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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biological pigment
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Accession:CHEBI:26130 term browser browse the term
Definition:An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
Synonyms:related_synonym: pigments


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all-trans-neoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO neoxanthin affects the localization of AIFM1 protein CTD PMID:17186379 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Casp3 caspase 3 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17186379 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:17186379 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
astaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] CTD PMID:16964424 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP astaxanthine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G Cat catalase multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] CTD PMID:16964424 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cntd1 cyclin N-terminal domain containing 1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] CTD PMID:16964424 NCBI chr11:101,279,203...101,288,701
Ensembl chr11:101,279,012...101,296,317
JBrowse link
G Cox15 cytochrome c oxidase assembly protein 15 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] CTD PMID:16964424 NCBI chr19:43,733,254...43,753,000
Ensembl chr19:43,733,254...43,753,000
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] CTD PMID:16964424 NCBI chr 9:57,517,328...57,532,427
Ensembl chr 9:57,521,274...57,532,426
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] CTD PMID:16964424 NCBI chr 1:36,691,487...36,693,388
Ensembl chr 1:36,691,449...36,693,681
JBrowse link
G Cox6b1 cytochrome c oxidase, subunit 6B1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] CTD PMID:16964424 NCBI chr 7:30,616,971...30,626,114
Ensembl chr 7:30,616,861...30,626,151
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] CTD PMID:16964424 NCBI chr15:35,931,976...35,938,246
Ensembl chr15:35,925,886...35,938,246
JBrowse link
G Csprs component of Sp100-rs decreases expression EXP astaxanthine results in decreased expression of CSPRS mRNA CTD PMID:19555370
G Ctss cathepsin S decreases expression EXP astaxanthine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions
decreases expression
ISO astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]
astaxanthine results in decreased expression of NOX2 mRNA
CTD PMID:23272707 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA
CTD PMID:21414371 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Foxo3 forkhead box O3 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity
multiple interactions
ISO astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein
CTD PMID:28665548 PMID:29975440 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP astaxanthine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
EXP astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]
CTD PMID:16091010 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gna13 guanine nucleotide binding protein, alpha 13 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] CTD PMID:16964424 NCBI chr11:109,362,794...109,401,369
Ensembl chr11:109,362,831...109,401,369
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] CTD PMID:16964424 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] CTD PMID:23538867 NCBI chr 2:25,291,177...25,319,187
Ensembl chr 2:25,291,181...25,319,187
JBrowse link
G Grn granulin multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] CTD PMID:16964424 NCBI chr11:102,430,507...102,436,809
Ensembl chr11:102,430,315...102,437,048
JBrowse link
G Gsr glutathione reductase multiple interactions ISO astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:29975440 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 multiple interactions
increases expression
ISO [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA
CTD PMID:24157545 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] CTD PMID:16964424 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
ISO astaxanthine results in increased expression of HMOX1 protein
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA
CTD PMID:20038455 PMID:23272707 PMID:24157545 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hoxa9 homeobox A9 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] CTD PMID:16964424 NCBI chr 6:52,223,097...52,227,370
Ensembl chr 6:52,223,100...52,231,089
JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] CTD PMID:16964424 NCBI chr 1:65,158,616...65,186,479
Ensembl chr 1:65,158,616...65,186,500
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein CTD PMID:21621527 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 decreases expression EXP astaxanthine results in decreased expression of IL6 mRNA CTD PMID:21621527 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lepr leptin receptor multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] CTD PMID:16964424 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] CTD PMID:16964424 NCBI chr  X:37,187,588...37,191,238
Ensembl chr  X:37,187,588...37,191,163
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] CTD PMID:16964424 NCBI chr 6:24,518,662...24,527,690
Ensembl chr 6:24,518,666...24,528,013
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] CTD PMID:16964424 NCBI chr 7:97,400,003...97,407,800
Ensembl chr 7:97,400,003...97,407,802
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] CTD PMID:16964424 NCBI chr17:66,078,795...66,101,559
Ensembl chr17:66,078,638...66,101,559
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
ISO astaxanthine results in increased expression of NFE2L2 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA
CTD PMID:20038455 PMID:23272707 PMID:24157545 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] CTD PMID:16964424 NCBI chr11:93,949,814...93,956,256
Ensembl chr11:93,949,814...93,956,259
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein
CTD PMID:20038455 PMID:24157545 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP astaxanthine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,521,795...87,584,137
Ensembl chr10:87,521,795...87,584,136
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity ISO astaxanthine results in increased activity of PGD protein CTD PMID:28665548 PMID:29975440 NCBI chr 4:149,149,991...149,166,705
Ensembl chr 4:149,149,991...149,166,771
JBrowse link
G Por P450 (cytochrome) oxidoreductase decreases activity
increases expression
ISO astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein
CTD PMID:21414371 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] CTD PMID:16964424 NCBI chr 5:32,458,848...32,493,713
Ensembl chr 5:32,458,843...32,517,433
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] CTD PMID:16964424 NCBI chr 4:116,685,599...116,700,000
Ensembl chr 4:116,685,544...116,700,822
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP astaxanthine results in decreased expression of PTGS2 mRNA CTD PMID:21621527 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rps2 ribosomal protein S2 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] CTD PMID:16964424 NCBI chr17:24,718,121...24,721,927
Ensembl chr17:24,718,116...24,721,929
JBrowse link
G Skap2 src family associated phosphoprotein 2 decreases expression EXP astaxanthine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 6:51,859,165...52,012,549
Ensembl chr 6:51,857,422...52,012,549
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] CTD PMID:16964424 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] CTD PMID:23538867 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] CTD PMID:16964424 NCBI chr 2:158,116,405...158,146,392
Ensembl chr 2:158,116,402...158,146,436
JBrowse link
G Tkt transketolase multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] CTD PMID:16964424 NCBI chr14:30,549,131...30,574,724
Ensembl chr14:30,548,359...30,574,720
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP astaxanthine results in decreased expression of TNF protein CTD PMID:21621527 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] CTD PMID:20038455 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ubb ubiquitin B multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] CTD PMID:16964424 NCBI chr11:62,551,171...62,553,213
Ensembl chr11:62,551,171...62,553,213
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] CTD PMID:16964424 NCBI chr13:66,900,576...66,905,350
Ensembl chr13:66,900,617...66,905,378
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions EXP astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 7:120,635,189...120,659,523
Ensembl chr 7:120,635,176...120,659,524
JBrowse link
beta-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad9 acyl-Coenzyme A dehydrogenase family, member 9 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA CTD PMID:24657404 NCBI chr 3:36,065,979...36,092,857
Ensembl chr 3:36,065,979...36,092,853
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO beta Carotene results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 3:138,437,200...138,455,499
Ensembl chr 3:138,443,093...138,455,499
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression EXP beta Carotene results in decreased expression of ADIPOQ mRNA CTD PMID:21569430 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Aebp1 AE binding protein 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA CTD PMID:24657404 NCBI chr11:5,861,866...5,872,248
Ensembl chr11:5,861,947...5,872,088
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation ISO beta Carotene results in decreased phosphorylation of AKT1 protein CTD PMID:26733226 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions EXP beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] CTD PMID:25542264 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO beta Carotene results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr19:3,913,491...3,930,898
Ensembl chr19:3,913,491...3,929,808
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO beta Carotene results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 4:139,622,871...139,649,691
Ensembl chr 4:139,622,866...139,649,690
JBrowse link
G Ank2 ankyrin 2, brain increases expression ISO beta Carotene results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 3:126,921,607...127,500,347
Ensembl chr 3:126,921,612...127,499,350
JBrowse link
G Ank3 ankyrin 3, epithelial increases expression ISO beta Carotene results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr10:69,533,486...70,027,436
Ensembl chr10:69,398,773...70,027,438
JBrowse link
G Appbp2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA CTD PMID:24657404 NCBI chr11:85,191,308...85,235,120
Ensembl chr11:85,187,262...85,235,130
JBrowse link
G Arhgap26 Rho GTPase activating protein 26 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA CTD PMID:24657404 NCBI chr18:38,601,617...39,376,285
Ensembl chr18:38,993,145...39,376,284
Ensembl chr18:38,993,145...39,376,284
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO beta Carotene results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr 8:41,340,646...41,397,644
Ensembl chr 8:41,340,197...41,374,773
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO beta Carotene results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 1:91,540,001...91,559,590
Ensembl chr 1:91,540,544...91,559,589
JBrowse link
G Asb9 ankyrin repeat and SOCS box-containing 9 increases expression ISO beta Carotene results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:164,497,903...164,539,752
Ensembl chr  X:164,506,327...164,539,752
JBrowse link
G Atp8b1 ATPase, class I, type 8B, member 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA CTD PMID:24657404 NCBI chr18:64,528,979...64,661,272
Ensembl chr18:64,528,967...64,661,267
JBrowse link
G Bag3 BCL2-associated athanogene 3 decreases expression ISO beta Carotene results in decreased expression of BAG3 mRNA CTD PMID:17034753 NCBI chr 7:128,523,583...128,546,981
Ensembl chr 7:128,523,616...128,546,981
JBrowse link
G Bag4 BCL2-associated athanogene 4 decreases expression ISO beta Carotene results in decreased expression of BAG4 mRNA CTD PMID:17034753 NCBI chr 8:25,764,538...25,785,209
Ensembl chr 8:25,764,538...25,785,287
JBrowse link
G Bag5 BCL2-associated athanogene 5 decreases expression ISO beta Carotene results in decreased expression of BAG5 mRNA CTD PMID:17034753 NCBI chr12:111,709,488...111,713,256
Ensembl chr12:111,709,488...111,713,257
JBrowse link
G Bax BCL2-associated X protein decreases expression
increases expression
ISO beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein
CTD PMID:15949688 PMID:17034753 PMID:26733226 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO beta Carotene results in decreased expression of BCL2 protein CTD PMID:26733226 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bco1 beta-carotene oxygenase 1 multiple interactions
affects response to substance
increases oxidation
increases expression
ISO
EXP
beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]
CTD PMID:9526112 PMID:16186334 PMID:24657404 NCBI chr 8:117,095,851...117,133,720
Ensembl chr 8:117,095,854...117,133,720
JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions
increases metabolic processing
EXP [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal CTD PMID:21106934 NCBI chr 9:50,533,087...50,555,214
Ensembl chr 9:50,533,087...50,555,181
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein
CTD PMID:17618090 PMID:26733226 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase multiple interactions ISO
EXP
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]
CTD PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein decreases expression ISO beta Carotene results in decreased expression of CAV1 protein CTD PMID:26733226 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta Carotene results in decreased expression of CCND1 protein CTD PMID:26733226 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Cdca8 cell division cycle associated 8 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA CTD PMID:24657404 NCBI chr 4:124,918,465...124,936,917
Ensembl chr 4:124,918,465...124,939,311
JBrowse link
G Cdh1 cadherin 1 increases expression ISO beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein CTD PMID:17034753 PMID:26733226 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression EXP beta Carotene results in decreased expression of CEBPA mRNA CTD PMID:21569430 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cenpe centromere protein E multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA CTD PMID:24657404 NCBI chr 3:135,212,563...135,273,540
Ensembl chr 3:135,212,537...135,273,611
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO beta Carotene results in increased expression of CFLAR mRNA CTD PMID:17034753 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA CTD PMID:24657404 NCBI chr 8:60,910,389...60,983,317
Ensembl chr 8:60,910,389...60,983,300
JBrowse link
G Cldn10 claudin 10 increases expression ISO beta Carotene results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr14:118,787,871...118,874,525
Ensembl chr14:118,787,908...118,875,489
JBrowse link
G Cldn18 claudin 18 increases expression ISO beta Carotene results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 9:99,690,796...99,717,267
Ensembl chr 9:99,689,461...99,717,267
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO beta Carotene results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression ISO beta Carotene results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826
JBrowse link
G Col4a2 collagen, type IV, alpha 2 decreases expression ISO beta Carotene results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr 8:11,312,805...11,449,287
Ensembl chr 8:11,312,805...11,449,287
JBrowse link
G Coq7 demethyl-Q 7 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA CTD PMID:24657404 NCBI chr 7:118,509,659...118,533,356
Ensembl chr 7:118,509,659...118,533,356
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle decreases expression EXP beta Carotene results in decreased expression of CPT1B mRNA CTD PMID:21569430 NCBI chr15:89,416,405...89,425,862
Ensembl chr15:89,416,405...89,425,863
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression ISO beta Carotene results in increased expression of CRADD mRNA CTD PMID:17034753 NCBI chr10:95,174,739...95,324,138
Ensembl chr10:95,174,746...95,324,133
JBrowse link
G Ctnnal1 catenin (cadherin associated protein), alpha-like 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA CTD PMID:24657404 NCBI chr 4:56,810,935...56,865,375
Ensembl chr 4:56,810,935...56,865,188
JBrowse link
G Ctsb cathepsin B decreases expression ISO beta Carotene results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 increases expression ISO beta Carotene results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO beta Carotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein] CTD PMID:19135038 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl5 chemokine (C-X-C motif) ligand 5 increases expression ISO beta Carotene results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr 5:90,759,298...90,761,625
Ensembl chr 5:90,759,360...90,761,624
JBrowse link
G Cxcl9 chemokine (C-X-C motif) ligand 9 increases expression ISO beta Carotene results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr 5:92,321,331...92,328,079
Ensembl chr 5:92,321,347...92,328,079
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 increases expression ISO beta Carotene results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] CTD PMID:16970932 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO beta Carotene results in increased expression of CYP26A1 mRNA CTD PMID:16186334 PMID:22542753 NCBI chr19:37,697,738...37,701,536
Ensembl chr19:37,697,798...37,701,536
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases expression ISO beta Carotene results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases expression ISO beta Carotene results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions ISO beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 NCBI chr13:92,354,783...92,389,053
Ensembl chr13:92,354,726...92,389,053
JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO beta Carotene results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 2:71,543,408...71,546,754
Ensembl chr 2:71,543,408...71,546,754
JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO beta Carotene results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr11:95,140,447...95,146,294
Ensembl chr11:95,140,447...95,146,263
JBrowse link
G Dtwd2 DTW domain containing 2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA CTD PMID:24657404 NCBI chr18:49,696,145...49,755,651
Ensembl chr18:49,696,145...49,755,601
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA CTD PMID:24657404 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA CTD PMID:24657404 NCBI chr12:78,862,072...78,887,010
Ensembl chr12:78,861,819...78,887,010
JBrowse link
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 decreases expression ISO beta Carotene results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 7:19,382,017...19,395,694
Ensembl chr 7:19,382,010...19,395,694
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:17051425 PMID:19340624 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] CTD PMID:17051425 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP beta Carotene results in decreased expression of FABP4 mRNA CTD PMID:21569430 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression ISO beta Carotene results in increased expression of FAIM2 mRNA CTD PMID:17034753 NCBI chr15:99,497,005...99,534,880
Ensembl chr15:99,497,012...99,528,165
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO beta Carotene results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP beta Carotene results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO beta Carotene results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr12:57,540,628...57,548,029
Ensembl chr12:57,540,628...57,546,916
JBrowse link
G Foxm1 forkhead box M1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA CTD PMID:24657404 NCBI chr 6:128,362,994...128,375,886
Ensembl chr 6:128,362,967...128,376,146
JBrowse link
G Fzd6 frizzled class receptor 6 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA CTD PMID:24657404 NCBI chr15:39,006,149...39,038,192
Ensembl chr15:39,006,034...39,038,188
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO beta Carotene results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635
JBrowse link
G Gbp2b guanylate binding protein 2b increases expression ISO beta Carotene results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 3:142,594,816...142,619,179
Ensembl chr 3:142,594,847...142,619,179
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
EXP
ISO
beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]
CTD PMID:16091010 PMID:27154496 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gsr glutathione reductase multiple interactions EXP beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] CTD PMID:25542264 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO beta Carotene results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression ISO beta Carotene results in increased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstm4 glutathione S-transferase, mu 4 decreases expression ISO beta Carotene results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 3:108,030,571...108,045,179
Ensembl chr 3:108,040,408...108,044,894
JBrowse link
G Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) decreases expression ISO beta Carotene results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr12:87,147,161...87,164,723
Ensembl chr12:87,147,165...87,164,723
JBrowse link
G Hoxa7 homeobox A7 increases expression ISO beta Carotene results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 6:52,215,623...52,218,573
Ensembl chr 6:52,214,491...52,221,854
JBrowse link
G Hoxb6 homeobox B6 increases expression ISO beta Carotene results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr11:96,292,814...96,301,569
Ensembl chr11:96,292,476...96,301,569
JBrowse link
G Hoxc10 homeobox C10 increases expression ISO beta Carotene results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr15:102,966,796...102,971,898
Ensembl chr15:102,966,796...102,971,893
JBrowse link
G Hprt hypoxanthine guanine phosphoribosyl transferase multiple interactions ISO beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 NCBI chr  X:52,988,078...53,021,660
Ensembl chr  X:52,988,137...53,021,659
JBrowse link
G Ifna14 interferon alpha 14 increases expression ISO beta Carotene results in increased expression of IFNA14 mRNA CTD PMID:17034753 NCBI chr 4:88,571,229...88,571,798
Ensembl chr 4:88,571,229...88,571,798
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA CTD PMID:23859036 NCBI chr 1:72,858,065...72,874,865
Ensembl chr 1:72,857,932...72,874,884
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] CTD PMID:21447443 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO beta Carotene results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr 8:120,736,358...120,756,694
Ensembl chr 8:120,736,358...120,756,694
JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression
multiple interactions
ISO
EXP
beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA
CTD PMID:17034753 PMID:24657404 NCBI chr13:73,259,589...73,269,622
Ensembl chr13:73,260,479...73,269,608
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO beta Carotene results in decreased expression of ITGB1 mRNA CTD PMID:17034753 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Itgb4 integrin beta 4 decreases expression ISO beta Carotene results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr11:115,974,725...116,008,412
Ensembl chr11:115,974,709...116,008,412
JBrowse link
G Itm2a integral membrane protein 2A multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA CTD PMID:24657404 NCBI chr  X:107,397,195...107,403,360
Ensembl chr  X:107,397,099...107,403,376
JBrowse link
G Ivl involucrin increases expression ISO beta Carotene results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 3:92,570,899...92,573,790
Ensembl chr 3:92,570,902...92,573,735
JBrowse link
G Jun jun proto-oncogene increases expression EXP beta Carotene results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kif11 kinesin family member 11 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA CTD PMID:24657404 NCBI chr19:37,376,382...37,421,863
Ensembl chr19:37,376,403...37,421,859
JBrowse link
G Krt18 keratin 18 increases expression ISO beta Carotene results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr15:102,028,216...102,032,026
Ensembl chr15:102,028,180...102,032,027
JBrowse link
G Krt19 keratin 19 increases expression ISO beta Carotene results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr11:100,140,810...100,145,926
Ensembl chr11:100,140,810...100,148,665
JBrowse link
G Krt2 keratin 2 increases expression ISO beta Carotene results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr15:101,810,689...101,818,956
Ensembl chr15:101,810,689...101,818,169
JBrowse link
G Krt7 keratin 7 affects expression ISO beta Carotene affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr15:101,412,403...101,427,806
Ensembl chr15:101,411,043...101,430,313
JBrowse link
G Krt8 keratin 8 decreases expression ISO beta Carotene results in decreased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr15:101,996,711...102,004,342
Ensembl chr15:101,996,698...102,004,482
JBrowse link
G Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA CTD PMID:24657404 NCBI chr 1:67,000,517...67,038,891
Ensembl chr 1:67,000,517...67,038,872
JBrowse link
G Lhx3 LIM homeobox protein 3 increases expression ISO beta Carotene results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 2:26,200,212...26,208,249
Ensembl chr 2:26,200,212...26,208,289
JBrowse link
G Lmnb2 lamin B2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA CTD PMID:24657404 NCBI chr10:80,901,363...80,918,245
Ensembl chr10:80,901,203...80,918,245
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP beta Carotene results in decreased expression of LPL mRNA CTD PMID:21569430 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
ISO beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
CTD PMID:16206275 PMID:27154496 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
ISO beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:16206275 PMID:27154496 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 multiple interactions ISO MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] CTD PMID:16960176 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 affects expression ISO beta Carotene affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO beta Carotene results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 2:115,861,264...116,067,537
Ensembl chr 2:115,863,064...116,065,839
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO beta Carotene results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr11:101,877,510...101,894,354
Ensembl chr11:101,877,510...101,894,374
JBrowse link
G Mettl21a methyltransferase like 21A multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA CTD PMID:24657404 NCBI chr 1:64,606,473...64,620,466
Ensembl chr 1:64,606,473...64,617,242
JBrowse link
G Mettl9 methyltransferase like 9 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA CTD PMID:24657404 NCBI chr 7:121,032,384...121,076,835
Ensembl chr 7:121,034,445...121,078,329
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase affects response to substance ISO MGMT gene SNP affects the susceptibility to beta Carotene CTD PMID:16014702 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA CTD PMID:23859036 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO beta Carotene results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 5:29,473,823...29,478,470
Ensembl chr 5:29,473,034...29,478,470
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] CTD PMID:31022331 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA CTD PMID:24657404 NCBI chr14:57,826,228...57,829,087
Ensembl chr14:57,826,234...57,829,296
JBrowse link
G Msh5 mutS homolog 5 increases expression ISO beta Carotene results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr17:35,028,605...35,046,997
Ensembl chr17:35,028,605...35,046,745
JBrowse link
G Mtch2 mitochondrial carrier 2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA CTD PMID:24657404 NCBI chr 2:90,847,090...90,866,810
Ensembl chr 2:90,847,155...90,866,810
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric increases expression ISO beta Carotene results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Nckap1 NCK-associated protein 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA CTD PMID:24657404 NCBI chr 2:80,500,512...80,581,182
Ensembl chr 2:80,500,512...80,581,380
JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA CTD PMID:24657404 NCBI chr 5:29,434,659...29,452,169
Ensembl chr 5:29,434,664...29,457,843
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO beta Carotene results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] CTD PMID:18779489 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein
CTD PMID:15949683 PMID:16632523 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 increases expression ISO beta Carotene results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 6:129,479,150...129,507,350
Ensembl chr 6:129,485,244...129,507,165
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA CTD PMID:24657404 NCBI chr 8:105,701,148...105,703,494
Ensembl chr 8:105,701,148...105,703,496
JBrowse link
G Pcdh1 protocadherin 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA CTD PMID:24657404 NCBI chr18:38,185,914...38,212,048
Ensembl chr18:38,185,914...38,212,053
JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO beta Carotene results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:37,806,410...37,841,873
Ensembl chr18:37,806,364...37,841,873
JBrowse link
G Pdgfrb platelet derived growth factor receptor, beta polypeptide multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein CTD PMID:23859036 NCBI chr18:61,045,127...61,085,067
Ensembl chr18:61,045,150...61,085,061
JBrowse link
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 increases expression EXP beta Carotene results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr11:68,432,125...68,497,849
Ensembl chr11:68,432,121...68,497,849
JBrowse link
G Plat plasminogen activator, tissue multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA CTD PMID:24657404 NCBI chr 8:22,757,722...22,782,848
Ensembl chr 8:22,757,727...22,782,844
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO beta Carotene results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 9:92,250,194...92,272,561
Ensembl chr 9:92,249,750...92,272,278
JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO beta Carotene results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr11:69,846,372...69,852,058
Ensembl chr11:69,846,376...69,852,058
JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO beta Carotene results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 9:92,457,372...92,493,513
Ensembl chr 9:92,457,373...92,492,456
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP beta Carotene results in decreased expression of PPARA mRNA CTD PMID:21569430 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP beta Carotene results in decreased expression of PPARG mRNA CTD PMID:21569430 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Prl2c3 prolactin family 2, subfamily c, member 3 increases expression EXP beta Carotene results in increased expression of PRL2C3 protein CTD PMID:20025956 NCBI chr13:12,790,816...12,800,093
Ensembl chr13:12,790,816...12,800,079
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO beta Carotene results in decreased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 6:126,923,415...126,939,621
Ensembl chr 6:126,923,050...126,939,587
JBrowse link
G Rad51d RAD51 paralog D increases expression ISO beta Carotene results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr11:82,871,960...82,890,624
Ensembl chr11:82,876,434...82,890,614
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO beta Carotene results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO beta Carotene results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr14:16,430,839...17,082,331
Ensembl chr14:16,430,839...16,819,156
JBrowse link
G Rarres1 retinoic acid receptor responder (tazarotene induced) 1 increases expression ISO beta Carotene results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:67,478,886...67,515,523
Ensembl chr 3:67,478,972...67,515,523
JBrowse link
G Rbp4 retinol binding protein 4, plasma multiple interactions EXP
ISO
beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein CTD PMID:22542753 NCBI chr19:38,116,620...38,125,321
Ensembl chr19:38,116,629...38,125,281
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases phosphorylation ISO beta Carotene results in decreased phosphorylation of RELA protein CTD PMID:26733226 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rpp14 ribonuclease P 14 subunit multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA CTD PMID:24657404 NCBI chr14:8,080,313...8,091,846
Ensembl chr14:8,080,367...8,091,834
JBrowse link
G Rrm1 ribonucleotide reductase M1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA CTD PMID:24657404 NCBI chr 7:102,441,695...102,469,771
Ensembl chr 7:102,441,695...102,469,771
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases transport ISO SCARB1 protein results in increased transport of beta Carotene CTD PMID:16177187 NCBI chr 5:125,277,087...125,341,094
Ensembl chr 5:125,277,087...125,341,094
JBrowse link
G Six6 sine oculis-related homeobox 6 increases expression ISO beta Carotene results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr12:72,939,882...72,944,899
Ensembl chr12:72,939,892...72,944,899
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 decreases expression EXP beta Carotene results in decreased expression of SLC2A4 mRNA CTD PMID:21569430 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression ISO beta Carotene results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:18779489 PMID:23859036 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO beta Carotene affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr12:87,305,058...87,388,355
Ensembl chr12:87,305,058...87,388,355
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO beta Carotene results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tfcp2 transcription factor CP2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA CTD PMID:24657404 NCBI chr15:100,497,781...100,552,014
Ensembl chr15:100,498,012...100,552,008
JBrowse link
G Tgm2 transglutaminase 2, C polypeptide increases expression ISO beta Carotene results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 2:158,116,405...158,146,392
Ensembl chr 2:158,116,402...158,146,436
JBrowse link
G Tgm4 transglutaminase 4 (prostate) increases expression ISO beta Carotene results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 9:123,034,741...123,067,558
Ensembl chr 9:123,034,726...123,067,561
JBrowse link
G Thoc7 THO complex 7 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA CTD PMID:24657404 NCBI chr14:13,949,012...13,961,995
Ensembl chr14:13,949,012...13,961,852
JBrowse link
G Tmem209 transmembrane protein 209 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA CTD PMID:24657404 NCBI chr 6:30,481,022...30,509,787
Ensembl chr 6:30,479,053...30,509,783
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19135038 PMID:21447443 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 increases expression ISO beta Carotene results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 4:150,920,155...150,946,104
Ensembl chr 4:150,914,562...150,946,102
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 increases expression ISO beta Carotene results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA CTD PMID:24657404 NCBI chr 2:66,183,787...66,256,674
Ensembl chr 2:66,184,327...66,256,617
JBrowse link
G Twf1 twinfilin actin binding protein 1 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA CTD PMID:24657404 NCBI chr15:94,577,948...94,589,884
Ensembl chr15:94,577,951...94,589,889
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO beta Carotene results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 1:37,983,867...37,997,294
Ensembl chr 1:37,985,189...37,997,893
JBrowse link
G Tymp thymidine phosphorylase multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA CTD PMID:24657404 NCBI chr15:89,371,631...89,377,036
Ensembl chr15:89,371,931...89,377,039
JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 increases expression ISO beta Carotene results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr12:111,803,192...111,813,893
Ensembl chr12:111,803,192...111,813,873
JBrowse link
G Ythdc2 YTH domain containing 2 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA CTD PMID:24657404 NCBI chr18:44,827,730...44,889,720
Ensembl chr18:44,827,746...44,889,724
JBrowse link
G Zdhhc3 zinc finger, DHHC domain containing 3 multiple interactions EXP [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA CTD PMID:24657404 NCBI chr 9:123,066,159...123,113,194
Ensembl chr 9:123,066,160...123,113,205
JBrowse link
bixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases ubiquitination ISO bixin results in decreased ubiquitination of NFE2L2 protein CTD PMID:30698894 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
brazilein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 decreases expression ISO brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein CTD PMID:23948132 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression ISO brazilein results in decreased expression of CTNNB1 protein CTD PMID:23948132 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO brazilein results in decreased expression of GSK3B protein modified form CTD PMID:23948132 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA
CTD PMID:23707804 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:23707804 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases expression ISO brazilein results in decreased expression of RELA protein CTD PMID:23707804 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
brazilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO brazilin results in increased expression of BAX protein CTD PMID:28063998 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO brazilin results in decreased expression of BCL2 protein CTD PMID:28063998 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein]
brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein
CTD PMID:28063998 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] CTD PMID:28063998 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression
multiple interactions
ISO brazilin results in increased expression of PARP1 protein modified form
bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]
CTD PMID:28063998 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] CTD PMID:28063998 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein] CTD PMID:28063998 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
canthaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP
ISO
Canthaxanthin results in increased expression of CYP1A1 mRNA CTD PMID:9271336 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Canthaxanthin results in increased expression of CYP1A2 mRNA CTD PMID:9271336 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4galt alpha 1,4-galactosyltransferase multiple interactions ISO Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] CTD PMID:16819191 NCBI chr15:83,226,722...83,251,729
Ensembl chr15:83,226,722...83,251,774
JBrowse link
G Aars alanyl-tRNA synthetase decreases expression ISO Curcumin results in decreased expression of AARS1 mRNA CTD PMID:17198877 NCBI chr 8:111,027,778...111,055,569
Ensembl chr 8:111,033,144...111,057,664
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression
decreases response to substance
affects response to substance
multiple interactions
ISO
EXP
Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
ABCB1 protein results in decreased susceptibility to Curcumin
ABCB1 affects the susceptibility to Curcumin
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein
CTD PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 PMID:18439772 PMID:20816778 PMID:26689174 PMID:27318188 PMID:31628941 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B multiple interactions
decreases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]
Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein
CTD PMID:18006147 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases activity
decreases expression
ISO Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA
CTD PMID:15885658 PMID:16021489 PMID:26409325 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 decreases activity ISO Curcumin results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 multiple interactions ISO [Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Curcumin results in increased expression of ABCG1 mRNA CTD PMID:16713233 PMID:21594647 NCBI chr17:31,057,694...31,117,984
Ensembl chr17:31,057,675...31,117,988
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases expression
ISO AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] CTD PMID:17077187 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases phosphorylation
decreases expression
affects expression
multiple interactions
ISO
EXP
Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
CTD PMID:18790744 PMID:19297423 PMID:27208389 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 multiple interactions ISO Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] CTD PMID:10666014 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP
ISO
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
CTD PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 PMID:28527659 PMID:31714633 PMID:31820278 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression ISO Curcumin results in increased expression of ACKR3 mRNA CTD PMID:21594647 NCBI chr 1:90,203,980...90,215,724
Ensembl chr 1:90,203,980...90,216,751
JBrowse link
G Acly ATP citrate lyase affects expression
decreases expression
EXP
ISO
Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA
CTD PMID:27208389 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions ISO Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] CTD PMID:25130536 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein
CTD PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 multiple interactions ISO Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] CTD PMID:17666914 NCBI chr12:21,323,509...21,373,632
Ensembl chr12:21,323,509...21,373,632
JBrowse link
G Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 increases expression ISO Curcumin results in increased expression of ADAMTS4 mRNA CTD PMID:18321735 NCBI chr 1:171,250,129...171,262,267
Ensembl chr 1:171,250,421...171,260,637
JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO Curcumin results in decreased expression of ADCY9 mRNA CTD PMID:15713895 NCBI chr16:4,284,886...4,437,236
Ensembl chr16:4,287,529...4,420,498
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Curcumin results in decreased expression of ADGRE1 mRNA CTD PMID:18403477 NCBI chr17:57,358,581...57,483,529
Ensembl chr17:57,358,691...57,483,527
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
affects expression
EXP
ISO
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
CTD PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] CTD PMID:31820278 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] CTD PMID:29480285 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Agr2 anterior gradient 2 decreases expression ISO Curcumin results in decreased expression of AGR2 mRNA CTD PMID:17198877 NCBI chr12:35,992,925...36,004,081
Ensembl chr12:35,992,907...36,004,087
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO
EXP
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]
CTD PMID:26612707 PMID:31820278 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
affects binding
increases degradation
ISO
EXP
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein CTD PMID:25866362 NCBI chr 2:32,621,758...32,635,058
Ensembl chr 2:32,621,758...32,635,058
JBrowse link
G Akap6 A kinase (PRKA) anchor protein 6 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]
CTD PMID:18200517 PMID:18421014 NCBI chr12:52,698,588...53,155,568
Ensembl chr12:52,699,383...53,155,599
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases expression
multiple interactions
increases activity
EXP
ISO
Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein
CTD PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression ISO Curcumin results in increased expression of AKR1B8 mRNA CTD PMID:18299980 NCBI chr 6:34,354,146...34,368,461
Ensembl chr 6:34,354,119...34,368,463
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; arsenic trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin results in decreased activity of AKT1 protein
CTD PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 PMID:17372590 PMID:17535857 PMID:17596214 PMID:17640564 PMID:17640567 PMID:17918158 PMID:18006147 PMID:18214481 PMID:18660423 PMID:18790744 PMID:19372569 PMID:20605902 PMID:20727180 PMID:20938987 PMID:23222814 PMID:23452621 PMID:23555722 PMID:23880231 PMID:24211270 PMID:24365254 PMID:24831732 PMID:25541178 PMID:26409325 PMID:27208389 PMID:27966075 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA
CTD PMID:23452621 PMID:26409325 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO
EXP
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]
CTD PMID:22704994 PMID:23292317 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alas1 aminolevulinic acid synthase 1 increases expression ISO Curcumin results in increased expression of ALAS1 mRNA CTD PMID:18299980 NCBI chr 9:106,233,455...106,247,954
Ensembl chr 9:106,233,455...106,248,654
JBrowse link
G Alb albumin multiple interactions ISO [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein] CTD PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 multiple interactions
decreases expression
EXP
ISO
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein
CTD PMID:31628941 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldoc aldolase C, fructose-bisphosphate decreases expression ISO Curcumin results in decreased expression of ALDOC mRNA CTD PMID:17198877 NCBI chr11:78,323,073...78,327,781
Ensembl chr11:78,322,968...78,327,781
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
ISO [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein
CTD PMID:16956363 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Curcumin results in increased expression of AMPD3 mRNA CTD PMID:18299980 NCBI chr 7:110,767,790...110,812,409
Ensembl chr 7:110,768,206...110,812,405
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Curcumin results in decreased expression of ANKRD37 mRNA CTD PMID:17198877 NCBI chr 8:45,996,908...46,000,414
Ensembl chr 8:45,996,902...46,005,707
JBrowse link
G Ankrd50 ankyrin repeat domain 50 decreases expression ISO Curcumin results in decreased expression of ANKRD50 mRNA CTD PMID:17999991 NCBI chr 3:38,449,259...38,484,862
Ensembl chr 3:38,449,259...38,484,844
JBrowse link
G Ankzf1 ankyrin repeat and zinc finger domain containing 1 decreases expression ISO Curcumin results in decreased expression of ANKZF1 mRNA CTD PMID:17198877 NCBI chr 1:75,192,160...75,199,387
Ensembl chr 1:75,192,151...75,199,387
JBrowse link
G Aoc1 amine oxidase, copper-containing 1 multiple interactions ISO Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] CTD PMID:20885979 NCBI chr 6:48,895,255...48,909,188
Ensembl chr 6:48,872,896...48,909,188
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]
CTD PMID:17277231 PMID:20869986 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Apc APC, WNT signaling pathway regulator decreases expression ISO Curcumin results in decreased expression of APC mRNA CTD PMID:15713895 NCBI chr18:34,220,297...34,322,190
Ensembl chr18:34,220,924...34,322,552
JBrowse link
G Apoe apolipoprotein E affects expression EXP Curcumin affects the expression of APOE mRNA CTD PMID:27208389 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
increases expression
ISO Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
CTD PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Aqp3 aquaporin 3 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]
CTD PMID:18214481 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
decreases activity
decreases expression
ISO [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein
CTD PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] CTD PMID:18200517 NCBI chr 5:102,207,198...102,905,035
Ensembl chr 5:102,481,391...102,897,937
JBrowse link
G Arhgap30 Rho GTPase activating protein 30 decreases expression ISO Curcumin results in decreased expression of ARHGAP30 mRNA CTD PMID:18421014 NCBI chr 1:171,388,960...171,410,240
Ensembl chr 1:171,388,954...171,410,298
JBrowse link
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] CTD PMID:18200517 NCBI chr 6:136,923,655...136,941,899
Ensembl chr 6:136,923,655...136,941,899
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
increases degradation
decreases expression
ISO
EXP
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein
CTD PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] CTD PMID:23452621 NCBI chr15:100,227,859...100,261,248
Ensembl chr15:100,227,819...100,261,244
JBrowse link
G Atf2 activating transcription factor 2 decreases expression ISO Curcumin analog results in decreased expression of ATF2 mRNA CTD PMID:26409325 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein CTD PMID:15713895 PMID:18555241 PMID:18719366 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Atf6 activating transcription factor 6 increases expression EXP
ISO
Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA
CTD PMID:21793155 PMID:29723631 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions
increases phosphorylation
ISO [Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein
CTD PMID:19401701 PMID:21134073 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Aurka aurora kinase A decreases expression ISO Curcumin analog results in decreased expression of AURKA mRNA CTD PMID:26409325 NCBI chr 2:172,356,190...172,370,886
Ensembl chr 2:172,356,190...172,370,535
JBrowse link
G Aurkb aurora kinase B decreases expression ISO Curcumin analog results in decreased expression of AURKB mRNA CTD PMID:26409325 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Axin1 axin 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA
CTD PMID:25963729 NCBI chr17:26,131,217...26,195,811
Ensembl chr17:26,138,688...26,195,811
JBrowse link
G B3galt6 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 increases expression ISO Curcumin results in increased expression of B3GALT6 mRNA CTD PMID:17198877 NCBI chr 4:155,989,466...155,992,678
Ensembl chr 4:155,989,466...155,992,649
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA
CTD PMID:18583042 PMID:31521693 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]
CTD PMID:15569404 PMID:19235267 PMID:27430728 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
increases response to substance
ISO
EXP
TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:17332930 PMID:18226269 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions
decreases expression
increases expression
affects localization
increases response to substance
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein
CTD PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 PMID:17671742 PMID:18226269 PMID:19235267 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:23222814 PMID:23267840 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:27793699 PMID:27966075 PMID:30463061 PMID:30935902 PMID:31628941 PMID:32128952 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
decreases expression
ISO
EXP
Curcumin results in increased expression of BBC3 mRNA
Curcumin results in decreased expression of BBC3 mRNA
CTD PMID:17332930 PMID:22714040 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] CTD PMID:23452621 NCBI chr 3:145,924,262...145,934,366
Ensembl chr 3:145,922,804...145,934,356
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
CTD PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 PMID:16243823 PMID:17096185 PMID:17332930 PMID:17440100 PMID:17531121 PMID:17596214 PMID:17640567 PMID:17671737 PMID:17671742 PMID:18226269 PMID:18593936 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:19373661 PMID:19944674 PMID:20127174 PMID:20727180 PMID:20869986 PMID:21397623 PMID:21594647 PMID:21595920 PMID:21793155 PMID:22714040 PMID:23452621 PMID:24952339 PMID:25256401 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30935902 PMID:31628941 PMID:32128952 PMID:32569592 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression
multiple interactions
ISO Curcumin results in decreased expression of BCL2A1 mRNA
Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
CTD PMID:16219905 PMID:17596214 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA
CTD PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:17148446 PMID:17332930 PMID:17440100 PMID:17596214 PMID:17640567 PMID:17671737 PMID:18226269 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:23452621 PMID:30463061 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein
CTD PMID:17332930 PMID:27430728 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bcl2l2 BCL2-like 2 increases expression
multiple interactions
ISO Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein
CTD PMID:16101141 PMID:27430728 NCBI chr14:54,883,366...54,890,858
Ensembl chr14:54,892,500...54,898,169
Ensembl chr14:54,892,500...54,898,169
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 multiple interactions EXP
ISO
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]
CTD PMID:18200517 PMID:23452621 NCBI chr 7:19,808,462...19,822,824
Ensembl chr 7:19,808,462...19,822,770
JBrowse link
G Bcor BCL6 interacting corepressor increases expression ISO Curcumin results in increased expression of BCOR mRNA CTD PMID:17198877 NCBI chr  X:12,036,737...12,160,516
Ensembl chr  X:12,036,740...12,160,355
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
increases expression
affects expression
ISO
EXP
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 PMID:27966075 PMID:29723552 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bgn biglycan multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] CTD PMID:18200517 NCBI chr  X:73,483,601...73,495,936
Ensembl chr  X:73,483,602...73,495,933
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] CTD PMID:20605902 PMID:27430728 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions
ISO Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]
CTD PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 PMID:17671737 PMID:20727180 PMID:23452621 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
increases expression
decreases expression
ISO
EXP
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein
CTD PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 PMID:17596214 PMID:19372569 PMID:27430728 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO
EXP
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 PMID:19235267 PMID:19372569 PMID:20727180 PMID:23452621 PMID:24664296 PMID:26409325 PMID:27430728 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 (livin) increases expression
multiple interactions
ISO Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein
CTD PMID:15911101 PMID:27430728 NCBI chr 2:180,928,609...180,934,010
Ensembl chr 2:180,929,023...180,934,010
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression EXP Curcumin results in decreased expression of BMP2 mRNA CTD PMID:27237783 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Bsg basigin decreases response to substance EXP BSG protein results in decreased susceptibility to Curcumin CTD PMID:18379992 NCBI chr10:79,704,358...79,711,979
Ensembl chr10:79,704,491...79,711,969
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Curcumin results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] CTD PMID:18200517 NCBI chr 4:136,880,126...136,886,200
Ensembl chr 4:136,880,129...136,886,187
JBrowse link
G C3 complement component 3 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] CTD PMID:18200517 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G C4b complement component 4B (Chido blood group) multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] CTD PMID:18200517 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP
ISO
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]
CTD PMID:22911773 PMID:29723552 NCBI chr18:60,925,307...60,988,152
Ensembl chr18:60,925,618...60,988,152
JBrowse link
G Capg capping protein (actin filament), gelsolin-like multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] CTD PMID:18200517 NCBI chr 6:72,538,282...72,562,983
Ensembl chr 6:72,544,391...72,562,983
JBrowse link
G Car9 carbonic anhydrase 9 decreases expression ISO Curcumin results in decreased expression of CAR9 mRNA CTD PMID:18299980 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of CASP1 mRNA
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]
CTD PMID:16101141 PMID:23452621 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
CTD PMID:21793155 PMID:25541178 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp2 caspase 2 increases expression ISO Curcumin results in increased expression of CASP2 mRNA CTD PMID:16101141 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
CTD PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 PMID:17096185 PMID:17148446 PMID:17277231 PMID:17332930 PMID:17351913 PMID:17363495 PMID:17440100 PMID:17640567 PMID:17671742 PMID:17885582 PMID:18555241 PMID:19235267 PMID:19294764 PMID:19373661 PMID:19401701 PMID:20127174 PMID:20605902 PMID:20869986 PMID:21397623 PMID:21450334 PMID:21594647 PMID:21595920 PMID:22523229 PMID:23267840 PMID:23555722 PMID:23710286 PMID:24863870 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27375190 PMID:27430728 PMID:27535828 PMID:27966075 PMID:29315967 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30463061 PMID:30935902 PMID:31712109 PMID:31820278 PMID:32569592 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase increases expression ISO Curcumin results in increased expression of CASP4 mRNA CTD PMID:16101141 NCBI chr 9:5,308,849...5,336,791
Ensembl chr 9:5,308,828...5,336,783
JBrowse link
G Casp7 caspase 7 multiple interactions
increases expression
decreases expression
ISO [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA
CTD PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases cleavage
decreases expression
ISO Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]
CTD PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 PMID:23267840 PMID:23452621 PMID:25541178 PMID:27430728 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 decreases expression
multiple interactions
increases activity
increases expression
increases cleavage
ISO
EXP
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]
CTD PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 PMID:17440100 PMID:17671742 PMID:18555241 PMID:19095035 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:27375190 PMID:31628941 PMID:31712109 PMID:32128952 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
ISO
EXP
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
CTD PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 PMID:18392098 PMID:19481068 PMID:19631675 PMID:19913070 PMID:19914224 PMID:20112103 PMID:20593964 PMID:21574897 PMID:21976817 PMID:22704994 PMID:24113306 PMID:24347089 PMID:24760747 PMID:25123790 PMID:25169090 PMID:25461551 PMID:27375190 PMID:28951138 PMID:29205955 PMID:29315967 PMID:30138604 PMID:30423402 PMID:30934151 PMID:30946834 PMID:31081568 PMID:31330227 PMID:31407471 PMID:31521693 PMID:31714633 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] CTD PMID:25541467 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO
EXP
Curcumin results in increased expression of CCAR1 protein CTD PMID:21594647 NCBI chr10:62,743,928...62,792,368
Ensembl chr10:62,743,928...62,792,286
JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression EXP Curcumin results in increased expression of CCDC116 mRNA CTD PMID:18200517 NCBI chr16:17,139,064...17,147,802
Ensembl chr16:17,139,064...17,147,229
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
increases expression
ISO
EXP
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
Curcumin results in decreased expression of CCL2 mRNA
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA
CTD PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 PMID:19152916 PMID:20712904 PMID:22683883 PMID:23452621 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
CTD PMID:17965732 PMID:19764552 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein
CTD PMID:23222814 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein CTD PMID:17148446 PMID:18719366 PMID:19401701 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases degradation
ISO
EXP
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
CTD PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16959222 PMID:17041101 PMID:17148446 PMID:17440100 PMID:17531121 PMID:17602960 PMID:17640567 PMID:17885582 PMID:18156803 PMID:18226269 PMID:18316600 PMID:18593936 PMID:18640131 PMID:18790744 PMID:18829502 PMID:19189304 PMID:19372569 PMID:19501152 PMID:19573523 PMID:20727180 PMID:24211270 PMID:24508477 PMID:25822711 PMID:25963729 PMID:30935902 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein
CTD PMID:23222814 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691
JBrowse link
G Ccne1 cyclin E1 decreases expression
multiple interactions
increases degradation
ISO Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]
CTD PMID:17148446 PMID:18156803 PMID:18299980 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Ccpg1 cell cycle progression 1 increases expression ISO Curcumin results in increased expression of CCPG1 mRNA CTD PMID:17198877 NCBI chr 9:72,985,402...73,016,340
Ensembl chr 9:72,985,429...73,016,340
JBrowse link
G Ccr2 chemokine (C-C motif) receptor 2 decreases expression EXP Curcumin results in decreased expression of CCR2 mRNA CTD PMID:18403477 NCBI chr 9:124,101,918...124,109,140
Ensembl chr 9:124,101,950...124,113,557
JBrowse link
G Cd14 CD14 antigen multiple interactions ISO Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:18180316 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd36 CD36 molecule decreases expression
increases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein
CTD PMID:16713233 PMID:23386263 PMID:23603106 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd40 CD40 antigen decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CD40 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein
CTD PMID:16101141 PMID:27430728 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein CTD PMID:27430728 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Cd44 CD44 antigen increases expression ISO Curcumin results in increased expression of CD44 mRNA CTD PMID:15713895 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] CTD PMID:18200517 NCBI chr16:49,851,328...49,912,503
Ensembl chr16:49,800,533...49,915,010
JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement decreases expression ISO Curcumin results in decreased expression of CD55 mRNA CTD PMID:17999991 NCBI chr 1:130,429,798...130,465,009
Ensembl chr 1:130,439,027...130,462,744
JBrowse link
G Cdc14b CDC14 cell division cycle 14B increases expression ISO Curcumin results in increased expression of CDC14B mRNA CTD PMID:17198877 NCBI chr13:64,192,545...64,274,988
Ensembl chr13:64,189,268...64,275,290
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Curcumin results in decreased expression of CDC20 mRNA CTD PMID:22258452 NCBI chr 4:118,432,901...118,437,343
Ensembl chr 4:118,432,901...118,437,352
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO Curcumin results in increased phosphorylation of CDC25C protein CTD PMID:19401701 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]
CTD PMID:19573523 PMID:25656647 PMID:26191140 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh11 cadherin 11 decreases expression ISO Curcumin results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr 8:102,632,095...102,785,493
Ensembl chr 8:102,632,095...102,785,642
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO Curcumin results in decreased expression of CDH17 mRNA CTD PMID:17198877 NCBI chr 4:11,758,157...11,817,905
Ensembl chr 4:11,758,147...11,817,895
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:26191140 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein
CTD PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression
multiple interactions
ISO
EXP
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
CTD PMID:19501152 PMID:23222814 PMID:26409325 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein CTD PMID:18156803 PMID:24211270 PMID:26409325 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Curcumin analog results in decreased expression of CDK5 mRNA CTD PMID:26409325 NCBI chr 5:24,407,597...24,423,587
Ensembl chr 5:24,418,241...24,423,530
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Curcumin results in decreased expression of CDK6 protein CTD PMID:18156803 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008
JBrowse link
G Cdk7 cyclin-dependent kinase 7 decreases expression ISO Curcumin analog results in decreased expression of CDK7 mRNA CTD PMID:26409325 NCBI chr13:100,697,024...100,730,942
Ensembl chr13:100,702,631...100,730,939
JBrowse link
G Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) decreases expression ISO Curcumin analog results in decreased expression of CDK9 mRNA CTD PMID:26409325 NCBI chr 2:32,705,782...32,712,784
Ensembl chr 2:32,705,784...32,713,076
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
decreases expression
ISO
EXP
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]
CTD PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 PMID:18156803 PMID:18161303 PMID:18226269 PMID:18316600 PMID:18593936 PMID:20153625 PMID:23222814 PMID:25644192 PMID:25822711 PMID:27132804 PMID:27430728 PMID:30935902 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
decreases expression
ISO
EXP
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[arsenic trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein
CTD PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 PMID:21594647 PMID:25822711 PMID:27132804 PMID:27430728 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A decreases expression
increases expression
ISO Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein
CTD PMID:17148446 PMID:18156803 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cdx2 caudal type homeobox 2 increases expression ISO
EXP
Curcumin results in increased expression of CDX2 mRNA CTD PMID:18299980 PMID:27237783 NCBI chr 5:147,300,900...147,307,249
Ensembl chr 5:147,300,805...147,307,270
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions EXP Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:19297423 PMID:28595985 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] CTD PMID:18200517 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] CTD PMID:18200517 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces3b carboxylesterase 3B multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] CTD PMID:18200517 NCBI chr 8:105,083,733...105,093,929
Ensembl chr 8:105,083,753...105,093,929
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein
CTD PMID:16173963 PMID:16219905 PMID:23452621 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
increases activity
affects localization
ISO
EXP
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form
CTD PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Chat choline acetyltransferase multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] CTD PMID:21839772 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Chek1 checkpoint kinase 1 decreases response to substance
increases activity
increases phosphorylation
ISO CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein
CTD PMID:18602917 PMID:19401701 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Chil3 chitinase-like 3 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CHIL3 mRNA] CTD PMID:18200517 NCBI chr 3:106,147,554...106,167,564
Ensembl chr 3:106,147,554...106,167,564
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] CTD PMID:24952339 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions
decreases activity
ISO Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein
CTD PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Ckb creatine kinase, brain multiple interactions ISO Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr12:111,669,355...111,672,338
Ensembl chr12:111,669,361...111,672,338
JBrowse link
G Ckm creatine kinase, muscle multiple interactions ISO Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372 PMID:29315967 NCBI chr 7:19,411,094...19,421,583
Ensembl chr 7:19,404,776...19,422,841
JBrowse link
G Clca4a chloride channel accessory 4A multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA] CTD PMID:18200517 NCBI chr 3:144,952,486...144,975,045
Ensembl chr 3:144,952,480...144,975,045
JBrowse link
G Clcn6 chloride channel, voltage-sensitive 6 decreases expression ISO Curcumin results in decreased expression of CLCN6 mRNA CTD PMID:17198877 NCBI chr 4:148,004,259...148,038,813
Ensembl chr 4:148,004,259...148,038,821
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:139,800,808...139,811,386
Ensembl chr  X:139,800,828...139,811,386
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
decreases expression
ISO
EXP
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein
CTD PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 PMID:18006644 PMID:28700904 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] CTD PMID:18200517 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Col27a1 collagen, type XXVII, alpha 1 increases expression ISO Curcumin results in increased expression of COL27A1 mRNA CTD PMID:18299980 NCBI chr 4:63,214,009...63,334,991
Ensembl chr 4:63,214,004...63,334,991
JBrowse link
G Col2a1 collagen, type II, alpha 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein
CTD PMID:18321735 PMID:19889203 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions ISO Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] CTD PMID:22683883 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Col4a1 collagen, type IV, alpha 1 increases expression
multiple interactions
ISO
EXP
Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]
CTD PMID:18200517 PMID:21594647 PMID:28700904 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826
JBrowse link
G Col4a2 collagen, type IV, alpha 2 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] CTD PMID:18200517 NCBI chr 8:11,312,805...11,449,287
Ensembl chr 8:11,312,805...11,449,287
JBrowse link
G Col4a5 collagen, type IV, alpha 5 decreases expression ISO Curcumin results in decreased expression of COL4A5 mRNA CTD PMID:15713895 NCBI chr  X:141,475,370...141,689,236
Ensembl chr  X:141,475,385...141,689,234
JBrowse link
G Col5a1 collagen, type V, alpha 1 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] CTD PMID:18200517 NCBI chr 2:27,886,381...28,039,510
Ensembl chr 2:27,886,425...28,039,514
JBrowse link
G Col5a2 collagen, type V, alpha 2 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] CTD PMID:18200517 NCBI chr 1:45,374,331...45,503,282
Ensembl chr 1:45,374,321...45,503,282
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression EXP Curcumin results in increased expression of CPT1A mRNA CTD PMID:19297423 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions
increases phosphorylation
ISO
EXP
Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA
Curcumin results in increased phosphorylation of CREB1 protein
CTD PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Curcumin results in increased expression of CREB3 mRNA CTD PMID:18299980 NCBI chr 4:43,562,658...43,567,061
Ensembl chr 4:43,562,332...43,567,060
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] CTD PMID:22258452 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO
EXP
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]
CTD PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP
ISO
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD PMID:9764755 NCBI chr 9:50,745,951...50,756,636
Ensembl chr 9:50,751,325...50,756,636
JBrowse link
G Cs citrate synthase affects expression ISO Curcumin affects the expression of CS mRNA CTD PMID:18539377 NCBI chr10:128,337,727...128,362,482
Ensembl chr10:128,337,734...128,362,479
JBrowse link
G Csf1 colony stimulating factor 1 (macrophage) multiple interactions ISO Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] CTD PMID:15129424 NCBI chr 3:107,741,048...107,760,469
Ensembl chr 3:107,741,048...107,760,469
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions
increases expression
ISO
EXP
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA
CTD PMID:15129424 PMID:22714040 NCBI chr18:61,105,572...61,131,139
Ensembl chr18:61,100,598...61,132,149
JBrowse link
G Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) increases expression EXP Curcumin results in increased expression of CSF2RA mRNA CTD PMID:22714040 NCBI chr19:61,217,191...61,228,461
Ensembl chr19:61,223,957...61,228,429
JBrowse link
G Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] CTD PMID:18200517 NCBI chr15:78,282,507...78,305,721
Ensembl chr15:78,282,507...78,305,721
JBrowse link
G Csprs component of Sp100-rs decreases expression EXP Curcumin results in decreased expression of CSPRS mRNA CTD PMID:19555370
G Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTLA2A mRNA] CTD PMID:18200517 NCBI chr13:60,934,155...60,936,625
Ensembl chr13:60,934,155...60,936,625
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation
ISO
EXP
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein
CTD PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 PMID:27645308 PMID:30935902 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctsb cathepsin B multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsd cathepsin D multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA
CTD PMID:8534267 PMID:26409325 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctss cathepsin S decreases expression EXP Curcumin results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Cxcl1 chemokine (C-X-C motif) ligand 1 multiple interactions
decreases expression
ISO NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
CTD PMID:17999991 NCBI chr 5:90,891,245...90,893,121
Ensembl chr 5:90,891,241...90,893,115
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 multiple interactions ISO Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl14 chemokine (C-X-C motif) ligand 14 decreases expression EXP Curcumin results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr13:56,288,643...56,296,811
Ensembl chr13:56,288,643...56,296,551
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCL8 protein
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Acids results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Shiga Toxin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin results in decreased expression of and results in decreased secretion of CXCL8 protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]
CTD PMID:12216086 PMID:16819191 PMID:17000667 PMID:17151092 PMID:17273796 PMID:17666914 PMID:18226269 PMID:18413660 PMID:19074641 PMID:22142850 PMID:23452621 PMID:25540590 PMID:27393034 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]
CTD PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cxcl3 chemokine (C-X-C motif) ligand 3 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
CTD PMID:17999991 PMID:27194111 NCBI chr 5:90,786,101...90,788,093
Ensembl chr 5:90,786,103...90,789,600
JBrowse link
G Cxcr1 chemokine (C-X-C motif) receptor 1 increases expression ISO Curcumin results in increased expression of CXCR1 protein CTD PMID:12216086 NCBI chr 1:74,191,785...74,194,708
Ensembl chr 1:74,191,785...74,194,631
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 increases expression ISO Curcumin results in increased expression of CXCR2 protein CTD PMID:12216086 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]
CTD PMID:17198877 PMID:18660423 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Curcumin affects the localization of CYCS protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of CYCS protein
CTD PMID:19235267 PMID:27430728 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression
decreases activity
decreases expression
ISO
EXP
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 PMID:17880909 PMID:18321868 PMID:19018768 PMID:20015472 PMID:20816778 PMID:22867086 PMID:27041069 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO
EXP
Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:15841493 PMID:16288784 PMID:18321868 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA
CTD PMID:17637178 PMID:19018768 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein
CTD PMID:20153625 NCBI chr 2:170,482,957...170,497,145
Ensembl chr 2:170,482,708...170,497,145
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 affects expression
multiple interactions
ISO Curcumin affects the expression of CYP2B1 protein
Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine]
CTD PMID:16805852 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects expression
multiple interactions
increases expression
ISO
EXP
Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA
CTD PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression
decreases expression
multiple interactions
ISO Curcumin results in increased expression of CYP3A4 mRNA
Curcumin results in decreased expression of CYP3A4 mRNA
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CTD PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 PMID:20816778 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyth4 cytohesin 4 increases expression ISO Curcumin results in increased expression of CYTH4 mRNA CTD PMID:17198877 NCBI chr15:78,597,047...78,622,019
Ensembl chr15:78,597,047...78,622,019
JBrowse link
G Daxx Fas death domain-associated protein increases expression ISO Curcumin results in increased expression of DAXX mRNA CTD PMID:16101141 NCBI chr17:33,909,404...33,915,590
Ensembl chr17:33,909,414...33,915,590
JBrowse link
G Dbn1 drebrin 1 multiple interactions ISO Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] CTD PMID:23333261 NCBI chr13:55,473,428...55,488,126
Ensembl chr13:55,473,429...55,488,111
JBrowse link
G Dcn decorin increases expression ISO Curcumin results in increased expression of DCN mRNA CTD PMID:21594647 NCBI chr10:97,479,500...97,518,163
Ensembl chr10:97,479,609...97,518,143
JBrowse link
G Dcx doublecortin multiple interactions
increases expression
ISO Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin results in increased expression of DCX mRNA
CTD PMID:25963729 NCBI chr  X:143,855,842...143,933,396
Ensembl chr  X:143,855,842...143,933,311
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein
CTD PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 PMID:29723631 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like decreases expression
increases expression
ISO Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA
CTD PMID:17999991 PMID:18299980 NCBI chr 3:137,623,672...137,628,332
Ensembl chr 3:137,621,612...137,628,333
JBrowse link
G Dffb DNA fragmentation factor, beta subunit increases expression
decreases expression
EXP Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein
CTD PMID:21397623 PMID:22714040 NCBI chr 4:153,964,447...153,975,121
Ensembl chr 4:153,964,449...153,975,126
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression
affects expression
ISO
EXP
Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA
CTD PMID:27208389 NCBI chr 4:106,561,038...106,589,113
Ensembl chr 4:106,561,038...106,589,113
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression
decreases expression
EXP
ISO
Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA
CTD PMID:27208389 NCBI chr 7:143,823,167...143,848,410
Ensembl chr 7:143,823,145...143,848,410
JBrowse link
G Dhrs1 dehydrogenase/reductase (SDR family) member 1 decreases expression ISO Curcumin results in decreased expression of DHRS1 mRNA CTD PMID:17198877 NCBI chr14:55,739,020...55,745,684
Ensembl chr14:55,739,020...55,745,690
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein affects localization
multiple interactions
increases expression
increases response to substance
EXP
ISO
Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin
CTD PMID:17277231 PMID:23555722 PMID:27430728 NCBI chr 5:123,511,330...123,524,164
Ensembl chr 5:123,509,765...123,524,176
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]
CTD PMID:25963729 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] CTD PMID:29723552 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Curcumin results in increased expression of DNAJB9 mRNA CTD PMID:17999991 NCBI chr12:44,205,897...44,210,068
Ensembl chr12:44,205,559...44,210,326
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases expression
affects expression
increases activity
multiple interactions
ISO
EXP
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin results in increased activity of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein
CTD PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A decreases expression ISO
EXP
Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO
EXP
Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein
CTD PMID:23593078 PMID:26991801 PMID:29228771 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Dram1 DNA-damage regulated autophagy modulator 1 increases expression ISO Curcumin results in increased expression of DRAM1 mRNA CTD PMID:21594647 NCBI chr10:88,322,801...88,364,359
Ensembl chr10:88,322,804...88,379,080
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] CTD PMID:27966075 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]
CTD PMID:15713895 PMID:20885979 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Curcumin results in increased expression of DUSP10 mRNA CTD PMID:15713895 PMID:17151092 NCBI chr 1:184,034,381...184,075,636
Ensembl chr 1:184,013,302...184,075,636
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Curcumin results in increased expression of DUSP5 mRNA CTD PMID:17198877 NCBI chr19:53,529,145...53,541,809
Ensembl chr19:53,529,109...53,542,431
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 decreases expression
increases expression
multiple interactions
ISO Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]
CTD PMID:19573523 PMID:25963729 NCBI chr 4:155,847,402...155,859,303
Ensembl chr 4:155,847,402...155,859,303
JBrowse link
G Dynll1 dynein light chain LC8-type 1 increases expression ISO Curcumin results in increased expression of DYNLL1 mRNA CTD PMID:17198877 NCBI chr 5:115,297,110...115,300,990
Ensembl chr 5:115,297,110...115,300,999
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Curcumin results in decreased expression of E2F1 mRNA CTD PMID:18299980 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G E2f5 E2F transcription factor 5 decreases expression ISO Curcumin results in decreased expression of E2F5 mRNA CTD PMID:15713895 NCBI chr 3:14,578,602...14,606,309
Ensembl chr 3:14,578,641...14,606,309
JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression ISO Curcumin results in increased expression of ECH1 mRNA CTD PMID:18539377 NCBI chr 7:28,825,338...28,832,239
Ensembl chr 7:28,825,217...28,832,247
JBrowse link
G Edaradd EDAR (ectodysplasin-A receptor)-associated death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] CTD PMID:23452621 NCBI chr13:12,471,209...12,520,535
Ensembl chr13:12,472,632...12,520,438
JBrowse link
G Edil3 EGF-like repeats and discoidin I-like domains 3 decreases expression ISO Curcumin results in decreased expression of EDIL3 mRNA CTD PMID:18421014 NCBI chr13:88,821,472...89,323,225
Ensembl chr13:88,821,472...89,323,223
JBrowse link
G Egf epidermal growth factor decreases activity
multiple interactions
ISO Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
decreases expression
ISO Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
CTD PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 PMID:18006644 PMID:18214481 PMID:18332871 PMID:18719366 PMID:24508477 PMID:26409325 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
decreases expression
ISO EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA
CTD PMID:17198877 PMID:17999991 PMID:18316600 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression ISO Curcumin results in decreased expression of EIF1 mRNA CTD PMID:17999991 NCBI chr11:100,319,949...100,322,099
Ensembl chr11:100,319,885...100,322,096
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases expression
decreases phosphorylation
ISO calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein
CTD PMID:18790744 PMID:23222814 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4, gamma 1 decreases phosphorylation ISO Curcumin results in decreased phosphorylation of EIF4G1 protein CTD PMID:18790744 NCBI chr16:20,672,720...20,692,883
Ensembl chr16:20,668,313...20,692,884
JBrowse link
G Elf2 E74-like factor 2 decreases expression ISO Curcumin results in decreased expression of ELF2 mRNA CTD PMID:15713895 NCBI chr 3:51,252,720...51,340,683
Ensembl chr 3:51,252,720...51,340,663
JBrowse link
G Elk1 ELK1, member of ETS oncogene family multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] CTD PMID:18316600 PMID:23452621 NCBI chr  X:20,933,395...20,950,608
Ensembl chr  X:20,933,395...20,950,608
JBrowse link
G Emb embigin multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] CTD PMID:18200517 NCBI chr13:117,220,573...117,274,415
Ensembl chr13:117,208,536...117,274,415
JBrowse link
G Eno1 enolase 1, alpha non-neuron decreases expression ISO Curcumin results in decreased expression of ENO1 mRNA CTD PMID:16880289 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 increases expression ISO Curcumin results in increased expression of ENTPD5 mRNA CTD PMID:18299980 NCBI chr12:84,373,875...84,409,029
Ensembl chr12:84,373,857...84,409,029
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions
decreases activity
decreases expression
affects localization
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein
CTD PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions ISO Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:20554536 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Epo erythropoietin decreases expression ISO Curcumin results in decreased expression of EPO mRNA CTD PMID:16880289 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases response to substance
increases degradation
decreases expression
ISO [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein
CTD PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA
CTD PMID:15713895 PMID:17918158 PMID:26409325 NCBI chr10:128,567,523...128,589,635
Ensembl chr10:128,567,523...128,589,652
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 multiple interactions
decreases expression
ISO [Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein
CTD PMID:17596214 PMID:21493726 PMID:22228707 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
CTD PMID:22228707 NCBI chr16:13,109,366...13,152,009
Ensembl chr16:13,109,684...13,150,617
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 decreases expression
increases expression
ISO Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA
CTD PMID:17999991 PMID:29723631 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein
CTD PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Ets2 E26 avian leukemia oncogene 2, 3' domain decreases expression ISO Curcumin results in decreased expression of ETS2 protein CTD PMID:17332326 NCBI chr16:95,702,407...95,721,049
Ensembl chr16:95,702,075...95,721,051
JBrowse link
G F2 coagulation factor II multiple interactions ISO Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:18565277 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] CTD PMID:23452621 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G F3 coagulation factor III multiple interactions ISO Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] CTD PMID:23452621 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fads1 fatty acid desaturase 1 affects expression
decreases expression
EXP
ISO
Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA
CTD PMID:27208389 NCBI chr19:10,182,877...10,196,874
Ensembl chr19:10,182,888...10,196,877
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression
affects expression
ISO
EXP
Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA
CTD PMID:27208389 NCBI chr19:10,062,765...10,101,503
Ensembl chr19:10,062,765...10,101,746
JBrowse link
G Fam120b family with sequence similarity 120, member B decreases expression ISO Curcumin results in decreased expression of FAM120B mRNA CTD PMID:17999991 NCBI chr17:15,396,202...15,433,581
Ensembl chr17:15,396,202...15,433,583
JBrowse link
G Fancd2 Fanconi anemia, complementation group D2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 6:113,531,640...113,597,020
Ensembl chr 6:113,531,682...113,597,017
JBrowse link
G Fanci Fanconi anemia, complementation group I multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA
CTD PMID:24124520 NCBI chr 7:79,392,312...79,450,266
Ensembl chr 7:79,391,929...79,450,264
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein CTD PMID:27430728 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
decreases expression
ISO [arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA
CTD PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression
EXP
ISO
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA
CTD PMID:27208389 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbln2 fibulin 2 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] CTD PMID:18200517 NCBI chr 6:91,212,460...91,272,540
Ensembl chr 6:91,212,455...91,272,540
JBrowse link
G Fcgr4 Fc receptor, IgG, low affinity IV multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] CTD PMID:18200517 NCBI chr 1:171,018,926...171,029,761
Ensembl chr 1:171,018,920...171,029,761
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression ISO Curcumin results in decreased expression of FDFT1 mRNA CTD PMID:27208389 NCBI chr14:63,145,150...63,181,687
Ensembl chr14:63,145,150...63,179,578
JBrowse link
G Fdps farnesyl diphosphate synthetase increases expression
decreases expression
affects expression
ISO
EXP
Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA
CTD PMID:16713233 PMID:27208389 NCBI chr 3:89,093,588...89,101,967
Ensembl chr 3:89,093,588...89,101,959
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression
increases expression
ISO Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein
CTD PMID:23555722 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fgf5 fibroblast growth factor 5 decreases expression EXP Curcumin results in decreased expression of FGF5 mRNA CTD PMID:27237783 NCBI chr 5:98,254,184...98,277,033
Ensembl chr 5:98,254,184...98,277,030
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Curcumin results in decreased expression of FGFR2 mRNA CTD PMID:15713895 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Curcumin results in increased expression of FILIP1L mRNA CTD PMID:21594647 NCBI chr16:57,353,277...57,572,804
Ensembl chr16:57,353,093...57,573,126
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] CTD PMID:28698153 NCBI chr 5:136,953,275...136,966,234
Ensembl chr 5:136,953,275...136,966,234
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of FLT1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]
CTD PMID:18593936 PMID:23845850 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]
CTD PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta increases expression ISO Curcumin results in increased expression of FNTB mRNA CTD PMID:17999991 NCBI chr12:76,837,400...76,921,412
Ensembl chr12:76,765,589...76,921,412
JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression
multiple interactions
increases expression
ISO
EXP
Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
CTD PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 multiple interactions
increases ubiquitination
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein
CTD PMID:17148446 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Fosl2 fos-like antigen 2 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]
CTD PMID:17148446 PMID:17999991 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Foxa1 forkhead box A1 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] CTD PMID:22258452 NCBI chr12:57,540,628...57,548,029
Ensembl chr12:57,540,628...57,546,916
JBrowse link
G Foxa2 forkhead box A2 decreases expression EXP Curcumin results in decreased expression of FOXA2 mRNA CTD PMID:27237783 NCBI chr 2:148,042,877...148,046,969
Ensembl chr 2:148,042,877...148,046,969
JBrowse link
G Foxf2 forkhead box F2 decreases expression ISO Curcumin results in decreased expression of FOXF2 mRNA CTD PMID:15713895 NCBI chr13:31,625,816...31,631,406
Ensembl chr13:31,625,816...31,631,403
JBrowse link
G Foxo1 forkhead box O1 increases expression
decreases phosphorylation
EXP
ISO
Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein
CTD PMID:18403477 PMID:18790744 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Fpr3 formyl peptide receptor 3 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA] CTD PMID:18200517 NCBI chr17:17,970,458...17,971,677
Ensembl chr17:17,887,852...17,971,677
JBrowse link
G Fstl1 follistatin-like 1 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] CTD PMID:18200517 NCBI chr16:37,777,055...37,836,516
Ensembl chr16:37,776,873...37,836,514
JBrowse link
G Ftl1 ferritin light polypeptide 1 decreases expression EXP Curcumin results in decreased expression of FTL1 mRNA CTD PMID:24634837 NCBI chr 7:45,457,944...45,459,886
Ensembl chr 7:45,457,944...45,459,884
JBrowse link
G Fus fused in sarcoma increases expression
decreases expression
ISO Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA
CTD PMID:17198877 PMID:17999991 NCBI chr 7:127,966,789...127,982,032
Ensembl chr 7:127,967,457...127,985,701
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Curcumin results in decreased expression of FZD1 mRNA CTD PMID:15713895 NCBI chr 5:4,753,839...4,758,216
Ensembl chr 5:4,753,839...4,758,035
JBrowse link
G G6pc glucose-6-phosphatase, catalytic affects expression EXP Curcumin affects the expression of G6PC mRNA CTD PMID:27208389 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases expression ISO Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA CTD PMID:18299980 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 decreases expression ISO Curcumin results in decreased expression of GABRA1 mRNA CTD PMID:18299980 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] CTD PMID:23267840 NCBI chr 2:70,561,303...70,602,014
Ensembl chr 2:70,553,072...70,602,014
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Curcumin results in increased expression of GADD45A mRNA CTD PMID:16101141 PMID:18299980 PMID:18719366 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO Curcumin results in increased expression of GAS6 mRNA CTD PMID:21594647 NCBI chr 8:13,465,374...13,494,535
Ensembl chr 8:13,465,374...13,494,490
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] CTD PMID:22258452 NCBI chr 6:88,193,891...88,207,032
Ensembl chr 6:88,193,891...88,207,032
JBrowse link
G Gata4 GATA binding protein 4 decreases expression EXP Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein CTD PMID:27237783 NCBI chr14:63,198,914...63,271,712
Ensembl chr14:63,198,922...63,271,692
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
increases expression
ISO
EXP
Curcumin results in increased activity of GCLC protein
NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
CTD PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 PMID:19183254 PMID:23710286 PMID:23954767 PMID:29571711 PMID:31521693 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
increases expression
ISO
EXP
Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]
CTD PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 PMID:19168576 PMID:19183254 PMID:19188863 PMID:23386263 PMID:23710286 PMID:23954767 PMID:29571711 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gda guanine deaminase multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA] CTD PMID:18200517 NCBI chr19:21,391,307...21,472,661
Ensembl chr19:21,391,307...21,473,445
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]
CTD PMID:19555370 PMID:25963729 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]
CTD PMID:18299980 PMID:24704557 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Ggta1 glycoprotein galactosyltransferase alpha 1, 3 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA] CTD PMID:18200517 NCBI chr 2:35,400,179...35,464,381
Ensembl chr 2:35,400,179...35,463,231
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA] CTD PMID:23452621 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gli1 GLI-Kruppel family member GLI1 decreases expression EXP Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr10:127,329,882...127,341,579
Ensembl chr10:127,329,882...127,341,974
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Curcumin results in decreased activity of GLO1 protein CTD PMID:18946510 NCBI chr17:30,592,861...30,612,659
Ensembl chr17:30,584,936...30,626,871
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions ISO Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr19:43,499,752...43,524,605
Ensembl chr19:43,499,752...43,524,605
JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA] CTD PMID:18200517 NCBI chr 8:27,197,459...27,223,845
Ensembl chr 8:27,197,459...27,223,828
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
affects expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]
CTD PMID:19297423 PMID:27208389 NCBI chr19:55,067,635...55,127,319
Ensembl chr19:55,067,268...55,127,238
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 decreases expression ISO Curcumin results in decreased expression of GPER1 mRNA CTD PMID:17198877 NCBI chr 5:139,423,150...139,427,800
Ensembl chr 5:139,423,151...139,427,800
JBrowse link
G Gphn gephyrin affects expression ISO Curcumin affects the expression of GPHN mRNA CTD PMID:18539377 NCBI chr12:78,217,325...78,684,772
Ensembl chr12:78,226,379...78,684,772
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 PMID:29421648 PMID:30423402 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
ISO
EXP
Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]
CTD PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Grb10 growth factor receptor bound protein 10 multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA] CTD PMID:18200517 NCBI chr11:11,930,499...12,037,428
Ensembl chr11:11,930,508...12,038,683
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Curcumin analog results in decreased expression of GRB2 mRNA CTD PMID:26409325 NCBI chr11:115,644,045...115,708,597
Ensembl chr11:115,644,045...115,708,597
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA] CTD PMID:18200517 NCBI chr 2:113,748,675...113,758,648
Ensembl chr 2:113,746,164...113,758,646
JBrowse link
G Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) multiple interactions ISO Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] CTD PMID:23267840 NCBI chr 9:4,417,893...4,796,234
Ensembl chr 9:4,417,896...4,796,234
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein] CTD PMID:23267840 PMID:29723552 NCBI chr 2:25,291,177...25,319,187
Ensembl chr 2:25,291,181...25,319,187
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein] CTD PMID:29723552 NCBI chr16:9,567,901...9,996,083
Ensembl chr16:9,567,898...9,995,560
JBrowse link
G Grm2 glutamate receptor, metabotropic 2 decreases expression EXP Curcumin results in decreased expression of GRM2 protein CTD PMID:25406541 NCBI chr 9:106,644,534...106,656,109
Ensembl chr 9:106,643,095...106,656,082
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein
CTD PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 PMID:27645308 PMID:27966075 PMID:29723552 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsn gelsolin multiple interactions EXP Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA] CTD PMID:18200517 NCBI chr 2:35,256,359...35,307,902
Ensembl chr 2:35,256,380...35,307,892
JBrowse link
G Gsr glutathione reductase increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of GSR mRNA
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]
CTD PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 PMID:25632966 PMID:31407471 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gss glutathione synthetase increases expression EXP Curcumin results in increased expression of GSS mRNA CTD PMID:19183254 NCBI chr 2:155,563,181...155,592,810
Ensembl chr 2:155,563,181...155,592,810
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) increases expression ISO Curcumin results in increased expression of GSTA5 mRNA CTD PMID:18299980 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression EXP Curcumin results in increased expression of GSTA2 mRNA CTD PMID:18200517 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity ISO Curcumin results in increased activity of GSTA4 protein CTD PMID:10514034 NCBI chr 9:78,289,928...78,305,525
Ensembl chr 9:78,289,923...78,305,525
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA] CTD PMID:31521693 NCBI chr 6:42,245,935...42,250,441
Ensembl chr 6:42,245,935...42,250,447
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
affects expression
increases expression
decreases expression
ISO [sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein
CTD PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 PMID:17449203 PMID:18299980 PMID:18414057 PMID:22830632 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:8534267 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G H19 H19, imprinted maternally expressed transcript decreases expression ISO Curcumin results in decreased expression of H19 mRNA CTD PMID:18348204 NCBI chr 7:142,575,530...142,578,146
Ensembl chr 7:142,575,529...142,578,143
JBrowse link
G H1f10 H1.10 linker histone decreases expression ISO Curcumin results in decreased expression of H1-10 mRNA CTD PMID:17198877 NCBI chr 6:87,980,421...87,981,482
Ensembl chr 6:87,980,421...87,981,637
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein
CTD PMID:19401701 PMID:21134073 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G H2bc14 H2B clustered histone 14 increases expression ISO Curcumin results in increased expression of H2BC5 mRNA CTD PMID:17999991 NCBI chr13:21,722,044...21,722,526
Ensembl chr13:21,722,044...21,722,567
JBrowse link
G H2bc6 H2B clustered histone 6 increases expression ISO Curcumin results in increased expression of HIST1H2BQ mRNA CTD PMID:18299980 NCBI chr13:23,583,670...23,621,124
Ensembl chr13:23,583,670...23,621,124
JBrowse link
G H2bu2 H2B.U histone 2 increases expression ISO Curcumin results in increased expression of H2BU1 mRNA CTD PMID:15713895 NCBI chr11:58,948,911...58,949,372
Ensembl chr11:58,948,920...58,949,533
JBrowse link
G H3f4 H3.4 histone increases phosphorylation
increases acetylation
ISO Curcumin results in increased phosphorylation of H3F4 protein
Curcumin results in increased acetylation of H3F4 protein
CTD PMID:18204486 NCBI chr11:58,961,711...58,962,273
Ensembl chr11:58,961,812...58,962,222
JBrowse link
G H4c11 H4 clustered histone 11 increases expression ISO Curcumin results in increased expression of H4C11 mRNA CTD PMID:15713895 NCBI chr13:21,735,034...21,735,456
Ensembl chr13:21,735,064...21,735,837
JBrowse link
G H4c4 H4 clustered histone 4 increases expression ISO Curcumin results in increased expression of H4C15 mRNA CTD PMID:17198877 NCBI chr13:23,581,568...23,581,969
Ensembl chr13:23,581,598...23,582,735
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP Curcumin results in decreased expression of HAMP mRNA CTD PMID:24634837 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA
CTD PMID:24857828 NCBI chr11:57,828,713...57,832,147
Ensembl chr11:57,828,705...57,832,818
JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA
CTD PMID:24857828 NCBI chr 8:57,320,983...57,324,517
Ensembl chr 8:57,320,983...57,324,633
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein] CTD PMID:25119790 PMID:29421648 PMID:30431687 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hbs1l Hbs1-like (S. cerevisiae) decreases expression ISO Curcumin results in decreased expression of HBS1L mRNA CTD PMID:18421014 NCBI chr10:21,295,979...21,368,889
Ensembl chr10:21,295,979...21,368,898
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions
decreases expression
affects localization
ISO
EXP
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein
CTD PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hdac11 histone deacetylase 11 decreases expression ISO Curcumin analog results in decreased expression of HDAC11 mRNA CTD PMID:26409325 NCBI chr 6:91,156,670...91,174,692
Ensembl chr 6:91,156,665...91,174,692
JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA
CTD PMID:18421014 PMID:26409325 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889