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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:piperidinemonocarboxylic acid
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Accession:CHEBI:26148 term browser browse the term
Definition:Any member of the class of piperidines in which one of the carbons of the piperidine ring is substituted by a carboxy group.
Synonyms:related_synonym: piperidinemonocarboxylic acids
 alt_id: CHEBI:26150


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argatroban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein] CTD PMID:22841818 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA] CTD PMID:22841818 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:22841818 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA] CTD PMID:22841818 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA] CTD PMID:22841818 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO argatroban affects the reaction [Dietary Fats results in increased expression of CXCL2 mRNA] CTD PMID:22841818 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G F2 coagulation factor II multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein]
argatroban binds to and results in decreased activity of F2 protein
CTD PMID:15080313 PMID:16084352 PMID:18449412 PMID:22841818 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ICAM1 mRNA] CTD PMID:22841818 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides] CTD PMID:22841818 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA] CTD PMID:22841818 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
pipecolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pipox pipecolic acid and sarcosine oxidase multiple interactions
increases oxidation
ISO PIPOX protein results in increased oxidation of and results in increased degradation of pipecolic acid
PIPOX protein results in increased oxidation of pipecolic acid
CTD PMID:10642506 PMID:10772957 NCBI chr10:62,769,874...62,783,484
Ensembl chr10:62,769,900...62,782,370
JBrowse link
tiagabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP tiagabine results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
EXP Amino Acids, Peptides, and Proteins inhibits the reaction [tiagabine results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP tiagabine results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP tiagabine results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO tiagabine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP tiagabine results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases activity ISO tiagabine results in decreased activity of SLC6A1 protein CTD PMID:15788781 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        donor 18654
          Bronsted acid 18537
            oxoacid 18498
              carbon oxoacid 18378
                carboxylic acid 18373
                  monocarboxylic acid 17636
                    piperidinemonocarboxylic acid 18
                      (2R,4R)-4-methylpiperidine-2-carboxylic acid 0
                      (2S)-1-acetylpiperidine-2-carboxylic acid 0
                      1-[3-(4-carboxypiperidin-1-yl)-3-deoxy-beta-D-arabinofuranosyl]pyrimidine-2,4(1H,3H)-dione 0
                      1-piperideine-2-carboxylic acid 0
                      4-aminopiperidine-1-carboxylic acid 0
                      5-hydroxypipecolic acid + 0
                      N-[2-(4-aminophenyl)ethyl]-4-phenylisonipecotic acid + 0
                      N-hydroxypipecolic acid + 0
                      TOAC 0
                      argatroban 10
                      difenoxin + 0
                      nipecotic acid + 7
                      pipecolic acid + 1
                      piperidine-4-carboxylic acid 0
                      tiagabine 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          piperidinemonocarboxylic acid 18
                                            (2R,4R)-4-methylpiperidine-2-carboxylic acid 0
                                            (2S)-1-acetylpiperidine-2-carboxylic acid 0
                                            1-[3-(4-carboxypiperidin-1-yl)-3-deoxy-beta-D-arabinofuranosyl]pyrimidine-2,4(1H,3H)-dione 0
                                            1-piperideine-2-carboxylic acid 0
                                            4-aminopiperidine-1-carboxylic acid 0
                                            5-hydroxypipecolic acid + 0
                                            N-[2-(4-aminophenyl)ethyl]-4-phenylisonipecotic acid + 0
                                            N-hydroxypipecolic acid + 0
                                            TOAC 0
                                            argatroban 10
                                            difenoxin + 0
                                            nipecotic acid + 7
                                            pipecolic acid + 1
                                            piperidine-4-carboxylic acid 0
                                            tiagabine 7
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