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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biological pigment
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Accession:CHEBI:26130 term browser browse the term
Definition:An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
Synonyms:related_synonym: pigments


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all-trans-neoxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization EXP neoxanthin affects the localization of AIFM1 protein CTD PMID:17186379 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G CASP3 caspase 3 multiple interactions EXP neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:17186379 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP neoxanthin results in increased activity of CASP8 protein CTD PMID:17186379 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions EXP neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:17186379 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
astaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] CTD PMID:16964424 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G C1QA complement C1q A chain decreases expression ISO astaxanthine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G CAT catalase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] CTD PMID:16964424 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CNTD1 cyclin N-terminal domain containing 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] CTD PMID:16964424 NCBI chr17:42,798,749...42,811,587
Ensembl chr17:42,798,800...42,811,587
JBrowse link
G COX15 cytochrome c oxidase assembly homolog COX15 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] CTD PMID:16964424 NCBI chr10:99,694,293...99,732,131
Ensembl chr10:99,711,844...99,732,100
Ensembl chr10:99,711,844...99,732,100
JBrowse link
G COX5A cytochrome c oxidase subunit 5A multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] CTD PMID:16964424 NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083
JBrowse link
G COX5B cytochrome c oxidase subunit 5B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] CTD PMID:16964424 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383
JBrowse link
G COX6B1 cytochrome c oxidase subunit 6B1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] CTD PMID:16964424 NCBI chr19:35,648,323...35,658,782
Ensembl chr19:35,648,323...35,658,782
JBrowse link
G COX6C cytochrome c oxidase subunit 6C multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] CTD PMID:16964424 NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707
JBrowse link
G CTSS cathepsin S decreases expression ISO astaxanthine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,188...150,765,792
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions
decreases expression
ISO astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]
astaxanthine results in decreased expression of NOX2 mRNA
CTD PMID:23272707 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
ISO astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA
CTD PMID:21414371 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G FOXO3 forkhead box O3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases activity
multiple interactions
ISO astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein
CTD PMID:28665548, PMID:29975440 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO astaxanthine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GJA1 gap junction protein alpha 1 increases expression
multiple interactions
ISO astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]
CTD PMID:16091010 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GNA13 G protein subunit alpha 13 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] CTD PMID:16964424 NCBI chr17:65,009,289...65,056,740
Ensembl chr17:65,009,289...65,056,740
JBrowse link
G GPX3 glutathione peroxidase 3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] CTD PMID:16964424 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] CTD PMID:23538867 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GRN granulin precursor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] CTD PMID:16964424 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:29975440 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTM2 glutathione S-transferase mu 2 multiple interactions
increases expression
EXP [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA
CTD PMID:24157545 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] CTD PMID:16964424 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
ISO
EXP
astaxanthine results in increased expression of HMOX1 protein
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HOXA9 homeobox A9 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] CTD PMID:16964424 NCBI chr 7:27,162,438...27,165,537
Ensembl chr 7:27,162,438...27,175,180
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] CTD PMID:16964424 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G IL1B interleukin 1 beta decreases expression ISO astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein CTD PMID:21621527 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 decreases expression ISO astaxanthine results in decreased expression of IL6 mRNA CTD PMID:21621527 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LEPR leptin receptor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MT-ND6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] CTD PMID:16964424 NCBI chr MT:14,149...14,673
Ensembl chr MT:14,149...14,673
JBrowse link
G NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] CTD PMID:16964424 NCBI chr  X:119,871,832...119,876,662
Ensembl chr  X:119,871,832...119,876,662
JBrowse link
G NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] CTD PMID:16964424 NCBI chr 7:123,536,997...123,601,651
Ensembl chr 7:123,536,997...123,557,904
JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] CTD PMID:16964424 NCBI chr11:78,068,297...78,079,862
Ensembl chr11:78,068,297...78,079,862
JBrowse link
G NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] CTD PMID:16964424 NCBI chr18:9,102,642...9,134,341
Ensembl chr18:9,102,630...9,134,345
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
multiple interactions
ISO
EXP
astaxanthine results in increased expression of NFE2L2 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] CTD PMID:16964424 NCBI chr17:51,165,536...51,171,744
Ensembl chr17:51,165,435...51,171,744
Ensembl chr17:51,165,435...51,171,744
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO
EXP
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein
CTD PMID:20038455, PMID:24157545 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PAH phenylalanine hydroxylase decreases expression ISO astaxanthine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PGD phosphogluconate dehydrogenase increases activity ISO astaxanthine results in increased activity of PGD protein CTD PMID:28665548, PMID:29975440 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511
JBrowse link
G POR cytochrome p450 oxidoreductase decreases activity
increases expression
ISO astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein
CTD PMID:21414371 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPP1CB protein phosphatase 1 catalytic subunit beta multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] CTD PMID:16964424 NCBI chr 2:28,751,604...28,802,940
Ensembl chr 2:28,751,640...28,802,940
JBrowse link
G PRDX1 peroxiredoxin 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] CTD PMID:16964424 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression ISO astaxanthine results in decreased expression of PTGS2 mRNA CTD PMID:21621527 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RPS2 ribosomal protein S2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] CTD PMID:16964424 NCBI chr16:1,962,058...1,964,826
Ensembl chr16:1,962,058...1,964,841
JBrowse link
G SKAP2 src kinase associated phosphoprotein 2 decreases expression ISO astaxanthine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 7:26,654,772...26,864,623
Ensembl chr 7:26,667,068...26,995,239
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] CTD PMID:16964424 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] CTD PMID:23538867 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G TGM2 transglutaminase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] CTD PMID:16964424 NCBI chr20:38,127,385...38,166,508
Ensembl chr20:38,127,385...38,166,578
JBrowse link
G TKT transketolase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] CTD PMID:16964424 NCBI chr 3:53,224,712...53,256,052
Ensembl chr 3:53,224,712...53,256,052
JBrowse link
G TNF tumor necrosis factor decreases expression ISO astaxanthine results in decreased expression of TNF protein CTD PMID:21621527 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] CTD PMID:20038455 NCBI chr17:7,668,402...7,687,550
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G UBB ubiquitin B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] CTD PMID:16964424 NCBI chr17:16,380,779...16,382,745
Ensembl chr17:16,380,798...16,382,745
JBrowse link
G UQCRB ubiquinol-cytochrome c reductase binding protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] CTD PMID:16964424 NCBI chr 8:96,222,947...96,235,545
Ensembl chr 8:96,225,920...96,235,634
Ensembl chr 8:96,225,920...96,235,634
JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660
JBrowse link
beta-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAD9 acyl-CoA dehydrogenase family member 9 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA CTD PMID:24657404 NCBI chr 3:128,879,596...128,913,114
Ensembl chr 3:128,879,596...128,916,067
JBrowse link
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide increases expression EXP beta Carotene results in increased expression of ADH1A mRNA CTD PMID:17034753 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003
JBrowse link
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression EXP beta Carotene results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression ISO beta Carotene results in decreased expression of ADIPOQ mRNA CTD PMID:21569430 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AEBP1 AE binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA CTD PMID:24657404 NCBI chr 7:44,104,320...44,114,564
Ensembl chr 7:44,104,345...44,114,562
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP beta Carotene results in decreased phosphorylation of AKT1 protein CTD PMID:26733226 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] CTD PMID:25542264 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 decreases expression EXP beta Carotene results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,578...68,029,282
JBrowse link
G ALDH4A1 aldehyde dehydrogenase 4 family member A1 decreases expression EXP beta Carotene results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 1:18,871,430...18,902,580
Ensembl chr 1:18,871,430...18,902,724
JBrowse link
G ANK2 ankyrin 2 increases expression EXP beta Carotene results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221
JBrowse link
G ANK3 ankyrin 3 increases expression EXP beta Carotene results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr10:60,026,298...60,733,528
Ensembl chr10:60,026,298...60,733,490
JBrowse link
G APPBP2 amyloid beta precursor protein binding protein 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA CTD PMID:24657404 NCBI chr17:60,443,149...60,526,242
Ensembl chr17:60,443,158...60,526,242
JBrowse link
G ARHGAP26 Rho GTPase activating protein 26 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA CTD PMID:24657404 NCBI chr 5:142,770,370...143,229,011
Ensembl chr 5:142,770,377...143,229,011
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP beta Carotene results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ASB1 ankyrin repeat and SOCS box containing 1 increases expression EXP beta Carotene results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 2:238,426,927...238,452,250
Ensembl chr 2:238,426,742...238,452,250
JBrowse link
G ASB9 ankyrin repeat and SOCS box containing 9 increases expression EXP beta Carotene results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:15,243,987...15,270,476
Ensembl chr  X:15,235,288...15,270,467
JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA CTD PMID:24657404 NCBI chr18:57,646,426...57,803,822
Ensembl chr18:57,646,426...57,803,315
JBrowse link
G BAG3 BAG cochaperone 3 decreases expression EXP beta Carotene results in decreased expression of BAG3 mRNA CTD PMID:17034753 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,370...119,677,819
Ensembl chr10:119,651,370...119,677,819
JBrowse link
G BAG4 BAG cochaperone 4 decreases expression EXP beta Carotene results in decreased expression of BAG4 mRNA CTD PMID:17034753 NCBI chr 8:38,176,855...38,213,301
Ensembl chr 8:38,176,533...38,213,301
JBrowse link
G BAG5 BAG cochaperone 5 decreases expression EXP beta Carotene results in decreased expression of BAG5 mRNA CTD PMID:17034753 NCBI chr14:103,556,551...103,562,657
Ensembl chr14:103,556,544...103,562,831
JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
increases expression
EXP beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein
CTD PMID:15949688, PMID:17034753, PMID:26733226 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP beta Carotene results in decreased expression of BCL2 protein CTD PMID:26733226 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCO1 beta-carotene oxygenase 1 multiple interactions
affects response to substance
increases oxidation
increases expression
EXP
ISO
beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]
CTD PMID:9526112, PMID:16186334, PMID:24657404 NCBI chr16:81,238,448...81,291,142
Ensembl chr16:81,238,689...81,291,142
JBrowse link
G BCO2 beta-carotene oxygenase 2 multiple interactions
increases metabolic processing
ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal CTD PMID:21106934 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein
CTD PMID:17618090, PMID:26733226 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CAT catalase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]
CTD PMID:9306888, PMID:12500499, PMID:25542264, PMID:31022331 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 decreases expression EXP beta Carotene results in decreased expression of CAV1 protein CTD PMID:26733226 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,525,001...116,561,184
JBrowse link
G CCND1 cyclin D1 decreases expression EXP beta Carotene results in decreased expression of CCND1 protein CTD PMID:26733226 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDCA8 cell division cycle associated 8 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA CTD PMID:24657404 NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719
JBrowse link
G CDH1 cadherin 1 increases expression EXP beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein CTD PMID:17034753, PMID:26733226 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression ISO beta Carotene results in decreased expression of CEBPA mRNA CTD PMID:21569430 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CENPE centromere protein E multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA CTD PMID:24657404 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator increases expression EXP beta Carotene results in increased expression of CFLAR mRNA CTD PMID:17034753 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CLCN3 chloride voltage-gated channel 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA CTD PMID:24657404 NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673
JBrowse link
G CLDN10 claudin 10 increases expression EXP beta Carotene results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr13:95,433,588...95,579,759
Ensembl chr13:95,433,604...95,579,759
JBrowse link
G CLDN18 claudin 18 increases expression EXP beta Carotene results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP beta Carotene results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL4A1 collagen type IV alpha 1 chain decreases expression EXP beta Carotene results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157
JBrowse link
G COL4A2 collagen type IV alpha 2 chain decreases expression EXP beta Carotene results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209
JBrowse link
G COQ7 coenzyme Q7, hydroxylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA CTD PMID:24657404 NCBI chr16:19,067,595...19,080,095
Ensembl chr16:19,067,614...19,080,095
JBrowse link
G CPT1B carnitine palmitoyltransferase 1B decreases expression ISO beta Carotene results in decreased expression of CPT1B mRNA CTD PMID:21569430 NCBI chr22:50,568,861...50,578,612
Ensembl chr22:50,568,861...50,578,465
JBrowse link
G CRADD CASP2 and RIPK1 domain containing adaptor with death domain increases expression EXP beta Carotene results in increased expression of CRADD mRNA CTD PMID:17034753 NCBI chr12:93,677,342...93,894,840
Ensembl chr12:93,677,375...93,894,840
JBrowse link
G CTNNAL1 catenin alpha like 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA CTD PMID:24657404 NCBI chr 9:108,942,569...109,013,535
Ensembl chr 9:108,942,569...109,013,522
JBrowse link
G CTSB cathepsin B decreases expression EXP beta Carotene results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 increases expression EXP beta Carotene results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 increases expression EXP beta Carotene results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP beta Carotene promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein] CTD PMID:19135038 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 increases expression EXP beta Carotene results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP beta Carotene results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] CTD PMID:16970932 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases expression EXP beta Carotene results in increased expression of CYP26A1 mRNA CTD PMID:16186334, PMID:22542753 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases expression EXP beta Carotene results in increased expression of CYP2C9 mRNA CTD PMID:17034753 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A43 cytochrome P450 family 3 subfamily A member 43 increases expression EXP beta Carotene results in increased expression of CYP3A43 mRNA CTD PMID:17034753 NCBI chr 7:99,827,626...99,867,138
Ensembl chr 7:99,828,013...99,866,102
JBrowse link
G DHFR dihydrofolate reductase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DLX2 distal-less homeobox 2 increases expression EXP beta Carotene results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 2:172,099,438...172,102,900
Ensembl chr 2:172,099,438...172,102,900
JBrowse link
G DLX4 distal-less homeobox 4 increases expression EXP beta Carotene results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr17:49,968,970...49,974,959
Ensembl chr17:49,968,970...49,974,959
JBrowse link
G DTWD2 DTW domain containing 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA CTD PMID:24657404 NCBI chr 5:118,836,074...118,988,547
Ensembl chr 5:118,836,074...118,988,547
JBrowse link
G EDN1 endothelin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA CTD PMID:24657404 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA CTD PMID:24657404 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,151...67,386,516
Ensembl chr14:67,360,151...67,386,516
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression EXP beta Carotene results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr19:45,349,837...45,370,647
Ensembl chr19:45,349,837...45,370,918
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:17051425, PMID:19340624 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] CTD PMID:17051425 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression ISO beta Carotene results in decreased expression of FABP4 mRNA CTD PMID:21569430 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 increases expression EXP beta Carotene results in increased expression of FAIM2 mRNA CTD PMID:17034753 NCBI chr12:49,866,896...49,903,900
Ensembl chr12:49,866,896...49,904,217
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP beta Carotene results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FOXA1 forkhead box A1 increases expression EXP beta Carotene results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
G FOXM1 forkhead box M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA CTD PMID:24657404 NCBI chr12:2,857,680...2,877,174
Ensembl chr12:2,857,681...2,877,155
Ensembl chr12:2,857,681...2,877,155
JBrowse link
G FZD6 frizzled class receptor 6 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA CTD PMID:24657404 NCBI chr 8:103,298,494...103,332,866
Ensembl chr 8:103,298,433...103,332,866
JBrowse link
G GATA6 GATA binding protein 6 increases expression EXP beta Carotene results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G GBP1 guanylate binding protein 1 increases expression EXP beta Carotene results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,052,319...89,065,230
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases expression
ISO beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]
CTD PMID:16091010, PMID:27154496 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GJA9 gap junction protein alpha 9 increases expression EXP beta Carotene results in increased expression of GJA9 mRNA CTD PMID:17034753 NCBI chr 1:38,874,069...38,881,587
Ensembl chr 1:38,874,069...38,881,587
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] CTD PMID:25542264 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP beta Carotene results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression EXP beta Carotene results in increased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM4 glutathione S-transferase mu 4 decreases expression EXP beta Carotene results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 1:109,656,076...109,665,497
Ensembl chr 1:109,656,099...109,674,836
JBrowse link
G GSTM5 glutathione S-transferase mu 5 increases expression EXP beta Carotene results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 decreases expression EXP beta Carotene results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HOXA7 homeobox A7 increases expression EXP beta Carotene results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 7:27,153,716...27,156,675
Ensembl chr 7:27,153,716...27,157,936
JBrowse link
G HOXB6 homeobox B6 increases expression EXP beta Carotene results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr17:48,595,736...48,604,986
Ensembl chr17:48,595,751...48,604,992
JBrowse link
G HOXC10 homeobox C10 increases expression EXP beta Carotene results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr12:53,985,146...53,990,279
Ensembl chr12:53,985,065...53,990,279
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G IFNA14 interferon alpha 14 increases expression EXP beta Carotene results in increased expression of IFNA14 mRNA CTD PMID:17034753 NCBI chr 9:21,239,002...21,240,005
Ensembl chr 9:21,239,002...21,240,005
JBrowse link
G IFNA16 interferon alpha 16 increases expression EXP beta Carotene results in increased expression of IFNA16 mRNA CTD PMID:17034753 NCBI chr 9:21,216,373...21,217,311
Ensembl chr 9:21,216,373...21,217,311
JBrowse link
G IFNA17 interferon alpha 17 increases expression EXP beta Carotene results in increased expression of IFNA17 mRNA CTD PMID:17034753 NCBI chr 9:21,227,243...21,228,222
Ensembl chr 9:21,227,243...21,228,222
JBrowse link
G IFNA5 interferon alpha 5 increases expression EXP beta Carotene results in increased expression of IFNA5 mRNA CTD PMID:17034753 NCBI chr 9:21,304,326...21,305,313
Ensembl chr 9:21,304,326...21,305,312
JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA CTD PMID:23859036 NCBI chr 2:216,672,105...216,695,549
Ensembl chr 2:216,672,105...216,695,549
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] CTD PMID:21447443 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IRF8 interferon regulatory factor 8 increases expression EXP beta Carotene results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,162...85,922,606
JBrowse link
G IRX4 iroquois homeobox 4 decreases expression
multiple interactions
EXP
ISO
beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA
CTD PMID:17034753, PMID:24657404 NCBI chr 5:1,877,413...1,887,179
Ensembl chr 5:1,877,413...1,887,236
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP beta Carotene results in decreased expression of ITGB1 mRNA CTD PMID:17034753 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G ITGB4 integrin subunit beta 4 decreases expression EXP beta Carotene results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr17:75,721,339...75,757,819
Ensembl chr17:75,721,328...75,757,818
JBrowse link
G ITM2A integral membrane protein 2A multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA CTD PMID:24657404 NCBI chr  X:79,360,384...79,367,334
Ensembl chr  X:79,360,384...79,367,667
JBrowse link
G IVL involucrin increases expression EXP beta Carotene results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 1:152,908,545...152,911,886
Ensembl chr 1:152,908,546...152,911,886
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KIF11 kinesin family member 11 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA CTD PMID:24657404 NCBI chr10:92,593,130...92,655,395
Ensembl chr10:92,593,130...92,655,395
JBrowse link
G KRT18 keratin 18 increases expression EXP beta Carotene results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT19 keratin 19 increases expression EXP beta Carotene results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308
JBrowse link
G KRT2 keratin 2 increases expression EXP beta Carotene results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr12:52,644,558...52,652,211
Ensembl chr12:52,644,558...52,652,211
JBrowse link
G KRT7 keratin 7 affects expression EXP beta Carotene affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr12:52,233,243...52,252,667
Ensembl chr12:52,232,520...52,252,186
JBrowse link
G KRT8 keratin 8 decreases expression EXP beta Carotene results in decreased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
JBrowse link
G LANCL1 LanC like 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA CTD PMID:24657404 NCBI chr 2:210,431,251...210,477,618
Ensembl chr 2:210,431,249...210,477,652
JBrowse link
G LHX3 LIM homeobox 3 increases expression EXP beta Carotene results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128
JBrowse link
G LMNB2 lamin B2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA CTD PMID:24657404 NCBI chr19:2,428,166...2,456,959
Ensembl chr19:2,427,638...2,456,959
JBrowse link
G LPL lipoprotein lipase decreases expression ISO beta Carotene results in decreased expression of LPL mRNA CTD PMID:21569430 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP
ISO
beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
CTD PMID:16206275, PMID:27154496 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
EXP
ISO
beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:16206275, PMID:27154496 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MBL2 mannose binding lectin 2 multiple interactions EXP MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] CTD PMID:16960176 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member affects expression EXP beta Carotene affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G MEIS2 Meis homeobox 2 increases expression EXP beta Carotene results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299
JBrowse link
G MEOX1 mesenchyme homeobox 1 increases expression EXP beta Carotene results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr17:43,640,389...43,661,977
Ensembl chr17:43,640,389...43,661,922
JBrowse link
G METTL21A methyltransferase like 21A multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA CTD PMID:24657404 NCBI chr 2:207,580,635...207,626,053
Ensembl chr 2:207,580,631...207,625,928
JBrowse link
G METTL9 methyltransferase like 9 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA CTD PMID:24657404 NCBI chr16:21,597,208...21,657,471
Ensembl chr16:21,597,218...21,657,473
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase affects response to substance EXP MGMT gene SNP affects the susceptibility to beta Carotene CTD PMID:16014702 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA CTD PMID:23859036 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 increases expression EXP beta Carotene results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 7:157,004,854...157,010,663
Ensembl chr 7:156,994,051...157,010,663
JBrowse link
G MPO myeloperoxidase multiple interactions ISO [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] CTD PMID:31022331 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MRPL57 mitochondrial ribosomal protein L57 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA CTD PMID:24657404 NCBI chr13:21,176,649...21,179,084
Ensembl chr13:21,176,658...21,179,084
JBrowse link
G MSH5 mutS homolog 5 increases expression EXP beta Carotene results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr 6:31,740,005...31,762,676
Ensembl chr 6:31,739,677...31,762,676
Ensembl chr 6:31,739,677...31,762,676
JBrowse link
G MTCH2 mitochondrial carrier 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA CTD PMID:24657404 NCBI chr11:47,604,309...47,642,597
Ensembl chr11:47,617,315...47,642,607
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression EXP beta Carotene results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G NCKAP1 NCK associated protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA CTD PMID:24657404 NCBI chr 2:182,909,115...183,038,457
Ensembl chr 2:182,909,115...183,038,858
JBrowse link
G NOM1 nucleolar protein with MIF4G domain 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA CTD PMID:24657404 NCBI chr 7:156,949,712...156,973,176
Ensembl chr 7:156,949,712...156,973,176
JBrowse link
G NOS1 nitric oxide synthase 1 increases expression EXP beta Carotene results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] CTD PMID:18779489 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein
CTD PMID:15949683, PMID:16632523 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP beta Carotene results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PARD6A par-6 family cell polarity regulator alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA CTD PMID:24657404 NCBI chr16:67,660,956...67,662,774
Ensembl chr16:67,660,946...67,662,778
JBrowse link
G PCDH1 protocadherin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA CTD PMID:24657404 NCBI chr 5:141,850,393...141,878,410
Ensembl chr 5:141,853,111...141,879,246
JBrowse link
G PCDHGC3 protocadherin gamma subfamily C, 3 increases expression EXP beta Carotene results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977
JBrowse link
G PDGFRB platelet derived growth factor receptor beta multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein CTD PMID:23859036 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PIK3R5 phosphoinositide-3-kinase regulatory subunit 5 increases expression ISO beta Carotene results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA CTD PMID:24657404 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,676
JBrowse link
G PLSCR1 phospholipid scramblase 1 increases expression EXP beta Carotene results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 3:146,515,178...146,544,805
Ensembl chr 3:146,515,180...146,544,856
JBrowse link
G PLSCR3 phospholipid scramblase 3 increases expression EXP beta Carotene results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr17:7,389,727...7,394,525
Ensembl chr17:7,389,727...7,394,842
JBrowse link
G PLSCR4 phospholipid scramblase 4 increases expression EXP beta Carotene results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 3:146,192,335...146,251,125
Ensembl chr 3:146,192,335...146,251,179
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression ISO beta Carotene results in decreased expression of PPARA mRNA CTD PMID:21569430 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression ISO beta Carotene results in decreased expression of PPARG mRNA CTD PMID:21569430 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G RAD51AP1 RAD51 associated protein 1 decreases expression EXP beta Carotene results in decreased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr12:4,538,890...4,560,047
Ensembl chr12:4,538,798...4,560,048
JBrowse link
G RAD51D RAD51 paralog D increases expression EXP beta Carotene results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr17:35,092,221...35,119,860
Ensembl chr17:35,092,208...35,121,522
JBrowse link
G RARA retinoic acid receptor alpha decreases expression EXP beta Carotene results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G RARB retinoic acid receptor beta increases expression EXP beta Carotene results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:25,174,332...25,597,932
JBrowse link
G RARRES1 retinoic acid receptor responder 1 increases expression EXP beta Carotene results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 3:158,696,892...158,732,944
Ensembl chr 3:158,696,892...158,732,489
JBrowse link
G RBP4 retinol binding protein 4 multiple interactions ISO
EXP
beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein CTD PMID:22542753 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases phosphorylation EXP beta Carotene results in decreased phosphorylation of RELA protein CTD PMID:26733226 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RPP14 ribonuclease P/MRP subunit p14 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA CTD PMID:24657404 NCBI chr 3:58,306,245...58,320,193
Ensembl chr 3:58,306,247...58,324,695
JBrowse link
G RRM1 ribonucleotide reductase catalytic subunit M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA CTD PMID:24657404 NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions EXP beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SCARB1 scavenger receptor class B member 1 increases transport EXP SCARB1 protein results in increased transport of beta Carotene CTD PMID:16177187 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
JBrowse link
G SIX6 SIX homeobox 6 increases expression EXP beta Carotene results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr14:60,509,146...60,512,850
Ensembl chr14:60,509,146...60,512,850
JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression ISO beta Carotene results in decreased expression of SLC2A4 mRNA CTD PMID:21569430 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression EXP beta Carotene results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:18779489, PMID:23859036 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 affects expression EXP beta Carotene affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr14:77,505,997...77,616,663
Ensembl chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,637
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 increases expression EXP beta Carotene results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TFCP2 transcription factor CP2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA CTD PMID:24657404 NCBI chr12:51,093,656...51,173,135
Ensembl chr12:51,093,656...51,173,135
JBrowse link
G TGM2 transglutaminase 2 increases expression EXP beta Carotene results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr20:38,127,385...38,166,508
Ensembl chr20:38,127,385...38,166,578
JBrowse link
G TGM4 transglutaminase 4 increases expression EXP beta Carotene results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 3:44,874,608...44,914,990
Ensembl chr 3:44,874,608...44,914,990
JBrowse link
G THOC7 THO complex 7 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA CTD PMID:24657404 NCBI chr 3:63,833,870...63,864,478
Ensembl chr 3:63,833,870...63,863,868
JBrowse link
G TMEM209 transmembrane protein 209 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA CTD PMID:24657404 NCBI chr 7:130,164,713...130,205,406
Ensembl chr 7:130,164,713...130,207,770
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19135038, PMID:21447443 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 increases expression EXP beta Carotene results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 1:7,915,871...7,941,607
Ensembl chr 1:7,915,894...7,943,165
Ensembl chr 1:7,915,894...7,943,165
JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression EXP beta Carotene results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TTC21B tetratricopeptide repeat domain 21B multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA CTD PMID:24657404 NCBI chr 2:165,873,362...165,953,781
Ensembl chr 2:165,857,475...165,953,816
JBrowse link
G TWF1 twinfilin actin binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA CTD PMID:24657404 NCBI chr12:43,793,723...43,806,317
Ensembl chr12:43,793,723...43,806,328
Ensembl chr12:43,793,723...43,806,328
JBrowse link
G TXNDC9 thioredoxin domain containing 9 increases expression EXP beta Carotene results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 2:99,306,184...99,336,385
Ensembl chr 2:99,318,982...99,340,702
JBrowse link
G TYMP thymidine phosphorylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA CTD PMID:24657404 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
JBrowse link
G XRCC3 X-ray repair cross complementing 3 increases expression EXP beta Carotene results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr14:103,697,611...103,715,486
Ensembl chr14:103,697,609...103,715,504
JBrowse link
G YTHDC2 YTH domain containing 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA CTD PMID:24657404 NCBI chr 5:113,513,683...113,595,284
Ensembl chr 5:113,513,694...113,595,285
JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA CTD PMID:24657404 NCBI chr 3:44,915,261...44,976,182
Ensembl chr 3:44,915,257...44,976,185
JBrowse link
bixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases ubiquitination EXP bixin results in decreased ubiquitination of NFE2L2 protein CTD PMID:30698894 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
brazilein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 decreases expression EXP brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein CTD PMID:23948132 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP brazilein results in decreased expression of CTNNB1 protein CTD PMID:23948132 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases expression EXP brazilein results in decreased expression of GSK3B protein modified form CTD PMID:23948132 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [Wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; Wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]
brazilein results in decreased expression of MMP2 mRNA
CTD PMID:23707804 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein CTD PMID:23707804 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression EXP brazilein results in decreased expression of RELA protein CTD PMID:23707804 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
brazilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression EXP brazilin results in increased expression of BAX protein CTD PMID:28063998 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP brazilin results in decreased expression of BCL2 protein CTD PMID:28063998 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein]
brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein
CTD PMID:28063998 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] CTD PMID:28063998 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases expression
EXP bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] CTD PMID:28063998 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] CTD PMID:28063998 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SQSTM1 sequestosome 1 decreases expression
multiple interactions
EXP brazilin results in decreased expression of SQSTM1 protein
Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]
CTD PMID:28063998 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
canthaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO Canthaxanthin results in increased expression of CYP1A1 mRNA CTD PMID:9271336 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression ISO Canthaxanthin results in increased expression of CYP1A2 mRNA CTD PMID:9271336 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A4GALT alpha 1,4-galactosyltransferase (P blood group) multiple interactions EXP Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] CTD PMID:16819191 NCBI chr22:42,692,115...42,721,301
Ensembl chr22:42,692,121...42,721,298
JBrowse link
G AARS1 alanyl-tRNA synthetase 1 decreases expression EXP Curcumin results in decreased expression of AARS1 mRNA CTD PMID:17198877 NCBI chr16:70,252,295...70,289,509
Ensembl chr16:70,251,983...70,289,707
Ensembl chr16:70,251,983...70,289,707
Ensembl chr16:70,251,983...70,289,707
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
decreases response to substance
affects response to substance
multiple interactions
EXP
ISO
Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA
ABCB1 protein results in decreased susceptibility to Curcumin
ABCB1 affects the susceptibility to Curcumin
[Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA]
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein
CTD PMID:15476675, PMID:17121181, PMID:18200517, PMID:18385293, PMID:18414057, PMID:18439772, PMID:20816778, PMID:26689174, PMID:27318188, PMID:31628941 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases activity
decreases expression
EXP Curcumin results in decreased activity of ABCC1 protein
Curcumin analog results in decreased expression of ABCC1 mRNA
CTD PMID:15885658, PMID:16021489, PMID:26409325 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases activity EXP Curcumin results in decreased activity of ABCC2 protein CTD PMID:15885658 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions EXP [Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 increases expression EXP Curcumin results in increased expression of ABCG1 mRNA CTD PMID:16713233, PMID:21594647 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases expression
EXP AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] CTD PMID:17077187 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation
decreases expression
affects expression
multiple interactions
EXP
ISO
Curcumin results in increased phosphorylation of ACACA protein
Curcumin results in decreased expression of ACACA mRNA
Curcumin affects the expression of ACACA mRNA
Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein]
CTD PMID:18790744, PMID:19297423, PMID:27208389 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
JBrowse link
G ACE angiotensin I converting enzyme multiple interactions ISO Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] CTD PMID:10666014 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
decreases activity
ISO [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Curcumin results in decreased activity of ACHE protein
Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
CTD PMID:18809455, PMID:20369229, PMID:21839772, PMID:22783142, PMID:25199698, PMID:28527659, PMID:31714633, PMID:31820278 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACKR3 atypical chemokine receptor 3 increases expression EXP Curcumin results in increased expression of ACKR3 mRNA CTD PMID:21594647 NCBI chr 2:236,537,131...236,582,358
Ensembl chr 2:236,567,787...236,582,354
JBrowse link
G ACLY ATP citrate lyase affects expression
decreases expression
ISO Curcumin affects the expression of ACLY mRNA
Curcumin results in decreased expression of ACLY mRNA
CTD PMID:27208389 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G ACO2 aconitase 2 multiple interactions ISO Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] CTD PMID:25130536 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,469,117...41,528,989
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein
CTD PMID:17355460, PMID:17531121, PMID:18006644, PMID:22683883, PMID:27363783 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADAM17 ADAM metallopeptidase domain 17 multiple interactions EXP Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] CTD PMID:17666914 NCBI chr 2:9,488,486...9,555,830
Ensembl chr 2:9,488,486...9,556,732
JBrowse link
G ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 increases expression EXP Curcumin results in increased expression of ADAMTS4 mRNA CTD PMID:18321735 NCBI chr 1:161,184,302...161,202,339
Ensembl chr 1:161,184,302...161,199,054
JBrowse link
G ADCY9 adenylate cyclase 9 decreases expression EXP Curcumin results in decreased expression of ADCY9 mRNA CTD PMID:15713895 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442
JBrowse link
G ADGRE1 adhesion G protein-coupled receptor E1 decreases expression ISO Curcumin results in decreased expression of ADGRE1 mRNA CTD PMID:18403477 NCBI chr19:6,887,549...6,940,450
Ensembl chr19:6,887,566...6,940,459
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
affects expression
ISO Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]
Curcumin affects the expression of ADIPOQ mRNA
Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]
CTD PMID:18403477, PMID:26713546, PMID:27208389, PMID:28595985 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADORA2A adenosine A2a receptor multiple interactions ISO [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] CTD PMID:31820278 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G AGER advanced glycosylation end-product specific receptor multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] CTD PMID:29480285 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member decreases expression EXP Curcumin results in decreased expression of AGR2 mRNA CTD PMID:17198877 NCBI chr 7:16,791,811...16,804,999
Ensembl chr 7:16,791,811...16,833,433
JBrowse link
G AGT angiotensinogen multiple interactions ISO [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein]
CTD PMID:26612707, PMID:31820278 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
affects binding
increases degradation
EXP
ISO
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein]
Curcumin binds to AHR protein
Curcumin results in increased degradation of AHR protein
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
CTD PMID:17077187, PMID:17880909, PMID:18321868, PMID:19018768, PMID:25632966 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AK1 adenylate kinase 1 multiple interactions EXP [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein CTD PMID:25866362 NCBI chr 9:127,866,480...127,885,542
Ensembl chr 9:127,866,486...127,877,675
JBrowse link
G AKAP6 A-kinase anchoring protein 6 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of AKAP6 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA]
CTD PMID:18200517, PMID:18421014 NCBI chr14:32,203,610...32,837,684
Ensembl chr14:32,329,298...32,837,684
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases expression
multiple interactions
increases activity
ISO Curcumin results in increased expression of AKR1B1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein
Curcumin results in increased activity of AKR1B1 protein
CTD PMID:17640564, PMID:18200517, PMID:18299980, PMID:18588981 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
affects phosphorylation
decreases expression
decreases phosphorylation
increases expression
increases phosphorylation
decreases activity
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; arsenic trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [stearic acid results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]
Curcumin affects the phosphorylation of AKT1 protein
Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein
Curcumin results in increased expression of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]
Curcumin results in decreased activity of AKT1 protein
CTD PMID:16023083, PMID:16219905, PMID:17289836, PMID:17291458, PMID:17332930, PMID:17372590, PMID:17535857, PMID:17596214, PMID:17640564, PMID:17640567, PMID:17918158, PMID:18006147, PMID:18214481, PMID:18660423, PMID:18790744, PMID:19372569, PMID:20605902, PMID:20727180, PMID:20938987, PMID:23222814, PMID:23452621, PMID:23555722, PMID:23880231, PMID:24211270, PMID:24365254, PMID:24831732, PMID:25541178, PMID:26409325, PMID:27208389, PMID:27966075 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]
Curcumin analog results in decreased expression of AKT2 mRNA
CTD PMID:23452621, PMID:26409325 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein]
Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein]
CTD PMID:22704994, PMID:23292317 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALAS1 5'-aminolevulinate synthase 1 increases expression ISO Curcumin results in increased expression of ALAS1 mRNA CTD PMID:18299980 NCBI chr 3:52,198,083...52,214,327
Ensembl chr 3:52,198,086...52,214,327
JBrowse link
G ALB albumin multiple interactions ISO [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein] CTD PMID:18204486, PMID:18809455, PMID:20804811, PMID:24704557, PMID:27288928 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 multiple interactions
decreases expression
EXP
ISO
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]
Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein
[Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]
CTD PMID:31628941 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALDOA aldolase, fructose-bisphosphate A decreases expression EXP Curcumin results in decreased expression of ALDOA mRNA CTD PMID:16880289 NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457
Ensembl chr16:30,064,164...30,070,457
JBrowse link
G ALDOC aldolase, fructose-bisphosphate C decreases expression EXP Curcumin results in decreased expression of ALDOC mRNA CTD PMID:17198877 NCBI chr17:28,573,115...28,576,963
Ensembl chr17:28,573,115...28,576,948
JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
ISO [Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein
Curcumin results in decreased activity of ALOX5 protein
CTD PMID:16956363 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G AMPD3 adenosine monophosphate deaminase 3 increases expression ISO Curcumin results in increased expression of AMPD3 mRNA CTD PMID:18299980 NCBI chr11:10,450,388...10,507,579
Ensembl chr11:10,308,313...10,507,579
JBrowse link
G ANKRD37 ankyrin repeat domain 37 decreases expression EXP Curcumin results in decreased expression of ANKRD37 mRNA CTD PMID:17198877 NCBI chr 4:185,396,841...185,400,243
Ensembl chr 4:185,396,021...185,400,628
JBrowse link
G ANKRD50 ankyrin repeat domain 50 decreases expression EXP Curcumin results in decreased expression of ANKRD50 mRNA CTD PMID:17999991 NCBI chr 4:124,664,048...124,712,732
Ensembl chr 4:124,664,048...124,712,732
JBrowse link
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 decreases expression EXP Curcumin results in decreased expression of ANKZF1 mRNA CTD PMID:17198877 NCBI chr 2:219,229,806...219,236,679
Ensembl chr 2:219,229,783...219,236,679
JBrowse link
G AOC1 amine oxidase copper containing 1 multiple interactions ISO Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] CTD PMID:20885979 NCBI chr 7:150,824,875...150,861,504
Ensembl chr 7:150,824,627...150,861,504
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of APAF1 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA]
CTD PMID:17277231, PMID:20869986 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APC APC regulator of WNT signaling pathway decreases expression EXP Curcumin results in decreased expression of APC mRNA CTD PMID:15713895 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G APOE apolipoprotein E affects expression ISO Curcumin affects the expression of APOE mRNA CTD PMID:27208389 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APP amyloid beta precursor protein multiple interactions
increases expression
EXP
ISO
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein]
Curcumin results in increased expression of APP mRNA
[Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]
CTD PMID:18537544, PMID:18583042, PMID:27793699, PMID:30946834, PMID:31521693 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) decreases expression
multiple interactions
EXP Curcumin results in decreased expression of AQP3 protein
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]
CTD PMID:18214481 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G AR androgen receptor multiple interactions
increases expression
decreases activity
decreases expression
EXP [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein]
Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein
Curcumin results in decreased activity of AR protein
Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein
CTD PMID:12497104, PMID:18676361, PMID:18719366, PMID:22258452, PMID:27132804 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARHGAP24 Rho GTPase activating protein 24 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] CTD PMID:18200517 NCBI chr 4:85,475,150...86,002,666
Ensembl chr 4:85,475,150...86,002,668
JBrowse link
G ARHGAP30 Rho GTPase activating protein 30 decreases expression EXP Curcumin results in decreased expression of ARHGAP30 mRNA CTD PMID:18421014 NCBI chr 1:161,046,942...161,069,971
Ensembl chr 1:161,046,946...161,069,970
JBrowse link
G ARHGDIB Rho GDP dissociation inhibitor beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] CTD PMID:18200517 NCBI chr12:14,942,015...14,961,601
Ensembl chr12:14,942,031...14,961,728
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions
increases degradation
decreases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
Curcumin results in decreased expression of ARNT protein
CTD PMID:16880289, PMID:17880909, PMID:18682687, PMID:19018768 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G ATF1 activating transcription factor 1 multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] CTD PMID:23452621 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G ATF2 activating transcription factor 2 decreases expression EXP Curcumin analog results in decreased expression of ATF2 mRNA CTD PMID:26409325 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein CTD PMID:15713895, PMID:18555241, PMID:18719366 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATF6 activating transcription factor 6 increases expression ISO
EXP
Curcumin results in increased expression of ATF6 protein
Curcumin results in increased expression of ATF6 mRNA
CTD PMID:21793155, PMID:29723631 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases phosphorylation
EXP [Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein
Curcumin results in increased phosphorylation of ATM protein
CTD PMID:19401701, PMID:21134073 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G AURKA aurora kinase A decreases expression EXP Curcumin analog results in decreased expression of AURKA mRNA CTD PMID:26409325 NCBI chr20:56,369,390...56,392,308
Ensembl chr20:56,369,389...56,392,337
JBrowse link
G AURKB aurora kinase B decreases expression EXP Curcumin analog results in decreased expression of AURKB mRNA CTD PMID:26409325 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G AXIN1 axin 1 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA]
Curcumin results in increased expression of AXIN1 mRNA
CTD PMID:25963729 NCBI chr16:287,440...355,226
Ensembl chr16:287,440...352,723
JBrowse link
G B3GALT6 beta-1,3-galactosyltransferase 6 increases expression EXP Curcumin results in increased expression of B3GALT6 mRNA CTD PMID:17198877 NCBI chr 1:1,232,237...1,235,041
Ensembl chr 1:1,232,237...1,235,041
JBrowse link
G BACE1 beta-secretase 1 multiple interactions
increases expression
EXP Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA]
Curcumin results in increased expression of BACE1 mRNA
CTD PMID:18583042, PMID:31521693 NCBI chr11:117,285,207...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G BAD BCL2 associated agonist of cell death increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein]
CTD PMID:15569404, PMID:19235267, PMID:27430728 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions
increases expression
increases response to substance
EXP
ISO
TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]
Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein
BAK1 protein results in increased susceptibility to Curcumin
CTD PMID:17277231, PMID:17332930, PMID:18226269 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
affects localization
increases response to substance
EXP
ISO
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein]
Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein
Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]
BAX protein results in increased susceptibility to Curcumin
Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein
CTD PMID:15569404, PMID:17096185, PMID:17277231, PMID:17332930, PMID:17531121, PMID:17671742, PMID:18226269, PMID:19235267, PMID:19373661, PMID:20605902, PMID:20869986, PMID:21594647, PMID:23222814, PMID:23267840, PMID:24952339, PMID:25541178, PMID:25963729, PMID:26612707, PMID:27132804, PMID:27288928, PMID:27430728, PMID:27793699, PMID:27966075, PMID:30463061, PMID:30935902, PMID:31628941, PMID:32128952 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
decreases expression
EXP
ISO
Curcumin results in increased expression of BBC3 mRNA
Curcumin results in decreased expression of BBC3 mRNA
CTD PMID:17332930, PMID:22714040 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL10 BCL10 immune signaling adaptor multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] CTD PMID:23452621 NCBI chr 1:85,265,776...85,276,632
Ensembl chr 1:85,265,776...85,276,632
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]
Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein
Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]
CTD PMID:12497104, PMID:14724571, PMID:15569404, PMID:16023083, PMID:16219905, PMID:16243823, PMID:17096185, PMID:17332930, PMID:17440100, PMID:17531121, PMID:17596214, PMID:17640567, PMID:17671737, PMID:17671742, PMID:18226269, PMID:18593936, PMID:18640131, PMID:18829502, PMID:19235267, PMID:19250217, PMID:19372569, PMID:19373661, PMID:19944674, PMID:20127174, PMID:20727180, PMID:20869986, PMID:21397623, PMID:21594647, PMID:21595920, PMID:21793155, PMID:22714040, PMID:23452621, PMID:24952339, PMID:25256401, PMID:25541178, PMID:25963729, PMID:26409325, PMID:26612707, PMID:27132804, PMID:27288928, PMID:27430728, PMID:29571711, PMID:30138604, PMID:30431687, PMID:30935902, PMID:31628941, PMID:32128952, PMID:32569592 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]
Curcumin results in decreased expression of BCL2A1 mRNA
CTD PMID:16219905, PMID:17596214 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]
Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein
Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein]
[Curcumin co-treated with gemcitabine] results in decreased expression of BCL2L1 protein
Curcumin results in increased expression of BCL2L1 mRNA
CTD PMID:12497104, PMID:15569404, PMID:15911101, PMID:16023083, PMID:16173963, PMID:16219905, PMID:16243823, PMID:17148446, PMID:17332930, PMID:17440100, PMID:17596214, PMID:17640567, PMID:17671737, PMID:18226269, PMID:18640131, PMID:18829502, PMID:19235267, PMID:19250217, PMID:19372569, PMID:23452621, PMID:30463061 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 increases expression
multiple interactions
EXP Curcumin results in increased expression of BCL2L11 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein
CTD PMID:17332930, PMID:27430728 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BCL2L2 BCL2 like 2 increases expression
multiple interactions
EXP Curcumin results in increased expression of BCL2L2 mRNA
[arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein
CTD PMID:16101141, PMID:27430728 NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,759
Ensembl chr14:23,298,790...23,311,759
JBrowse link
G BCL3 BCL3 transcription coactivator multiple interactions ISO
EXP
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA]
CTD PMID:18200517, PMID:23452621 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G BCOR BCL6 corepressor increases expression EXP Curcumin results in increased expression of BCOR mRNA CTD PMID:17198877 NCBI chr  X:40,051,246...40,177,390
Ensembl chr  X:40,049,815...40,177,329
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
increases expression
affects expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein]
Curcumin results in increased expression of BDNF protein
Curcumin affects the expression of BDNF protein
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD PMID:17022948, PMID:17617388, PMID:17827730, PMID:19033880, PMID:22911773, PMID:27966075, PMID:29723552 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BGN biglycan multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] CTD PMID:18200517 NCBI chr  X:153,494,980...153,509,546
Ensembl chr  X:153,494,980...153,509,546
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP [arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] CTD PMID:20605902, PMID:27430728 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 decreases expression
multiple interactions
EXP Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]
CTD PMID:16023083, PMID:16219905, PMID:16243823, PMID:17596214, PMID:17640567, PMID:17671737, PMID:20727180, PMID:23452621 NCBI chr11:102,347,182...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions
increases expression
decreases expression
EXP
ISO
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC3 protein
Curcumin results in increased expression of BIRC3 mRNA
Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein
CTD PMID:15911101, PMID:16101141, PMID:16219905, PMID:16243823, PMID:17440100, PMID:17596214, PMID:19372569, PMID:27430728 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions
decreases expression
EXP
ISO
[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]
Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of BIRC5 protein
CTD PMID:16023083, PMID:17440100, PMID:17596214, PMID:17671737, PMID:18593936, PMID:19235267, PMID:19372569, PMID:20727180, PMID:23452621, PMID:24664296, PMID:26409325, PMID:27430728 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 increases expression
multiple interactions
EXP Curcumin results in increased expression of BIRC7 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein
CTD PMID:15911101, PMID:27430728 NCBI chr20:63,235,905...63,240,495
Ensembl chr20:63,235,883...63,240,495
JBrowse link
G BMP2 bone morphogenetic protein 2 decreases expression ISO Curcumin results in decreased expression of BMP2 mRNA CTD PMID:27237783 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BSG basigin (Ok blood group) decreases response to substance ISO BSG protein results in decreased susceptibility to Curcumin CTD PMID:18379992 NCBI chr19:571,283...583,493
Ensembl chr19:571,277...583,493
JBrowse link
G C1QA complement C1q A chain decreases expression ISO Curcumin results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G C1QB complement C1q B chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] CTD PMID:18200517 NCBI chr 1:22,653,236...22,661,637
Ensembl chr 1:22,652,762...22,661,637
JBrowse link
G C3 complement C3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] CTD PMID:18200517 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G C4B complement C4B (Chido blood group) multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] CTD PMID:18200517 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CA9 carbonic anhydrase 9 decreases expression ISO Curcumin results in decreased expression of CAR9 mRNA CTD PMID:18299980 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein]
CTD PMID:22911773, PMID:29723552 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,291
JBrowse link
G CAPG capping actin protein, gelsolin like multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] CTD PMID:18200517 NCBI chr 2:85,394,753...85,418,467
Ensembl chr 2:85,394,753...85,418,432
JBrowse link
G CASP1 caspase 1 increases expression
multiple interactions
EXP Curcumin results in increased expression of CASP1 mRNA
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA]
CTD PMID:16101141, PMID:23452621 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) increases expression
multiple interactions
ISO Curcumin results in increased expression of CASP12 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
CTD PMID:21793155, PMID:25541178 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP2 caspase 2 increases expression EXP Curcumin results in increased expression of CASP2 mRNA CTD PMID:16101141 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
increases cleavage
increases activity
decreases activity
increases expression
EXP
ISO
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]]
Curcumin results in decreased expression of CASP3 protein modified form
Curcumin results in increased cleavage of CASP3 protein
Curcumin results in decreased activity of CASP3 protein
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]
Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form
Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein
CTD PMID:15095415, PMID:15569404, PMID:16023083, PMID:16101141, PMID:17041101, PMID:17096185, PMID:17148446, PMID:17277231, PMID:17332930, PMID:17351913, PMID:17363495, PMID:17440100, PMID:17640567, PMID:17671742, PMID:17885582, PMID:18555241, PMID:19235267, PMID:19294764, PMID:19373661, PMID:19401701, PMID:20127174, PMID:20605902, PMID:20869986, PMID:21397623, PMID:21450334, PMID:21594647, PMID:21595920, PMID:22523229, PMID:23267840, PMID:23555722, PMID:23710286, PMID:24863870, PMID:24952339, PMID:25541178, PMID:25963729, PMID:26409325, PMID:26612707, PMID:27132804, PMID:27288928, PMID:27375190, PMID:27430728, PMID:27535828, PMID:27966075, PMID:29315967, PMID:29571711, PMID:30138604, PMID:30431687, PMID:30463061, PMID:30935902, PMID:31712109, PMID:31820278, PMID:32569592 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP4 caspase 4 increases expression EXP Curcumin results in increased expression of CASP4 mRNA CTD PMID:16101141 NCBI chr11:104,942,866...104,968,596
Ensembl chr11:104,942,866...104,969,366
JBrowse link
G CASP7 caspase 7 multiple interactions
increases expression
decreases expression
EXP [Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein
Curcumin results in increased expression of CASP7 protein
Curcumin results in decreased expression of CASP7 mRNA
CTD PMID:16023083, PMID:16101141, PMID:19373661, PMID:31628941 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
increases cleavage
decreases expression
EXP
ISO
Curcumin results in increased activity of CASP8 protein
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Curcumin results in increased cleavage of CASP8 protein
Curcumin results in decreased expression of CASP8 protein
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]
CTD PMID:14555224, PMID:16173963, PMID:17096185, PMID:17148446, PMID:22523229, PMID:23267840, PMID:23452621, PMID:25541178, PMID:27430728 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 decreases expression
multiple interactions
increases activity
increases expression
increases cleavage
EXP
ISO
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein
Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA]
Curcumin results in increased activity of CASP9 protein
Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CASP9 protein; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein
Curcumin results in increased cleavage of CASP9 protein
[Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]]
CTD PMID:14555224, PMID:16023083, PMID:16101141, PMID:17148446, PMID:17277231, PMID:17440100, PMID:17671742, PMID:18555241, PMID:19095035, PMID:19373661, PMID:20605902, PMID:20869986, PMID:21594647, PMID:27375190, PMID:31628941, PMID:31712109, PMID:32128952 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
increases activity
increases expression
EXP
ISO
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein]
Curcumin results in increased activity of CAT protein
Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein]
Curcumin results in increased expression of CAT mRNA
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein]
CTD PMID:16770732, PMID:17076682, PMID:17351913, PMID:17461496, PMID:18299980, PMID:18392098, PMID:19481068, PMID:19631675, PMID:19913070, PMID:19914224, PMID:20112103, PMID:20593964, PMID:21574897, PMID:21976817, PMID:22704994, PMID:24113306, PMID:24347089, PMID:24760747, PMID:25123790, PMID:25169090, PMID:25461551, PMID:27375190, PMID:28951138, PMID:29205955, PMID:29315967, PMID:30138604, PMID:30423402, PMID:30934151, PMID:30946834, PMID:31081568, PMID:31330227, PMID:31407471, PMID:31521693, PMID:31714633 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CBR1 carbonyl reductase 1 multiple interactions EXP [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] CTD PMID:25541467 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166
JBrowse link
G CCAR1 cell division cycle and apoptosis regulator 1 increases expression EXP
ISO
Curcumin results in increased expression of CCAR1 protein CTD PMID:21594647 NCBI chr10:68,721,239...68,792,377
Ensembl chr10:68,721,012...68,792,377
JBrowse link
G CCDC116 coiled-coil domain containing 116 increases expression ISO Curcumin results in increased expression of CCDC116 mRNA CTD PMID:18200517 NCBI chr22:21,632,121...21,637,329
Ensembl chr22:21,632,716...21,637,329
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
increases expression
EXP
ISO
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]
Curcumin results in decreased expression of CCL2 mRNA
Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein
Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Curcumin results in increased expression of CCL2 mRNA
CTD PMID:10925121, PMID:11053056, PMID:17198877, PMID:17666914, PMID:18403477, PMID:19152916, PMID:20712904, PMID:22683883, PMID:23452621 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCN2 cellular communication network factor 2 decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein
IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA]
CTD PMID:17965732, PMID:19764552 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CCNA2 cyclin A2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein]
Curcumin results in decreased expression of CCNA2 protein
CTD PMID:23222814 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein CTD PMID:17148446, PMID:18719366, PMID:19401701 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
decreases expression
increases degradation
EXP
ISO
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]
Curcumin results in increased expression of CCND1 mRNA
Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA]
Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein
[Curcumin co-treated with gemcitabine] results in decreased expression of CCND1 protein
Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein
CTD PMID:15486348, PMID:15489888, PMID:15738001, PMID:16023083, PMID:16219905, PMID:16243823, PMID:16959222, PMID:17041101, PMID:17148446, PMID:17440100, PMID:17531121, PMID:17602960, PMID:17640567, PMID:17885582, PMID:18156803, PMID:18226269, PMID:18316600, PMID:18593936, PMID:18640131, PMID:18790744, PMID:18829502, PMID:19189304, PMID:19372569, PMID:19501152, PMID:19573523, PMID:20727180, PMID:24211270, PMID:24508477, PMID:25822711, PMID:25963729, PMID:30935902 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein]
Curcumin results in decreased expression of CCND3 protein
CTD PMID:23222814 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CCNE1 cyclin E1 decreases expression
multiple interactions
increases degradation
EXP
ISO
Curcumin results in decreased expression of CCNE1 protein
Curcumin results in decreased expression of CCNE1 mRNA
lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein]
CTD PMID:17148446, PMID:18156803, PMID:18299980 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCPG1 cell cycle progression 1 increases expression EXP Curcumin results in increased expression of CCPG1 mRNA CTD PMID:17198877 NCBI chr15:55,355,239...55,408,359
Ensembl chr15:55,340,032...55,408,510
JBrowse link
G CCR2 C-C motif chemokine receptor 2 decreases expression ISO Curcumin results in decreased expression of CCR2 mRNA CTD PMID:18403477 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,744...46,360,940
Ensembl chr 3:46,353,744...46,360,940
JBrowse link
G CD14 CD14 molecule multiple interactions EXP Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] CTD PMID:18180316 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CD36 CD36 molecule decreases expression
increases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of CD36 mRNA
Curcumin results in increased expression of CD36 mRNA
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein]
Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein
CTD PMID:16713233, PMID:23386263, PMID:23603106 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD40 CD40 molecule decreases expression
multiple interactions
EXP Curcumin results in decreased expression of CD40 mRNA
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein
CTD PMID:16101141, PMID:27430728 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CD40LG CD40 ligand multiple interactions EXP [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein CTD PMID:27430728 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CD44 CD44 molecule (Indian blood group) increases expression EXP Curcumin results in increased expression of CD44 mRNA CTD PMID:15713895 NCBI chr11:35,139,168...35,232,402
Ensembl chr11:35,138,882...35,232,402
Ensembl chr11:35,138,882...35,232,402
JBrowse link
G CD47 CD47 molecule multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] CTD PMID:18200517 NCBI chr 3:108,043,091...108,094,200
Ensembl chr 3:108,043,091...108,091,862
JBrowse link
G CD55 CD55 molecule (Cromer blood group) decreases expression EXP Curcumin results in decreased expression of CD55 mRNA CTD PMID:17999991 NCBI chr 1:207,321,674...207,360,966
Ensembl chr 1:207,321,376...207,386,804
Ensembl chr 1:207,321,376...207,386,804
JBrowse link
G CDC14B cell division cycle 14B increases expression EXP Curcumin results in increased expression of CDC14B mRNA CTD PMID:17198877 NCBI chr 9:96,492,743...96,619,843
Ensembl chr 9:96,490,241...96,619,843
JBrowse link
G CDC20 cell division cycle 20 decreases expression EXP Curcumin results in decreased expression of CDC20 mRNA CTD PMID:22258452 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CDC25C cell division cycle 25C increases phosphorylation EXP Curcumin results in increased phosphorylation of CDC25C protein CTD PMID:19401701 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDH1 cadherin 1 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of CDH1 protein
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein]
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]
CTD PMID:19573523, PMID:25656647, PMID:26191140 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH11 cadherin 11 decreases expression EXP Curcumin results in decreased expression of CDH11 protein CTD PMID:18025290 NCBI chr16:64,943,753...65,126,112
Ensembl chr16:64,943,753...65,126,112
JBrowse link
G CDH17 cadherin 17 decreases expression EXP Curcumin results in decreased expression of CDH17 mRNA CTD PMID:17198877 NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
JBrowse link
G CDH2 cadherin 2 multiple interactions ISO Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] CTD PMID:26191140 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression ISO
EXP
Curcumin results in decreased expression of CDK1 mRNA
Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein
CTD PMID:17148446, PMID:18299980, PMID:19401701, PMID:22258452 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein]
Curcumin results in decreased expression of CDK2 protein
Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein
CTD PMID:19501152, PMID:23222814, PMID:26409325 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein CTD PMID:18156803, PMID:24211270, PMID:26409325 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK5 cyclin dependent kinase 5 decreases expression EXP Curcumin analog results in decreased expression of CDK5 mRNA CTD PMID:26409325 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Curcumin results in decreased expression of CDK6 protein CTD PMID:18156803 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDK7 cyclin dependent kinase 7 decreases expression EXP Curcumin analog results in decreased expression of CDK7 mRNA CTD PMID:26409325 NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430
JBrowse link
G CDK9 cyclin dependent kinase 9 decreases expression EXP Curcumin analog results in decreased expression of CDK9 mRNA CTD PMID:26409325 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
EXP
ISO
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein]
Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein]
CTD PMID:15713895, PMID:15738001, PMID:17148446, PMID:17332326, PMID:17602960, PMID:18156803, PMID:18161303, PMID:18226269, PMID:18316600, PMID:18593936, PMID:20153625, PMID:23222814, PMID:25644192, PMID:25822711, PMID:27132804, PMID:27430728, PMID:30935902 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
multiple interactions
decreases expression
EXP
ISO
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein
Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]
Curcumin results in decreased expression of CDKN1B protein
CTD PMID:15713895, PMID:17602960, PMID:18156803, PMID:18226269, PMID:18593936, PMID:21594647, PMID:25822711, PMID:27132804, PMID:27430728 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A decreases expression
increases expression
EXP Curcumin results in decreased expression of CDKN2A protein
Curcumin results in increased expression of CDKN2A protein
CTD PMID:17148446, PMID:18156803 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,753...21,995,301
JBrowse link
G CDX2 caudal type homeobox 2 increases expression ISO Curcumin results in increased expression of CDX2 mRNA CTD PMID:18299980, PMID:27237783 NCBI chr13:27,960,918...27,969,337
Ensembl chr13:27,960,918...27,969,315
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] CTD PMID:19297423, PMID:28595985 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] CTD PMID:18200517 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CES1 carboxylesterase 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] CTD PMID:18200517 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CES3 carboxylesterase 3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] CTD PMID:18200517 NCBI chr16:66,961,266...66,975,149
Ensembl chr16:66,961,245...66,975,149
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
Curcumin results in decreased expression of CFLAR protein
CTD PMID:16173963, PMID:16219905, PMID:23452621 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions
increases activity
affects localization
EXP
ISO
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid]
Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form
Curcumin affects the localization of CFTR protein mutant form
Curcumin affects the folding of and affects the localization of CFTR protein mutant form
CTD PMID:15105504, PMID:15280357, PMID:15582996, PMID:17178710, PMID:23978416 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHAT choline O-acetyltransferase multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] CTD PMID:21839772 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,665,104
Ensembl chr10:49,609,095...49,665,104
JBrowse link
G CHEK1 checkpoint kinase 1 decreases response to substance
increases activity
increases phosphorylation
EXP CHEK1 protein results in decreased susceptibility to Curcumin
Curcumin results in increased activity of CHEK1 protein
Curcumin results in increased phosphorylation of CHEK1 protein
CTD PMID:18602917, PMID:19401701 NCBI chr11:125,624,910...125,676,256
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases phosphorylation
EXP [Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein]
Curcumin results in increased phosphorylation of CHEK2 protein
CTD PMID:21134073 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] CTD PMID:24952339 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions
decreases activity
EXP Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]
Curcumin results in decreased activity of CHUK protein
CTD PMID:15129424, PMID:15489888, PMID:16023083, PMID:16219905 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CKB creatine kinase B multiple interactions ISO Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372, PMID:29315967 NCBI chr14:103,519,667...103,522,833
Ensembl chr14:103,519,667...103,522,833
JBrowse link
G CKM creatine kinase, M-type multiple interactions ISO Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:21378372, PMID:29315967 NCBI chr19:45,306,413...45,322,875
Ensembl chr19:45,306,413...45,322,875
JBrowse link
G CLCN6 chloride voltage-gated channel 6 decreases expression EXP Curcumin results in decreased expression of CLCN6 mRNA CTD PMID:17198877 NCBI chr 1:11,806,191...11,843,130
Ensembl chr 1:11,806,096...11,848,079
JBrowse link
G CLDN2 claudin 2 multiple interactions ISO Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] CTD PMID:25119790 NCBI chr  X:106,900,164...106,930,861
Ensembl chr  X:106,900,164...106,930,861
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]
Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein
CTD PMID:17355460, PMID:17434272, PMID:17531121, PMID:17602960, PMID:17965732, PMID:18006644, PMID:28700904 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] CTD PMID:18200517 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COL27A1 collagen type XXVII alpha 1 chain increases expression ISO Curcumin results in increased expression of COL27A1 mRNA CTD PMID:18299980 NCBI chr 9:114,154,271...114,312,511
Ensembl chr 9:114,155,537...114,312,511
JBrowse link
G COL2A1 collagen type II alpha 1 chain increases expression
multiple interactions
EXP Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein
[resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein
CTD PMID:18321735, PMID:19889203 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] CTD PMID:22683883 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COL4A1 collagen type IV alpha 1 chain increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of COL4A1 mRNA
Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]
CTD PMID:18200517, PMID:21594647, PMID:28700904 NCBI chr13:110,148,963...110,307,157
Ensembl chr13:110,148,963...110,307,157
JBrowse link
G COL4A2 collagen type IV alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] CTD PMID:18200517 NCBI chr13:110,307,284...110,513,209
Ensembl chr13:110,305,812...110,513,209
JBrowse link
G COL4A5 collagen type IV alpha 5 chain decreases expression EXP Curcumin results in decreased expression of COL4A5 mRNA CTD PMID:15713895 NCBI chr  X:108,439,838...108,697,545
Ensembl chr  X:108,439,844...108,697,545
Ensembl chr  X:108,439,844...108,697,545
JBrowse link
G COL5A1 collagen type V alpha 1 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] CTD PMID:18200517 NCBI chr 9:134,641,789...134,844,843
Ensembl chr 9:134,641,803...134,844,843
Ensembl chr 9:134,641,803...134,844,843
JBrowse link
G COL5A2 collagen type V alpha 2 chain multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] CTD PMID:18200517 NCBI chr 2:189,031,898...189,225,301
Ensembl chr 2:189,031,898...189,225,312
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Curcumin results in increased expression of CPT1A mRNA CTD PMID:19297423 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases expression
multiple interactions
increases phosphorylation
ISO Curcumin results in increased expression of CREB1 mRNA
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA
Curcumin results in increased phosphorylation of CREB1 protein
CTD PMID:17022948, PMID:18299980, PMID:22911773, PMID:27966075, PMID:29723552 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CREB3 cAMP responsive element binding protein 3 increases expression ISO Curcumin results in increased expression of CREB3 mRNA CTD PMID:18299980 NCBI chr 9:35,732,666...35,736,999
Ensembl chr 9:35,732,598...35,736,999
JBrowse link
G CREBBP CREB binding protein multiple interactions EXP Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] CTD PMID:22258452 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CRP C-reactive protein multiple interactions ISO Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein]
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein]
CTD PMID:21378372, PMID:26713546, PMID:30431687, PMID:31820278 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CRYAB crystallin alpha B multiple interactions ISO Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
[Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD PMID:9764755 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CS citrate synthase affects expression ISO Curcumin affects the expression of CS mRNA CTD PMID:18539377 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391
JBrowse link
G CSF1 colony stimulating factor 1 multiple interactions EXP Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] CTD PMID:15129424 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions
increases expression
EXP
ISO
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein]
Curcumin results in increased expression of CSF1R mRNA
CTD PMID:15129424, PMID:22714040 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CSF2RA colony stimulating factor 2 receptor subunit alpha increases expression ISO Curcumin results in increased expression of CSF2RA mRNA CTD PMID:22714040 NCBI chr  X:1,268,814...1,325,218
NCBI chr  Y:1,268,814...1,325,218
Ensembl chr  X:1,268,800...1,310,381
JBrowse link
G CSF2RB colony stimulating factor 2 receptor subunit beta multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] CTD PMID:18200517 NCBI chr22:36,913,574...36,940,449
Ensembl chr22:36,913,628...36,940,439
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression
multiple interactions
decreases phosphorylation
increases degradation
EXP
ISO
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein
Curcumin results in increased expression of CTNNB1 mRNA
Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein
Curcumin results in decreased phosphorylation of CTNNB1 protein
[piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein]
Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein
CTD PMID:10783313, PMID:17041101, PMID:19294764, PMID:19573523, PMID:25963729, PMID:27645308, PMID:30935902 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]
Curcumin analog results in decreased expression of CTSB mRNA
CTD PMID:8534267, PMID:26409325 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CTSD cathepsin D multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]
Curcumin analog results in decreased expression of CTSD mRNA
CTD PMID:8534267, PMID:26409325 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CTSS cathepsin S decreases expression ISO Curcumin results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,188...150,765,792
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]
CTD PMID:17999991, PMID:27194111 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions EXP Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 decreases expression ISO Curcumin results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein
Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA]
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]
CTD PMID:17999991, PMID:18001810, PMID:18200517, PMID:27194111 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression
multiple interactions
EXP Curcumin results in decreased expression of CXCL8 protein
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Acids results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [lauric acid results in increased expression of and results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Neurotensin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [Shiga Toxin results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin results in decreased expression of and results in decreased secretion of CXCL8 protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]
CTD PMID:12216086, PMID:16819191, PMID:17000667, PMID:17151092, PMID:17273796, PMID:17666914, PMID:18226269, PMID:18413660, PMID:19074641, PMID:22142850, PMID:23452621, PMID:25540590, PMID:27393034 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 increases expression EXP Curcumin results in increased expression of CXCR1 protein CTD PMID:12216086 NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962
JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 increases expression EXP Curcumin results in increased expression of CXCR2 protein CTD PMID:12216086 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
EXP Curcumin results in decreased expression of CXCR4 mRNA
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]
CTD PMID:17198877, PMID:18660423 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
EXP Curcumin affects the localization of CYCS protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of CYCS protein
CTD PMID:19235267, PMID:27430728 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases activity
increases expression
decreases activity
decreases expression
EXP
ISO
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]
Curcumin results in increased activity of CYP1A1 protein
Curcumin results in increased expression of CYP1A1 mRNA
Curcumin results in decreased activity of CYP1A1 protein
Curcumin results in decreased expression of CYP1A1 mRNA
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
CTD PMID:11454723, PMID:12628514, PMID:15841493, PMID:16288784, PMID:17012224, PMID:17880909, PMID:18321868, PMID:19018768, PMID:20015472, PMID:20816778, PMID:22867086, PMID:27041069 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity
multiple interactions
EXP
ISO
Curcumin results in decreased activity of CYP1A2 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:15841493, PMID:16288784, PMID:18321868 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Curcumin results in decreased expression of CYP1B1 mRNA
CTD PMID:17637178, PMID:19018768 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 multiple interactions
increases expression
EXP [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA
Curcumin results in increased expression of CYP24A1 protein
CTD PMID:20153625 NCBI chr20:54,145,731...54,174,032
Ensembl chr20:54,153,446...54,173,986
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects expression
multiple interactions
increases expression
ISO
EXP
Curcumin affects the expression of CYP2E1 protein
Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]
Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]
Curcumin results in increased expression of CYP2E1 mRNA
CTD PMID:16805852, PMID:18539377, PMID:24508477, PMID:30423402 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases expression
increases expression
EXP [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
Curcumin results in decreased expression of CYP3A4 mRNA
Curcumin results in increased expression of CYP3A4 mRNA
CTD PMID:17210444, PMID:17270371, PMID:17965521, PMID:18385293, PMID:20153625, PMID:20816778 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYTH4 cytohesin 4 increases expression EXP Curcumin results in increased expression of CYTH4 mRNA CTD PMID:17198877 NCBI chr22:37,282,508...37,315,341
Ensembl chr22:37,282,027...37,315,341
JBrowse link
G DAXX death domain associated protein increases expression EXP Curcumin results in increased expression of DAXX mRNA CTD PMID:16101141 NCBI chr 6:33,318,558...33,322,959
Ensembl chr 6:33,318,558...33,323,016
JBrowse link
G DBN1 drebrin 1 multiple interactions ISO Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] CTD PMID:23333261 NCBI chr 5:177,456,610...177,480,368
Ensembl chr 5:177,456,608...177,474,401
JBrowse link
G DCN decorin increases expression EXP Curcumin results in increased expression of DCN mRNA CTD PMID:21594647 NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
Ensembl chr12:91,140,484...91,183,217
JBrowse link
G DCX doublecortin multiple interactions
increases expression
ISO Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA]
Curcumin results in increased expression of DCX mRNA
CTD PMID:25963729 NCBI chr  X:111,293,779...111,412,205
Ensembl chr  X:111,293,779...111,412,429
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein
CTD PMID:16613838, PMID:17171638, PMID:18200517, PMID:18719366, PMID:21793155, PMID:29723631 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DDIT4L DNA damage inducible transcript 4 like decreases expression
increases expression
EXP
ISO
Curcumin results in decreased expression of DDIT4L mRNA
Curcumin results in increased expression of DDIT4L mRNA
CTD PMID:17999991, PMID:18299980 NCBI chr 4:100,185,870...100,190,468
Ensembl chr 4:100,185,870...100,190,782
JBrowse link
G DFFB DNA fragmentation factor subunit beta increases expression
decreases expression
ISO Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein
Curcumin results in decreased expression of DFFB protein
CTD PMID:21397623, PMID:22714040 NCBI chr 1:3,857,286...3,885,429
Ensembl chr 1:3,857,267...3,885,429
JBrowse link
G DHCR24 24-dehydrocholesterol reductase decreases expression
affects expression
ISO Curcumin results in decreased expression of DHCR24 mRNA
Curcumin affects the expression of DHCR24 mRNA
CTD PMID:27208389 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
JBrowse link
G DHCR7 7-dehydrocholesterol reductase affects expression
decreases expression
ISO Curcumin affects the expression of DHCR7 mRNA
Curcumin results in decreased expression of DHCR7 mRNA
CTD PMID:27208389 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G DHRS1 dehydrogenase/reductase 1 decreases expression EXP Curcumin results in decreased expression of DHRS1 mRNA CTD PMID:17198877 NCBI chr14:24,290,598...24,299,780
Ensembl chr14:24,290,598...24,299,780
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein affects localization
multiple interactions
increases expression
increases response to substance
ISO
EXP
Curcumin affects the localization of DIABLO protein
[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein
Curcumin results in increased expression of DIABLO mRNA
DIABLO protein results in increased susceptibility to Curcumin
CTD PMID:17277231, PMID:23555722, PMID:27430728 NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,663...122,227,456
Ensembl chr12:122,207,663...122,227,456
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein
Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein]
CTD PMID:25963729 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] CTD PMID:29723552 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Curcumin results in increased expression of DNAJB9 mRNA CTD PMID:17999991 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression
affects expression
increases activity
multiple interactions
EXP
ISO
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein
Curcumin analog affects the expression of DNMT1 protein
Curcumin results in increased activity of DNMT1 protein
Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]
Curcumin analog results in decreased expression of DNMT1 protein
CTD PMID:23593078, PMID:26991801, PMID:27132804, PMID:29228771 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha decreases expression EXP
ISO
Curcumin results in decreased expression of DNMT3A mRNA
Curcumin analog results in decreased expression of DNMT3A protein
CTD PMID:23593078, PMID:26991801, PMID:29228771 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP
ISO
Curcumin results in decreased expression of DNMT3B mRNA
Curcumin analog results in decreased expression of DNMT3B protein
CTD PMID:23593078, PMID:26991801, PMID:29228771 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DRAM1 DNA damage regulated autophagy modulator 1 increases expression EXP Curcumin results in increased expression of DRAM1 mRNA CTD PMID:21594647 NCBI chr12:101,877,327...101,923,623
Ensembl chr12:101,877,580...102,012,130
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] CTD PMID:27966075 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression
multiple interactions
EXP
ISO
Curcumin results in increased expression of DUSP1 mRNA
Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein]
CTD PMID:15713895, PMID:20885979 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G DUSP10 dual specificity phosphatase 10 increases expression EXP Curcumin results in increased expression of DUSP10 mRNA CTD PMID:15713895, PMID:17151092 NCBI chr 1:221,701,424...221,742,091
Ensembl chr 1:221,701,424...221,742,089
JBrowse link
G DUSP5 dual specificity phosphatase 5 increases expression EXP Curcumin results in increased expression of DUSP5 mRNA CTD PMID:17198877 NCBI chr10:110,497,907...110,511,533
Ensembl chr10:110,497,907...110,511,533
JBrowse link
G DVL1 dishevelled segment polarity protein 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of DVL1 protein
Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein]
CTD PMID:19573523, PMID:25963729 NCBI chr 1:1,335,278...1,349,418
Ensembl chr 1:1,335,276...1,349,418
JBrowse link
G DYNLL1 dynein light chain LC8-type 1 increases expression EXP Curcumin results in increased expression of DYNLL1 mRNA CTD PMID:17198877 NCBI chr12:120,469,842...120,498,493
Ensembl chr12:120,469,850...120,498,493
JBrowse link
G E2F1 E2F transcription factor 1 decreases expression ISO Curcumin results in decreased expression of E2F1 mRNA CTD PMID:18299980 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G E2F5 E2F transcription factor 5 decreases expression EXP Curcumin results in decreased expression of E2F5 mRNA CTD PMID:15713895 NCBI chr 8:85,177,154...85,214,518
Ensembl chr 8:85,177,154...85,217,158
JBrowse link
G ECH1 enoyl-CoA hydratase 1 increases expression ISO Curcumin results in increased expression of ECH1 mRNA CTD PMID:18539377 NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841
JBrowse link
G EDARADD EDAR associated death domain multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] CTD PMID:23452621 NCBI chr 1:236,394,286...236,484,930
Ensembl chr 1:236,348,257...236,502,915
JBrowse link
G EDIL3 EGF like repeats and discoidin domains 3 decreases expression EXP Curcumin results in decreased expression of EDIL3 mRNA CTD PMID:18421014 NCBI chr 5:83,940,554...84,384,880
Ensembl chr 5:83,940,554...84,384,880
JBrowse link
G EGF epidermal growth factor decreases activity
multiple interactions
EXP
ISO
Curcumin results in decreased activity of EGF protein
Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein]
CTD PMID:10851300, PMID:15129424, PMID:15486348, PMID:17372590, PMID:18214481 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases phosphorylation
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein]
Curcumin results in decreased phosphorylation of EGFR protein
Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]
Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein
CTD PMID:10851300, PMID:15129424, PMID:15486348, PMID:17372590, PMID:17918158, PMID:18006644, PMID:18214481, PMID:18332871, PMID:18719366, PMID:24508477, PMID:26409325 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 multiple interactions
increases expression
decreases expression
EXP
ISO
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein]
Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein
Curcumin results in decreased expression of EGR1 mRNA
CTD PMID:17198877, PMID:17999991, PMID:18316600 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EIF1 eukaryotic translation initiation factor 1 decreases expression EXP Curcumin results in decreased expression of EIF1 mRNA CTD PMID:17999991 NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases expression
decreases phosphorylation
EXP calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein]
Curcumin results in decreased expression of EIF4EBP1 protein
CTD PMID:18790744, PMID:23222814 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EIF4G1 eukaryotic translation initiation factor 4 gamma 1 decreases phosphorylation EXP Curcumin results in decreased phosphorylation of EIF4G1 protein CTD PMID:18790744 NCBI chr 3:184,314,606...184,335,358
Ensembl chr 3:184,314,495...184,335,358
JBrowse link
G ELF2 E74 like ETS transcription factor 2 decreases expression EXP Curcumin results in decreased expression of ELF2 mRNA CTD PMID:15713895 NCBI chr 4:139,057,220...139,177,218
Ensembl chr 4:139,028,112...139,177,218
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions
increases phosphorylation
EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] CTD PMID:18316600, PMID:23452621 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G EMB embigin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] CTD PMID:18200517 NCBI chr 5:50,396,192...50,443,299
Ensembl chr 5:50,396,192...50,443,248
JBrowse link
G ENO1 enolase 1 decreases expression EXP Curcumin results in decreased expression of ENO1 mRNA CTD PMID:16880289 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) increases expression ISO Curcumin results in increased expression of ENTPD5 mRNA CTD PMID:18299980 NCBI chr14:73,955,329...74,019,326
Ensembl chr14:73,958,010...74,019,399
JBrowse link
G EP300 E1A binding protein p300 multiple interactions
decreases activity
decreases expression
affects localization
EXP
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]
Curcumin results in decreased activity of EP300 protein
Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]
Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein
CTD PMID:17927689, PMID:22228707, PMID:22258452, PMID:26612707 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G EPAS1 endothelial PAS domain protein 1 multiple interactions EXP Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:20554536 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G EPO erythropoietin decreases expression EXP Curcumin results in decreased expression of EPO mRNA CTD PMID:16880289 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions
increases response to substance
increases degradation
decreases expression
EXP [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein
Curcumin analog results in increased degradation of ERBB2 protein
Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein
CTD PMID:17041101, PMID:17918158, PMID:18719366, PMID:25866362, PMID:26409325 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
EXP Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]
Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA
CTD PMID:15713895, PMID:17918158, PMID:26409325 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions
decreases expression
EXP
ISO
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein]
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein
CTD PMID:17596214, PMID:21493726, PMID:22228707 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,333...45,478,828
Ensembl chr19:45,407,333...45,478,828
JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit multiple interactions
decreases expression
ISO
EXP
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein]
Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein
CTD PMID:22228707 NCBI chr16:13,920,137...13,952,348
Ensembl chr16:13,920,154...13,952,348
Ensembl chr16:13,920,154...13,952,348
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 decreases expression
increases expression
EXP Curcumin results in decreased expression of ERN1 mRNA
Curcumin results in increased expression of ERN1 mRNA
CTD PMID:17999991, PMID:29723631 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein]
Curcumin results in decreased expression of ESR1 protein
CTD PMID:15899841, PMID:18347134, PMID:23222814, PMID:24211270 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ETS2 ETS proto-oncogene 2, transcription factor decreases expression EXP Curcumin results in decreased expression of ETS2 protein CTD PMID:17332326 NCBI chr21:38,805,183...38,824,955
Ensembl chr21:38,805,183...38,824,955
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:18565277 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G F2R coagulation factor II thrombin receptor multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] CTD PMID:23452621 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FADD Fas associated via death domain multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] CTD PMID:23452621 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,163...70,207,390
Ensembl chr11:70,203,163...70,207,390
JBrowse link
G FADS1 fatty acid desaturase 1 affects expression
decreases expression
ISO Curcumin affects the expression of FADS1 mRNA
Curcumin results in decreased expression of FADS1 mRNA
CTD PMID:27208389 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FADS2 fatty acid desaturase 2 decreases expression
affects expression
ISO Curcumin results in decreased expression of FADS2 mRNA
Curcumin affects the expression of FADS2 mRNA
CTD PMID:27208389 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
JBrowse link
G FAM120B family with sequence similarity 120B decreases expression EXP Curcumin results in decreased expression of FAM120B mRNA CTD PMID:17999991 NCBI chr 6:170,290,703...170,407,748
Ensembl chr 6:170,290,703...170,407,067
Ensembl chr 6:170,290,703...170,407,067
JBrowse link
G FANCD2 FA complementation group D2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]
Curcumin results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,414...10,101,932
Ensembl chr 3:10,026,414...10,101,932
JBrowse link
G FANCI FA complementation group I multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
Curcumin results in decreased expression of FANCI mRNA
CTD PMID:24124520 NCBI chr15:89,243,973...89,317,259
Ensembl chr15:89,243,945...89,317,261
Ensembl chr15:89,243,945...89,317,261
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP [arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein CTD PMID:27430728 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand multiple interactions
decreases expression
EXP
ISO
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA]
Curcumin results in decreased expression of FASLG mRNA
CTD PMID:10925121, PMID:16101141, PMID:17351739, PMID:23452621, PMID:27430728 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase affects expression
decreases expression
ISO Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein
Curcumin results in decreased expression of FASN mRNA
CTD PMID:27208389 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FBLN2 fibulin 2 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] CTD PMID:18200517 NCBI chr 3:13,549,125...13,638,408
Ensembl chr 3:13,549,125...13,638,422
JBrowse link
G FCGR3A Fc fragment of IgG receptor IIIa multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] CTD PMID:18200517 NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,737
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 decreases expression ISO Curcumin results in decreased expression of FDFT1 mRNA CTD PMID:27208389 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,304
JBrowse link
G FDPS farnesyl diphosphate synthase increases expression
decreases expression
affects expression
EXP
ISO
Curcumin results in increased expression of FDPS mRNA
Curcumin results in decreased expression of FDPS mRNA
Curcumin affects the expression of FDPS mRNA
CTD PMID:16713233, PMID:27208389 NCBI chr 1:155,308,801...155,320,665
Ensembl chr 1:155,308,748...155,320,666
JBrowse link
G FGF2 fibroblast growth factor 2 decreases expression
increases expression
EXP Curcumin results in decreased expression of FGF2 protein
Curcumin results in increased expression of FGF2 protein
CTD PMID:23555722 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G FGF5 fibroblast growth factor 5 decreases expression ISO Curcumin results in decreased expression of FGF5 mRNA CTD PMID:27237783 NCBI chr 4:80,266,588...80,291,017
Ensembl chr 4:80,266,599...80,336,680
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP Curcumin results in decreased expression of FGFR2 mRNA CTD PMID:15713895 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,334...121,598,458
Ensembl chr10:121,478,334...121,598,458
JBrowse link
G FILIP1L filamin A interacting protein 1 like increases expression EXP Curcumin results in increased expression of FILIP1L mRNA CTD PMID:21594647 NCBI chr 3:99,833,144...100,114,501
Ensembl chr 3:99,830,141...100,114,513
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions ISO Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] CTD PMID:28698153 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 decreases expression
multiple interactions
EXP
ISO
Curcumin results in decreased expression of FLT1 protein
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]
CTD PMID:18593936, PMID:23845850 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FN1 fibronectin 1 multiple interactions
decreases expression
EXP
ISO
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein]
Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
Curcumin results in decreased expression of FN1 mRNA
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA]
CTD PMID:12388107, PMID:18200517, PMID:18555241, PMID:21998146, PMID:22228707 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FNTB farnesyltransferase, CAAX box, beta increases expression EXP Curcumin results in increased expression of FNTB mRNA CTD PMID:17999991 NCBI chr14:64,986,895...65,062,650
Ensembl chr14:64,986,895...65,062,652
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
increases expression
EXP
ISO
Curcumin results in decreased expression of FOS mRNA
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein]
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA]
Curcumin results in increased expression of FOS mRNA
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
CTD PMID:15713895, PMID:17827730, PMID:17999991, PMID:23452621, PMID:26191140 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit multiple interactions
increases ubiquitination
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]
Curcumin results in increased ubiquitination of FOSL1 protein
CTD PMID:17148446 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit decreases expression
multiple interactions
EXP Curcumin results in decreased expression of FOSL2 mRNA
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]
CTD PMID:17148446, PMID:17999991 NCBI chr 2:28,392,855...28,417,317
Ensembl chr 2:28,392,448...28,417,317
JBrowse link
G FOXA1 forkhead box A1 multiple interactions EXP Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] CTD PMID:22258452 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
G FOXA2 forkhead box A2 decreases expression ISO Curcumin results in decreased expression of FOXA2 mRNA CTD PMID:27237783 NCBI chr20:22,580,998...22,585,490
Ensembl chr20:22,581,005...22,585,455
JBrowse link
G FOXF2 forkhead box F2 decreases expression EXP Curcumin results in decreased expression of FOXF2 mRNA CTD PMID:15713895 NCBI chr 6:1,389,576...1,395,603
Ensembl chr 6:1,389,576...1,395,603
JBrowse link
G FOXO1 forkhead box O1 increases expression
decreases phosphorylation
ISO
EXP
Curcumin results in increased expression of FOXO1 mRNA
Curcumin results in decreased phosphorylation of FOXO1 protein
CTD PMID:18403477, PMID:18790744 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FPR3 formyl peptide receptor 3 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA] CTD PMID:18200517 NCBI chr19:51,795,157...51,826,207
Ensembl chr19:51,795,157...51,826,190
JBrowse link
G FSTL1 follistatin like 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] CTD PMID:18200517 NCBI chr 3:120,392,293...120,450,993
Ensembl chr 3:120,392,293...120,450,993
JBrowse link
G FTL ferritin light chain decreases expression ISO Curcumin results in decreased expression of FTL1 mRNA CTD PMID:24634837 NCBI chr19:48,963,941...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G FUS FUS RNA binding protein increases expression
decreases expression
EXP Curcumin results in increased expression of FUS mRNA
Curcumin results in decreased expression of FUS mRNA
CTD PMID:17198877, PMID:17999991 NCBI chr16:31,180,110...31,194,871
Ensembl chr16:31,180,110...31,194,871
Ensembl chr16:31,180,110...31,194,871
JBrowse link
G FZD1 frizzled class receptor 1 decreases expression EXP Curcumin results in decreased expression of FZD1 mRNA CTD PMID:15713895 NCBI chr 7:91,264,433...91,271,326
Ensembl chr 7:91,264,433...91,271,326
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 affects expression ISO Curcumin affects the expression of G6PC mRNA CTD PMID:27208389 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase increases expression ISO Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA CTD PMID:18299980 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 decreases expression ISO Curcumin results in decreased expression of GABRA1 mRNA CTD PMID:18299980 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981
JBrowse link
G GAD1 glutamate decarboxylase 1 multiple interactions ISO Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] CTD PMID:23267840 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO
EXP
Curcumin results in increased expression of GADD45A mRNA CTD PMID:16101141, PMID:18299980, PMID:18719366 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GAS6 growth arrest specific 6 increases expression EXP Curcumin results in increased expression of GAS6 mRNA CTD PMID:21594647 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076
JBrowse link
G GATA2 GATA binding protein 2 multiple interactions EXP Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] CTD PMID:22258452 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201
Ensembl chr 3:128,479,427...128,493,201
JBrowse link
G GATA4 GATA binding protein 4 decreases expression ISO Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein CTD PMID:27237783 NCBI chr 8:11,676,931...11,760,002
Ensembl chr 8:11,676,959...11,760,002
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases activity
multiple interactions
increases expression
EXP
ISO
Curcumin results in increased activity of GCLC protein
NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]
Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein
Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
CTD PMID:10514034, PMID:17602960, PMID:18299980, PMID:18332871, PMID:19168576, PMID:19183254, PMID:23710286, PMID:23954767, PMID:29571711, PMID:31521693 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
increases expression
ISO
EXP
Curcumin results in increased activity of [GCLC protein binds to GCLM protein]
Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein
NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]
CTD PMID:17198877, PMID:17535857, PMID:17602960, PMID:17999991, PMID:18332871, PMID:19168576, PMID:19183254, PMID:19188863, PMID:23386263, PMID:23710286, PMID:23954767, PMID:29571711 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GDA guanine deaminase multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA] CTD PMID:18200517 NCBI chr 9:72,114,595...72,256,045
Ensembl chr 9:72,114,595...72,257,193
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression
multiple interactions
ISO Curcumin results in decreased expression of GFAP mRNA
Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA]
CTD PMID:19555370, PMID:25963729 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GGT1 gamma-glutamyltransferase 1 increases expression
multiple interactions
ISO Curcumin results in increased expression of GGT1 mRNA
Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein]
CTD PMID:18299980, PMID:24704557 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA] CTD PMID:18200517 NCBI chr 9:121,444,990...121,499,844
Ensembl chr 9:121,444,991...121,500,027
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions EXP Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA] CTD PMID:23452621 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLI1 GLI family zinc finger 1 decreases expression ISO Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr12:57,459,785...57,472,451
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G GLO1 glyoxalase I decreases activity EXP Curcumin results in decreased activity of GLO1 protein CTD PMID:18946510 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 multiple interactions ISO Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] CTD PMID:16956363 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
JBrowse link
G GOT1L1 glutamic-oxaloacetic transaminase 1 like 1 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA] CTD PMID:18200517 NCBI chr 8:37,933,548...37,940,503
Ensembl chr 8:37,934,281...37,940,124
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
affects expression
multiple interactions
ISO Curcumin results in decreased expression of GPAM mRNA
Curcumin affects the expression of GPAM mRNA
Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]
CTD PMID:19297423, PMID:27208389 NCBI chr10:112,149,865...112,216,306
Ensembl chr10:112,149,865...112,215,377
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 decreases expression EXP Curcumin results in decreased expression of GPER1 mRNA CTD PMID:17198877 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G GPHN gephyrin affects expression ISO Curcumin affects the expression of GPHN mRNA CTD PMID:18539377 NCBI chr14:66,507,934...67,181,805
Ensembl chr14:66,507,407...67,181,803
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein]
CTD PMID:16956363, PMID:20804811, PMID:24704557, PMID:25123790, PMID:27288928, PMID:29421648, PMID:30423402 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression
multiple interactions
ISO Curcumin results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA]
CTD PMID:18299980, PMID:19914224, PMID:23267840, PMID:30934151 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GRB10 growth factor receptor bound protein 10 multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA] CTD PMID:18200517 NCBI chr 7:50,590,068...50,793,453
Ensembl chr 7:50,590,063...50,793,462
JBrowse link
G GRB2 growth factor receptor bound protein 2 decreases expression EXP Curcumin analog results in decreased expression of GRB2 mRNA CTD PMID:26409325 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709
JBrowse link
G GREM1 gremlin 1, DAN family BMP antagonist multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA] CTD PMID:18200517 NCBI chr15:32,718,004...32,745,106
Ensembl chr15:32,718,004...32,745,106
JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 multiple interactions ISO Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] CTD PMID:23267840 NCBI chr11:105,609,540...105,982,090
Ensembl chr11:105,609,994...105,982,092
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein] CTD PMID:23267840, PMID:29723552 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein] CTD PMID:29723552 NCBI chr16:9,753,404...10,182,928
Ensembl chr16:9,753,404...10,182,928
Ensembl chr16:9,753,404...10,182,928
JBrowse link
G GRM2 glutamate metabotropic receptor 2 decreases expression ISO Curcumin results in decreased expression of GRM2 protein CTD PMID:25406541 NCBI chr 3:51,707,068...51,718,616
Ensembl chr 3:51,707,068...51,718,613
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases phosphorylation
decreases expression
multiple interactions
increases phosphorylation
increases expression
EXP
ISO
Curcumin results in decreased phosphorylation of GSK3B protein
Curcumin results in decreased expression of GSK3B mRNA
Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein
Curcumin results in increased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]
Curcumin results in increased expression of GSK3B protein
CTD PMID:18006147, PMID:18790744, PMID:19573523, PMID:25541178, PMID:25963729, PMID:27645308, PMID:27966075, PMID:29723552 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSN gelsolin multiple interactions ISO Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA] CTD PMID:18200517 NCBI chr 9:121,201,483...121,332,844
Ensembl chr 9:121,207,794...121,332,843
JBrowse link
G GSR glutathione-disulfide reductase increases expression
multiple interactions
ISO Curcumin results in increased expression of GSR mRNA
[Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR]
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]
CTD PMID:19168576, PMID:19914224, PMID:20593964, PMID:21976817, PMID:24347089, PMID:25632966, PMID:31407471 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase increases expression ISO Curcumin results in increased expression of GSS mRNA CTD PMID:19183254 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases activity EXP Curcumin results in increased activity of GSTA4 protein CTD PMID:10514034 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression ISO Curcumin results in increased expression of GSTA5 mRNA CTD PMID:18299980 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 multiple interactions EXP Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA] CTD PMID:31521693 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
affects expression
increases expression
decreases expression
EXP
ISO
[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]
Curcumin affects the expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA
Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein
Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein
CTD PMID:9463521, PMID:14555224, PMID:14742295, PMID:15999103, PMID:16101141, PMID:17449203, PMID:18299980, PMID:18414057, PMID:22830632 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:8534267 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G H1-10 H1.10 linker histone decreases expression EXP Curcumin results in decreased expression of H1-10 mRNA CTD PMID:17198877 NCBI chr 3:129,314,771...129,316,286
Ensembl chr 3:129,314,771...129,316,286
JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression EXP Curcumin results in decreased expression of H19 mRNA CTD PMID:18348204 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,176...2,001,470
JBrowse link
G H2AX H2A.X variant histone multiple interactions
increases phosphorylation
EXP [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein
Curcumin results in increased phosphorylation of H2AX protein
CTD PMID:19401701, PMID:21134073 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G H2BC5 H2B clustered histone 5 increases expression EXP Curcumin results in increased expression of H2BC5 mRNA CTD PMID:17999991 NCBI chr 6:26,158,008...26,171,349
Ensembl chr 6:26,158,146...26,171,349
JBrowse link
G H2BC7 H2B clustered histone 7 increases expression ISO Curcumin results in increased expression of HIST1H2BQ mRNA CTD PMID:18299980 NCBI chr 6:26,199,516...26,199,988
Ensembl chr 6:26,199,520...26,200,715
JBrowse link
G H2BU1 H2B.U histone 1 increases expression EXP Curcumin results in increased expression of H2BU1 mRNA CTD PMID:15713895 NCBI chr 1:228,458,103...228,458,558
Ensembl chr 1:228,458,107...228,460,470
JBrowse link
G H3-4 H3.4 histone increases phosphorylation
increases acetylation
ISO Curcumin results in increased phosphorylation of H3F4 protein
Curcumin results in increased acetylation of H3F4 protein
CTD PMID:18204486 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,325
Ensembl chr 1:228,424,845...228,425,325
JBrowse link
G H4C11 H4 clustered histone 11 increases expression EXP Curcumin results in increased expression of H4C11 mRNA CTD PMID:15713895 NCBI chr 6:27,824,092...27,824,480
Ensembl chr 6:27,824,108...27,824,480
Ensembl chr 6:27,824,108...27,824,480
JBrowse link
G H4C15 H4 clustered histone 15 increases expression EXP Curcumin results in increased expression of H4C15 mRNA CTD PMID:17198877 NCBI chr 1:149,853,262...149,861,159
Ensembl chr 1:149,854,045...149,861,210
JBrowse link
G HAMP hepcidin antimicrobial peptide decreases expression ISO Curcumin results in decreased expression of HAMP mRNA CTD PMID:24634837 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
JBrowse link
G HAND1 heart and neural crest derivatives expressed 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]
Curcumin results in decreased expression of HAND1 mRNA
CTD PMID:24857828 NCBI chr 5:154,474,972...154,478,227
Ensembl chr 5:154,474,972...154,478,227
JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA]
Curcumin results in decreased expression of HAND2 mRNA
CTD PMID:24857828 NCBI chr 4:173,526,091...173,530,229
Ensembl chr 4:173,524,969...173,530,229
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein] CTD PMID:25119790, PMID:29421648, PMID:30431687 NCBI chr 5:157,028,383...157,069,633
Ensembl chr 5:157,029,413...157,059,119
JBrowse link
G HBS1L HBS1 like translational GTPase decreases expression EXP Curcumin results in decreased expression of HBS1L mRNA CTD PMID:18421014 NCBI chr 6:134,960,378...135,054,826
Ensembl chr 6:134,960,378...135,103,056
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
decreases expression
affects localization
EXP
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein]
Curcumin analog results in decreased expression of HDAC1 protein
Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein
CTD PMID:17927689, PMID:18161303, PMID:23593078, PMID:26409325, PMID:29228771 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HDAC11 histone deacetylase 11 decreases expression EXP Curcumin analog results in decreased expression of HDAC11 mRNA CTD PMID:26409325 NCBI chr 3:13,478,903...13,506,416
Ensembl chr 3:13,479,724...13,506,424
JBrowse link
G HDAC2 histone deacetylase 2 multiple interactions
decreases expression
EXP Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein]
Curcumin analog results in decreased expression of HDAC2 mRNA
CTD PMID:18421014, PMID:26409325 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HDAC3 histone deacetylase 3 decreases expression EXP Curcumin results in decreased expression of HDAC3 protein CTD PMID:17927689 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849
JBrowse link
G HDAC4 histone deacetylase 4 decreases expression EXP
ISO
Curcumin analog results in decreased expression of HDAC4 mRNA
Curcumin analog results in decreased expression of HDAC4 protein
CTD PMID:26409325, PMID:26991801, PMID:29228771 NCBI chr 2:239,048,168...239,401,649
Ensembl chr 2:239,048,168...239,401,654
JBrowse link
G HDAC6 histone deacetylase 6 decreases expression EXP Curcumin analog results in decreased expression of HDAC6 mRNA CTD PMID:26409325 NCBI chr  X:48,801,398...48,824,982
Ensembl chr &nb