CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: polyene antibiotic
Accession: CHEBI:26177
browse the term
Definition: A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of Streptomyces.
Synonyms: related_synonym: polyene antibiotics
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Arhgef26
Rho guanine nucleotide exchange factor 26
increases expression
ISO
Amphotericin B results in increased expression of ARHGEF26 mRNA
CTD
PMID:20849824
NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions
ISO
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]
CTD
PMID:16189267
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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Atg3
autophagy related 3
decreases expression
ISO
Amphotericin B results in decreased expression of ATG3 mRNA
CTD
PMID:20849824
NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
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Casp3
caspase 3
increases expression
ISO
Amphotericin B results in increased expression of CASP3 protein
CTD
PMID:23988732
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
decreases expression
EXP
Amphotericin B results in decreased expression of CAT mRNA
CTD
PMID:20623750
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccr2
C-C motif chemokine receptor 2
decreases expression
EXP
Amphotericin B results in decreased expression of CCR2 mRNA
CTD
PMID:20623750
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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Clu
clusterin
affects expression
EXP
Amphotericin B affects the expression of CLU mRNA
CTD
PMID:20623750
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Ednrb
endothelin receptor type B
increases expression
ISO
Amphotericin B results in increased expression of EDNRB mRNA
CTD
PMID:20849824
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Eno1
enolase 1
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]; Amphotericin B results in increased expression of and results in increased secretion of ENO1 protein
CTD
PMID:16189267 PMID:26259607
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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Ep300
E1A binding protein p300
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]
CTD
PMID:16189267
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Epo
erythropoietin
multiple interactions decreases expression
ISO EXP
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] Amphotericin B results in decreased expression of EPO protein
CTD
PMID:697352 PMID:2299214 PMID:16189267
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Glod4
glyoxalase domain containing 4
decreases expression
ISO
Amphotericin B results in decreased expression of GLOD4 mRNA
CTD
PMID:20849824
NCBI chr10:61,077,535...61,095,876
Ensembl chr10:61,066,421...61,095,898
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Gpr20
G protein-coupled receptor 20
increases expression
ISO
Amphotericin B results in increased expression of GPR20 mRNA
CTD
PMID:20849824
NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430
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Gstp1
glutathione S-transferase pi 1
decreases expression multiple interactions
EXP ISO
Amphotericin B results in decreased expression of GSTP1 mRNA Amphotericin B inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:20623750 PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Gstt1
glutathione S-transferase theta 1
decreases expression
EXP
Amphotericin B results in decreased expression of GSTT1 mRNA
CTD
PMID:20623750
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions decreases activity
ISO
Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein] Amphotericin B results in decreased activity of HIF1A protein
CTD
PMID:16189267
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hif1an
hypoxia inducible factor 1 subunit alpha inhibitor
multiple interactions
ISO
Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]
CTD
PMID:16189267
NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
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Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
Amphotericin B results in increased expression of and results in increased secretion of HSPA8 protein
CTD
PMID:26259607
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Ifng
interferon gamma
multiple interactions
ISO
[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein
CTD
PMID:17911647 PMID:29594315
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifngr1
interferon gamma receptor 1
increases expression
ISO
Amphotericin B results in increased expression of IFNGR1
CTD
PMID:12803856
NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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Igfbp5
insulin-like growth factor binding protein 5
decreases expression
ISO
Amphotericin B results in decreased expression of IGFBP5 mRNA
CTD
PMID:20849824
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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Il10
interleukin 10
multiple interactions
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein
CTD
PMID:17911647
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
increases expression
ISO
Amphotericin B results in increased expression of IL1B mRNA
CTD
PMID:29594315
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD
PMID:29594315
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Kcnq4
potassium voltage-gated channel subfamily Q member 4
decreases expression
ISO
Amphotericin B results in decreased expression of KCNQ4 mRNA
CTD
PMID:20849824
NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932
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Lsg1
large 60S subunit nuclear export GTPase 1
decreases expression
ISO
Amphotericin B results in decreased expression of LSG1 mRNA
CTD
PMID:20849824
NCBI chr11:70,132,919...70,168,526
Ensembl chr11:70,143,847...70,168,518
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
Amphotericin B results in increased expression of MAP1LC3B protein
CTD
PMID:23988732
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Nprl2
NPR2-like, GATOR1 complex subunit
decreases expression
ISO
Amphotericin B results in decreased expression of NPRL2 mRNA
CTD
PMID:20849824
NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
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Nt5c2
5'-nucleotidase, cytosolic II
increases expression
ISO
Amphotericin B results in increased expression of NT5C2 mRNA
CTD
PMID:20849824
NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913
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Paip1
poly(A) binding protein interacting protein 1
decreases expression
ISO
Amphotericin B results in decreased expression of PAIP1 mRNA
CTD
PMID:20849824
NCBI chr 2:51,523,142...51,550,241
Ensembl chr 2:51,522,921...51,550,241
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Pard3
par-3 family cell polarity regulator
decreases expression
ISO
Amphotericin B results in decreased expression of PARD3 mRNA
CTD
PMID:20849824
NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
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Pgk1
phosphoglycerate kinase 1
multiple interactions
ISO
Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]
CTD
PMID:16189267
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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Polm
DNA polymerase mu
increases expression
ISO
Amphotericin B results in increased expression of POLM mRNA
CTD
PMID:20849824
NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086
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RT1-CE5
RT1 class I, locus CE5
increases expression
ISO
Amphotericin B results in increased expression of HLA-F mRNA
CTD
PMID:20849824
NCBI chr20:3,403,418...3,479,476
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Runx3
RUNX family transcription factor 3
decreases expression
ISO
Amphotericin B results in decreased expression of RUNX3 mRNA
CTD
PMID:20849824
NCBI chr 5:147,393,926...147,419,161
Ensembl chr 5:147,360,994...147,419,156
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Slit1
slit guidance ligand 1
decreases expression
ISO
Amphotericin B results in decreased expression of SLIT1 mRNA
CTD
PMID:20849824
NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127
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Spp1
secreted phosphoprotein 1
affects expression
EXP
Amphotericin B affects the expression of SPP1 mRNA
CTD
PMID:20623750
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein
CTD
PMID:17911647
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
increases expression
EXP
Amphotericin B results in increased expression of TNF mRNA
CTD
PMID:20623750
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
affects expression
EXP
Amphotericin B affects the expression of UGT1A9 mRNA
CTD
PMID:20623750
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Usp36
ubiquitin specific peptidase 36
increases expression
ISO
Amphotericin B results in increased expression of USP36 mRNA
CTD
PMID:20849824
NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877
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Havcr1
hepatitis A virus cellular receptor 1
increases expression
ISO
methylamphotericin B results in increased expression of HAVCR1 mRNA
CTD
PMID:22863853
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Lcn2
lipocalin 2
increases expression
ISO
methylamphotericin B results in increased expression of LCN2 mRNA
CTD
PMID:22863853
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Spp1
secreted phosphoprotein 1
increases expression
ISO
methylamphotericin B results in increased expression of SPP1 mRNA
CTD
PMID:22863853
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
methylamphotericin B results in increased expression of TIMP1 mRNA
CTD
PMID:22863853
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Clu
clusterin
increases expression
ISO
Natamycin results in increased expression of CLU mRNA
CTD
PMID:22863853
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cp
ceruloplasmin
increases expression
ISO
Natamycin results in increased expression of CP mRNA
CTD
PMID:22863853
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Fga
fibrinogen alpha chain
increases expression
ISO
Natamycin results in increased expression of FGA mRNA
CTD
PMID:22863853
NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528
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Fgg
fibrinogen gamma chain
increases expression
ISO
Natamycin results in increased expression of FGG mRNA
CTD
PMID:22863853
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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Havcr1
hepatitis A virus cellular receptor 1
increases expression
ISO
Natamycin results in increased expression of HAVCR1 mRNA
CTD
PMID:22863853
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Krt19
keratin 19
increases expression
ISO
Natamycin results in increased expression of KRT19 mRNA
CTD
PMID:22863853
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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Lcn2
lipocalin 2
increases expression
ISO
Natamycin results in increased expression of LCN2 mRNA
CTD
PMID:22863853
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Natamycin results in increased expression of SPP1 mRNA
CTD
PMID:22863853
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
Natamycin results in increased expression of TIMP1 mRNA
CTD
PMID:22863853
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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