE5
RT1 class I, locus CE5
increases expression
ISO
Amphotericin B results in increased expression of HLA-F mRNA
CTD
PMID:20849824
NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
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Runx3
RUNX family transcription factor 3
decreases expression
ISO
Amphotericin B results in decreased expression of RUNX3 mRNA
CTD
PMID:20849824
NCBI chr 5:153,507,093...153,531,137
Ensembl chr 5:153,507,093...153,531,137
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Slit1
slit guidance ligand 1
decreases expression
ISO
Amphotericin B results in decreased expression of SLIT1 mRNA
CTD
PMID:20849824
NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
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Spp1
secreted phosphoprotein 1
affects expression
EXP
Amphotericin B affects the expression of SPP1 mRNA
CTD
PMID:20623750
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein
CTD
PMID:17911647
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Tnf
tumor necrosis factor
increases expression
EXP
Amphotericin B results in increased expression of TNF mRNA
CTD
PMID:20623750
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
affects expression
EXP
Amphotericin B affects the expression of UGT1A9 mRNA
CTD
PMID:20623750
NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Usp36
ubiquitin specific peptidase 36
increases expression
ISO
Amphotericin B results in increased expression of USP36 mRNA
CTD
PMID:20849824
NCBI chr10:107,292,828...107,324,355
Ensembl chr10:107,292,828...107,324,355
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Havcr1
hepatitis A virus cellular receptor 1
increases expression
ISO
methylamphotericin B results in increased expression of HAVCR1 mRNA
CTD
PMID:22863853
NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
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Lcn2
lipocalin 2
increases expression
ISO
methylamphotericin B results in increased expression of LCN2 mRNA
CTD
PMID:22863853
NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
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Spp1
secreted phosphoprotein 1
increases expression
ISO
methylamphotericin B results in increased expression of SPP1 mRNA
CTD
PMID:22863853
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
methylamphotericin B results in increased expression of TIMP1 mRNA
CTD
PMID:22863853
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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