|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization |
ISO |
neoxanthin affects the localization of AIFM1 protein |
CTD |
PMID:17186379 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
neoxanthin results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:17186379 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
neoxanthin results in increased activity of CASP8 protein |
CTD |
PMID:17186379 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
neoxanthin results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:17186379 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:33008094 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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|
G |
Alb |
albumin |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein] |
CTD |
PMID:34564187 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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|
G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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|
G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of ARG1 mRNA] |
CTD |
PMID:33008094 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
G |
Atg12 |
autophagy related 12 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG12 mRNA] |
CTD |
PMID:34439521 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
|
|
G |
Atg14 |
autophagy related 14 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of ATG14 mRNA] |
CTD |
PMID:34439521 |
|
NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA] |
CTD |
PMID:33212048 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 mRNA]; astaxanthine inhibits the reaction [bisphenol A results in increased expression of BECN1 protein] |
CTD |
PMID:34439521 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
|
|
G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
astaxanthine results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA] |
CTD |
PMID:33212048 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein] |
CTD |
PMID:16964424 PMID:34564187 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Cntd1 |
cyclin N-terminal domain containing 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:86,221,430...86,231,812
|
|
G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] |
CTD |
PMID:36084724 |
|
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
|
|
G |
Cox15 |
cytochrome c oxidase assembly homolog COX15 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
|
|
G |
Cox5a |
cytochrome c oxidase subunit 5A |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
|
|
G |
Cox5b |
cytochrome c oxidase subunit 5B |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
|
|
G |
Cox6b1 |
cytochrome c oxidase subunit 6B1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001 Ensembl chr 2:85,875,109...85,884,001
|
|
G |
Cox6c |
cytochrome c oxidase subunit 6C |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
|
|
G |
Ctss |
cathepsin S |
decreases expression |
ISO |
astaxanthine results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
|
|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions decreases expression |
EXP |
astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA]] astaxanthine results in decreased expression of CYBB mRNA |
CTD |
PMID:23272707 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression |
EXP |
astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein astaxanthine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:21414371 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Foxo3 |
forkhead box O3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases activity multiple interactions |
EXP |
astaxanthine results in increased activity of G6PD protein [Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein |
CTD |
PMID:28665548 PMID:29975440 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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|
G |
Gfap |
glial fibrillary acidic protein |
decreases expression |
ISO |
astaxanthine results in decreased expression of GFAP mRNA |
CTD |
PMID:19555370 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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|
G |
Gja1 |
gap junction protein, alpha 1 |
increases expression multiple interactions |
ISO |
astaxanthine results in increased expression of GJA1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein] |
CTD |
PMID:16091010 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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|
G |
Gna13 |
G protein subunit alpha 13 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein] |
CTD |
PMID:34564187 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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|
G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions increases expression |
EXP ISO |
astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein] astaxanthine results in increased expression of GPX4 protein astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein] |
CTD |
PMID:36084724 PMID:37648051 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
EXP |
[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] |
CTD |
PMID:23538867 |
|
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grn |
granulin precursor |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] |
CTD |
PMID:29975440 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions increases expression |
ISO |
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA astaxanthine results in increased expression of GSTM2 mRNA |
CTD |
PMID:24157545 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA] |
CTD |
PMID:16964424 PMID:34564187 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
astaxanthine results in increased expression of HMOX1 protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein] astaxanthine results in decreased expression of HMOX1 mRNA [astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]] astaxanthine results in increased expression of HMOX1 mRNA [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA] |
CTD |
PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hoxa9 |
homeobox A9 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358
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G |
Idh1 |
isocitrate dehydrogenase (NADP(+)) 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
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|
G |
Ifng |
interferon gamma |
increases expression |
ISO |
astaxanthine results in increased expression of IFNG protein |
CTD |
PMID:33132140 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of IL10 mRNA] astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein] |
CTD |
PMID:33008094 PMID:34564187 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il11 |
interleukin 11 |
increases expression |
ISO |
astaxanthine results in increased expression of IL11 protein |
CTD |
PMID:33132140 |
|
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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G |
Il1b |
interleukin 1 beta |
decreases expression multiple interactions |
ISO EXP |
astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein astaxanthine inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; astaxanthine inhibits the reaction [IL1B protein results in decreased expression of GPX4 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of P53 protein]; astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein] astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA] |
CTD |
PMID:21621527 PMID:33008094 PMID:34564187 PMID:36084724 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
ISO |
astaxanthine results in decreased expression of IL6 mRNA astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL6 mRNA] |
CTD |
PMID:21621527 PMID:33008094 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins1 |
insulin 1 |
decreases expression |
ISO |
astaxanthine results in decreased expression of INS1 protein |
CTD |
PMID:33132140 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Lepr |
leptin receptor |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:34439521 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:34439521 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:33008094 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] |
CTD |
PMID:36084724 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
|
|
G |
Mt-nd6 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
|
|
G |
Ndufa1 |
NADH:ubiquinone oxidoreductase subunit A1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633
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G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
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G |
Ndufc2 |
NADH:ubiquinone oxidoreductase subunit C2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
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G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions |
EXP ISO |
astaxanthine results in increased expression of NFE2L2 protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein] [astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]] astaxanthine results in increased expression of NFE2L2 mRNA [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:20038455 PMID:23272707 PMID:24157545 PMID:33008094 PMID:33212048 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nme2 |
NME/NM23 nucleoside diphosphate kinase 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 mRNA]; astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of NOS2 protein] astaxanthine inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA] |
CTD |
PMID:33008094 PMID:34564187 PMID:36084724 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
EXP ISO |
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA; astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of NQO1 mRNA] astaxanthine results in increased expression of NQO1 mRNA astaxanthine results in increased expression of NQO1 protein |
CTD |
PMID:20038455 PMID:24157545 PMID:33212048 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pah |
phenylalanine hydroxylase |
decreases expression |
ISO |
astaxanthine results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
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G |
Pgd |
phosphogluconate dehydrogenase |
increases activity |
EXP |
astaxanthine results in increased activity of PGD protein |
CTD |
PMID:28665548 PMID:29975440 |
|
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Por |
cytochrome p450 oxidoreductase |
decreases activity increases expression |
EXP |
astaxanthine results in decreased activity of POR protein astaxanthine results in increased expression of POR protein |
CTD |
PMID:21414371 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppp1cb |
protein phosphatase 1 catalytic subunit beta |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] |
CTD |
PMID:33212048 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
astaxanthine results in decreased expression of PTGS2 mRNA astaxanthine inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21621527 PMID:33008094 PMID:36084724 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein] |
CTD |
PMID:34439521 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps2 |
ribosomal protein S2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163
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G |
Skap2 |
src kinase associated phosphoprotein 2 |
decreases expression |
ISO |
astaxanthine results in decreased expression of SKAP2 mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
EXP |
[mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] |
CTD |
PMID:23538867 |
|
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Tgm2 |
transglutaminase 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Tkt |
transketolase |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR2 mRNA] |
CTD |
PMID:33008094 |
|
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA] |
CTD |
PMID:33008094 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions increases expression |
ISO |
astaxanthine results in decreased expression of TNF protein astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA] astaxanthine results in increased expression of TNF protein |
CTD |
PMID:21621527 PMID:33008094 PMID:33132140 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] |
CTD |
PMID:20038455 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Trem2 |
triggering receptor expressed on myeloid cells 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TREM2 mRNA] |
CTD |
PMID:33008094 |
|
NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
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G |
Ubb |
ubiquitin B |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333
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G |
Uqcrb |
ubiquinol-cytochrome c reductase binding protein |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
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G |
Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
multiple interactions |
ISO |
astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] |
CTD |
PMID:16964424 |
|
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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G |
Acad9 |
acyl-CoA dehydrogenase family, member 9 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
increases expression |
ISO |
beta Carotene results in increased expression of ADH5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression |
ISO |
beta Carotene results in decreased expression of ADIPOQ mRNA |
CTD |
PMID:21569430 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Aebp1 |
AE binding protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
beta Carotene results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:26733226 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] |
CTD |
PMID:25542264 |
|
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Aldh3b1 |
aldehyde dehydrogenase 3 family, member B1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ALDH3B1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
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G |
Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ALDH4A1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
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G |
Ank2 |
ankyrin 2 |
increases expression |
ISO |
beta Carotene results in increased expression of ANK2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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G |
Ank3 |
ankyrin 3 |
increases expression |
ISO |
beta Carotene results in increased expression of ANK3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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G |
Appbp2 |
amyloid beta precursor protein binding protein 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835
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G |
Arhgap26 |
Rho GTPase activating protein 26 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194
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G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of ASAH1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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G |
Asb1 |
ankyrin repeat and SOCS box-containing 1 |
increases expression |
ISO |
beta Carotene results in increased expression of ASB1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 9:92,120,332...92,140,790
Ensembl chr 9:92,120,306...92,136,376
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G |
Asb9 |
ankyrin repeat and SOCS box-containing 9 |
increases expression |
ISO |
beta Carotene results in increased expression of ASB9 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr X:29,956,576...30,001,436
Ensembl chr X:29,956,576...30,001,105
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G |
Atp8b1 |
ATPase phospholipid transporting 8B1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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G |
Bag3 |
BAG cochaperone 3 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
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G |
Bag4 |
BAG cochaperone 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663
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G |
Bag5 |
BAG cochaperone 5 |
decreases expression |
ISO |
beta Carotene results in decreased expression of BAG5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:130,768,467...130,772,122
Ensembl chr 6:130,768,141...130,772,970
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression increases expression |
ISO |
beta Carotene results in decreased expression of BAX mRNA beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein |
CTD |
PMID:15949688 PMID:17034753 PMID:26733226 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
beta Carotene results in decreased expression of BCL2 protein |
CTD |
PMID:26733226 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bco1 |
beta-carotene oxygenase 1 |
multiple interactions affects response to substance increases oxidation increases expression |
ISO EXP |
beta Carotene results in increased expression of and results in increased activity of BCO1 protein [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA BCO1 protein results in increased oxidation of beta Carotene beta Carotene results in increased expression of BCO1 mRNA Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]] |
CTD |
PMID:9526112 PMID:16186334 PMID:24657404 |
|
NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
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G |
Bco2 |
beta-carotene oxygenase 2 |
multiple interactions increases metabolic processing |
ISO |
[BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal |
CTD |
PMID:21106934 |
|
NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein] beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein |
CTD |
PMID:17618090 PMID:26733226 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein] beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] |
CTD |
PMID:9306888 PMID:12500499 PMID:25542264 PMID:31022331 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of CAV1 protein |
CTD |
PMID:26733226 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of CCND1 protein |
CTD |
PMID:26733226 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdca8 |
cell division cycle associated 8 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein |
CTD |
PMID:17034753 PMID:26733226 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of CEBPA mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpe |
centromere protein E |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
beta Carotene results in increased expression of CFLAR mRNA |
CTD |
PMID:17034753 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Clcn3 |
chloride voltage-gated channel 3 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119
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G |
Cldn10 |
claudin 10 |
increases expression |
ISO |
beta Carotene results in increased expression of CLDN10 mRNA |
CTD |
PMID:17034753 |
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NCBI chr15:95,862,785...95,954,526
Ensembl chr15:95,862,760...95,954,526
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G |
Cldn18 |
claudin 18 |
increases expression |
ISO |
beta Carotene results in increased expression of CLDN18 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:100,246,499...100,265,797
Ensembl chr 8:100,247,633...100,273,351
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G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL1A1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col4a1 |
collagen type IV alpha 1 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL4A1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a2 |
collagen type IV alpha 2 chain |
decreases expression |
ISO |
beta Carotene results in decreased expression of COL4A2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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G |
Coq7 |
coenzyme Q7, hydroxylase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
decreases expression |
ISO |
beta Carotene results in decreased expression of CPT1B mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cradd |
CASP2 and RIPK1 domain containing adaptor with death domain |
increases expression |
ISO |
beta Carotene results in increased expression of CRADD mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:29,940,240...29,952,907
Ensembl chr 7:29,798,586...29,952,907
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G |
Ctnnal1 |
catenin alpha-like 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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G |
Ctsb |
cathepsin B |
decreases expression |
ISO |
beta Carotene results in decreased expression of CTSB mRNA |
CTD |
PMID:17034753 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL12 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCL9 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
increases expression |
ISO |
beta Carotene results in increased expression of CXCR4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] |
CTD |
PMID:16970932 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
increases expression |
ISO |
beta Carotene results in increased expression of CYP26A1 mRNA |
CTD |
PMID:16186334 PMID:22542753 |
|
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp3a18 |
cytochrome P450, family 3, subfamily a, polypeptide 18 |
increases expression |
ISO |
beta Carotene results in increased expression of CYP3A43 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Dhfr |
dihydrofolate reductase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
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G |
Dlx2 |
distal-less homeobox 2 |
increases expression |
ISO |
beta Carotene results in increased expression of DLX2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:56,370,238...56,373,581
Ensembl chr 3:56,370,483...56,373,597
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G |
Dlx4 |
distal-less homeobox 4 |
increases expression |
ISO |
beta Carotene results in increased expression of DLX4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:80,085,037...80,090,434
Ensembl chr10:80,085,465...80,090,456
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G |
Dpp4 |
dipeptidylpeptidase 4 |
multiple interactions |
ISO |
[Xiao-Ke-An results in increased abundance of beta Carotene] which results in decreased activity of DPP4 protein |
CTD |
PMID:32535096 |
|
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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G |
Dtwd2 |
DTW domain containing 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr18:42,811,783...42,902,040
Ensembl chr18:42,816,681...42,901,832
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Ercc2 |
ERCC excision repair 2, TFIIH core complex helicase subunit |
decreases expression |
ISO |
beta Carotene results in decreased expression of ERCC2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] |
CTD |
PMID:17051425 PMID:19340624 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] |
CTD |
PMID:17051425 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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|
G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of FABP4 mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Faim2 |
Fas apoptotic inhibitory molecule 2 |
increases expression |
ISO |
beta Carotene results in increased expression of FAIM2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
beta Carotene results in increased expression of FAS mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
beta Carotene results in increased expression of FOSL1 protein |
CTD |
PMID:20025956 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Foxa1 |
forkhead box A1 |
increases expression |
ISO |
beta Carotene results in increased expression of FOXA1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxm1 |
forkhead box M1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
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G |
Fzd6 |
frizzled class receptor 6 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776
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G |
Gata6 |
GATA binding protein 6 |
increases expression |
ISO |
beta Carotene results in increased expression of GATA6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
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G |
Gbp1 |
guanylate binding protein 1 |
increases expression |
ISO |
beta Carotene results in increased expression of GBP1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions increases expression |
ISO EXP |
beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein] |
CTD |
PMID:16091010 PMID:27154496 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] |
CTD |
PMID:25542264 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTK1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
ISO |
beta Carotene results in increased expression of GSTM2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm4 |
glutathione S-transferase mu 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTM4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
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G |
Gstm5l |
glutathione S-transferase, mu 5-like |
increases expression |
ISO |
beta Carotene results in increased expression of GSTM5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstz1 |
glutathione S-transferase zeta 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of GSTZ1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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G |
Hoxa7 |
homeobox A7 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXA7 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659
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G |
Hoxb6 |
homeo box B6 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXB6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:81,258,726...81,267,458
Ensembl chr10:81,265,056...81,267,449
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G |
Hoxc10 |
homeo box C10 |
increases expression |
ISO |
beta Carotene results in increased expression of HOXC10 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
multiple interactions |
EXP |
beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] |
CTD |
PMID:12467141 |
|
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA |
CTD |
PMID:23859036 |
|
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] |
CTD |
PMID:21447443 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Irf8 |
interferon regulatory factor 8 |
increases expression |
ISO |
beta Carotene results in increased expression of IRF8 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
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G |
Irx4 |
iroquois homeobox 4 |
decreases expression multiple interactions |
ISO |
beta Carotene results in decreased expression of IRX4 mRNA [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA |
CTD |
PMID:17034753 PMID:24657404 |
|
NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549
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G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ITGB1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb4 |
integrin subunit beta 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of ITGB4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Itm2a |
integral membrane protein 2A |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Ivl |
involucrin |
increases expression |
ISO |
beta Carotene results in increased expression of IVL mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
beta Carotene results in increased expression of JUN protein |
CTD |
PMID:20025956 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Kif11 |
kinesin family member 11 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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G |
Krt18 |
keratin 18 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT18 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Krt19 |
keratin 19 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT19 mRNA |
CTD |
PMID:17034753 |
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NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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G |
Krt2 |
keratin 2 |
increases expression |
ISO |
beta Carotene results in increased expression of KRT2 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963
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G |
Krt7 |
keratin 7 |
affects expression |
ISO |
beta Carotene affects the expression of KRT7 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
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G |
Krt8 |
keratin 8 |
decreases expression |
ISO |
beta Carotene results in decreased expression of KRT8 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Lancl1 |
LanC like glutathione S-transferase 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 9:68,515,052...68,548,646
Ensembl chr 9:68,518,574...68,548,628
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Lhx3 |
LIM homeobox 3 |
increases expression |
ISO |
beta Carotene results in increased expression of LHX3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480
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G |
Lmnb2 |
lamin B2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665
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LOC100912356 |
interferon alpha-1-like |
increases expression |
ISO |
beta Carotene results in increased expression of IFNA5 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 5:103,227,820...103,230,500
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Lpl |
lipoprotein lipase |
decreases expression |
ISO |
beta Carotene results in decreased expression of LPL mRNA |
CTD |
PMID:21569430 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO EXP |
beta Carotene results in increased phosphorylation of MAPK1 protein beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:16206275 PMID:27154496 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO EXP |
beta Carotene results in increased phosphorylation of MAPK3 protein beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:16206275 PMID:27154496 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mbl2 |
mannose binding lectin 2 |
multiple interactions |
ISO |
MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] |
CTD |
PMID:16960176 |
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NCBI chr 1:228,016,439...228,024,736
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
affects expression |
ISO |
beta Carotene affects the expression of MCL1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Meis2 |
Meis homeobox 2 |
increases expression |
ISO |
beta Carotene results in increased expression of MEIS2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:102,742,904...102,944,833
Ensembl chr 3:102,742,900...102,949,696
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G |
Meox1 |
mesenchyme homeobox 1 |
increases expression |
ISO |
beta Carotene results in increased expression of MEOX1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
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G |
Mettl21a |
methyltransferase 21A, HSPA lysine |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550
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G |
Mettl9 |
methyltransferase 9, His-X-His N1(pi)-histidine |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:175,575,805...175,623,065
Ensembl chr 1:175,577,890...175,623,061
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
affects response to substance |
ISO |
MGMT gene SNP affects the susceptibility to beta Carotene |
CTD |
PMID:16014702 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA |
CTD |
PMID:23859036 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mnx1 |
motor neuron and pancreas homeobox 1 |
increases expression |
ISO |
beta Carotene results in increased expression of MNX1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:5,866,506...5,871,465
Ensembl chr 4:5,866,506...5,871,465
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] |
CTD |
PMID:31022331 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrpl57 |
mitochondrial ribosomal protein L57 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr15:31,970,904...31,971,766
Ensembl chr15:31,970,860...31,973,993
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G |
Msh5 |
mutS homolog 5 |
increases expression |
ISO |
beta Carotene results in increased expression of MSH5 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
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G |
Mtch2 |
mitochondrial carrier 2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
increases expression |
ISO |
beta Carotene results in increased expression of MUC5AC mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nckap1 |
NCK-associated protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
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G |
Nom1 |
nucleolar protein with MIF4G domain 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 4:5,891,220...5,910,741
Ensembl chr 4:5,892,909...5,909,709
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G |
Nos1 |
nitric oxide synthase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of NOS1 mRNA |
CTD |
PMID:17034753 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] |
CTD |
PMID:18779489 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] beta Carotene results in increased activity of NR1I2 protein |
CTD |
PMID:15949683 PMID:16632523 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
increases expression |
ISO |
beta Carotene results in increased expression of OLR1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Pard6a |
par-6 family cell polarity regulator alpha |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA |
CTD |
PMID:24657404 |
|
NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900
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G |
Pcdh1 |
protocadherin 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr18:30,011,692...30,039,679
Ensembl chr18:30,013,185...30,039,318
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G |
Pcdhgc3 |
protocadherin gamma subfamily C, 3 |
increases expression |
ISO |
beta Carotene results in increased expression of PCDHGC3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein |
CTD |
PMID:23859036 |
|
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Pik3r5 |
phosphoinositide-3-kinase, regulatory subunit 5 |
increases expression |
ISO |
beta Carotene results in increased expression of PIK3R5 protein |
CTD |
PMID:20025956 |
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NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA |
CTD |
PMID:24657404 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Plscr1 |
phospholipid scramblase 1 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
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G |
Plscr3 |
phospholipid scramblase 3 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR3 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:54,566,556...54,573,240
Ensembl chr10:54,566,873...54,578,709
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G |
Plscr4 |
phospholipid scramblase 4 |
increases expression |
ISO |
beta Carotene results in increased expression of PLSCR4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of PPARA mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
beta Carotene results in decreased expression of PPARG mRNA |
CTD |
PMID:21569430 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Rad51ap1 |
RAD51 associated protein 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of RAD51AP1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524
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G |
Rad51d |
RAD51 paralog D |
increases expression |
ISO |
beta Carotene results in increased expression of RAD51D mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434
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G |
Rara |
retinoic acid receptor, alpha |
decreases expression |
ISO |
beta Carotene results in decreased expression of RARA mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rarb |
retinoic acid receptor, beta |
increases expression |
ISO |
beta Carotene results in increased expression of RARB mRNA |
CTD |
PMID:17034753 |
|
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarres1 |
retinoic acid receptor responder 1 |
increases expression |
ISO |
beta Carotene results in increased expression of RARRES1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
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G |
Rbp4 |
retinol binding protein 4 |
multiple interactions |
ISO |
beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein |
CTD |
PMID:22542753 |
|
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases phosphorylation |
ISO |
beta Carotene results in decreased phosphorylation of RELA protein |
CTD |
PMID:26733226 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rpp14 |
ribonuclease P/MRP subunit p14 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101 Ensembl chr15:16,836,859...16,852,101
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G |
Rrm1 |
ribonucleotide reductase catalytic subunit M1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:16632523 |
|
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Scarb1 |
scavenger receptor class B, member 1 |
increases transport |
ISO |
SCARB1 protein results in increased transport of beta Carotene |
CTD |
PMID:16177187 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Six6 |
SIX homeobox 6 |
increases expression |
ISO |
beta Carotene results in increased expression of SIX6 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:91,634,568...91,639,548
Ensembl chr 6:91,634,568...91,639,548
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G |
Slc2a4 |
solute carrier family 2 member 4 |
decreases expression |
ISO |
beta Carotene results in decreased expression of SLC2A4 mRNA |
CTD |
PMID:21569430 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression |
ISO |
beta Carotene results in decreased expression of SOD1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] |
CTD |
PMID:18779489 PMID:23859036 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sptlc2 |
serine palmitoyltransferase, long chain base subunit 2 |
affects expression |
ISO |
beta Carotene affects the expression of SPTLC2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
ISO |
beta Carotene results in increased expression of SREBF1 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Tfcp2 |
transcription factor CP2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:131,616,777...131,658,995
Ensembl chr 7:131,616,785...131,658,939
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G |
Tgm2 |
transglutaminase 2 |
increases expression |
ISO |
beta Carotene results in increased expression of TGM2 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Tgm4 |
transglutaminase 4 |
increases expression |
ISO |
beta Carotene results in increased expression of TGM4 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 8:122,689,429...122,726,463
Ensembl chr 8:122,689,429...122,726,463
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G |
Thoc7 |
THO complex subunit 7 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr15:11,262,362...11,277,200
Ensembl chr15:11,262,613...11,277,193
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G |
Tmem209 |
transmembrane protein 209 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 4:59,102,943...59,128,636
Ensembl chr 4:59,101,550...59,128,630
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]] beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:19135038 PMID:21447443 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
increases expression |
ISO |
beta Carotene results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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G |
Tnfsf10 |
TNF superfamily member 10 |
increases expression |
ISO |
beta Carotene results in increased expression of TNFSF10 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Ttc21b |
tetratricopeptide repeat domain 21B |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 3:50,861,367...50,935,880
Ensembl chr 3:50,861,367...50,935,903
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G |
Twf1 |
twinfilin actin-binding protein 1 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA |
CTD |
PMID:24657404 |
|
NCBI chr 7:125,715,938...125,727,834
Ensembl chr 7:125,716,015...125,727,894
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G |
Txndc9 |
thioredoxin domain containing 9 |
increases expression |
ISO |
beta Carotene results in increased expression of TXNDC9 mRNA |
CTD |
PMID:17034753 |
|
NCBI chr 9:40,211,818...40,221,953
Ensembl chr 9:40,211,412...40,384,279 Ensembl chr 9:40,211,412...40,384,279
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G |
Tymp |
thymidine phosphorylase |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA |
CTD |
PMID:24657404 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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G |
Xrcc3 |
X-ray repair cross complementing 3 |
increases expression |
ISO |
beta Carotene results in increased expression of XRCC3 mRNA |
CTD |
PMID:17034753 |
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NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
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G |
Ythdc2 |
YTH N6-methyladenosine RNA binding protein C2 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA |
CTD |
PMID:24657404 |
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NCBI chr18:37,266,559...37,331,681
Ensembl chr18:37,265,836...37,331,023
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G |
Zdhhc3 |
zinc finger DHHC-type palmitoyltransferase 3 |
multiple interactions |
ISO |
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA |
CTD |
PMID:24657404 |
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NCBI chr 8:122,725,206...122,773,542
Ensembl chr 8:122,715,111...122,773,529
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases ubiquitination |
ISO |
bixin results in decreased ubiquitination of NFE2L2 protein |
CTD |
PMID:30698894 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
brazilein results in decreased expression of CCND1 mRNA; brazilein results in decreased expression of CCND1 protein |
CTD |
PMID:23948132 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
ISO |
brazilein results in decreased expression of CTNNB1 protein |
CTD |
PMID:23948132 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression |
ISO |
brazilein results in decreased expression of GSK3B protein modified form |
CTD |
PMID:23948132 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
brazilein promotes the reaction [SB 203580 results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; brazilein results in decreased expression of and results in decreased activity of MMP2 protein; SB 203580 promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein] brazilein results in decreased expression of MMP2 mRNA |
CTD |
PMID:23707804 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
brazilein results in decreased expression of and results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:23707804 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
brazilein results in decreased expression of RELA protein |
CTD |
PMID:23707804 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
brazilin results in increased expression of BAX protein |
CTD |
PMID:28063998 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
brazilin results in decreased expression of BCL2 protein |
CTD |
PMID:28063998 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein |
CTD |
PMID:28063998 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
brazilin results in increased activity of CASP3 protein Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] |
CTD |
PMID:28063998 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] |
CTD |
PMID:28063998 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] |
CTD |
PMID:28063998 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sqstm1 |
sequestosome 1 |
decreases expression multiple interactions |
ISO |
brazilin results in decreased expression of SQSTM1 protein Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28063998 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO EXP |
Canthaxanthin results in increased expression of CYP1A1 mRNA |
CTD |
PMID:9271336 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP ISO |
Canthaxanthin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:9271336 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
A4galt |
alpha 1,4-galactosyltransferase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA] |
CTD |
PMID:16819191 |
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NCBI chr 7:114,368,525...114,392,872
Ensembl chr 7:114,368,276...114,396,071
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of AARS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]] |
CTD |
PMID:33952798 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
affects response to substance decreases response to substance decreases expression multiple interactions |
ISO |
ABCB1 affects the susceptibility to Curcumin ABCB1 protein results in decreased susceptibility to Curcumin Curcumin analog results in decreased expression of ABCB1 protein; Curcumin results in decreased expression of ABCB1 mRNA; Curcumin results in decreased expression of ABCB1B mRNA [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ABCB1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [sulfinosine co-treated with Curcumin] results in decreased expression of ABCB1 mRNA; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vinblastine]; Curcumin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Curcumin results in decreased expression of and results in decreased activity of ABCB1 protein |
CTD |
PMID:15476675 PMID:17121181 PMID:18200517 PMID:18385293 PMID:18414057 PMID:18439772 PMID:20816778 PMID:26689174 PMID:27318188 PMID:31628941 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions decreases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]; [Curcumin results in decreased expression of ABCB1B protein] which results in increased susceptibility to Doxorubicin; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA] Curcumin results in decreased expression of ABCB1B mRNA; Curcumin results in decreased expression of ABCB1B protein |
CTD |
PMID:18006147 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity decreases expression |
ISO |
Curcumin results in decreased activity of ABCC1 protein Curcumin analog results in decreased expression of ABCC1 mRNA |
CTD |
PMID:15885658 PMID:16021489 PMID:26409325 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of ABCC2 protein [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC2 protein |
CTD |
PMID:15885658 PMID:35243748 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
[Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of ABCC4 protein |
CTD |
PMID:35243748 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
[Curcumin analog binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; [Curcumin binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; Curcumin analog binds to and results in decreased activity of ABCC5 protein; Curcumin analog inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid]; Curcumin binds to and results in decreased activity of ABCC5 protein; Curcumin inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] |
CTD |
PMID:23978416 |
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NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
Curcumin results in increased expression of ABCG1 mRNA |
CTD |
PMID:16713233 PMID:21594647 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions decreases expression increases expression |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin results in decreased expression of ABCG2 mRNA |
CTD |
PMID:17077187 PMID:33539684 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation decreases expression affects expression multiple interactions |
ISO EXP |
Curcumin results in increased phosphorylation of ACACA protein Curcumin results in decreased expression of ACACA mRNA Curcumin affects the expression of ACACA mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACA protein]; Curcumin inhibits the reaction [Dietary Fats results in decreased phosphorylation of ACACA protein] |
CTD |
PMID:18790744 PMID:19297423 PMID:27208389 PMID:37701206 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of ACACB protein] |
CTD |
PMID:37701206 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Paraquat affects the expression of ACE protein] |
CTD |
PMID:10666014 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions affects binding |
EXP ISO |
Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein] Curcumin binds to ACE2 protein |
CTD |
PMID:26648693 PMID:34138966 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO EXP |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein] Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein] Curcumin results in decreased activity of ACHE protein Curcumin inhibits the reaction [Acrylamide results in increased activity of ACHE protein]; Curcumin inhibits the reaction [aluminum acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of ACHE protein]; Curcumin inhibits the reaction [lead acetate results in decreased activity of ACHE protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]] |
CTD |
PMID:18809455 PMID:20369229 PMID:21839772 PMID:22783142 PMID:25199698 PMID:25496357 PMID:28527659 PMID:31714633 PMID:31820278 PMID:36924976 More...
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Ackr3 |
atypical chemokine receptor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ACKR3 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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G |
Acly |
ATP citrate lyase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of ACLY mRNA Curcumin results in decreased expression of ACLY mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco2 |
aconitase 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in decreased activity of ACO2 protein] |
CTD |
PMID:25130536 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP ISO |
Curcumin results in decreased expression of ACTA2 mRNA; Curcumin results in decreased expression of ACTA2 protein Curcumin inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Arsenic Trioxide promotes the reaction [Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of ACTA2 protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:17355460 PMID:17531121 PMID:18006644 PMID:22683883 PMID:27363783 PMID:31612257 PMID:32718261 PMID:35716765 More...
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA] |
CTD |
PMID:17666914 |
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NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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G |
Adamts4 |
ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
increases expression |
ISO |
Curcumin results in increased expression of ADAMTS4 mRNA |
CTD |
PMID:18321735 |
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NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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G |
Adcy9 |
adenylate cyclase 9 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADCY9 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ADGRE1 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression multiple interactions affects expression |
ISO EXP |
Curcumin results in increased expression of ADIPOQ mRNA; Curcumin results in increased expression of ADIPOQ protein Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]] Curcumin affects the expression of ADIPOQ mRNA Curcumin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein] |
CTD |
PMID:18403477 PMID:26713546 PMID:27208389 PMID:28595985 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adora2a |
adenosine A2a receptor |
multiple interactions |
ISO |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA]; Curcumin inhibits the reaction [Rotenone results in increased expression of ADORA2A mRNA] |
CTD |
PMID:31820278 |
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NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein] |
CTD |
PMID:29480285 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Agr2 |
anterior gradient 2, protein disulphide isomerase family member |
decreases expression |
ISO |
Curcumin results in decreased expression of AGR2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP ISO |
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of ACE2 protein]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of AGT protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of AGT protein] |
CTD |
PMID:26612707 PMID:26648693 PMID:31820278 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr2 |
angiotensin II receptor, type 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [AGT protein results in decreased expression of AGTR2 protein] |
CTD |
PMID:26648693 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects binding increases degradation |
ISO |
AHR protein promotes the reaction [Curcumin results in increased expression of ABCG2 protein] Curcumin binds to AHR protein Curcumin results in increased degradation of AHR protein [Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene affects the localization of AHR protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of AHR protein]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]; Curcumin promotes the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein] |
CTD |
PMID:17077187 PMID:17880909 PMID:18321868 PMID:19018768 PMID:25632966 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ak1 |
adenylate kinase 1 |
multiple interactions |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein |
CTD |
PMID:25866362 |
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NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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G |
Akap6 |
A-kinase anchoring protein 6 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of AKAP6 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of AKAP6 mRNA] |
CTD |
PMID:18200517 PMID:18421014 |
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NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression multiple interactions increases activity |
ISO EXP |
Curcumin results in increased expression of AKR1B1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Curcumin results in increased expression of AKR1B1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] Curcumin results in increased expression of AKR1B1 mRNA; Curcumin results in increased expression of AKR1B1 protein Curcumin results in increased activity of AKR1B1 protein |
CTD |
PMID:17640564 PMID:18200517 PMID:18299980 PMID:18588981 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects phosphorylation decreases expression decreases phosphorylation increases expression increases phosphorylation decreases activity |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin affects the phosphorylation of AKT1 protein Curcumin analog results in decreased expression of AKT1 mRNA; Curcumin results in decreased expression of AKT1 protein Curcumin results in increased expression of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of AKT1 protein AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein] Curcumin results in decreased activity of AKT1 protein |
CTD |
PMID:16023083 PMID:16219905 PMID:17289836 PMID:17291458 PMID:17332930 PMID:17372590 PMID:17535857 PMID:17596214 PMID:17640564 PMID:17640567 PMID:17918158 PMID:18006147 PMID:18214481 PMID:18660423 PMID:18790744 PMID:19372569 PMID:20605902 PMID:20727180 PMID:20938987 PMID:23222814 PMID:23452621 PMID:23555722 PMID:24211270 PMID:24365254 PMID:24831732 PMID:25541178 PMID:26409325 PMID:27208389 PMID:27966075 PMID:34577062 PMID:34634291 PMID:35752269 PMID:36640941 PMID:37471645 More...
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions decreases phosphorylation decreases expression |
ISO |
4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of AKT2 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT2 protein ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein] Curcumin analog results in decreased expression of AKT2 mRNA |
CTD |
PMID:23452621 PMID:26409325 PMID:36640941 |
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NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein] Curcumin results in decreased expression of AKT3 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of AKT3 protein; MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein] |
CTD |
PMID:36640941 PMID:37471645 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP ISO |
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of ALAD protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of ALAD protein] Curcumin inhibits the reaction [lead acetate results in decreased activity of ALAD protein] |
CTD |
PMID:22704994 PMID:23292317 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ALAS1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Alb |
albumin |
multiple interactions |
EXP |
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of ALB protein]; [Curcumin analog co-treated with Hydrogels] results in increased expression of ALB protein; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of ALB protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of ALB protein]] |
CTD |
PMID:18204486 PMID:18809455 PMID:20804811 PMID:24704557 PMID:27288928 PMID:32718261 More...
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Alcam |
activated leukocyte cell adhesion molecule |
decreases expression |
ISO |
Curcumin results in decreased expression of ALCAM mRNA |
CTD |
PMID:33539684 |
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NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions decreases expression |
ISO |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 mRNA]; [Calcitriol co-treated with Paclitaxel] promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA]; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; [Curcumin co-treated with Paclitaxel] promotes the reaction [Calcitriol results in decreased expression of ALDH1A1 mRNA]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein]; Paclitaxel promotes the reaction [Curcumin results in decreased expression of ALDH1A1 mRNA] [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in decreased expression of ALDH1A1 protein] Curcumin results in decreased expression of ALDH1A1 mRNA; Curcumin results in decreased expression of ALDH1A1 protein |
CTD |
PMID:31628941 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOA mRNA |
CTD |
PMID:16880289 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Curcumin results in decreased expression of ALDOC mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions decreases activity |
EXP |
[Capsaicin co-treated with Curcumin] results in decreased activity of ALOX5 protein Curcumin results in decreased activity of ALOX5 protein |
CTD |
PMID:16956363 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Ampd1 |
adenosine monophosphate deaminase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein] |
CTD |
PMID:36924976 |
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NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938
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G |
Ampd3 |
adenosine monophosphate deaminase 3 |
increases expression |
EXP |
Curcumin results in increased expression of AMPD3 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
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G |
Ankrd37 |
ankyrin repeat domain 37 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD37 mRNA |
CTD |
PMID:17198877 |
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NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963
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G |
Ankrd50 |
ankyrin repeat domain containing 50 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKRD50 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 2:121,466,275...121,500,758
Ensembl chr 2:121,468,573...121,500,752
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G |
Ankzf1 |
ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ANKZF1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469
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G |
Aoc1 |
amine oxidase, copper containing 1 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] Curcumin inhibits the reaction [deoxynivalenol results in increased activity of AOC1 protein] |
CTD |
PMID:20885979 PMID:35817260 |
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NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of APAF1 protein Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] |
CTD |
PMID:17277231 PMID:20869986 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apc |
APC regulator of WNT signaling pathway |
decreases expression |
ISO |
Curcumin results in decreased expression of APC mRNA |
CTD |
PMID:15713895 |
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NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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G |
Apoe |
apolipoprotein E |
affects expression |
ISO |
Curcumin affects the expression of APOE mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions increases expression |
ISO EXP |
Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of APP protein] Curcumin results in increased expression of APP mRNA [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] |
CTD |
PMID:18537544 PMID:18583042 PMID:27793699 PMID:30946834 PMID:31521693 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of AQP3 protein Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein] |
CTD |
PMID:18214481 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Aqp9 |
aquaporin 9 |
increases expression |
ISO |
Curcumin results in increased expression of AQP9 mRNA; Curcumin results in increased expression of AQP9 protein |
CTD |
PMID:34675983 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Ar |
androgen receptor |
multiple interactions increases expression decreases activity decreases expression |
ISO |
[[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR mRNA; [[Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter] which results in increased expression of AR protein; [Quercetin co-treated with Curcumin] results in decreased methylation of AR promoter; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin promotes the reaction [Quercetin results in increased expression of AR mRNA]; Curcumin promotes the reaction [Quercetin results in increased expression of AR protein]; Quercetin promotes the reaction [Curcumin results in increased expression of AR mRNA]; Quercetin promotes the reaction [Curcumin results in increased expression of AR protein] Curcumin results in increased expression of AR mRNA; Curcumin results in increased expression of AR protein Curcumin results in decreased activity of AR protein Curcumin results in decreased expression of AR mRNA; Curcumin results in decreased expression of AR protein |
CTD |
PMID:12497104 PMID:18676361 PMID:18719366 PMID:22258452 PMID:27132804 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Arhgap24 |
Rho GTPase activating protein 24 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of ARHGAP24 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823
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G |
Arhgap30 |
Rho GTPase activating protein 30 |
decreases expression |
ISO |
Curcumin results in decreased expression of ARHGAP30 mRNA |
CTD |
PMID:18421014 |
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NCBI chr13:83,822,290...83,843,634
Ensembl chr13:83,822,283...83,854,885
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G |
Arhgdib |
Rho GDP dissociation inhibitor beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ARHGDIB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions increases degradation decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in increased degradation of ARNT protein]; Curcumin results in increased ubiquitination of and results in increased degradation of ARNT protein Curcumin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein co-treated with ARNT protein]]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] Curcumin results in decreased expression of ARNT protein |
CTD |
PMID:16880289 PMID:17880909 PMID:18682687 PMID:19018768 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ATF1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Atf2 |
activating transcription factor 2 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of ATF2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
Curcumin results in increased expression of ATF3 mRNA; Curcumin results in increased expression of ATF3 protein |
CTD |
PMID:15713895 PMID:18555241 PMID:18719366 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions decreases expression |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of AKT3 protein]; ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein] ATF4 inhibits the reaction [Curcumin results in decreased expression of ATF4 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to AKT1 protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein] |
CTD |
PMID:36640941 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of ATF6 protein Curcumin results in increased expression of ATF6 mRNA |
CTD |
PMID:21793155 PMID:29723631 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg4b |
autophagy related 4B, cysteine peptidase |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG4B protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of ATG4B protein]; Curcumin inhibits the reaction [ATF4 protein binds to ATG4B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG4B protein] |
CTD |
PMID:36640941 |
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NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
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G |
Atg5 |
autophagy related 5 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of ATG5 protein Curcumin inhibits the reaction [Tunicamycin results in increased expression of ATG5 protein] |
CTD |
PMID:36640941 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions increases phosphorylation |
ISO |
[Isoflavones co-treated with Curcumin] results in increased phosphorylation of ATM protein Curcumin results in increased phosphorylation of ATM protein |
CTD |
PMID:19401701 PMID:21134073 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Aurka |
aurora kinase A |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKA mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Curcumin analog results in decreased expression of AURKB mRNA |
CTD |
PMID:26409325 |
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NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Axin1 |
axin 1 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of AXIN1 mRNA] Curcumin results in increased expression of AXIN1 mRNA |
CTD |
PMID:25963729 |
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NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
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G |
B3galt6 |
Beta-1,3-galactosyltransferase 6 |
increases expression |
ISO |
Curcumin results in increased expression of B3GALT6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:166,584,202...166,586,338
Ensembl chr 5:166,584,202...166,586,338
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G |
Bace1 |
beta-secretase 1 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Copper results in increased expression of BACE1 mRNA]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of BACE1 mRNA] Curcumin results in increased expression of BACE1 mRNA |
CTD |
PMID:18583042 PMID:31521693 |
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NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of BAD mRNA; Curcumin results in increased expression of BAD protein [arsenic trioxide co-treated with Curcumin] results in increased expression of BAD protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAD protein] |
CTD |
PMID:15569404 PMID:19235267 PMID:27430728 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions decreases expression increases expression increases response to substance |
ISO |
TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein] Curcumin results in decreased expression of BAK1 mRNA Curcumin results in increased expression of BAK1 mRNA; Curcumin results in increased expression of BAK1 protein BAK1 protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:17332930 PMID:18226269 PMID:33582110 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions affects expression decreases expression increases expression affects localization increases response to substance |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of BAX protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of BAX protein; [Curcumin co-treated with Quercetin] results in increased expression of BAX protein; [Curcumin co-treated with Sirolimus] results in increased expression of BAX; [Doxorubicin co-treated with Curcumin] results in increased expression of BAX mRNA; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; Arsenic Trioxide promotes the reaction [Curcumin affects the localization of BAX protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BAX protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of BAX protein]; Curcumin promotes the reaction [Arsenic Trioxide affects the localization of BAX protein]; Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; piperine inhibits the reaction [Curcumin results in decreased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of BAX protein] Curcumin affects the expression of BAX protein Curcumin results in decreased expression of BAX mRNA; Curcumin results in decreased expression of BAX protein Curcumin results in increased expression of BAX mRNA; Curcumin results in increased expression of BAX protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of BAX protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of BAX mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of BAX protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] BAX protein results in increased susceptibility to Curcumin [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin affects the localization of and results in increased expression of and results in increased activity of BAX protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BAX protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of BAX protein] |
CTD |
PMID:15569404 PMID:17096185 PMID:17277231 PMID:17332930 PMID:17531121 PMID:17671742 PMID:18226269 PMID:19235267 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:23222814 PMID:23267840 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:27793699 PMID:27966075 PMID:28681665 PMID:30463061 PMID:30935902 PMID:31628941 PMID:32128952 PMID:33582110 PMID:34577062 PMID:35817260 PMID:36037877 PMID:36305173 PMID:36352148 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of BBC3 mRNA Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] Curcumin results in decreased expression of BBC3 mRNA |
CTD |
PMID:17332930 PMID:22714040 PMID:34047412 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl10 |
BCL10, immune signaling adaptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL10 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] affects the expression of BCL2 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased expression of BCL2 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2 protein; [Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein; [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of BCL2 protein; [Doxorubicin co-treated with Curcumin] results in decreased expression of BCL2 mRNA; [piperine co-treated with Curcumin] results in decreased expression of BCL2 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of BCL2 protein; Curcumin inhibits the reaction [Docetaxel results in increased phosphorylation of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin promotes the reaction [Calcitriol promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]]; Curcumin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Curcumin results in increased ubiquitination of and results in increased degradation of BCL2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein] Curcumin results in increased expression of BCL2 mRNA; Curcumin results in increased expression of BCL2 protein Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein Curcumin analog results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 mRNA; Curcumin results in decreased expression of BCL2 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein] 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of BCL2 protein]; [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 mRNA]; carboxymethyl-chitosan analog promotes the reaction [Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin results in increased expression of BCL2 protein]; Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]; Curcumin promotes the reaction [AGT protein modified form results in increased expression of BCL2 protein] |
CTD |
PMID:12497104 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16219905 PMID:16243823 PMID:17096185 PMID:17332930 PMID:17440100 PMID:17531121 PMID:17596214 PMID:17640567 PMID:17671737 PMID:17671742 PMID:18226269 PMID:18593936 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:19373661 PMID:19944674 PMID:20127174 PMID:20727180 PMID:20869986 PMID:21397623 PMID:21594647 PMID:21595920 PMID:21793155 PMID:22714040 PMID:23452621 PMID:24952339 PMID:25256401 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27430728 PMID:28681665 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30935902 PMID:31628941 PMID:32128952 PMID:32569592 PMID:33582110 PMID:33617879 PMID:34577062 PMID:34675983 PMID:34758851 PMID:35817260 PMID:36037877 PMID:36305173 PMID:36352148 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] Curcumin results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:16219905 PMID:17596214 |
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NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
[Curcumin co-treated with Doxorubicin] affects the expression of BCL2L1 mRNA; [Curcumin co-treated with Isoflavones] results in decreased expression of BCL2L1 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2L1 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein] Curcumin analog results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 mRNA; Curcumin results in decreased expression of BCL2L1 protein Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2L1 protein] [Curcumin co-treated with Gemcitabine] results in decreased expression of BCL2L1 protein Curcumin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:12497104 PMID:15569404 PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:17148446 PMID:17332930 PMID:17440100 PMID:17596214 PMID:17640567 PMID:17671737 PMID:18226269 PMID:18640131 PMID:18829502 PMID:19235267 PMID:19250217 PMID:19372569 PMID:23452621 PMID:30463061 More...
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L11 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BCL2L11 protein |
CTD |
PMID:17332930 PMID:27430728 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bcl2l2 |
Bcl2-like 2 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BCL2L2 mRNA [arsenic trioxide co-treated with Curcumin] affects the expression of BCL2L2 protein |
CTD |
PMID:16101141 PMID:27430728 |
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NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
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G |
Bcl3 |
BCL3, transcription coactivator |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BCL3 mRNA] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BCL3 mRNA] |
CTD |
PMID:18200517 PMID:23452621 |
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NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcor |
BCL6 co-repressor |
increases expression |
ISO |
Curcumin results in increased expression of BCOR mRNA |
CTD |
PMID:17198877 |
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NCBI chr X:10,609,756...10,729,613
Ensembl chr X:10,687,732...10,729,613
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression affects expression |
EXP ISO |
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BDNF protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of BDNF protein] Curcumin results in increased expression of BDNF protein Curcumin affects the expression of BDNF protein [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of BDNF mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of BDNF protein]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA] |
CTD |
PMID:17022948 PMID:17617388 PMID:17827730 PMID:19033880 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 PMID:34577062 More...
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of BECN1 protein Curcumin results in decreased expression of BECN1 protein |
CTD |
PMID:34634291 PMID:36640941 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bgn |
biglycan |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BGN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BID protein; [arsenic trioxide co-treated with Curcumin] results in increased expression of BID protein; Curcumin promotes the reaction [arsenic trioxide results in increased activity of BID protein] |
CTD |
PMID:20605902 PMID:27430728 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 mRNA; Curcumin results in decreased expression of BIRC2 protein Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] |
CTD |
PMID:16023083 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17640567 PMID:17671737 PMID:20727180 PMID:23452621 More...
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression decreases expression |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of BIRC3 protein; [Curcumin co-treated with Doxorubicin] affects the expression of BIRC3 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of BIRC3 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA] [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC3 protein Curcumin results in increased expression of BIRC3 mRNA Curcumin results in decreased expression of BIRC3 mRNA; Curcumin results in decreased expression of BIRC3 protein |
CTD |
PMID:15911101 PMID:16101141 PMID:16219905 PMID:16243823 PMID:17440100 PMID:17596214 PMID:19372569 PMID:27430728 More...
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in decreased expression of BIRC5 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BIRC5 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of BIRC5 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of BIRC5 protein] Curcumin inhibits the reaction [Doxorubicin results in decreased expression of BIRC5 protein] Curcumin analog results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 mRNA; Curcumin results in decreased expression of BIRC5 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of BIRC5 protein |
CTD |
PMID:16023083 PMID:17440100 PMID:17596214 PMID:17671737 PMID:18593936 PMID:19235267 PMID:19372569 PMID:20727180 PMID:23452621 PMID:24664296 PMID:26409325 PMID:27430728 PMID:34047412 PMID:34233590 More...
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Birc7 |
baculoviral IAP repeat-containing 7 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of BIRC7 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of BIRC7 protein |
CTD |
PMID:15911101 PMID:27430728 |
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NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
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G |
Bmp2 |
bone morphogenetic protein 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of BMP2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Brca1 |
BRCA1, DNA repair associated |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein] |
CTD |
PMID:27996348 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Bsg |
basigin (Ok blood group) |
decreases response to substance |
ISO |
BSG protein results in decreased susceptibility to Curcumin |
CTD |
PMID:18379992 |
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NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
Curcumin results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
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NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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G |
C1qb |
complement C1q B chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C1QB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
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G |
C3 |
complement C3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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G |
C4b |
complement C4B |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of C4B mRNA] |
CTD |
PMID:18200517 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
multiple interactions |
ISO EXP |
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CAMK2A mRNA Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CAMK2A protein] |
CTD |
PMID:22911773 PMID:29723552 |
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NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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G |
Capg |
capping actin protein, gelsolin like |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CAPG mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856
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G |
Car9 |
carbonic anhydrase 9 |
decreases expression |
EXP |
Curcumin results in decreased expression of CAR9 mRNA |
CTD |
PMID:18299980 |
|
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Casp1 |
caspase 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of CASP1 mRNA [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of CASP1 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP1 mRNA] |
CTD |
PMID:16101141 PMID:23452621 PMID:34998855 PMID:35063475 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of CASP12 protein Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein] |
CTD |
PMID:21793155 PMID:25541178 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp2 |
caspase 2 |
increases expression |
ISO |
Curcumin results in increased expression of CASP2 mRNA |
CTD |
PMID:16101141 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases cleavage increases activity decreases activity increases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP3 protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of and results in increased cleavage of CASP3 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CASP3 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP3 protein]] Curcumin results in decreased expression of CASP3 protein modified form Curcumin results in increased cleavage of CASP3 protein Curcumin results in decreased activity of CASP3 protein [Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased expression of CASP3 mRNA]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Atrazine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CASP3 protein]; Curcumin inhibits the reaction [Cyclosporine results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]; Curcumin results in decreased cleavage of and results in decreased activity of CASP3 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP3 protein; [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP3 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Curcumin inhibits the reaction [Rotenone results in increased activity of CASP3 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP3 protein; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form] Curcumin results in increased expression of CASP3 mRNA; Curcumin results in increased expression of CASP3 protein; Curcumin results in increased expression of CASP3 protein modified form Curcumin analog results in increased activity of CASP3 protein; Curcumin results in increased activity of CASP3; Curcumin results in increased activity of CASP3 protein Curcumin results in decreased expression of CASP3 mRNA; Curcumin results in decreased expression of CASP3 protein |
CTD |
PMID:15095415 PMID:15569404 PMID:16023083 PMID:16101141 PMID:17041101 PMID:17096185 PMID:17148446 PMID:17277231 PMID:17332930 PMID:17351913 PMID:17363495 PMID:17440100 PMID:17640567 PMID:17671742 PMID:17885582 PMID:18555241 PMID:19235267 PMID:19294764 PMID:19373661 PMID:19401701 PMID:20127174 PMID:20605902 PMID:20869986 PMID:21397623 PMID:21450334 PMID:21594647 PMID:21595920 PMID:22523229 PMID:23267840 PMID:23555722 PMID:23710286 PMID:24863870 PMID:24952339 PMID:25541178 PMID:25963729 PMID:26409325 PMID:26612707 PMID:27132804 PMID:27288928 PMID:27375190 PMID:27430728 PMID:27535828 PMID:27966075 PMID:28681665 PMID:29315967 PMID:29571711 PMID:30138604 PMID:30431687 PMID:30463061 PMID:30935902 PMID:31712109 PMID:31820278 PMID:32569592 PMID:33582110 PMID:33617879 PMID:34042043 PMID:34577062 PMID:34675983 PMID:34994998 PMID:35817260 PMID:36037877 PMID:36305173 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
ISO |
Curcumin results in increased expression of CASP4 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
multiple interactions increases expression decreases expression |
ISO |
[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP7 protein Curcumin results in increased expression of CASP7 protein Curcumin results in decreased expression of CASP7 mRNA |
CTD |
PMID:16023083 PMID:16101141 PMID:19373661 PMID:31628941 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions increases cleavage decreases expression |
ISO EXP |
Curcumin results in increased activity of CASP8 protein Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA] Curcumin results in increased cleavage of CASP8 protein Curcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein] |
CTD |
PMID:14555224 PMID:16173963 PMID:17096185 PMID:17148446 PMID:22523229 PMID:23267840 PMID:23452621 PMID:25541178 PMID:27430728 PMID:33582110 More...
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
decreases expression multiple interactions increases activity increases expression increases cleavage |
ISO EXP |
Curcumin results in decreased expression of CASP9 mRNA; Curcumin results in decreased expression of CASP9 protein Curcumin inhibits the reaction [aristolochic acid I results in increased expression of and results in increased cleavage of CASP9 protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased expression of CASP9 mRNA]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of CASP9 mRNA] Curcumin results in increased activity of CASP9 protein Curcumin results in increased expression of CASP9 mRNA; Curcumin results in increased expression of CASP9 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CASP9 protein; [Quercetin co-treated with Curcumin] inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CASP9 protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein Curcumin results in increased cleavage of CASP9 protein [Curcumin co-treated with Arsenic Trioxide] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Calcitriol] promotes the reaction [Paclitaxel results in increased expression of CASP9 protein]; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Doxorubicin co-treated with Curcumin] results in increased expression of CASP9 mRNA; [Paclitaxel co-treated with Calcitriol] promotes the reaction [Curcumin results in increased expression of CASP9 protein]; [Paclitaxel co-treated with Curcumin] promotes the reaction [Calcitriol results in increased expression of CASP9 protein]; Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]; Curcumin promotes the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of CASP9 protein]; Curcumin results in increased cleavage of and results in increased activity of CASP9 protein; Paclitaxel promotes the reaction [Curcumin results in increased expression of CASP9 protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased activity of CASP9 protein]] |
CTD |
PMID:14555224 PMID:16023083 PMID:16101141 PMID:17148446 PMID:17277231 PMID:17440100 PMID:17671742 PMID:18555241 PMID:19095035 PMID:19373661 PMID:20605902 PMID:20869986 PMID:21594647 PMID:27375190 PMID:28681665 PMID:31628941 PMID:31712109 PMID:32128952 PMID:33582110 PMID:34994998 PMID:36037877 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
[arsenite co-treated with Curcumin] results in increased expression of CAT protein; Curcumin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]; Curcumin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Vehicle Emissions promotes the reaction [Cisplatin results in decreased activity of CAT protein]]; Curcumin inhibits the reaction [Vehicle Emissions results in decreased activity of CAT protein] Curcumin results in increased expression of CAT protein Curcumin results in increased activity of CAT protein Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Chloranil results in decreased activity of CAT protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CAT]; Curcumin metabolite inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; sodium arsenite inhibits the reaction [Curcumin results in increased activity of CAT protein] Curcumin results in increased expression of CAT mRNA [Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased activity of CAT protein]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylonitrile results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased activity of CAT protein]; Curcumin inhibits the reaction [APP protein modified form results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Arsenic results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Colistin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Paraquat results in decreased activity of CAT protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of CAT protein] |
CTD |
PMID:16770732 PMID:17076682 PMID:17351913 PMID:17461496 PMID:18299980 PMID:18392098 PMID:19481068 PMID:19631675 PMID:19913070 PMID:19914224 PMID:20112103 PMID:20593964 PMID:21574897 PMID:21976817 PMID:22704994 PMID:24113306 PMID:24347089 PMID:24760747 PMID:25123790 PMID:25169090 PMID:25461551 PMID:27375190 PMID:28951138 PMID:29205955 PMID:29315967 PMID:30138604 PMID:30423402 PMID:30934151 PMID:30946834 PMID:31081568 PMID:31199764 PMID:31330227 PMID:31407471 PMID:31521693 PMID:31714633 PMID:32735850 PMID:33350580 PMID:34577062 PMID:34758851 PMID:34802538 PMID:35063475 PMID:35817260 PMID:36924976 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cbr1 |
carbonyl reductase 1 |
multiple interactions |
ISO |
[[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; Curcumin binds to and results in decreased activity of CBR1 protein; Curcumin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]; Curcumin inhibits the reaction [NADP metabolite binds to and results in increased activity of CBR1 protein] |
CTD |
PMID:25541467 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCAR1 protein |
CTD |
PMID:21594647 |
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NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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G |
Ccdc116 |
coiled-coil domain containing 116 |
increases expression |
ISO |
Curcumin results in increased expression of CCDC116 mRNA |
CTD |
PMID:18200517 |
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NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression increases expression |
ISO EXP |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]] Curcumin results in decreased expression of CCL2 mRNA; Curcumin results in decreased expression of CCL2 protein Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA] Curcumin results in increased expression of CCL2 mRNA |
CTD |
PMID:10925121 PMID:11053056 PMID:17198877 PMID:17666914 PMID:18403477 PMID:19152916 PMID:20712904 PMID:22683883 PMID:23452621 PMID:33952798 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CCN2 mRNA; Curcumin results in decreased expression of CCN2 protein IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; Lipopolysaccharides inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA]; PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA] |
CTD |
PMID:17965732 PMID:19764552 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCNA2 protein] Curcumin results in decreased expression of CCNA2 protein |
CTD |
PMID:23222814 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCNB1 mRNA; Curcumin results in decreased expression of CCNB1 protein |
CTD |
PMID:17148446 PMID:18719366 PMID:19401701 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions increases expression decreases expression increases degradation |
ISO EXP |
[Curcumin co-treated with Isoflavones] results in decreased expression of CCND1 protein; calyculin A inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein]; piperine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] Curcumin results in increased expression of CCND1 mRNA Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of CCND1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA] Curcumin results in decreased expression of CCND1; Curcumin results in decreased expression of CCND1 protein [Curcumin co-treated with Gemcitabine] results in decreased expression of CCND1 protein Curcumin analog results in decreased expression of CCND1 protein; Curcumin results in decreased expression of CCND1 mRNA; Curcumin results in decreased expression of CCND1 protein |
CTD |
PMID:15486348 PMID:15489888 PMID:15738001 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16959222 PMID:17041101 PMID:17148446 PMID:17440100 PMID:17531121 PMID:17602960 PMID:17640567 PMID:17885582 PMID:18156803 PMID:18226269 PMID:18316600 PMID:18593936 PMID:18640131 PMID:18790744 PMID:18829502 PMID:19189304 PMID:19372569 PMID:19501152 PMID:19573523 PMID:20727180 PMID:24211270 PMID:24508477 PMID:25822711 PMID:25963729 PMID:27996348 PMID:30935902 PMID:34233590 PMID:36640941 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CCND3 protein] Curcumin results in decreased expression of CCND3 protein |
CTD |
PMID:23222814 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
decreases expression multiple interactions increases degradation |
ISO EXP |
Curcumin results in decreased expression of CCNE1 protein Curcumin results in decreased expression of CCNE1 mRNA Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of CCNE1 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]; lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] |
CTD |
PMID:17148446 PMID:18156803 PMID:18299980 PMID:36640941 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccpg1 |
cell cycle progression 1 |
increases expression |
ISO |
Curcumin results in increased expression of CCPG1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of CCR2 mRNA |
CTD |
PMID:18403477 |
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NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Cd14 |
CD14 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein] |
CTD |
PMID:18180316 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd36 |
CD36 molecule |
decreases expression increases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CD36 mRNA Curcumin results in increased expression of CD36 mRNA Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 protein] Curcumin results in decreased expression of CD36 mRNA; Curcumin results in decreased expression of CD36 protein |
CTD |
PMID:16713233 PMID:23386263 PMID:23603106 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40 |
CD40 molecule |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CD40 mRNA CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein] [arsenic trioxide co-treated with Curcumin] results in increased expression of CD40 protein |
CTD |
PMID:16101141 PMID:27430728 PMID:35549587 |
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NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in increased expression of CD40LG protein |
CTD |
PMID:27430728 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Curcumin results in increased expression of CD44 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd47 |
Cd47 molecule |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CD47 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
decreases expression |
ISO |
Curcumin results in decreased expression of CD55 mRNA |
CTD |
PMID:17999991 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cdc14b |
cell division cycle 14B |
increases expression |
ISO |
Curcumin results in increased expression of CDC14B mRNA |
CTD |
PMID:17198877 |
|
NCBI chr17:844,686...934,787
Ensembl chr17:844,685...933,235
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G |
Cdc20 |
cell division cycle 20 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDC20 mRNA |
CTD |
PMID:22258452 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc25c |
cell division cycle 25C |
increases phosphorylation |
ISO |
Curcumin results in increased phosphorylation of CDC25C protein |
CTD |
PMID:19401701 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdh1 |
cadherin 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of CDH1 protein Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of CDH1 protein] [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDH1 mRNA; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in decreased expression of CDH1 protein] |
CTD |
PMID:19573523 PMID:25656647 PMID:26191140 PMID:34233590 PMID:35487055 PMID:36640941 More...
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh11 |
cadherin 11 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH11 protein |
CTD |
PMID:18025290 |
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NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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G |
Cdh17 |
cadherin 17 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDH17 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
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G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Trichloroethylene results in increased expression of CDH2 protein] Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]] |
CTD |
PMID:26191140 PMID:34233590 PMID:35549587 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
EXP ISO |
Curcumin results in decreased expression of CDK1 mRNA Curcumin results in decreased expression of CDK1 mRNA; Curcumin results in decreased expression of CDK1 protein |
CTD |
PMID:17148446 PMID:18299980 PMID:19401701 PMID:22258452 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of CDK2 protein] Curcumin results in decreased expression of CDK2 protein Curcumin analog results in decreased expression of CDK2 mRNA; Curcumin results in decreased expression of CDK2 protein |
CTD |
PMID:19501152 PMID:23222814 PMID:26409325 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK4 mRNA; Curcumin results in decreased expression of CDK4 protein |
CTD |
PMID:18156803 PMID:24211270 PMID:26409325 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk5 |
cyclin-dependent kinase 5 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK5 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CDK6 protein |
CTD |
PMID:18156803 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK7 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdk9 |
cyclin-dependent kinase 9 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of CDK9 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression decreases expression |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1A protein; [bicalutamide co-treated with Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein; [piperine co-treated with Curcumin] results in decreased expression of CDKN1A protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1A protein]; EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CDKN1A protein] [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDKN1A protein] Curcumin results in increased expression of CDKN1A; Curcumin results in increased expression of CDKN1A mRNA; Curcumin results in increased expression of CDKN1A protein [Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of CDKN1A protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] |
CTD |
PMID:15713895 PMID:15738001 PMID:17148446 PMID:17332326 PMID:17602960 PMID:18156803 PMID:18161303 PMID:18226269 PMID:18316600 PMID:18593936 PMID:20153625 PMID:23222814 PMID:25644192 PMID:25822711 PMID:27132804 PMID:27430728 PMID:28681665 PMID:30935902 PMID:33582110 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of CDKN1B mRNA; Curcumin results in increased expression of CDKN1B protein Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein; AR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; Dihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein] Curcumin results in decreased expression of CDKN1B protein |
CTD |
PMID:15713895 PMID:17602960 PMID:18156803 PMID:18226269 PMID:18593936 PMID:21594647 PMID:25822711 PMID:27132804 PMID:27430728 PMID:36352148 More...
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of CDKN2A protein Curcumin results in increased expression of CDKN2A protein |
CTD |
PMID:17148446 PMID:18156803 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cdkn2d |
cyclin dependent kinase inhibitor 2D |
decreases expression |
EXP |
Curcumin results in decreased expression of CDKN2D mRNA |
CTD |
PMID:18299980 |
|
NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
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G |
Cdx2 |
caudal type homeo box 2 |
increases expression |
EXP ISO |
Curcumin results in increased expression of CDX2 mRNA |
CTD |
PMID:18299980 PMID:27237783 |
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NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of CEBPA mRNA] |
CTD |
PMID:19297423 PMID:28595985 |
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NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CEBPB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces3a |
carboxylesterase 3a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CES3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr19:32,992,386...33,000,562
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] Curcumin results in decreased expression of CFLAR protein |
CTD |
PMID:16173963 PMID:16219905 PMID:23452621 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions increases activity affects localization |
ISO |
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form]; Curcumin analog inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] Curcumin results in increased activity of CFTR protein; Curcumin results in increased activity of CFTR protein mutant form Curcumin affects the localization of CFTR protein mutant form Curcumin affects the folding of and affects the localization of CFTR protein mutant form |
CTD |
PMID:15105504 PMID:15280357 PMID:15582996 PMID:17178710 PMID:23978416 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHAT protein] |
CTD |
PMID:21839772 |
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NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
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G |
Chek1 |
checkpoint kinase 1 |
decreases response to substance multiple interactions increases activity increases phosphorylation |
ISO |
CHEK1 protein results in decreased susceptibility to Curcumin Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein] Curcumin results in increased activity of CHEK1 protein Curcumin results in increased phosphorylation of CHEK1 protein |
CTD |
PMID:18602917 PMID:19401701 PMID:27996348 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions increases phosphorylation |
ISO |
[Curcumin co-treated with Dihydrotestosterone] results in increased phosphorylation of CHEK2 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of CHEK2 protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein; Flutamide inhibits the reaction [[Dihydrotestosterone co-treated with Curcumin] results in increased phosphorylation of CHEK2 protein] Curcumin results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:21134073 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chrm2 |
cholinergic receptor, muscarinic 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of CHRM2 mRNA] |
CTD |
PMID:24952339 |
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NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions decreases activity |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein] Curcumin results in decreased activity of CHUK protein |
CTD |
PMID:15129424 PMID:15489888 PMID:16023083 PMID:16219905 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Ckb |
creatine kinase B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Ckm |
creatine kinase, M-type |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [lead acetate results in increased secretion of [CKM protein binds to CKB protein]] |
CTD |
PMID:21378372 PMID:29315967 |
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NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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G |
Clca4 |
chloride channel accessory 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CLCA4A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
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G |
Clcn6 |
chloride voltage-gated channel 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of CLCN6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
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G |
Cldn1 |
claudin 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein] |
CTD |
PMID:35817260 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cldn2 |
claudin 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [maleic acid results in decreased expression of CLDN2] |
CTD |
PMID:25119790 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
EXP ISO |
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]] Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA] Curcumin results in decreased expression of COL1A1 mRNA; Curcumin results in decreased expression of COL1A1 protein |
CTD |
PMID:17355460 PMID:17434272 PMID:17531121 PMID:17602960 PMID:17965732 PMID:18006644 PMID:28700904 PMID:32718261 More...
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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G |
Col27a1 |
collagen type XXVII alpha 1 chain |
increases expression |
EXP |
Curcumin results in increased expression of COL27A1 mRNA |
CTD |
PMID:18299980 |
|
NCBI chr 5:76,647,302...76,765,989
Ensembl chr 5:76,647,429...76,765,174
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G |
Col2a1 |
collagen type II alpha 1 chain |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of COL2A1 mRNA; Curcumin results in increased expression of COL2A1 protein [resveratrol co-treated with Curcumin] results in increased expression of COL2A1 protein |
CTD |
PMID:18321735 PMID:19889203 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] |
CTD |
PMID:22683883 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a1 |
collagen type IV alpha 1 chain |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of COL4A1 mRNA Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA] Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA] |
CTD |
PMID:18200517 PMID:21594647 PMID:28700904 |
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NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Col4a2 |
collagen type IV alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
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G |
Col4a5 |
collagen type IV alpha 5 chain |
decreases expression |
ISO |
Curcumin results in decreased expression of COL4A5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692
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G |
Col5a1 |
collagen type V alpha 1 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL5A2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Curcumin results in increased expression of CPT1A mRNA |
CTD |
PMID:19297423 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions increases phosphorylation |
EXP ISO |
Curcumin results in increased expression of CREB1 mRNA 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein] [Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of CREB1 mRNA; Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CREB1 protein] Curcumin results in increased phosphorylation of CREB1 protein |
CTD |
PMID:17022948 PMID:18299980 PMID:22911773 PMID:27966075 PMID:29723552 PMID:32735850 More...
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3 |
cAMP responsive element binding protein 3 |
increases expression |
EXP |
Curcumin results in increased expression of CREB3 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:57,817,865...57,823,233
Ensembl chr 5:57,817,832...57,824,390
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G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Crp |
C-reactive protein |
multiple interactions |
EXP ISO |
Curcumin analog inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased secretion of CRP protein]; Curcumin inhibits the reaction [Fructose results in increased expression of CRP protein]; Curcumin inhibits the reaction [lead acetate results in increased secretion of CRP protein] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of CRP protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of CRP protein] |
CTD |
PMID:21378372 PMID:26713546 PMID:30431687 PMID:31820278 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
ISO EXP |
Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] [Curcumin co-treated with arsenite] results in increased expression of CRYAB mRNA; [Curcumin co-treated with Cadmium Chloride] results in increased expression of CRYAB protein; Curcumin promotes the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:9764755 |
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NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cs |
citrate synthase |
affects expression |
EXP |
Curcumin affects the expression of CS mRNA |
CTD |
PMID:18539377 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] |
CTD |
PMID:15129424 |
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NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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G |
Csf1r |
colony stimulating factor 1 receptor |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [CSF1 protein results in increased phosphorylation of CSF1R protein] Curcumin results in increased expression of CSF1R mRNA |
CTD |
PMID:15129424 PMID:22714040 |
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NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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G |
Csf2ra |
colony stimulating factor 2 receptor subunit alpha |
increases expression |
ISO |
Curcumin results in increased expression of CSF2RA mRNA |
CTD |
PMID:22714040 |
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NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128
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G |
Csf2rb |
colony stimulating factor 2 receptor subunit beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CSF2RB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression increases expression multiple interactions decreases phosphorylation increases degradation |
ISO EXP |
Curcumin analog results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 mRNA; Curcumin results in decreased expression of CTNNB1 protein Curcumin results in increased expression of CTNNB1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; Curcumin results in decreased phosphorylation of and affects the localization of CTNNB1 protein Curcumin results in decreased phosphorylation of CTNNB1 protein [piperine co-treated with Curcumin] results in decreased expression of CTNNB1 protein; Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]; Vitamin E inhibits the reaction [Curcumin results in decreased expression of CTNNB1 protein] Curcumin analog results in increased degradation of CTNNB1 protein; Curcumin results in increased degradation of CTNNB1 protein |
CTD |
PMID:10783313 PMID:17041101 PMID:19294764 PMID:19573523 PMID:25963729 PMID:27645308 PMID:30935902 More...
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein] Curcumin analog results in decreased expression of CTSB mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsd |
cathepsin D |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; Curcumin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] Curcumin analog results in decreased expression of CTSD mRNA |
CTD |
PMID:8534267 PMID:26409325 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Ctsl |
cathepsin L |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSL protein |
CTD |
PMID:34138966 |
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NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Ctss |
cathepsin S |
decreases expression |
ISO |
Curcumin results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
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NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions decreases expression |
ISO |
NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein |
CTD |
PMID:17999991 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:18660423 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
Curcumin results in decreased expression of CXCL14 mRNA |
CTD |
PMID:19555370 |
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NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of CXCL2 mRNA; Curcumin results in decreased expression of CXCL2 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CXCL2 mRNA] Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA] |
CTD |
PMID:17999991 PMID:18001810 PMID:18200517 PMID:27194111 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCL1 mRNA; Curcumin results in decreased expression of CXCL1 protein Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 mRNA]; Curcumin inhibits the reaction [Fluorouracil results in increased expression of CXCL1 protein] NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA] |
CTD |
PMID:17999991 PMID:27194111 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcr1 |
C-X-C motif chemokine receptor 1 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR1 protein |
CTD |
PMID:12216086 |
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NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
increases expression |
ISO |
Curcumin results in increased expression of CXCR2 protein |
CTD |
PMID:12216086 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of CXCR4 mRNA Curcumin inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 mRNA] |
CTD |
PMID:17198877 PMID:18660423 |
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NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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G |
Cycs |
cytochrome c, somatic |
affects localization multiple interactions |
ISO |
Curcumin affects the localization of CYCS protein [Arsenic Trioxide co-treated with Curcumin] results in increased expression of CYCS protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in increased expression of CYCS protein |
CTD |
PMID:19235267 PMID:27430728 PMID:33617879 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases activity increases expression decreases activity decreases expression |
ISO EXP |
Acetylcysteine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; Curcumin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; decitabine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; trichostatin A affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A1 mRNA] Curcumin results in increased activity of CYP1A1 protein Curcumin results in increased expression of CYP1A1 mRNA Curcumin results in decreased activity of CYP1A1 protein Curcumin results in decreased expression of CYP1A1 mRNA Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:11454723 PMID:12628514 PMID:15841493 PMID:16288784 PMID:17012224 PMID:17880909 PMID:18321868 PMID:19018768 PMID:20015472 PMID:20816778 PMID:22867086 PMID:27041069 PMID:34802538 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity multiple interactions |
ISO EXP |
Curcumin results in decreased activity of CYP1A2 protein Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA] Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
CTD |
PMID:15841493 PMID:16288784 PMID:18321868 PMID:34802538 PMID:35063475 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Curcumin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Curcumin results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:17637178 PMID:19018768 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA Curcumin results in increased expression of CYP24A1 protein |
CTD |
PMID:20153625 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
affects expression multiple interactions |
EXP |
Curcumin affects the expression of CYP2B1 protein Curcumin inhibits the reaction [CYP2B1 protein results in increased metabolism of nitrosobenzylmethylamine] |
CTD |
PMID:16805852 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2c7 |
cytochrome P450, family 2, subfamily c, polypeptide 7 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CYP2C9 protein] |
CTD |
PMID:16288784 |
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NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of CYP2D6 mRNA |
CTD |
PMID:33582110 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Curcumin affects the expression of CYP2E1 protein Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA] Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein] Curcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein] Curcumin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:16805852 PMID:18539377 PMID:24508477 PMID:30423402 PMID:33350580 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases expression multiple interactions increases expression |
ISO |
Curcumin results in decreased expression of CYP3A4 mRNA [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Curcumin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] Curcumin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:17210444 PMID:17270371 PMID:17965521 PMID:18385293 PMID:20153625 PMID:20816778 More...
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Curcumin results in increased expression of CYP4A3 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyth4 |
cytohesin 4 |
increases expression |
ISO |
Curcumin results in increased expression of CYTH4 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
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G |
Daxx |
death-domain associated protein |
increases expression |
ISO |
Curcumin results in increased expression of DAXX mRNA |
CTD |
PMID:16101141 |
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NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Dbn1 |
drebrin 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Glucose results in decreased expression of DBN1 mRNA] |
CTD |
PMID:23333261 |
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NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
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G |
Dcn |
decorin |
increases expression |
ISO |
Curcumin results in increased expression of DCN mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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G |
Dcx |
doublecortin |
multiple interactions increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DCX mRNA] Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DCX protein] Curcumin results in increased expression of DCX mRNA |
CTD |
PMID:25963729 PMID:32735850 |
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NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] Curcumin results in increased expression of DDIT3 mRNA; Curcumin results in increased expression of DDIT3 protein |
CTD |
PMID:16613838 PMID:17171638 PMID:18200517 PMID:18719366 PMID:21793155 PMID:27996348 PMID:29723631 More...
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
decreases expression increases expression |
ISO EXP |
Curcumin results in decreased expression of DDIT4L mRNA Curcumin results in increased expression of DDIT4L mRNA |
CTD |
PMID:17999991 PMID:18299980 |
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NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Dffb |
DNA fragmentation factor subunit beta |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of DFFB mRNA; Curcumin results in increased expression of DFFB protein Curcumin results in decreased expression of DFFB protein |
CTD |
PMID:21397623 PMID:22714040 |
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NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of DHCR24 mRNA Curcumin affects the expression of DHCR24 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of DHCR7 mRNA Curcumin results in decreased expression of DHCR7 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhrs1 |
dehydrogenase/reductase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of DHRS1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr15:29,236,522...29,243,807
Ensembl chr15:29,236,522...29,243,838
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects localization multiple interactions increases expression increases response to substance |
ISO |
Curcumin affects the localization of DIABLO protein [arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein Curcumin results in increased expression of DIABLO mRNA DIABLO protein results in increased susceptibility to Curcumin |
CTD |
PMID:17277231 PMID:23555722 PMID:27430728 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
decreases expression multiple interactions |
EXP |
Curcumin results in decreased expression of DKK1 mRNA; Curcumin results in decreased expression of DKK1 protein Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of DKK1 protein] |
CTD |
PMID:25963729 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DLG4 protein] |
CTD |
PMID:29723552 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO |
Curcumin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Potassium Dichromate results in increased expression of DNM1L protein] |
CTD |
PMID:32980475 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression affects expression multiple interactions increases activity |
ISO |
Curcumin results in decreased expression of DNMT1 mRNA; Curcumin results in decreased expression of DNMT1 protein Curcumin analog affects the expression of DNMT1 protein Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]; Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein] Curcumin analog results in decreased expression of DNMT1 protein |
CTD |
PMID:23593078 PMID:26991801 PMID:27132804 PMID:29228771 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3A mRNA Curcumin analog results in decreased expression of DNMT3A protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression |
ISO |
Curcumin results in decreased expression of DNMT3B mRNA Curcumin analog results in decreased expression of DNMT3B protein |
CTD |
PMID:23593078 PMID:26991801 PMID:29228771 |
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NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
increases expression |
ISO |
Curcumin results in increased expression of DRAM1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of DRD2 protein] |
CTD |
PMID:27966075 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of DUSP1 mRNA Curcumin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of DUSP1 protein] |
CTD |
PMID:15713895 PMID:20885979 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp10 |
dual specificity phosphatase 10 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP10 mRNA |
CTD |
PMID:15713895 PMID:17151092 |
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NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
Curcumin results in increased expression of DUSP5 mRNA |
CTD |
PMID:17198877 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dvl1 |
dishevelled segment polarity protein 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of DVL1 protein] Curcumin results in decreased expression of DVL1 protein Curcumin results in increased expression of DVL1 mRNA; Curcumin results in increased expression of DVL1 protein |
CTD |
PMID:19573523 PMID:25963729 |
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NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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G |
Dynll1 |
dynein light chain LC8-type 1 |
increases expression |
ISO |
Curcumin results in increased expression of DYNLL1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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G |
Dyrk2 |
dual specificity tyrosine phosphorylation regulated kinase 2 |
decreases activity multiple interactions |
ISO |
Curcumin results in decreased activity of DYRK2 protein [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein |
CTD |
PMID:33617879 |
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NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of E2F1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f5 |
E2F transcription factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of E2F5 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
EXP |
Curcumin results in increased expression of ECH1 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Edaradd |
EDAR associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA] |
CTD |
PMID:23452621 |
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NCBI chr17:85,866,629...85,910,612
Ensembl chr17:85,656,905...85,910,447
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G |
Edil3 |
EGF like repeats and discoidin domains 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of EDIL3 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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G |
Egf |
epidermal growth factor |
multiple interactions decreases activity |
ISO EXP |
Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] Curcumin results in decreased activity of EGF protein Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein] |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:18214481 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions decreases phosphorylation decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Acrylamide results in increased expression of EGFR protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of EGFR protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of EGFR protein]; Curcumin results in decreased expression of and results in decreased activity of EGFR protein; Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of EGFR protein]; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of EGFR protein] Curcumin results in decreased phosphorylation of EGFR protein Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA] Curcumin analog results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR mRNA; Curcumin results in decreased expression of EGFR protein |
CTD |
PMID:10851300 PMID:15129424 PMID:15486348 PMID:17372590 PMID:17918158 PMID:18006644 PMID:18214481 PMID:18332871 PMID:18719366 PMID:24508477 PMID:26409325 PMID:34994998 More...
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
EGR1 protein affects the reaction [Curcumin results in increased expression of CDKN1A protein]; EGR1 protein promotes the reaction [Curcumin results in increased expression of CDKN1A mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of EGR1 protein]; U 0126 inhibits the reaction [Curcumin results in increased expression of EGR1 protein] Curcumin results in increased expression of EGR1 mRNA; Curcumin results in increased expression of EGR1 protein Curcumin results in decreased expression of EGR1 mRNA |
CTD |
PMID:17198877 PMID:17999991 PMID:18316600 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of EIF1 mRNA |
CTD |
PMID:17999991 |
|
NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of EIF4EBP1 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of EIF4EBP1 protein] Curcumin results in decreased expression of EIF4EBP1 protein |
CTD |
PMID:18790744 PMID:23222814 PMID:34634291 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eif4g1 |
eukaryotic translation initiation factor 4 gamma 1 |
decreases phosphorylation |
ISO |
Curcumin results in decreased phosphorylation of EIF4G1 protein |
CTD |
PMID:18790744 |
|
NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941
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G |
Elf2 |
E74 like ETS transcription factor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of ELF2 mRNA |
CTD |
PMID:15713895 |
|
NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947
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G |
Elk1 |
ETS transcription factor ELK1 |
multiple interactions increases phosphorylation |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of ELK1 mRNA]; pyrazolanthrone inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of ELK1 protein] |
CTD |
PMID:18316600 PMID:23452621 |
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NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
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G |
Emb |
embigin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of EMB mRNA] |
CTD |
PMID:18200517 |
|
NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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G |
Eno1 |
enolase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ENO1 mRNA |
CTD |
PMID:16880289 |
|
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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G |
Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
increases expression |
EXP |
Curcumin results in increased expression of ENTPD5 mRNA |
CTD |
PMID:18299980 |
|
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions decreases activity decreases expression affects localization |
ISO EXP |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of EP300 protein]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]] Curcumin results in decreased activity of EP300 protein Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein] Curcumin results in decreased expression of EP300 mRNA; Curcumin results in decreased expression of EP300 protein |
CTD |
PMID:17927689 PMID:22228707 PMID:22258452 PMID:26612707 |
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NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] |
CTD |
PMID:20554536 |
|
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Epcam |
epithelial cell adhesion molecule |
multiple interactions decreases expression |
ISO |
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein] Curcumin results in decreased expression of EPCAM mRNA; Curcumin results in decreased expression of EPCAM protein |
CTD |
PMID:33539684 |
|
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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G |
Epo |
erythropoietin |
decreases expression |
ISO |
Curcumin results in decreased expression of EPO mRNA |
CTD |
PMID:16880289 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Epx |
eosinophil peroxidase |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of EPX protein] |
CTD |
PMID:34998855 |
|
NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions increases response to substance increases degradation decreases expression |
ISO |
[ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Doxorubicin]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased expression of and results in decreased activity of ERBB2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB2 protein ERBB2 protein results in increased susceptibility to Curcumin; ERBB2 protein results in increased susceptibility to Curcumin analog Curcumin analog results in increased degradation of ERBB2 protein Curcumin analog results in decreased expression of ERBB2 mRNA; Curcumin analog results in decreased expression of ERBB2 protein; Curcumin results in decreased expression of ERBB2 mRNA; Curcumin results in decreased expression of ERBB2 protein |
CTD |
PMID:17041101 PMID:17918158 PMID:18719366 PMID:25866362 PMID:26409325 PMID:34291863 More...
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
multiple interactions decreases expression |
ISO |
Curcumin promotes the reaction [Folfox protocol results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein; Fluorouracil promotes the reaction [Curcumin results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of ERBB3 protein] Curcumin analog results in decreased expression of ERBB3 mRNA; Curcumin results in decreased expression of ERBB3 mRNA |
CTD |
PMID:15713895 PMID:17918158 PMID:26409325 |
|
NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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G |
Ercc1 |
ERCC excision repair 1, endonuclease non-catalytic subunit |
multiple interactions decreases expression |
ISO EXP |
[Curcumin results in decreased expression of ERCC1 protein] which results in increased susceptibility to Cisplatin; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC1 protein] Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA] Curcumin results in decreased expression of ERCC1 mRNA; Curcumin results in decreased expression of ERCC1 protein |
CTD |
PMID:17596214 PMID:21493726 PMID:22228707 |
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NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA] Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ERCC4 protein] Curcumin results in decreased expression of ERCC4 mRNA; Curcumin results in decreased expression of ERCC4 protein |
CTD |
PMID:22228707 |
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NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of ERN1 mRNA Curcumin results in increased expression of ERN1 mRNA |
CTD |
PMID:17999991 PMID:29723631 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased degradation of ESR1 protein]; Curcumin inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; Curcumin inhibits the reaction [fulvestrant results in increased degradation of ESR1 protein] Curcumin results in decreased expression of ESR1 protein |
CTD |
PMID:15899841 PMID:18347134 PMID:23222814 PMID:24211270 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of ETS2 protein |
CTD |
PMID:17332326 |
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NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein] |
CTD |
PMID:18565277 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of F2R mRNA] |
CTD |
PMID:23452621 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
F3 |
coagulation factor III, tissue factor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA] |
CTD |
PMID:18983524 |
|
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fadd |
Fas associated via death domain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FADD mRNA] |
CTD |
PMID:23452621 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fads1 |
fatty acid desaturase 1 |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FADS1 mRNA Curcumin results in decreased expression of FADS1 mRNA |
CTD |
PMID:27208389 |
|
NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of FADS2 mRNA Curcumin affects the expression of FADS2 mRNA |
CTD |
PMID:27208389 |
|
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fam120b |
family with sequence similarity 120 member B |
decreases expression |
ISO |
Curcumin results in decreased expression of FAM120B mRNA |
CTD |
PMID:17999991 |
|
NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] Curcumin results in decreased expression of FANCD2 mRNA |
CTD |
PMID:24124520 |
|
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fanci |
FA complementation group I |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] Curcumin results in decreased expression of FANCI mRNA |
CTD |
PMID:24124520 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FAS protein |
CTD |
PMID:27430728 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions decreases expression |
ISO EXP |
[arsenic trioxide co-treated with Curcumin] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FASLG mRNA] Curcumin results in decreased expression of FASLG mRNA |
CTD |
PMID:10925121 PMID:16101141 PMID:17351739 PMID:23452621 PMID:27430728 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of FASN mRNA; Curcumin affects the expression of FASN protein Curcumin results in decreased expression of FASN mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbln2 |
fibulin 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FBLN2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948
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G |
Fcgr3a |
Fc gamma receptor 3A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FCGR3A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of FDFT1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression decreases expression affects expression |
ISO EXP |
Curcumin results in increased expression of FDPS mRNA Curcumin results in decreased expression of FDPS mRNA Curcumin affects the expression of FDPS mRNA |
CTD |
PMID:16713233 PMID:27208389 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of FGF2 protein Curcumin results in increased expression of FGF2 protein |
CTD |
PMID:23555722 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgf5 |
fibroblast growth factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGF5 mRNA |
CTD |
PMID:27237783 |
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NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FGFR2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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G |
Filip1l |
filamin A interacting protein 1-like |
increases expression |
ISO |
Curcumin results in increased expression of FILIP1L mRNA |
CTD |
PMID:21594647 |
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NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of FIS1 protein] |
CTD |
PMID:28698153 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein] Curcumin results in decreased expression of FLT1 protein |
CTD |
PMID:18593936 PMID:23845850 |
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NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
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G |
Fn1 |
fibronectin 1 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of FN1 protein] Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] Curcumin results in decreased expression of FN1 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FN1 mRNA] |
CTD |
PMID:12388107 PMID:18200517 PMID:18555241 PMID:21998146 PMID:22228707 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fntb |
farnesyltransferase, CAAX box, subunit beta |
increases expression |
ISO |
Curcumin results in increased expression of FNTB mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression multiple interactions increases expression |
ISO EXP |
Curcumin results in decreased expression of FOS mRNA Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of FOS protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of FOS mRNA] Curcumin results in increased expression of FOS mRNA [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein] |
CTD |
PMID:15713895 PMID:17827730 PMID:17999991 PMID:23452621 PMID:26191140 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL1 protein] Curcumin results in increased ubiquitination of FOSL1 protein |
CTD |
PMID:17148446 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of FOSL2 mRNA Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein] |
CTD |
PMID:17148446 PMID:17999991 |
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NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxa1 |
forkhead box A1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] |
CTD |
PMID:22258452 |
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NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G |
Foxa2 |
forkhead box A2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXA2 mRNA |
CTD |
PMID:27237783 |
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NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Foxf2 |
forkhead box F2 |
decreases expression |
ISO |
Curcumin results in decreased expression of FOXF2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
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G |
Foxo1 |
forkhead box O1 |
increases expression decreases phosphorylation |
ISO |
Curcumin results in increased expression of FOXO1 mRNA Curcumin results in decreased phosphorylation of FOXO1 protein |
CTD |
PMID:18403477 PMID:18790744 |
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NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Fpr3 |
formyl peptide receptor 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:58,884,427...58,893,472
Ensembl chr 1:58,845,118...58,893,467
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] |
CTD |
PMID:31199764 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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G |
Ftl1 |
ferritin light chain 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of FTL1 mRNA |
CTD |
PMID:24634837 |
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NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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G |
Fus |
Fus RNA binding protein |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of FUS mRNA Curcumin results in decreased expression of FUS mRNA |
CTD |
PMID:17198877 PMID:17999991 |
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NCBI chr 1:182,576,479...182,590,417
Ensembl chr 1:182,576,545...182,590,414
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G |
Fzd1 |
frizzled class receptor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of FZD1 mRNA |
CTD |
PMID:15713895 |
|
NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643 Ensembl chr 4:29,310,091...29,312,643
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
affects expression |
ISO |
Curcumin affects the expression of G6PC1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression multiple interactions |
EXP ISO |
Curcumin results in increased expression of G6PD mRNA; Curcumin results in increased expression of G6PDX mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein] |
CTD |
PMID:18299980 PMID:36924976 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of GABRA1 mRNA |
CTD |
PMID:18299980 |
|
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] |
CTD |
PMID:23267840 |
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NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP ISO |
Curcumin results in increased expression of GADD45A mRNA |
CTD |
PMID:16101141 PMID:18299980 PMID:18719366 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gas6 |
growth arrest specific 6 |
increases expression |
ISO |
Curcumin results in increased expression of GAS6 mRNA |
CTD |
PMID:21594647 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA] |
CTD |
PMID:22258452 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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G |
Gata4 |
GATA binding protein 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of GATA4 mRNA; Curcumin results in decreased expression of GATA4 protein |
CTD |
PMID:27237783 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases activity multiple interactions increases expression |
ISO EXP |
Curcumin results in increased activity of GCLC protein Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of GCLC mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLC protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] Curcumin analog results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC mRNA Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA] Curcumin results in increased expression of GCLC mRNA; Curcumin results in increased expression of GCLC protein Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of GCLC protein]; Curcumin results in increased activity of [GCLC protein binds to GCLM protein] |
CTD |
PMID:10514034 PMID:17602960 PMID:18299980 PMID:18332871 PMID:19168576 PMID:19183254 PMID:23710286 PMID:23954767 PMID:27837179 PMID:29571711 PMID:31521693 PMID:34272803 PMID:35063475 PMID:35817260 PMID:36305173 More...
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
EXP ISO |
Curcumin results in increased activity of [GCLC protein binds to GCLM protein] Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA] Curcumin analog results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM mRNA; Curcumin results in increased expression of GCLM protein NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA] |
CTD |
PMID:17198877 PMID:17535857 PMID:17602960 PMID:17999991 PMID:18332871 PMID:19168576 PMID:19183254 PMID:19188863 PMID:23386263 PMID:23710286 PMID:23954767 PMID:29571711 PMID:34272803 More...
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gda |
guanine deaminase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GDA mRNA] |
CTD |
PMID:18200517 |
|
NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GFAP mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of GFAP mRNA] |
CTD |
PMID:19555370 PMID:25963729 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of GGT1 mRNA Curcumin inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] |
CTD |
PMID:18299980 PMID:24704557 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Ggta1 |
glycoprotein alpha-galactosyltransferase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GGTA1 mRNA] |
CTD |
PMID:18200517 |
|
NCBI chr 3:18,732,985...18,824,916
Ensembl chr 3:18,732,991...18,809,908
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA] |
CTD |
PMID:23452621 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Gli1 |
GLI family zinc finger 1 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GLI1 mRNA; Curcumin results in decreased expression of GLI1 protein [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of GLI1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI1 protein] |
CTD |
PMID:20395211 PMID:31612257 |
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NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
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G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]; Curcumin promotes the reaction [Arsenic Trioxide inhibits the reaction [Cisplatin results in increased expression of GLI2 protein]] |
CTD |
PMID:31612257 |
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NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
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G |
Glo1 |
glyoxalase 1 |
decreases activity |
ISO |
Curcumin results in decreased activity of GLO1 protein |
CTD |
PMID:18946510 |
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NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GOT1 protein]; Curcumin inhibits the reaction [Iron results in increased activity of GOT1 protein] |
CTD |
PMID:16956363 PMID:36037877 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Got1l1 |
glutamic-oxaloacetic transaminase 1-like 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GOT1L1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
decreases expression affects expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of GPAM mRNA Curcumin affects the expression of GPAM mRNA Curcumin inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA] |
CTD |
PMID:19297423 PMID:27208389 |
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NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gper1 |
G protein-coupled estrogen receptor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of GPER1 mRNA |
CTD |
PMID:17198877 |
|
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Gphn |
gephyrin |
affects expression |
EXP |
Curcumin affects the expression of GPHN mRNA |
CTD |
PMID:18539377 |
|
NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
[Curcumin analog co-treated with Hydrogels] inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [Acetaminophen affects the activity of GPT protein]; Curcumin inhibits the reaction [aristolochic acid I results in increased activity of GPT protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased activity of GPT protein]; Curcumin inhibits the reaction [Fenitrothion results in increased expression of GPT protein]; Curcumin inhibits the reaction [ferric sulfate results in increased activity of GPT protein]; Curcumin inhibits the reaction [Iron results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of GPT protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased activity of GPT protein]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased activity of GPT protein]; Curcumin inhibits the reaction [bisphenol A results in increased activity of GPT protein]; Curcumin inhibits the reaction [Chloranil results in increased activity of GPT protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of GPT protein] |
CTD |
PMID:16956363 PMID:20804811 PMID:24704557 PMID:25123790 PMID:27288928 PMID:29421648 PMID:30423402 PMID:32718261 PMID:34802538 PMID:35063475 PMID:36037877 PMID:37701206 More...
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression multiple interactions |
EXP ISO |
Curcumin results in decreased expression of GPX1 mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein] Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GPX1 mRNA] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased expression of GPX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GPX1 mRNA] |
CTD |
PMID:18299980 PMID:19914224 PMID:23267840 PMID:30934151 PMID:36924976 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Grb10 |
growth factor receptor bound protein 10 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA] |
CTD |
PMID:18200517 |
|
NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of GRB2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Grem1 |
gremlin 1, DAN family BMP antagonist |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GREM1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
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G |
Gria4 |
glutamate ionotropic receptor AMPA type subunit 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] |
CTD |
PMID:23267840 |
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NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein] |
CTD |
PMID:23267840 PMID:29723552 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2A protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GRIN2A protein] |
CTD |
PMID:25496357 PMID:29723552 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [aluminum acetate results in decreased expression of GRIN2B protein] |
CTD |
PMID:25496357 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Grm2 |
glutamate metabotropic receptor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of GRM2 protein |
CTD |
PMID:25406541 |
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NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
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G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GSDMD protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of GSDMD protein] |
CTD |
PMID:34998855 PMID:35063475 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation decreases expression multiple interactions increases phosphorylation increases expression |
ISO EXP |
Curcumin results in decreased phosphorylation of GSK3B protein Curcumin results in decreased expression of GSK3B mRNA Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin results in increased expression of and results in increased phosphorylation of GSK3B protein Curcumin results in increased phosphorylation of GSK3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] Curcumin results in increased expression of GSK3B protein |
CTD |
PMID:18006147 PMID:18790744 PMID:19573523 PMID:25541178 PMID:25963729 PMID:27645308 PMID:27966075 PMID:29723552 PMID:34577062 More...
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of GSN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of GSR mRNA Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein] [Curcumin co-treated with resveratrol] inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of GSR] [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; Curcumin analog inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Fenitrothion results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of GSR mRNA] |
CTD |
PMID:19168576 PMID:19914224 PMID:20593964 PMID:21976817 PMID:24347089 PMID:25632966 PMID:31407471 PMID:34802538 PMID:36924976 More...
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gss |
glutathione synthetase |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of GSS mRNA Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of GSS mRNA] |
CTD |
PMID:19183254 PMID:35063475 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
Curcumin results in increased expression of GSTA2 mRNA |
CTD |
PMID:18200517 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta4 |
glutathione S-transferase alpha 4 |
increases activity |
ISO |
Curcumin results in increased activity of GSTA4 protein |
CTD |
PMID:10514034 |
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NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
Curcumin results in increased expression of GSTA5 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstk1 |
glutathione S-transferase kappa 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of GSTK1 mRNA] |
CTD |
PMID:31521693 |
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NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of GSTO1 mRNA Curcumin promotes the reaction [sodium arsenite results in increased expression of GSTO1 mRNA] |
CTD |
PMID:34272803 |
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NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions affects expression increases expression decreases expression |
ISO EXP |
[sulfinosine co-treated with Curcumin] results in decreased expression of GSTP1 mRNA; Curcumin binds to and results in decreased activity of GSTP1 protein; Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA] Curcumin affects the expression of GSTP1 protein Curcumin results in increased expression of GSTP1 mRNA Curcumin results in decreased expression of GSTP1 mRNA; Curcumin results in decreased expression of GSTP1 protein Curcumin results in increased expression of GSTP1 mRNA; Curcumin results in increased expression of GSTP1 protein |
CTD |
PMID:9463521 PMID:14555224 PMID:14742295 PMID:15999103 PMID:16101141 PMID:17449203 PMID:18299980 PMID:18414057 PMID:22830632 More...
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] |
CTD |
PMID:8534267 |
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NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905
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G |
H19 |
H19 imprinted maternally expressed transcript |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of H19 mRNA curcumin inhibits the reaction [platelet- derived growth factor increases expression of H19 RNA in aortic vascular smooth muscle cells] curcumin inhibits the reaction [carotid balloon injury increases expression of H19 RNA in carotid artery segment] |
CTD RGD |
PMID:18348204 PMID:34487706 PMID:34487706 |
RGD:156430326, RGD:156430326 |
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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G |
H1f10 |
H1.10 linker histone |
decreases expression |
ISO |
Curcumin results in decreased expression of H1-10 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 4:120,440,515...120,441,578
Ensembl chr 4:120,440,870...120,441,448
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation |
ISO |
[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein; [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein Curcumin results in increased phosphorylation of H2AX protein |
CTD |
PMID:19401701 PMID:21134073 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
H2bu1 |
H2B.U histone 1 |
increases expression |
ISO |
Curcumin results in increased expression of H2BC26 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:43,732,737...43,733,484
Ensembl chr10:43,732,864...43,736,277
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G |
H3f4 |
H3.4 histone, cluster member |
increases acetylation increases phosphorylation |
EXP |
Curcumin results in increased acetylation of H3F4 protein Curcumin results in increased phosphorylation of H3F4 protein |
CTD |
PMID:18204486 |
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NCBI chr10:43,740,702...43,741,262
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression |
ISO |
Curcumin results in decreased expression of HAMP mRNA |
CTD |
PMID:24634837 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Hand1 |
heart and neural crest derivatives expressed 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA] Curcumin results in decreased expression of HAND1 mRNA |
CTD |
PMID:24857828 |
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NCBI chr10:42,006,646...42,009,213
Ensembl chr10:42,006,651...42,009,213
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G |
Hand2 |
heart and neural crest derivatives expressed 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Alcohols results in increased expression of HAND2 mRNA] Curcumin results in decreased expression of HAND2 mRNA |
CTD |
PMID:24857828 |
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NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of HAVCR1 protein]; Curcumin inhibits the reaction [maleic acid results in increased expression of HAVCR1 protein] |
CTD |
PMID:25119790 PMID:29421648 PMID:30431687 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hbs1l |
HBS1-like translational GTPase |
decreases expression |
ISO |
Curcumin results in decreased expression of HBS1L mRNA |
CTD |
PMID:18421014 |
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NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074
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G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
decreases activity multiple interactions |
ISO |
Curcumin analog results in decreased activity of HCK protein [Curcumin binds to 3,4,5-trimethoxybenzaldehyde] which results in decreased activity of HCK protein; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [HCK protein binds to Adenosine Triphosphate]; [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which binds to and results in decreased phosphorylation of and results in decreased activity of HCK protein |
CTD |
PMID:33617879 |
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NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions decreases expression affects localization |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of HDAC1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of HDAC1 protein] Curcumin analog results in decreased expression of HDAC1 protein Curcumin analog results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 mRNA; Curcumin results in decreased expression of HDAC1 protein |
CTD |
PMID:17927689 PMID:18161303 PMID:23593078 PMID:26409325 PMID:29228771 |
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NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac11 |
histone deacetylase 11 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC11 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405
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G |
Hdac2 |
histone deacetylase 2 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in decreased activity of HDAC2 protein]; Curcumin inhibits the reaction [Smoke results in increased degradation of and results in decreased expression of HDAC2 protein] Curcumin analog results in decreased expression of HDAC2 mRNA |
CTD |
PMID:18421014 PMID:26409325 |
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NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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G |
Hdac3 |
histone deacetylase 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of HDAC3 protein |
CTD |
PMID:17927689 |
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NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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G |
Hdac4 |
histone deacetylase 4 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC4 mRNA Curcumin analog results in decreased expression of HDAC4 protein |
CTD |
PMID:26409325 PMID:26991801 PMID:29228771 |
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NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hdac6 |
histone deacetylase 6 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC6 mRNA |
CTD |
PMID:26409325 |
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NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441
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G |
Hdac7 |
histone deacetylase 7 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC7 protein |
CTD |
PMID:29228771 |
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NCBI chr 7:128,923,918...128,961,926
Ensembl chr 7:128,923,920...128,962,072
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G |
Hdac8 |
histone deacetylase 8 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HDAC8 mRNA |
CTD |
PMID:26409325 |
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NCBI chr X:67,385,288...67,593,014
Ensembl chr X:67,385,289...67,592,923
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G |
Hebp2 |
heme binding protein 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HEBP2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:13,194,982...13,201,777
Ensembl chr 1:13,194,982...13,201,777
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
[1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of HES1 mRNA |
CTD |
PMID:22982865 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hgf |
hepatocyte growth factor |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of HGF protein Curcumin results in decreased expression of HGF protein |
CTD |
PMID:23555722 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions decreases expression decreases activity |
ISO EXP |
[Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; Curcumin analog inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein modified form]; Curcumin analog inhibits the reaction [Ionomycin promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; Curcumin analog inhibits the reaction [Ionomycin results in increased activity of HIF1A protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; Curcumin results in decreased expression of and results in decreased activity of HIF1A protein; VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HIF1A protein] Curcumin results in decreased expression of HIF1A mRNA Curcumin analog results in decreased expression of HIF1A mRNA; Curcumin results in decreased expression of HIF1A mRNA Curcumin results in decreased activity of HIF1A protein |
CTD |
PMID:16880289 PMID:18682687 PMID:20554536 PMID:21397623 PMID:23845850 PMID:26409325 More...
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hist1h2bd |
histone cluster 1 H2B family member D |
increases expression |
ISO |
Curcumin results in increased expression of H2BC5 mRNA |
CTD |
PMID:17999991 |
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NCBI chr17:42,792,887...42,793,268
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G |
Hist1h2bq |
histone cluster 1 H2B family member Q |
increases expression |
EXP |
Curcumin results in increased expression of HIST1H2BQ mRNA |
CTD |
PMID:18299980 |
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NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
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G |
Hk1 |
hexokinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein] |
CTD |
PMID:36924976 |
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NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131
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G |
Hk2 |
hexokinase 2 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of HK2 protein 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; ATF4 inhibits the reaction [Curcumin results in decreased expression of HK2 protein]; Curcumin promotes the reaction [Sirolimus results in decreased expression of HK2 protein] |
CTD |
PMID:36640941 |
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NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein] |
CTD |
PMID:22683883 PMID:29480285 |
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NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression multiple interactions decreases expression affects expression |
ISO EXP |
Curcumin results in increased expression of HMGCR mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of HMGCR protein] Curcumin results in decreased expression of HMGCR mRNA Curcumin affects the expression of HMGCR mRNA; Curcumin affects the expression of HMGCR protein |
CTD |
PMID:16713233 PMID:27208389 PMID:37701206 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of HMGCS1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases expression increases expression decreases response to substance increases activity |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased activity of HMOX1 protein]; Curcumin promotes the reaction [quinocetone results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; Cycloheximide inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Egtazic Acid inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Go 6976 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein] Curcumin results in decreased expression of HMOX1 mRNA Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Chloranil] results in increased expression of HMOX1 protein; [Curcumin co-treated with piperine] results in increased expression of HMOX1 mRNA; [Curcumin co-treated with piperine] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [[Curcumin co-treated with piperine] results in increased expression of HMOX1 protein]; AKT1 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein] Curcumin analog results in increased expression of HMOX1 mRNA; Curcumin analog results in increased expression of HMOX1 protein; Curcumin results in increased expression of HMOX1; Curcumin results in increased expression of HMOX1 mRNA; Curcumin results in increased expression of HMOX1 protein HMOX1 protein results in decreased susceptibility to Curcumin 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [Curcumin co-treated with Fructose] results in increased expression of HMOX1 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Atrazine results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Ethanol results in decreased activity of HMOX1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 mRNA]; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of HMOX1 protein]; Curcumin results in increased expression of and results in increased activity of HMOX1 protein; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of HMOX1 mRNA]]; Quartz promotes the reaction [Curcumin results in increased expression of HMOX1 mRNA]; tin protoporphyrin IX inhibits the reaction [Curcumin results in increased activity of HMOX1 protein] |
CTD |
PMID:10925121 PMID:14742295 PMID:17464175 PMID:17535857 PMID:17627722 PMID:17973899 PMID:17999991 PMID:18001810 PMID:18006204 PMID:18299980 PMID:18357586 PMID:18719366 PMID:18784349 PMID:19168576 PMID:19177192 PMID:19188863 PMID:20080166 PMID:20938987 PMID:22771723 PMID:23266269 PMID:23386263 PMID:23452621 PMID:23710286 PMID:23871787 PMID:23942037 PMID:23954767 PMID:24211270 PMID:24863870 PMID:24952339 PMID:25123790 PMID:25169090 PMID:25268984 PMID:25387343 PMID:25541178 PMID:26260164 PMID:26361869 PMID:26991801 PMID:27375190 PMID:27837179 PMID:27966075 PMID:27996348 PMID:29228771 PMID:29480285 PMID:29571711 PMID:30946834 PMID:31187328 PMID:31330227 PMID:31454128 PMID:31521693 PMID:32718261 PMID:33350580 PMID:34272803 PMID:34758851 PMID:35063475 PMID:35817260 PMID:36037877 PMID:36305173 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
decreases expression |
ISO |
Curcumin results in decreased expression of HNRNPA1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
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G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
decreases expression |
ISO |
Curcumin results in decreased expression of HNRNPD mRNA |
CTD |
PMID:17999991 |
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NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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G |
Hopx |
HOP homeobox |
increases expression |
EXP |
Curcumin results in increased expression of HOPX mRNA |
CTD |
PMID:18299980 |
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NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
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G |
Hoxb5 |
homeo box B5 |
increases expression |
ISO |
Curcumin results in increased expression of HOXB5 mRNA |
CTD |
PMID:18421014 |
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NCBI chr10:81,269,372...81,271,580
Ensembl chr10:81,269,372...81,271,580
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases expression |
ISO |
Curcumin results in increased expression of HPRT1 mRNA |
CTD |
PMID:16101141 |
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NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions |
EXP ISO |
[arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein] |
CTD |
PMID:9764755 PMID:11322385 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HSP90AA1 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
multiple interactions |
EXP |
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSP90AB1 mRNA] |
CTD |
PMID:26361869 |
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NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of HSPA1A mRNA; Curcumin results in increased expression of HSPA1A protein Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPA1A mRNA] Curcumin results in decreased expression of HSPA1A protein |
CTD |
PMID:23555722 PMID:26361869 |
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NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
increases expression |
ISO |
Curcumin results in increased expression of HSPA4 mRNA; Curcumin results in increased expression of HSPA4 protein |
CTD |
PMID:11322385 |
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NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression decreases expression multiple interactions |
ISO |
Curcumin results in increased expression of HSPA5 mRNA Curcumin results in decreased expression of HSPA5 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of HSPA5 protein]; Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] |
CTD |
PMID:18200517 PMID:27996348 PMID:29723631 PMID:36640941 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]; Curcumin promotes the reaction [Isoproterenol results in increased expression of HSPB1 protein] |
CTD |
PMID:18204486 PMID:20125031 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb7 |
heat shock protein family B (small) member 7 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HSPB7 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
EXP ISO |
Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of HSPD1 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of HSPD1 protein |
CTD |
PMID:26361869 PMID:27430728 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
affects expression |
EXP |
Curcumin affects the expression of HTR1A mRNA |
CTD |
PMID:17617388 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression affects expression |
ISO EXP |
[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] Curcumin analog inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of ICAM1 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CDH2 protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [Curcumin co-treated with Gemcitabine] results in decreased expression of ICAM1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 mRNA] Curcumin results in decreased expression of ICAM1 protein Curcumin affects the expression of ICAM1 mRNA |
CTD |
PMID:16219905 PMID:16243823 PMID:17440100 PMID:17666914 PMID:17973899 PMID:18200517 PMID:18752423 PMID:20885979 PMID:28700904 PMID:29244817 PMID:35549587 More...
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id1 |
inhibitor of DNA binding 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID2 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of ID3 mRNA |
CTD |
PMID:21594647 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of IDO1 mRNA |
CTD |
PMID:18348204 |
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NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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G |
Ifna1 |
interferon, alpha 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNA1 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein] |
CTD |
PMID:17979888 PMID:23452621 |
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NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifnar1 |
interferon alpha and beta receptor subunit 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein] |
CTD |
PMID:17979888 |
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NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
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G |
Ifnar2 |
interferon alpha and beta receptor subunit 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IFNA1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein] |
CTD |
PMID:17979888 |
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NCBI chr11:30,613,576...30,645,958
Ensembl chr11:30,613,767...30,668,124
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G |
Ifnb1 |
interferon beta 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR2 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein] |
CTD |
PMID:17979888 |
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NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions increases secretion |
ISO EXP |
Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA] [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IFNG mRNA]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] Curcumin results in increased secretion of IFNG protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] |
CTD |
PMID:16782535 PMID:16867261 PMID:16959222 PMID:18006644 PMID:22714040 PMID:23452621 PMID:23942037 PMID:25541178 PMID:34047412 PMID:34272803 More...
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifnk |
interferon kappa |
decreases expression |
ISO |
Curcumin results in decreased expression of IFNK mRNA |
CTD |
PMID:18421014 |
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NCBI chr 5:49,732,073...49,734,281
Ensembl chr 5:49,732,073...49,734,281
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G |
Igf1 |
insulin-like growth factor 1 |
decreases activity multiple interactions decreases expression decreases secretion |
ISO |
Curcumin results in decreased activity of IGF1 protein Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein] Curcumin analog results in decreased expression of IGF1 mRNA Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGF1 mRNA] Curcumin results in decreased secretion of IGF1 protein |
CTD |
PMID:17458902 PMID:17499312 PMID:18200517 PMID:26409325 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [IGF1 protein results in increased activity of IGF1R protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of IGF1R protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein; Fluorouracil promotes the reaction [Curcumin results in decreased phosphorylation of and results in decreased activity of IGF1R protein] Curcumin analog results in decreased expression of IGF1R mRNA; Curcumin results in decreased expression of IGF1R mRNA |
CTD |
PMID:17499312 PMID:17918158 PMID:26409325 |
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NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2 |
insulin-like growth factor 2 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of IGF2 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of IGF2 protein |
CTD |
PMID:26409325 PMID:27430728 |
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NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP1 protein |
CTD |
PMID:27430728 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Igfbp2 |
insulin-like growth factor binding protein 2 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of IGFBP2 protein |
CTD |
PMID:27430728 |
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NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression multiple interactions increases secretion increases expression |
ISO EXP |
Curcumin results in decreased expression of IGFBP3 mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP3 protein Curcumin results in increased secretion of IGFBP3 protein Curcumin results in increased expression of IGFBP3 mRNA |
CTD |
PMID:16101141 PMID:17499312 PMID:18299980 PMID:21594647 PMID:27430728 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G |
Igfbp4 |
insulin-like growth factor binding protein 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP4 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP4 protein |
CTD |
PMID:18200517 PMID:27430728 |
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NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IGFBP5 mRNA] [arsenic trioxide co-treated with Curcumin] results in increased expression of IGFBP5 protein |
CTD |
PMID:18200517 PMID:27430728 |
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NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
increases expression |
ISO |
Curcumin results in increased expression of IGFBP7 mRNA |
CTD |
PMID:21594647 |
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NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions decreases activity |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of IKBKB protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKB mRNA]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; IKBKB protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA] Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] Curcumin results in decreased activity of IKBKB protein |
CTD |
PMID:16023083 PMID:16219905 PMID:16678799 PMID:17965732 PMID:20054000 PMID:23452621 PMID:29793316 More...
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IKBKG mRNA] |
CTD |
PMID:23452621 |
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NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA]; Curcumin promotes the reaction [IFNA1 protein results in increased expression of IL10 protein]; Curcumin promotes the reaction [IFNB1 protein results in increased expression of IL10 protein] Curcumin results in decreased expression of IL10 protein CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]; Curcumin analog inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Copper Sulfate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL10 protein]] |
CTD |
PMID:15604057 PMID:16867261 PMID:17979888 PMID:20885979 PMID:21397623 PMID:23452621 PMID:30016632 PMID:30431687 PMID:35549587 More...
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12A mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IL12B mRNA] |
CTD |
PMID:16867261 PMID:23452621 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL17A protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL17A mRNA] |
CTD |
PMID:34998855 PMID:35716765 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]] Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL18 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL18 protein] Curcumin results in decreased expression of IL18 mRNA Curcumin results in decreased expression of IL18 mRNA; Curcumin results in decreased expression of IL18 protein |
CTD |
PMID:16368150 PMID:16751071 PMID:17399992 PMID:35063475 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein] Curcumin inhibits the reaction [Soot results in increased secretion of IL1A protein] |
CTD |
PMID:18719352 PMID:19782127 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
affects expression multiple interactions decreases expression |
ISO EXP |
Curcumin affects the expression of IL1B mRNA Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [IL1B protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of GSK3B mRNA]; Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CTNNB1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of GSK3B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA] [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL1B protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of IL1B protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA] [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [Soot results in increased secretion of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]] |
CTD |
PMID:15604057 PMID:15793857 PMID:16751071 PMID:16782535 PMID:16819191 PMID:16867261 PMID:17151092 PMID:17273796 PMID:17291458 PMID:17383825 PMID:17887948 PMID:18001810 PMID:18200517 PMID:18368483 PMID:18549505 PMID:18752423 PMID:18946510 PMID:19782127 PMID:20712904 PMID:20816778 PMID:25123790 PMID:25541178 PMID:27393034 PMID:27645308 PMID:29315967 PMID:29571711 PMID:30016632 PMID:30098273 PMID:31407471 PMID:31454128 PMID:31712109 PMID:32718261 PMID:33350580 PMID:34272803 PMID:34719837 PMID:34998855 PMID:35063475 PMID:35817260 PMID:36156276 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Curcumin results in decreased expression of and results in decreased secretion of IL2 protein |
CTD |
PMID:19761891 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2RA protein] |
CTD |
PMID:18340409 |
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NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il4 |
interleukin 4 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL4 protein] Curcumin results in decreased expression of IL4 protein |
CTD |
PMID:16782535 PMID:16867261 PMID:21397623 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL5 protein] |
CTD |
PMID:34998855 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression increases expression affects expression |
ISO EXP |
Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Acids results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [cadmium sulfate results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of AR protein]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] [Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Chloranil results in increased expression of IL6 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA] Curcumin results in increased expression of IL6 protein Curcumin results in increased expression of IL6 mRNA 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of IL6 protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Colistin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of IL6 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Soot results in increased secretion of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of IL6 protein]] Curcumin affects the expression of IL6 mRNA; Curcumin affects the expression of IL6 protein |
CTD |
PMID:16751071 PMID:17151092 PMID:17273796 PMID:17383825 PMID:17999991 PMID:18006644 PMID:18025290 PMID:18200517 PMID:18209571 PMID:18357586 PMID:18379247 PMID:18549505 PMID:18676361 PMID:18752423 PMID:19074641 PMID:19782127 PMID:20712904 PMID:21397623 PMID:21594647 PMID:21811692 PMID:22142850 PMID:22465177 PMID:22683883 PMID:23396138 PMID:24760747 PMID:25123790 PMID:25387343 PMID:28063877 PMID:28700904 PMID:28951138 PMID:29480285 PMID:29571711 PMID:29793316 PMID:30016632 PMID:30138604 PMID:31199764 PMID:31454128 PMID:31820278 PMID:33350580 PMID:33952798 PMID:34042043 PMID:34272803 PMID:34577062 PMID:35549587 PMID:35716765 PMID:35817260 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6r |
interleukin 6 receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6R protein] |
CTD |
PMID:34233590 |
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NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trichloroethylene results in increased expression of IL6ST protein] |
CTD |
PMID:34233590 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] Curcumin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] |
CTD |
PMID:23267840 PMID:25541178 PMID:27208389 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Fructose results in increased expression of INS protein] Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADIPOQ mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]] |
CTD |
PMID:25268984 PMID:26713546 PMID:28595985 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig2 |
insulin induced gene 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA] |
CTD |
PMID:18704882 |
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NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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G |
Insr |
insulin receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of INSR protein modified form] |
CTD |
PMID:29793316 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Irag2 |
inositol 1,4,5-triphosphate receptor associated 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of IRAG2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 4:178,088,902...178,143,569
Ensembl chr 4:178,088,507...178,143,557
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK1 mRNA] |
CTD |
PMID:16678799 PMID:23452621 |
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NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of IRAK2 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein] |
CTD |
PMID:16678799 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Irf5 |
interferon regulatory factor 5 |
increases expression |
ISO |
Curcumin analog results in increased expression of IRF5 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions affects phosphorylation |
EXP ISO |
Curcumin inhibits the reaction [Fructose affects the phosphorylation of IRS1 protein] Curcumin inhibits the reaction [bisphenol A results in increased expression of IRS1 protein modified form] Curcumin affects the phosphorylation of IRS1 protein |
CTD |
PMID:26713546 PMID:27208389 PMID:29793316 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
affects phosphorylation |
ISO |
Curcumin affects the phosphorylation of IRS2 protein |
CTD |
PMID:27208389 |
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NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Itga2b |
integrin subunit alpha 2b |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein] |
CTD |
PMID:18565277 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
Calcitriol promotes the reaction [Curcumin results in increased expression of ITGAM]; Tretinoin promotes the reaction [Curcumin results in increased expression of ITGAM] |
CTD |
PMID:9112257 |
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NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein] Curcumin results in increased expression of ITGB1 protein |
CTD |
PMID:17291458 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein] |
CTD |
PMID:18565277 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Itm2a |
integral membrane protein 2A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ITM2A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Ivl |
involucrin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA] |
CTD |
PMID:17148446 |
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NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
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G |
Jak2 |
Janus kinase 2 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of JAK2 protein Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:16959222 PMID:34233590 PMID:36352148 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jak3 |
Janus kinase 3 |
decreases activity |
ISO |
Curcumin results in decreased activity of JAK3 protein |
CTD |
PMID:16932349 |
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NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation multiple interactions increases expression decreases activity |
ISO EXP |
Curcumin results in decreased phosphorylation of JUN protein Curcumin inhibits the reaction [[IGF1 protein co-treated with Estradiol] results in increased expression of JUN protein]; Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of JUN protein] Curcumin results in increased expression of JUN mRNA [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein] Curcumin results in decreased activity of JUN protein |
CTD |
PMID:11035063 PMID:15713895 PMID:17148446 PMID:17458902 PMID:17596214 PMID:17827730 PMID:18628248 PMID:23452621 PMID:26191140 PMID:27535828 PMID:31587482 PMID:35716765 More...
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases ubiquitination |
ISO |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [FOSL1 protein binds to JUNB protein]]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUNB protein] Curcumin results in increased ubiquitination of JUNB protein |
CTD |
PMID:17148446 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUND protein] |
CTD |
PMID:17148446 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Curcumin results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnmb2 |
potassium calcium-activated channel subfamily M regulatory beta subunit 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of KCNMB2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 2:114,670,027...114,975,374
Ensembl chr 2:114,935,976...114,975,173
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G |
Kdr |
kinase insert domain receptor |
affects expression multiple interactions |
ISO EXP |
Curcumin affects the expression of KDR mRNA [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein] Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein] Curcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA] |
CTD |
PMID:17960570 PMID:19297423 PMID:23845850 PMID:35752269 |
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NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA] Curcumin results in decreased expression of KEAP1 mRNA Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein] Curcumin analog results in decreased expression of KEAP1 protein; Curcumin results in decreased expression of KEAP1 protein Curcumin analog promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of KEAP1 protein]; Curcumin promotes the reaction [APP protein modified form results in decreased expression of KEAP1 protein] Curcumin results in increased expression of KEAP1 mRNA |
CTD |
PMID:17535857 PMID:23710286 PMID:26991801 PMID:30946834 PMID:31521693 PMID:34758851 PMID:35063475 PMID:36037877 More...
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
multiple interactions |
EXP |
[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of KIT protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of KIT protein |
CTD |
PMID:26612707 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Klf10 |
KLF transcription factor 10 |
decreases expression |
ISO |
Curcumin results in decreased expression of KLF10 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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G |
Klf6 |
KLF transcription factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of KLF6 mRNA |
CTD |
PMID:15713895 |
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NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G |
Klhl21 |
kelch-like family member 21 |
increases expression |
ISO |
Curcumin results in increased expression of KLHL21 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545
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G |
Klhl24 |
kelch-like family member 24 |
decreases expression |
ISO |
Curcumin results in decreased expression of KLHL24 mRNA |
CTD |
PMID:17198877 |
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NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636
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G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of KLK3 mRNA; Curcumin results in decreased expression of KLK3 protein Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [CREBBP protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to KLK3 enhancer]]; Curcumin inhibits the reaction [GATA2 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [IL6 protein results in increased expression of KLK3 protein]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 mRNA]; Curcumin inhibits the reaction [Metribolone results in increased expression of KLK3 protein]; Curcumin results in decreased expression of and results in decreased secretion of KLK3 protein; trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA] |
CTD |
PMID:12497104 PMID:18676361 PMID:18719366 PMID:21134073 PMID:22258452 |
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NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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G |
Kmt5a |
lysine methyltransferase 5A |
decreases expression |
ISO |
Curcumin results in decreased expression of KMT5A mRNA; Curcumin results in decreased expression of KMT5A protein |
CTD |
PMID:25256401 |
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NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711
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G |
Kras |
KRAS proto-oncogene, GTPase |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of KRAS mRNA; Curcumin results in decreased expression of KRAS mRNA Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] |
CTD |
PMID:17041101 PMID:21519798 |
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NCBI chr 4:178,185,418...178,218,484
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G |
Krtap2-1 |
keratin associated protein 2-1 |
decreases expression |
ISO |
Curcumin results in decreased expression of KRTAP2-1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr10:84,572,164...84,572,587
Ensembl chr10:84,572,164...84,572,556
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G |
Kynu |
kynureninase |
increases expression |
ISO |
Curcumin results in increased expression of KYNU mRNA |
CTD |
PMID:18421014 |
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NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
affects expression multiple interactions |
EXP ISO |
Curcumin affects the expression of LAMP1 mRNA Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]] |
CTD |
PMID:18539377 PMID:34758851 |
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NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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G |
Lbp |
lipopolysaccharide binding protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LBP mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCN2 mRNA] Curcumin inhibits the reaction [Cadmium Chloride results in increased export of LCN2 protein]; Curcumin inhibits the reaction [maleic acid results in increased secretion of LCN2 protein] |
CTD |
PMID:18200517 PMID:25119790 PMID:29421648 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lcp1 |
lymphocyte cytosolic protein 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LCP1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
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G |
Lcp2 |
lymphocyte cytosolic protein 2 |
increases expression |
ISO |
Curcumin results in increased expression of LCP2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions decreases expression |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased expression of LDHA protein]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of LDHA protein] |
CTD |
PMID:36640941 PMID:36924976 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions affects expression increases expression |
ISO |
Curcumin inhibits the reaction [INSIG2 protein results in decreased expression of LDLR mRNA]; Curcumin results in increased expression of and results in increased activity of LDLR protein Curcumin affects the expression of LDLR mRNA Curcumin results in increased expression of LDLR mRNA; Curcumin results in increased expression of LDLR protein |
CTD |
PMID:16713233 PMID:16963807 PMID:18704882 PMID:27208389 |
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NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Lef1 |
lymphoid enhancer binding factor 1 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of LEF1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of LEF1 mRNA] |
CTD |
PMID:25963729 |
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NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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G |
Lgmn |
legumain |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of LHB protein] |
CTD |
PMID:31199764 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhx5 |
LIM homeobox 5 |
affects expression |
EXP |
Curcumin affects the expression of LHX5 mRNA |
CTD |
PMID:18539377 |
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NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625
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G |
Lig3 |
DNA ligase 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG3 protein] |
CTD |
PMID:21332098 |
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NCBI chr10:67,717,808...67,741,141
Ensembl chr10:67,717,812...67,798,414
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G |
Lig4 |
DNA ligase 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of LIG4 protein] |
CTD |
PMID:21332098 |
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NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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G |
Lipc |
lipase C, hepatic type |
affects expression |
ISO |
Curcumin affects the expression of LIPC mRNA |
CTD |
PMID:27208389 |
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NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
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G |
Lox |
lysyl oxidase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LOX mRNA] |
CTD |
PMID:18200517 |
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NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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G |
Lpar1 |
lysophosphatidic acid receptor 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of LPAR1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
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G |
Lpl |
lipoprotein lipase |
affects expression |
ISO |
Curcumin affects the expression of LPL mRNA |
CTD |
PMID:27208389 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrp5 |
LDL receptor related protein 5 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP5 mRNA] Curcumin results in increased expression of LRP5 mRNA |
CTD |
PMID:25963729 |
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NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
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G |
Lrp6 |
LDL receptor related protein 6 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of LRP6 mRNA] Curcumin results in increased expression of LRP6 mRNA |
CTD |
PMID:25963729 |
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NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497
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G |
Lrrn3 |
leucine rich repeat neuronal 3 |
increases expression |
ISO |
Curcumin results in increased expression of LRRN3 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 6:58,489,060...58,520,322
Ensembl chr 6:58,489,010...58,520,330
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G |
Lss |
lanosterol synthase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of LSS mRNA Curcumin results in decreased expression of LSS mRNA |
CTD |
PMID:27208389 |
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NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Lta |
lymphotoxin alpha |
decreases expression multiple interactions increases expression |
ISO |
Curcumin results in decreased expression of LTA mRNA [arsenic trioxide co-treated with Curcumin] results in increased expression of LTA protein Curcumin results in increased expression of LTA mRNA |
CTD |
PMID:16101141 PMID:17198877 PMID:27430728 |
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NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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G |
Ltb |
lymphotoxin beta |
increases expression decreases expression |
ISO |
Curcumin results in increased expression of LTB mRNA Curcumin results in decreased expression of LTB mRNA |
CTD |
PMID:16751071 PMID:17198877 |
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NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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G |
Ltbr |
lymphotoxin beta receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of LTBR mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
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G |
Lyz2 |
lysozyme 2 |
multiple interactions affects expression |
ISO EXP |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LYZ mRNA] Curcumin affects the expression of LYZ2 mRNA |
CTD |
PMID:18200517 PMID:18539377 |
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NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MAOA mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases lipidation decreases expression increases expression multiple interactions |
ISO |
Curcumin results in increased lipidation of MAP1LC3B protein Curcumin results in decreased expression of MAP1LC3B protein Curcumin results in increased expression of MAP1LC3B mRNA 3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; Curcumin inhibits the reaction [4-phenylbutyric acid results in decreased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of MAP1LC3B protein]; Sirolimus promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; U 0126 inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:34634291 PMID:36640941 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K1 results in decreased susceptibility to [Curcumin co-treated with Mitomycin] |
CTD |
PMID:21810436 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
ISO |
MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 results in decreased susceptibility to [Curcumin co-treated with Mitomycin] |
CTD |
PMID:21810436 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Map2k3 |
mitogen activated protein kinase kinase 3 |
increases expression |
ISO |
Curcumin results in increased expression of MAP2K3 mRNA |
CTD |
PMID:15713895 |
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NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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G |
Map2k4 |
mitogen activated protein kinase kinase 4 |
decreases expression increases phosphorylation |
ISO |
Curcumin results in decreased expression of MAP2K4 mRNA Curcumin increases phosphorylation of MAP2K4 protein in uterine cervix |
CTD RGD |
PMID:15713895 PMID:25198898 |
RGD:150429751 |
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
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G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MAP3K1 mRNA] Curcumin results in decreased expression of MAP3K1 mRNA |
CTD |
PMID:15713895 PMID:17148446 PMID:23452621 |
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NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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G |
Map3k5 |
mitogen-activated protein kinase kinase kinase 5 |
increases phosphorylation |
ISO |
Curcumin increases phosphorylation of MAP3K5 protein in uterine cervix |
RGD |
PMID:25198898 |
RGD:150429751 |
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation decreases expression decreases activity |
ISO EXP |
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [Curcumin results in decreased activity of MAPK1 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK1 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]]; MAPK1 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK1 protein]] Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK1 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]] [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK1 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein] Curcumin results in decreased expression of MAPK1 protein |
CTD |
PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 PMID:17965732 PMID:18214481 PMID:18316600 PMID:18321868 PMID:18332871 PMID:18357586 PMID:18555241 PMID:18784349 PMID:19074641 PMID:19175364 PMID:19383353 PMID:19501152 PMID:20605902 PMID:20727180 PMID:21493726 PMID:21810436 PMID:22142850 PMID:24307199 PMID:25866362 PMID:26191140 PMID:26713546 PMID:27996348 PMID:29723552 PMID:31081568 PMID:33617879 PMID:34272803 PMID:34634291 PMID:35752269 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk10 |
mitogen activated protein kinase 10 |
multiple interactions |
EXP |
Curcumin analog inhibits the reaction [Rotenone results in increased phosphorylation of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK10 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK10 protein] |
CTD |
PMID:24952339 PMID:27535828 PMID:27966075 |
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NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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G |
Mapk12 |
mitogen-activated protein kinase 12 |
increases activity |
ISO |
Curcumin results in increased activity of MAPK12 protein |
CTD |
PMID:21594647 |
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NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 mRNA]; MAPK14 protein affects the reaction [Curcumin results in increased expression of HMOX1 protein] |
CTD |
PMID:17151092 PMID:18357586 PMID:31521693 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation increases phosphorylation decreases expression decreases activity |
ISO EXP |
[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin results in decreased activity of MAPK3 protein] which results in increased susceptibility to Cisplatin; [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of MAPK3 protein; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Acids results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [bromopyruvate results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; U 0126 inhibits the reaction [Curcumin results in increased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased phosphorylation of MAPK3 protein]] Curcumin inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Fructose results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK3 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]] [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; [piperlongumine co-treated with Curcumin] results in decreased activity of MAPK3 protein; Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein] Curcumin results in decreased expression of MAPK3 protein |
CTD |
PMID:11035063 PMID:11981161 PMID:16934299 PMID:17372590 PMID:17535857 PMID:17965732 PMID:18214481 PMID:18316600 PMID:18321868 PMID:18332871 PMID:18357586 PMID:18555241 PMID:18784349 PMID:19074641 PMID:19175364 PMID:19383353 PMID:19501152 PMID:20605902 PMID:20727180 PMID:21493726 PMID:21810436 PMID:22142850 PMID:24307199 PMID:25866362 PMID:26191140 PMID:26713546 PMID:29723552 PMID:31081568 PMID:33617879 PMID:34272803 PMID:34634291 PMID:35752269 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation decreases phosphorylation increases expression |
ISO EXP |
Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK8 mRNA]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; MAPK8 protein affects the reaction [Curcumin results in increased expression of CDKN1A mRNA] Curcumin increases phosphorylation of MAPK8 protein in uterine cervix Curcumin results in decreased phosphorylation of MAPK8 protein Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK8 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK8 protein Curcumin inhibits the reaction [Acrylamide results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Bleomycin results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein] Curcumin results in increased expression of MAPK8 mRNA Curcumin results in increased phosphorylation of MAPK8 protein |
CTD RGD |
PMID:11981161 PMID:16101141 PMID:16678799 PMID:16934299 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 PMID:20727180 PMID:24952339 PMID:27966075 PMID:31081568 PMID:31521693 PMID:34272803 PMID:34634291 PMID:35716765 PMID:25198898 More...
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RGD:150429751 |
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions decreases phosphorylation increases phosphorylation |
ISO EXP |
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein] Curcumin results in decreased phosphorylation of MAPK9 protein Curcumin results in increased phosphorylation of MAPK9 protein Curcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 protein |
CTD |
PMID:11981161 PMID:17372590 PMID:18316600 PMID:18321868 PMID:18332871 PMID:24952339 PMID:27966075 PMID:34272803 More...
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of MAPT mRNA] |
CTD |
PMID:31521693 |
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NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of MCL1 protein alternative form [Curcumin co-treated with Arsenic Trioxide] results in decreased expression of MCL1 protein |
CTD |
PMID:18829502 PMID:34675983 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm2 |
minichromosome maintenance complex component 2 |
decreases expression |
EXP |
Curcumin results in decreased expression of MCM2 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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G |
Mcm7 |
minichromosome maintenance complex component 7 |
decreases expression |
ISO |
Curcumin results in decreased expression of MCM7 mRNA |
CTD |
PMID:17198877 |
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NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression increases expression multiple interactions |
ISO |
[Curcumin results in decreased expression of MDM2 protein] which results in decreased expression of CDKN1A mRNA; Curcumin results in decreased expression of MDM2 mRNA; Curcumin results in decreased expression of MDM2 protein Curcumin analog results in increased expression of MDM2 mRNA Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of MDM2 protein] |
CTD |
PMID:17332326 PMID:24831732 PMID:26409325 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mecp2 |
methyl CpG binding protein 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of MECP2 protein |
CTD |
PMID:23593078 |
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NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689
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G |
Mef2c |
myocyte enhancer factor 2C |
decreases expression |
ISO |
Curcumin results in decreased expression of MEF2C mRNA |
CTD |
PMID:27237783 |
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NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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G |
Meltf |
melanotransferrin |
decreases expression |
ISO |
Curcumin results in decreased expression of MELTF mRNA |
CTD |
PMID:17198877 |
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NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300
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G |
Mfn1 |
mitofusin 1 |
increases expression |
EXP |
Curcumin results in increased expression of MFN1 protein |
CTD |
PMID:28698153 |
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NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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G |
Mfng |
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
increases expression |
ISO |
Curcumin results in increased expression of MFNG mRNA |
CTD |
PMID:17198877 |
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NCBI chr 7:110,310,810...110,328,653
Ensembl chr 7:110,310,812...110,328,653
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases expression increases expression decreases activity multiple interactions |
ISO |
Curcumin results in decreased expression of MGMT mRNA Curcumin results in increased expression of MGMT mRNA Curcumin results in decreased activity of MGMT protein Curcumin results in increased expression of and results in increased activity of MGMT protein |
CTD |
PMID:16950796 PMID:17596214 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
EXP |
Curcumin results in increased expression of MGST1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Mir125a |
microRNA 125a |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of MIR125A mRNA Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MIR125A mRNA]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]] |
CTD |
PMID:29723631 PMID:33952798 |
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NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
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G |
Mir146a |
microRNA 146a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA] |
CTD |
PMID:22099153 |
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NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mir19a |
microRNA 19a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of MIR19A mRNA] |
CTD |
PMID:24831732 |
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NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
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G |
Mir21 |
microRNA 21 |
decreases expression |
ISO |
Curcumin results in decreased expression of MIR21 mRNA |
CTD |
PMID:29723631 |
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NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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G |
Mir22 |
microRNA 22 |
increases expression |
ISO |
Curcumin results in increased expression of MIR22 |
CTD |
PMID:26244872 |
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NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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G |
Mir222 |
microRNA 222 |
decreases expression |
ISO |
Curcumin results in decreased expression of MIR222 mRNA |
CTD |
PMID:29723631 |
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NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006
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G |
Mir223 |
microRNA 223 |
increases expression |
ISO |
Curcumin results in increased expression of MIR223 mRNA |
CTD |
PMID:29723631 |
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NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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G |
Mir27a |
microRNA 27a |
decreases expression |
ISO |
Curcumin results in decreased expression of MIR27A mRNA |
CTD |
PMID:29723631 |
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NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
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G |
Mir27b |
microRNA 27b |
decreases expression |
ISO |
Curcumin results in decreased expression of MIR27B mRNA |
CTD |
PMID:29723631 |
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NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
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G |
Mir30a |
microRNA 30a |
increases expression |
ISO |
Curcumin results in increased expression of MIR30A mRNA |
CTD |
PMID:29723631 |
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NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670
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G |
Mir34a |
microRNA 34a |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cyclosporine results in increased expression of MIR34A mRNA] |
CTD |
PMID:32569592 |
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NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103
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G |
Mir532 |
microRNA 532 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of MIR532 mRNA MIR532 affects the reaction [Curcumin results in decreased expression of AKT3 protein]; MIR532 affects the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]; NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA] |
CTD |
PMID:37471645 |
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NCBI chr X:15,247,315...15,247,393
Ensembl chr X:15,247,315...15,247,393
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G |
Mir802 |
microRNA 802 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Acetaminophen results in increased expression of MIR802 mRNA] |
CTD |
PMID:33350580 |
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NCBI chr11:32,626,525...32,626,620
Ensembl chr11:32,626,525...32,626,620
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G |
Mir99a |
microRNA 99a |
multiple interactions |
ISO |
Curcumin inhibits the reaction [benzyl isothiocyanate results in increased expression of MIR99A mRNA] |
CTD |
PMID:31587482 |
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NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions decreases expression |
ISO |
[Curcumin co-treated with Gemcitabine] results in decreased expression of MKI67 protein Curcumin results in decreased expression of MKI67 protein |
CTD |
PMID:17440100 PMID:18226269 PMID:19372569 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mme |
membrane metallo-endopeptidase |
decreases expression |
ISO |
Curcumin results in decreased expression of MME mRNA |
CTD |
PMID:17198877 |
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NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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G |
Mmp1 |
matrix metallopeptidase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] |
CTD |
PMID:30098273 |
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NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp10 |
matrix metallopeptidase 10 |
increases expression |
ISO |
Curcumin results in increased expression of MMP10 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA] |
CTD |
PMID:20338993 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp14 |
matrix metallopeptidase 14 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of MMP14 protein Curcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA] |
CTD |
PMID:16934674 PMID:18200517 PMID:18495463 |
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NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression decreases activity increases activity |
ISO EXP |
Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin results in decreased secretion of and results in decreased activity of MMP2 protein modified form; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein] Curcumin results in decreased activity of MMP2 protein Curcumin results in increased activity of MMP2 protein Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP2 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP2 mRNA] 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein] |
CTD |
PMID:16934674 PMID:17531121 PMID:17996675 PMID:18200517 PMID:18226269 PMID:18495463 PMID:19189304 PMID:22771723 PMID:25447407 PMID:35716765 PMID:36640941 More...
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
increases expression |
ISO |
Curcumin results in increased expression of MMP3 mRNA |
CTD |
PMID:15713895 PMID:18321735 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp7 |
matrix metallopeptidase 7 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]; Curcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA] |
CTD |
PMID:17928719 PMID:23452621 |
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NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases activity decreases expression increases activity affects expression |
ISO EXP |
3-caffeoyl-4-dihydrocaffeoylquinic acid promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine promotes the reaction [Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin promotes the reaction [3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; Curcumin promotes the reaction [4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]]; Curcumin results in decreased secretion of and results in decreased activity of MMP9 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein] Curcumin results in decreased activity of MMP9 protein Curcumin results in increased activity of MMP9 protein Curcumin affects the expression of MMP9 mRNA; Curcumin affects the expression of MMP9 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased activity of MMP9 protein]; [Zinc binds to Curcumin] inhibits the reaction [Acetic Acid results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA] [Curcumin co-treated with Gemcitabine] results in decreased expression of MMP9 protein; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of and results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of and results in increased secretion of MMP9 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of MMP9 mRNA] |
CTD |
PMID:16219905 PMID:16243823 PMID:17291458 PMID:17440100 PMID:17531121 PMID:17640567 PMID:17887948 PMID:17996675 PMID:18226269 PMID:18379247 PMID:18495463 PMID:18628248 PMID:18829502 PMID:19189304 PMID:20152819 PMID:20599481 PMID:21354279 PMID:22771723 PMID:23933360 PMID:24211270 PMID:25656647 PMID:26514923 PMID:34998855 PMID:35716765 PMID:36640941 More...
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mphosph6 |
M phase phosphoprotein 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of MPHOSPH6 mRNA |
CTD |
PMID:18421014 |
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NCBI chr19:45,860,152...45,870,117
Ensembl chr19:45,860,154...45,870,170
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G |
Mpo |
myeloperoxidase |
multiple interactions decreases activity |
EXP ISO |
Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Curcumin inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Curcumin inhibits the reaction [Methotrexate results in increased expression of MPO protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of MPO protein]] [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased activity of MPO protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of MPO protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of MPO protein] Curcumin analog results in decreased activity of MPO protein Curcumin results in decreased activity of MPO protein |
CTD |
PMID:16804969 PMID:16867261 PMID:17276891 PMID:17351913 PMID:17373747 PMID:17461496 PMID:17973899 PMID:19002562 PMID:20885979 PMID:23291280 PMID:25461551 PMID:32718261 PMID:34272803 PMID:34998855 More...
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrpl1 |
mitochondrial ribosomal protein L1 |
increases expression |
ISO |
Curcumin results in increased expression of MRPL1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721
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G |
Mrpl47 |
mitochondrial ribosomal protein L47 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of MRPL47 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:115,507,842...115,520,093
Ensembl chr 2:115,500,264...115,518,994
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G |
Ms4a1 |
membrane spanning 4-domains A1 |
decreases expression increases expression |
ISO |
Curcumin results in decreased expression of MS4A1 mRNA Curcumin results in increased expression of MS4A1 mRNA |
CTD |
PMID:17198877 PMID:18421014 |
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NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
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G |
Msmo1 |
methylsterol monooxygenase 1 |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of MSMO1 mRNA Curcumin results in decreased expression of MSMO1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Msn |
moesin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628
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G |
Msr1 |
macrophage scavenger receptor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of MSR1 mRNA]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] |
CTD |
PMID:23386263 |
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NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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G |
Mst1r |
macrophage stimulating 1 receptor |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA] Curcumin results in decreased expression of MST1R mRNA; Curcumin results in decreased expression of MST1R protein |
CTD |
PMID:18593918 |
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NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455
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G |
Mt1 |
metallothionein 1 |
multiple interactions increases expression |
EXP |
Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT1A mRNA] Curcumin results in increased expression of MT1A mRNA |
CTD |
PMID:20229497 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mt2A |
metallothionein 2A |
multiple interactions increases expression |
EXP |
Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA] Curcumin results in increased expression of MT2A mRNA |
CTD |
PMID:20229497 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation multiple interactions decreases expression |
ISO |
Curcumin results in decreased phosphorylation of MTOR protein ATF4 inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of MTOR protein] 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased phosphorylation of MTOR protein]; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of MTOR protein]; Curcumin inhibits the reaction [Tunicamycin results in increased expression of and results in increased phosphorylation of MTOR protein]; Curcumin promotes the reaction [Sirolimus results in decreased phosphorylation of MTOR protein]; Curcumin results in decreased expression of and results in decreased phosphorylation of MTOR protein Curcumin analog results in decreased expression of MTOR mRNA; Curcumin results in decreased expression of MTOR mRNA |
CTD |
PMID:20554536 PMID:21450334 PMID:26409325 PMID:27363783 PMID:33582110 PMID:36640941 More...
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
Curcumin inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA] |
CTD |
PMID:34167450 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Mvd |
mevalonate diphosphate decarboxylase |
decreases expression |
ISO |
Curcumin results in decreased expression of MVD mRNA |
CTD |
PMID:17198877 |
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NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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G |
Mvk |
mevalonate kinase |
affects expression decreases expression |
ISO EXP |
Curcumin affects the expression of MVK mRNA Curcumin results in decreased expression of MVK mRNA |
CTD |
PMID:27208389 |
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NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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G |
Mxd1 |
max dimerization protein 1 |
increases expression |
ISO |
Curcumin results in increased expression of MXD1 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
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G |
Mxd3 |
Max dimerization protein 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of MXD3 mRNA |
CTD |
PMID:15713895 PMID:17198877 |
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NCBI chr17:9,301,430...9,305,156
Ensembl chr17:9,301,399...9,305,157
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression decreases expression |
ISO |
[Curcumin co-treated with Doxorubicin] affects the expression of MYC mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased expression of MYC protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA] [Curcumin co-treated with Gemcitabine] results in decreased expression of MYC protein Curcumin results in increased expression of MYC mRNA Curcumin analog results in decreased expression of MYC protein; Curcumin results in decreased expression of MYC mRNA; Curcumin results in decreased expression of MYC protein |
CTD |
PMID:15713895 PMID:15911101 PMID:16219905 PMID:16243823 PMID:17041101 PMID:17440100 More...
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA] Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of MYD88 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein] |
CTD |
PMID:19002562 PMID:23452621 PMID:34719837 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Myh1 |
myosin heavy chain 1 |
decreases expression |
EXP |
Curcumin results in decreased expression of MYH1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr10:51,885,913...51,909,699
Ensembl chr10:51,885,913...51,946,295
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G |
Myh6 |
myosin heavy chain 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of MYH6 mRNA |
CTD |
PMID:27237783 |
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NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions decreases expression |
EXP |
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of MYH7 mRNA]; Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] |
CTD |
PMID:25093688 PMID:26612707 |
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NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myl12a |
myosin light chain 12A |
increases expression |
ISO |
Curcumin results in increased expression of MYL12A mRNA |
CTD |
PMID:17999991 |
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NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
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G |
Myl4 |
myosin, light chain 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of MYL4 mRNA |
CTD |
PMID:27237783 |
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NCBI chr10:89,449,456...89,485,365
Ensembl chr10:89,449,443...89,485,363
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G |
Myl9 |
myosin light chain 9 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYL9 protein modified form] |
CTD |
PMID:35817260 |
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NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
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G |
Mylk |
myosin light chain kinase |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of MYLK mRNA Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of MYLK protein] |
CTD |
PMID:21594647 PMID:35817260 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Myo18a |
myosin XVIIIa |
increases expression |
ISO |
Curcumin results in increased expression of MYO18A mRNA |
CTD |
PMID:18421014 |
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NCBI chr10:62,654,218...62,755,465
Ensembl chr10:62,654,281...62,755,468
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G |
Naip6 |
NLR family, apoptosis inhibitory protein 6 |
decreases expression multiple interactions |
ISO |
Curcumin analog results in decreased expression of NAIP mRNA; Curcumin results in decreased expression of NAIP mRNA [Curcumin co-treated with Doxorubicin] affects the expression of NAIP mRNA; [Curcumin co-treated with Oxygen deficiency] results in decreased expression of NAIP protein |
CTD |
PMID:15911101 PMID:17671737 PMID:19250217 PMID:23452621 |
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NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
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G |
Nanog |
Nanog homeobox |
multiple interactions increases expression |
ISO |
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA] Curcumin results in increased expression of NANOG mRNA; Curcumin results in increased expression of NANOG protein |
CTD |
PMID:25822711 PMID:27237783 |
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NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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G |
Nanos1 |
nanos C2HC-type zinc finger 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of NANOS1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 1:259,897,663...259,901,561
Ensembl chr 1:259,897,939...259,898,730
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G |
Ncam1 |
neural cell adhesion molecule 1 |
increases expression |
EXP |
Curcumin results in increased expression of NCAM1 protein modified form |
CTD |
PMID:19161989 |
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NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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G |
Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [VDR protein binds to NCOA1 protein] |
CTD |
PMID:20153625 |
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NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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G |
Nefm |
neurofilament medium chain |
increases expression |
EXP |
Curcumin results in increased expression of NEFM mRNA |
CTD |
PMID:18299980 |
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NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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G |
Neil1 |
nei-like DNA glycosylase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Copper binds to and results in decreased activity of NEIL1 protein]; Curcumin inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] |
CTD |
PMID:20622253 |
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NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
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G |
Nes |
nestin |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of NES mRNA] Curcumin results in increased expression of NES mRNA |
CTD |
PMID:25963729 |
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NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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G |
Neurod1 |
neuronal differentiation 1 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROD1 mRNA] Curcumin results in increased expression of NEUROD1 mRNA |
CTD |
PMID:25963729 |
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NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649
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G |
Neurog1 |
neurogenin 1 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of NEUROG1 mRNA] Curcumin results in increased expression of NEUROG1 mRNA |
CTD |
PMID:25963729 |
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NCBI chr17:8,362,878...8,364,397
Ensembl chr17:8,362,821...8,364,571
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G |
Nfe2l1 |
NFE2 like bZIP transcription factor 1 |
increases expression |
ISO |
Curcumin results in increased expression of NFE2L1 protein |
CTD |
PMID:23710286 |
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NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression increases activity decreases response to substance decreases methylation affects localization increases localization |
ISO EXP |
[Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; Curcumin inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [NFE2L2 protein binds to GSTP1 promoter]; Curcumin promotes the reaction [NFE2L2 protein results in increased expression of GSTP1 mRNA]; Curcumin promotes the reaction [quinocetone results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein] Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 protein modified form Curcumin results in increased activity of NFE2L2 protein NFE2L2 gene mutant form results in decreased susceptibility to Curcumin Curcumin analog results in decreased methylation of NFE2L2 promoter Curcumin affects the localization of NFE2L2 protein; Curcumin analog affects the localization of NFE2L2 protein Curcumin results in increased localization of NFE2L2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Curcumin co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [decamethrin results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [maleic acid affects the expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Curcumin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 mRNA]; NFE2L2 protein promotes the reaction [Curcumin results in increased expression of AKR1B1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in decreased expression of NFE2L2 mRNA]]; pyrazolanthrone inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; SB 203580 inhibits the reaction [Curcumin affects the localization of NFE2L2 protein] Curcumin analog results in increased expression of NFE2L2 mRNA; Curcumin analog results in increased expression of NFE2L2 protein; Curcumin results in increased expression of NFE2L2 mRNA; Curcumin results in increased expression of NFE2L2 protein [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [Curcumin co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form affects the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of CASP3 protein modified form]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL1B mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of IL6 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of BCL2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Curcumin results in increased expression of HMOX1 mRNA] |
CTD |
PMID:17449203 PMID:17535857 PMID:17640564 PMID:18006204 PMID:18321868 PMID:18588981 PMID:19177192 PMID:19183254 PMID:23710286 PMID:23871787 PMID:23954767 PMID:24952339 PMID:25119790 PMID:25169090 PMID:25387343 PMID:25541178 PMID:26361869 PMID:26991801 PMID:27375190 PMID:27837179 PMID:27996348 PMID:29228771 PMID:29571711 PMID:30114225 PMID:30946834 PMID:31187328 PMID:31330227 PMID:31454128 PMID:31521693 PMID:32718261 PMID:33350580 PMID:34272803 PMID:34758851 PMID:35063475 PMID:35243748 PMID:36037877 PMID:36305173 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases activity decreases expression decreases localization |
ISO EXP |
Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [NFKB1 protein binds to IL18 promoter]]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] Curcumin analog results in decreased activity of NFKB1 protein; Curcumin results in decreased activity of NFKB1 protein [Zinc binds to Curcumin] which affects the expression of NFKB1 mRNA; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]] Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of NFKB1 mRNA] Curcumin results in decreased expression of NFKB1 protein Curcumin results in decreased localization of NFKB1 protein |
CTD |
PMID:15489888 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:16299251 PMID:17041101 PMID:17399992 PMID:17596214 PMID:17640567 PMID:17887948 PMID:18006147 PMID:18555241 PMID:18593936 PMID:18752423 PMID:19225048 PMID:19589337 PMID:21811692 PMID:23452621 PMID:34272803 More...
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
decreases activity |
ISO |
Curcumin results in decreased activity of NFKB2 protein |
CTD |
PMID:16173963 |
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NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases phosphorylation increases expression decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NFKBIA protein modified form]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Sodium Fluoride results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL1 mRNA]; NFKBIA protein affects the reaction [Curcumin results in decreased expression of CXCL2 mRNA]; NFKBIA protein inhibits the reaction [Curcumin results in decreased expression of CCN2 mRNA] Curcumin inhibits the reaction [Fluorouracil results in decreased expression of NFKBIA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein] Curcumin results in decreased phosphorylation of NFKBIA protein Curcumin results in increased expression of NFKBIA protein CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of NFKBIA mRNA]; Curcumin inhibits the reaction [Fructose results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]] Curcumin results in decreased expression of NFKBIA protein |
CTD |
PMID:12216086 PMID:15489888 PMID:15793857 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16819191 PMID:16934299 PMID:17289836 PMID:17291458 PMID:17666914 PMID:17885582 PMID:17927689 PMID:17965732 PMID:17999991 PMID:18413660 PMID:23452621 PMID:25540590 PMID:26713546 PMID:27194111 PMID:29793316 PMID:30431687 PMID:31521693 PMID:34272803 PMID:35549587 More...
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] |
CTD |
PMID:16934299 |
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NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nfya |
nuclear transcription factor Y subunit alpha |
decreases expression |
ISO |
Curcumin results in decreased expression of NFYA mRNA |
CTD |
PMID:15713895 |
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NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898
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G |
Ngfr |
nerve growth factor receptor |
decreases expression |
ISO |
Curcumin results in decreased expression of NGFR mRNA |
CTD |
PMID:33539684 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Nhlrc2 |
NHL repeat containing 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of NHLRC2 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 1:255,589,743...255,648,904
Ensembl chr 1:255,589,742...255,651,408
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G |
Nkx2-5 |
NK2 homeobox 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of NKX2-5 mRNA |
CTD |
PMID:27237783 |
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NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
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G |
Nkx3-1 |
NK3 homeobox 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of NKX3-1 mRNA; Curcumin results in decreased expression of NKX3-1 protein |
CTD |
PMID:17303007 PMID:18719366 |
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NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
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G |
Nlrp12 |
NLR family, pyrin domain containing 12 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of NLRP3 protein] |
CTD |
PMID:34998855 PMID:35063475 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nme1 |
NME/NM23 nucleoside diphosphate kinase 1 |
increases expression |
ISO |
Curcumin results in increased expression of NME1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408
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G |
Nmt2 |
N-myristoyltransferase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NMT2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr17:74,917,833...74,964,788
Ensembl chr17:74,917,833...74,961,080
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G |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] |
CTD |
PMID:18413660 |
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NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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G |
Nos1 |
nitric oxide synthase 1 |
multiple interactions |
EXP ISO |
Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA] Curcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS1 protein] |
CTD |
PMID:17627722 PMID:24662163 |
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NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases activity affects expression affects activity |
ISO EXP |
Curcumin inhibits the reaction [Paraquat results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [quinocetone results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] Curcumin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]] Curcumin results in decreased activity of NOS2 protein [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin analog inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Dinitrochlorobenzene results in decreased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Sodium Selenite results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]] Curcumin affects the expression of NOS2 mRNA Curcumin affects the activity of NOS2 protein |
CTD |
PMID:7530002 PMID:12628514 PMID:16934299 PMID:17373747 PMID:17434272 PMID:17461496 PMID:17640567 PMID:17827730 PMID:18368483 PMID:18481332 PMID:18752423 PMID:18838107 PMID:19148301 PMID:19188055 PMID:19481068 PMID:19526292 PMID:20712904 PMID:22982865 PMID:23500011 PMID:25123790 PMID:25387343 PMID:25541178 PMID:27375190 PMID:27535828 PMID:29315967 PMID:32718261 PMID:33350580 More...
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein modified form]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOS3 protein] |
CTD |
PMID:18660423 PMID:23452621 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of NOTCH1 mRNA; Curcumin results in decreased expression of NOTCH1 protein [Curcumin co-treated with Isoflavones] results in decreased expression of NOTCH1 protein |
CTD |
PMID:17927689 PMID:18640131 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cyclosporine results in increased expression of NOX4 protein] |
CTD |
PMID:32569592 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Npc1l1 |
NPC1 like intracellular cholesterol transporter 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of NPC1L1 protein] |
CTD |
PMID:37701206 |
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NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
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G |
Npc2 |
NPC intracellular cholesterol transporter 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of NPC2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
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G |
Nppa |
natriuretic peptide A |
multiple interactions decreases expression |
EXP |
carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased expression of NPPA mRNA] |
CTD |
PMID:26612707 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression increases activity multiple interactions |
EXP ISO |
Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein Curcumin results in increased activity of NQO1 protein Curcumin analog results in increased expression of NQO1 mRNA; Curcumin analog results in increased expression of NQO1 protein; Curcumin results in increased expression of NQO1 mRNA; Curcumin results in increased expression of NQO1 protein Curcumin analog inhibits the reaction [Rotenone results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of NQO1 protein] [Curcumin co-treated with Chloranil] results in increased expression of NQO1 protein; Curcumin affects the expression of and results in increased activity of NQO1 protein; Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of NQO1 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein] Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin analog results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Curcumin results in increased expression of NQO1 protein] |
CTD |
PMID:12628514 PMID:17198877 PMID:17535857 PMID:18299980 PMID:18321868 PMID:19188863 PMID:21464371 PMID:23710286 PMID:23871787 PMID:23954767 PMID:25123790 PMID:25169090 PMID:26473469 PMID:26623679 PMID:26991801 PMID:27535828 PMID:29228771 PMID:29571711 PMID:31330227 PMID:31521693 PMID:33350580 PMID:34272803 PMID:35063475 PMID:36037877 PMID:36305173 More...
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of NR1H3 mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of NR1H3 protein] [Curcumin cotreated with oxidized LDL] increases expression of Nr1h3 protein in macrophages |
CTD RGD |
PMID:16713233 PMID:37701206 PMID:25064633 |
RGD:401850557 |
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity affects expression |
ISO |
Curcumin results in increased activity of NR1I2 protein Curcumin affects the expression of NR1I2 mRNA |
CTD |
PMID:17210444 PMID:29933105 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression multiple interactions |
EXP ISO |
Curcumin results in increased expression of NR3C1 mRNA Curcumin inhibits the reaction [Dexamethasone results in increased phosphorylation of NR3C1 protein] |
CTD |
PMID:17022948 PMID:18483179 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of NR4A2 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nrip1 |
nuclear receptor interacting protein 1 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of NRIP1 mRNA alternative form NRIP1 mRNA alternative form inhibits the reaction [Curcumin results in increased expression of MIR532 mRNA] |
CTD |
PMID:37471645 |
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NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Ntn1 |
netrin 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of NTN1 protein] |
CTD |
PMID:29421648 |
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NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
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G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NTRK2 protein] |
CTD |
PMID:29723552 |
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NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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G |
Nup98 |
nucleoporin 98 and 96 precursor |
increases expression |
ISO |
Curcumin results in increased expression of NUP98 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:156,494,423...156,591,415
Ensembl chr 1:156,494,423...156,591,415
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G |
Oat |
ornithine aminotransferase |
affects expression |
EXP |
Curcumin affects the expression of OAT mRNA |
CTD |
PMID:18539377 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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G |
Ocln |
occludin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein] |
CTD |
PMID:35817260 |
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NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G |
Odc1 |
ornithine decarboxylase 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of ODC1 mRNA Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] |
CTD |
PMID:12628514 PMID:17198877 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein] |
CTD |
PMID:21332098 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OLR1 mRNA] |
CTD |
PMID:23386263 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein] |
CTD |
PMID:28698153 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Osmr |
oncostatin M receptor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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G |
Otud7b |
OTU deubiquitinase 7B |
decreases expression |
ISO |
Curcumin results in decreased expression of OTUD7B mRNA |
CTD |
PMID:18421014 |
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NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674
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G |
Pah |
phenylalanine hydroxylase |
decreases expression |
ISO |
Curcumin results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
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NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
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G |
Pak2 |
p21 (RAC1) activated kinase 2 |
decreases cleavage |
ISO |
Curcumin results in decreased cleavage of PAK2 protein |
CTD |
PMID:15095415 |
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NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression decreases cleavage decreases expression increases degradation increases cleavage |
ISO EXP |
[Curcumin co-treated with Bortezomib] results in increased cleavage of PARP1 protein; [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein; arsenic trioxide promotes the reaction [Curcumin results in increased expression of PARP1 protein modified form]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PARP1 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PARP1 protein]; Curcumin inhibits the reaction [docetaxel results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Curcumin promotes the reaction [arsenic trioxide results in increased expression of PARP1 protein modified form]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; Curcumin results in increased cleavage of and results in increased activity of PARP1 protein Curcumin results in decreased cleavage of PARP1 protein Curcumin analog results in decreased expression of PARP1 mRNA Curcumin results in increased degradation of PARP1 Curcumin results in increased cleavage of PARP1 protein [Doxorubicin co-treated with Curcumin] results in increased cleavage of PARP1 protein; Curcumin inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] carboxymethyl-chitosan analog promotes the reaction [Curcumin results in decreased cleavage of PARP1 protein]; Curcumin inhibits the reaction [AGT protein modified form results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of PARP1 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein] |
CTD |
PMID:11035063 PMID:14555224 PMID:14724571 PMID:15569404 PMID:16023083 PMID:16173963 PMID:17671742 PMID:18006147 PMID:18392098 PMID:18593936 PMID:19235267 PMID:19372569 PMID:19401701 PMID:21332098 PMID:21594647 PMID:21595920 PMID:23710286 PMID:24664296 PMID:25541178 PMID:26409325 PMID:26612707 PMID:27430728 More...
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pax6 |
paired box 6 |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of PAX6 mRNA] Curcumin results in increased expression of PAX6 mRNA |
CTD |
PMID:25963729 |
|
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
decreases expression affects expression |
ISO |
Curcumin results in decreased expression of PCK1 mRNA Curcumin affects the expression of PCK1 mRNA |
CTD |
PMID:17198877 PMID:27208389 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression multiple interactions increases expression |
ISO EXP |
Curcumin results in decreased expression of PCNA protein [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of PCNA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of PCNA protein [Dihydrotestosterone co-treated with Curcumin co-treated with Quercetin] results in increased expression of PCNA protein; Curcumin inhibits the reaction [bisphenol A results in increased expression of PCNA protein] Curcumin results in increased expression of PCNA mRNA |
CTD |
PMID:16101141 PMID:18226269 PMID:23222814 PMID:24831732 PMID:26612707 PMID:27132804 More...
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
affects expression |
ISO |
Curcumin affects the expression of PCSK9 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]; tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]] |
CTD |
PMID:18006644 PMID:18784349 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
increases expression decreases phosphorylation multiple interactions decreases expression |
ISO EXP |
Curcumin results in increased expression of PDGFRB mRNA Curcumin results in decreased phosphorylation of PDGFRB protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA] Curcumin results in decreased expression of PDGFRB mRNA; Curcumin results in decreased expression of PDGFRB protein |
CTD |
PMID:17372590 PMID:18006644 PMID:18332871 PMID:21594647 |
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NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
increases expression |
ISO |
Curcumin results in increased expression of PDIA3 mRNA |
CTD |
PMID:29723631 |
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NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] |
CTD |
PMID:17171638 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
decreases phosphorylation |
ISO |
Curcumin results in decreased phosphorylation of PDPK1 protein |
CTD |
PMID:34634291 |
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NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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G |
Pdpn |
podoplanin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PDPN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
affects expression multiple interactions increases expression decreases expression |
ISO EXP |
Curcumin affects the expression of PECAM1 protein Curcumin inhibits the reaction [Particulate Matter results in increased expression of PECAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of PECAM1 protein] Curcumin results in increased expression of PECAM1 protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PECAM1 protein] Gemcitabine promotes the reaction [Curcumin results in decreased expression of PECAM1 protein] |
CTD |
PMID:17440100 PMID:17960570 PMID:23845850 PMID:29244817 |
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NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Per2 |
period circadian regulator 2 |
increases expression |
ISO |
Curcumin results in increased expression of PER2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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G |
Pfkfb4 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of PFKFB4 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634
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G |
Pgd |
phosphogluconate dehydrogenase |
increases expression |
EXP |
Curcumin results in increased expression of PGD mRNA |
CTD |
PMID:18299980 |
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NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Pgf |
placental growth factor |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PGF mRNA] |
CTD |
PMID:23845850 |
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NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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G |
Pgs1 |
phosphatidylglycerophosphate synthase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PGS1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254
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G |
Phb1 |
prohibitin 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of PHB1 protein |
CTD |
PMID:19137819 |
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NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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G |
Phyh |
phytanoyl-CoA 2-hydroxylase |
decreases expression |
EXP |
Curcumin results in decreased expression of PHYH mRNA |
CTD |
PMID:18539377 |
|
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
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G |
Pik3c2a |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
decreases expression |
ISO |
Curcumin analog results in decreased expression of PIK3C2A mRNA |
CTD |
PMID:26409325 |
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NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
decreases expression |
ISO |
Curcumin analog results in decreased expression of PIK3CA mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein] |
CTD |
PMID:28698153 |
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NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
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G |
Pir |
pirin |
increases expression |
EXP |
Curcumin results in increased expression of PIR mRNA |
CTD |
PMID:18299980 |
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NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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G |
Pirb |
paired Ig-like receptor B |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LILRB3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
ISO |
ATF4 inhibits the reaction [Curcumin results in decreased expression of PKM protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of PKM protein]; Curcumin inhibits the reaction [Sirolimus results in increased expression of PKM protein] |
CTD |
PMID:36640941 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pla2g2a |
phospholipase A2 group IIA |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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G |
Plau |
plasminogen activator, urokinase |
decreases secretion multiple interactions increases expression decreases expression |
ISO |
Curcumin results in decreased secretion of PLAU protein Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAU protein] Curcumin results in increased expression of PLAU mRNA TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein] |
CTD |
PMID:18025290 PMID:18226269 PMID:18495463 PMID:35716765 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Plaur |
plasminogen activator, urokinase receptor |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of PLAUR mRNA Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR mRNA]; Curcumin inhibits the reaction [Bleomycin results in decreased expression of PLAUR protein] |
CTD |
PMID:15713895 PMID:35716765 |
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NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions |
EXP |
curcumin inhibits the reaction [azoxymethane increases activity of Plcg1 protein in colonic mucosa] |
RGD |
PMID:7812955 |
RGD:151356942 |
NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Plekhh2 |
pleckstrin homology, MyTH4 and FERM domain containing H2 |
increases expression |
ISO |
Curcumin results in increased expression of PLEKHH2 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794
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G |
Plk1 |
polo-like kinase 1 |
decreases expression |
ISO |
Curcumin analog results in decreased expression of PLK1 mRNA |
CTD |
PMID:26409325 |
|
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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G |
Plk2 |
polo-like kinase 2 |
increases expression |
ISO |
Curcumin analog results in increased expression of PLK2 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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G |
Plk3 |
polo-like kinase 3 |
increases expression |
ISO |
Curcumin analog results in increased expression of PLK3 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
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G |
Plk4 |
polo-like kinase 4 |
increases expression |
ISO |
Curcumin analog results in increased expression of PLK4 mRNA |
CTD |
PMID:26409325 |
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NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
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G |
Plod2 |
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLOD2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
Curcumin results in increased expression of PMAIP1 mRNA |
CTD |
PMID:17332930 |
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NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Pmepa1 |
prostate transmembrane protein, androgen induced 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of PMEPA1 mRNA |
CTD |
PMID:18719366 |
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NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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G |
Pola2 |
DNA polymerase alpha 2, accessory subunit |
decreases expression |
EXP |
Curcumin results in decreased expression of POLA2 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
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G |
Polb |
DNA polymerase beta |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of POLB protein] Curcumin results in decreased expression of POLB protein |
CTD |
PMID:19401701 PMID:21332098 |
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NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
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G |
Pole |
DNA polymerase epsilon, catalytic subunit |
decreases expression |
EXP |
Curcumin results in decreased expression of POLE mRNA |
CTD |
PMID:18299980 |
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NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
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G |
Porcn |
porcupine O-acyltransferase |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of PORCN mRNA] Curcumin results in increased expression of PORCN mRNA |
CTD |
PMID:25963729 |
|
NCBI chr X:14,285,864...14,298,481
Ensembl chr X:14,285,871...14,298,481
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G |
Postn |
periostin |
increases expression |
ISO |
Curcumin results in increased expression of POSTN mRNA |
CTD |
PMID:21594647 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions decreases expression increases expression |
ISO |
2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA] Curcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 protein WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein] Curcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 protein |
CTD |
PMID:25822711 PMID:27237783 PMID:33539684 |
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NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
decreases expression |
ISO |
Curcumin results in decreased expression of PPARD mRNA; Curcumin results in decreased expression of PPARD protein |
CTD |
PMID:19294764 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects binding decreases expression increases expression increases activity affects localization multiple interactions |
ISO EXP |
Curcumin binds to PPARG protein Curcumin results in decreased expression of PPARG mRNA Curcumin results in increased expression of PPARG mRNA; Curcumin results in increased expression of PPARG protein Curcumin results in increased activity of PPARG protein Curcumin results in decreased expression of PPARG protein Curcumin affects the localization of PPARG protein Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]]; Curcumin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]; Curcumin results in decreased expression of and results in decreased activity of PPARG protein 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]; Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased activity of PPARG protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein] PPARG protein promotes the reaction [Curcumin results in decreased expression of CCN2 mRNA] Curcumin results in decreased expression of PPARG protein modified form |
CTD |
PMID:15486348 PMID:15713005 PMID:16782535 PMID:16959952 PMID:17372590 PMID:17531121 PMID:17602960 PMID:17965732 PMID:18006644 PMID:18332871 PMID:19225048 PMID:19297423 PMID:23603106 PMID:28595985 PMID:29480285 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of PPARGC1A protein]; Curcumin inhibits the reaction [Potassium Dichromate results in decreased expression of PPARGC1A protein] Curcumin results in increased expression of PPARGC1A protein |
CTD |
PMID:28951138 PMID:32980475 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppdpf |
pancreatic progenitor cell differentiation and proliferation factor |
increases expression |
ISO |
Curcumin results in increased expression of PPDPF mRNA |
CTD |
PMID:17198877 |
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NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
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G |
Ppif |
peptidylprolyl isomerase F |
increases expression |
ISO |
Curcumin results in increased expression of PPIF mRNA |
CTD |
PMID:17198877 |
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NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
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G |
Ppp1ca |
protein phosphatase 1 catalytic subunit alpha |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of PPP1CA protein] |
CTD |
PMID:27966075 |
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NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of PPP1R1B protein] |
CTD |
PMID:27966075 |
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NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP2CA mRNA] |
CTD |
PMID:31521693 |
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NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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G |
Ppp3cc |
protein phosphatase 3 catalytic subunit gamma |
decreases expression |
ISO |
Curcumin results in decreased expression of PPP3CC mRNA |
CTD |
PMID:17198877 |
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NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
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G |
Ppp5c |
protein phosphatase 5, catalytic subunit |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PPP5C mRNA] |
CTD |
PMID:31521693 |
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NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
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G |
Prdx5 |
peroxiredoxin 5 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein] |
CTD |
PMID:36924976 |
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NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases phosphorylation |
ISO |
Curcumin results in increased phosphorylation of PRKAA1 protein |
CTD |
PMID:18790744 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkca |
protein kinase C, alpha |
multiple interactions decreases expression |
ISO |
[PRKCA protein results in increased phosphorylation of CFTR protein] promotes the reaction [Curcumin results in increased activity of CFTR protein]; PRKCA protein affects the reaction [Curcumin results in increased expression of HMOX1 protein] Curcumin analog results in decreased expression of PRKCA mRNA |
CTD |
PMID:17178710 PMID:18357586 PMID:26409325 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcd |
protein kinase C, delta |
multiple interactions affects binding increases phosphorylation |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; PRKCD protein affects the reaction [Curcumin results in increased expression of HMOX1 protein]; PRKCD protein promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Staurosporine inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; Wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein] Curcumin results in increased phosphorylation of and results in increased degradation of PRKCD protein Curcumin binds to PRKCD protein |
CTD |
PMID:17148446 PMID:17171638 PMID:18357586 PMID:19161989 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions decreases expression decreases response to substance |
ISO |
Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA] Curcumin analog results in decreased expression of PRKCE mRNA PRKCE protein results in decreased susceptibility to Curcumin |
CTD |
PMID:14742295 PMID:17148446 PMID:26409325 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Prkch |
protein kinase C, eta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA] |
CTD |
PMID:17148446 |
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NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
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G |
Prkcq |
protein kinase C, theta |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein] |
CTD |
PMID:26713546 |
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NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of PRKDC protein] Curcumin results in decreased expression of PRKDC mRNA |
CTD |
PMID:17596214 PMID:21332098 |
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NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein] |
CTD |
PMID:28698153 |
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NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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G |
Prlr |
prolactin receptor |
increases expression |
ISO |
Curcumin results in increased expression of PRLR mRNA |
CTD |
PMID:18421014 |
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NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
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G |
Prom1 |
prominin 1 |
multiple interactions decreases expression |
ISO |
WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein] Curcumin results in decreased expression of PROM1 mRNA; Curcumin results in decreased expression of PROM1 protein |
CTD |
PMID:33539684 |
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NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
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G |
Ptch1 |
patched 1 |
multiple interactions |
EXP |
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of PTCH1 mRNA] |
CTD |
PMID:31612257 |
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NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein] |
CTD |
PMID:24831732 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptges |
prostaglandin E synthase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGES protein] |
CTD |
PMID:27645308 |
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NCBI chr 3:14,177,892...14,189,236
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G |
Ptges2 |
prostaglandin E synthase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGES2 protein] |
CTD |
PMID:18321868 |
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NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of PTGS1 mRNA |
CTD |
PMID:20816778 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression increases expression multiple interactions affects expression |
ISO EXP |
Curcumin analog results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 mRNA; Curcumin results in decreased expression of PTGS2 protein Curcumin analog results in increased expression of PTGS2 mRNA [Curcumin co-treated with Gemcitabine] results in decreased expression of PTGS2 protein; Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Chloranil results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]] Curcumin results in increased expression of PTGS2 mRNA [Curcumin co-treated with Azoxymethane] results in increased expression of PTGS2 mRNA; [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Fructose results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Quartz results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein] Curcumin affects the expression of PTGS2 mRNA [Fluorouracil co-treated with Curcumin] results in decreased expression of PTGS2 protein; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin promotes the reaction [Fluorouracil results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin promotes the reaction [Folfox protocol results in decreased phosphorylation of and results in decreased activity of PTGS2 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of PTGS2 protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein] |
CTD |
PMID:15129424 PMID:15489888 PMID:15841493 PMID:15911101 PMID:16023083 PMID:16219905 PMID:16243823 PMID:16309195 PMID:16340194 PMID:16678799 PMID:16782535 PMID:16804969 PMID:16934760 PMID:17151092 PMID:17190766 PMID:17291458 PMID:17363495 PMID:17434257 PMID:17436566 PMID:17440100 PMID:17640567 PMID:17671737 PMID:17671742 PMID:17827730 PMID:17885582 PMID:17918158 PMID:17999991 PMID:18001810 PMID:18200517 PMID:18226269 PMID:18348204 PMID:18368483 PMID:18549505 PMID:18596194 PMID:18752423 PMID:18829502 PMID:19250217 PMID:20727180 PMID:23500011 PMID:23845850 PMID:25123790 PMID:25387343 PMID:26409325 PMID:26713546 PMID:29315967 PMID:35063475 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Pthlh |
parathyroid hormone-like hormone |
multiple interactions |
ISO |
Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] |
CTD |
PMID:15129424 |
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NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
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G |
Ptpn13 |
protein tyrosine phosphatase, non-receptor type 13 |
decreases expression |
ISO |
Curcumin results in decreased expression of PTPN13 mRNA |
CTD |
PMID:15713895 |
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NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
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G |
Ptpn6 |
protein tyrosine phosphatase, non-receptor type 6 |
increases expression |
ISO |
Curcumin results in increased expression of PTPN6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
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G |
Ptpn7 |
protein tyrosine phosphatase, non-receptor type 7 |
increases expression |
ISO |
Curcumin results in increased expression of PTPN7 mRNA |
CTD |
PMID:17198877 |
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NCBI chr13:46,570,904...46,584,048
Ensembl chr13:46,571,712...46,583,308
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G |
Ptpro |
protein tyrosine phosphatase, receptor type, O |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTPRO mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:170,164,071...170,374,790
Ensembl chr 4:170,164,431...170,374,771
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G |
Ptprr |
protein tyrosine phosphatase, receptor type, R |
decreases expression |
ISO |
Curcumin results in decreased expression of PTPRR mRNA |
CTD |
PMID:21594647 |
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NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
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G |
Ptx3 |
pentraxin 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTX3 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of PYCARD mRNA] |
CTD |
PMID:35063475 |
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NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Rab8a |
RAB8A, member RAS oncogene family |
decreases expression |
ISO |
Curcumin results in decreased expression of RAB8A mRNA |
CTD |
PMID:21594647 |
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NCBI chr16:17,654,027...17,675,385
Ensembl chr16:17,654,034...17,675,678
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of RAC1 mRNA] |
CTD |
PMID:34047412 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rad51 |
RAD51 recombinase |
multiple interactions |
ISO |
[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA; acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]; MAP2K1 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; MAP2K2 protein inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]]; RAD51 results in decreased susceptibility to [Curcumin co-treated with Mitomycin]; U 0126 promotes the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; U 0126 promotes the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] |
CTD |
PMID:21810436 |
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NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases activity multiple interactions |
ISO |
Curcumin results in increased activity of RAF1 protein piperlongumine inhibits the reaction [Curcumin results in increased activity of RAF1 protein] |
CTD |
PMID:19501152 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Ramp1 |
receptor activity modifying protein 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of RAMP1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] |
CTD |
PMID:8940178 |
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rassf2 |
Ras association domain family member 2 |
increases expression |
ISO |
Curcumin results in increased expression of RASSF2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
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G |
Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation multiple interactions |
ISO |
Curcumin results in decreased phosphorylation of RB1 protein Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of RB1 protein] |
CTD |
PMID:15738001 PMID:18156803 PMID:23222814 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rbm39 |
RNA binding motif protein 39 |
increases expression |
ISO |
Curcumin results in increased expression of RBM39 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
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G |
Rbp1 |
retinol binding protein 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RBP1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
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G |
Reg3b |
regenerating family member 3 beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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G |
Reg3g |
regenerating family member 3 gamma |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of REG3G mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
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G |
Rel |
REL proto-oncogene, NF-kB subunit |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Hydrogen Peroxide results in increased expression of REL mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of REL mRNA]; Curcumin promotes the reaction [Hydrogen Peroxide results in increased expression of REL protein] Curcumin results in increased expression of REL protein |
CTD |
PMID:23452621 PMID:31521693 |
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NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases expression increases activity affects activity increases expression decreases localization decreases activity |
ISO EXP |
[Curcumin co-treated with Isoflavones] results in decreased activity of RELA protein; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Acids results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acrylamide results in increased expression of RELA protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of RELA protein modified form]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA]; Curcumin inhibits the reaction [Formaldehyde results in increased expression of RELA protein]; Curcumin inhibits the reaction [Glucose results in increased activity of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [IL1B protein results in increased phosphorylation of and results in increased activity of and results in increased localization of RELA protein]; Curcumin inhibits the reaction [lauric acid results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to IL18 promoter]]; Curcumin inhibits the reaction [NFKBIA protein results in increased degradation of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased activity of RELA protein]; Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]; Curcumin inhibits the reaction [RELA protein binds to MST1R promoter]; Curcumin inhibits the reaction [RELA protein results in increased expression of MST1R mRNA]; Curcumin inhibits the reaction [Sodium Fluoride results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin results in decreased activity of [NFKB1 protein binds to RELA protein]; Curcumin results in decreased expression of and results in decreased activity of RELA protein; Curcumin results in decreased phosphorylation of and affects the localization of RELA protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; zinc protoporphyrin inhibits the reaction [Curcumin inhibits the reaction [quinocetone results in increased expression of RELA mRNA]] [Curcumin co-treated with Gemcitabine] results in decreased expression of RELA protein; Curcumin analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of RELA protein]; Curcumin inhibits the reaction [Chloranil affects the localization of RELA protein modified form]; Curcumin inhibits the reaction [Chloranil results in increased expression of RELA protein]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [NFKB1 protein binds to RELA protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] Curcumin results in decreased expression of RELA protein Curcumin results in increased activity of RELA protein 2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of RELA protein]; [Curcumin binds to carboxymethyl-chitosan analog] which results in decreased expression of and results in decreased phosphorylation of RELA protein; CD40 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Curcumin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]]; Curcumin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [Streptozocin affects the localization of RELA protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]; Curcumin results in increased expression of and results in increased activity of RELA protein; ICAM1 protein affects the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; NFE2L2 protein promotes the reaction [Curcumin results in increased activity of RELA protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of RELA protein]] Curcumin affects the activity of RELA protein Curcumin results in increased expression of RELA Curcumin results in decreased localization of RELA protein Curcumin results in decreased expression of RELA; Curcumin results in decreased expression of RELA mRNA; Curcumin results in decreased expression of RELA protein |
CTD |
PMID:12216086 PMID:12388107 PMID:15489888 PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:16819191 PMID:16934299 PMID:17273796 PMID:17291458 PMID:17399992 PMID:17440100 PMID:17531121 PMID:17640567 PMID:17666914 PMID:17887948 PMID:17927689 PMID:17999991 PMID:18006147 PMID:18226269 PMID:18389075 PMID:18403477 PMID:18413660 PMID:18555241 PMID:18588981 PMID:18593918 PMID:18593936 PMID:18640131 PMID:18752423 PMID:18829502 PMID:19074641 PMID:19372569 PMID:20885979 PMID:21782934 PMID:23059809 PMID:23452621 PMID:24508477 PMID:25123790 PMID:25540590 PMID:25541178 PMID:26612707 PMID:27375190 PMID:29793316 PMID:31712109 PMID:32718261 PMID:34047412 PMID:34272803 PMID:34577062 PMID:34719837 PMID:34998855 PMID:35549587 PMID:36156276 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Relb |
RELB proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RELB mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
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G |
Reln |
reelin |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA] Curcumin results in increased expression of RELN mRNA |
CTD |
PMID:25963729 |
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NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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G |
Retnlb |
resistin like beta |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RETNLB mRNA] |
CTD |
PMID:18200517 |
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NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368
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G |
Rev3l |
REV3 like, DNA directed polymerase zeta catalytic subunit |
increases expression |
ISO |
Curcumin results in increased expression of REV3L protein |
CTD |
PMID:19137819 |
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NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
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G |
Rfxap |
regulatory factor X-associated protein |
decreases expression |
ISO |
Curcumin results in decreased expression of RFXAP mRNA |
CTD |
PMID:17999991 |
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NCBI chr 2:139,008,052...139,012,235
Ensembl chr 2:139,008,055...139,012,259
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G |
Rgs16 |
regulator of G-protein signaling 16 |
increases expression |
ISO |
Curcumin results in increased expression of RGS16 mRNA |
CTD |
PMID:17198877 |
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NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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G |
Rgs4 |
regulator of G-protein signaling 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of RGS4 mRNA |
CTD |
PMID:21594647 |
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NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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G |
Rgs7 |
regulator of G-protein signaling 7 |
decreases expression |
ISO |
Curcumin results in decreased expression of RGS7 mRNA |
CTD |
PMID:17999991 |
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NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888
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G |
Rhoa |
ras homolog family member A |
decreases expression |
ISO |
Curcumin analog results in decreased expression of RHOA mRNA |
CTD |
PMID:26409325 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Rhob |
ras homolog family member B |
decreases expression |
ISO |
Curcumin analog results in decreased expression of RHOB mRNA |
CTD |
PMID:26409325 |
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NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rims2 |
regulating synaptic membrane exocytosis 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of RIMS2 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of RIPK1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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G |
Rpl31 |
ribosomal protein L31 |
increases expression |
ISO |
Curcumin results in increased expression of RPL31 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 9:41,647,397...41,651,441
Ensembl chr 9:41,647,426...41,662,129
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G |
Rps6 |
ribosomal protein S6 |
multiple interactions decreases phosphorylation |
ISO |
calyculin A inhibits the reaction [Curcumin results in decreased phosphorylation of RPS6 protein]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased expression of RPS6 protein]; Curcumin results in decreased phosphorylation of and results in decreased expression of RPS6 protein |
CTD |
PMID:18790744 PMID:21450334 PMID:23222814 PMID:34634291 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation multiple interactions |
ISO |
Curcumin results in decreased phosphorylation of RPS6KB1 protein Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of RPS6KB1 protein] Curcumin analog inhibits the reaction [Oxygen deficiency results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:18790744 PMID:20554536 PMID:27363783 PMID:34634291 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Rreb1 |
ras responsive element binding protein 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of RREB1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr17:26,876,687...27,002,554
Ensembl chr17:26,876,697...27,002,615
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G |
Rtkn |
rhotekin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Butyrates]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Fluorouracil]; Curcumin inhibits the reaction [RTKN protein results in decreased susceptibility to Paclitaxel] |
CTD |
PMID:15480428 |
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NCBI chr 4:115,640,813...115,657,952
Ensembl chr 4:115,640,774...115,657,952
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G |
Runx2 |
RUNX family transcription factor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of RUNX2 protein |
CTD |
PMID:15129424 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Curcumin promotes the reaction [VDR protein binds to RXRA protein] |
CTD |
PMID:20153625 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
S100a8 |
S100 calcium binding protein A8 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A8 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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G |
S100a9 |
S100 calcium binding protein A9 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of S100A9 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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G |
S100g |
S100 calcium binding protein G |
affects expression |
EXP |
Curcumin affects the expression of S100G mRNA |
CTD |
PMID:18539377 |
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NCBI chr X:31,705,853...31,708,422
Ensembl chr X:31,705,866...31,708,433
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G |
Scarb1 |
scavenger receptor class B, member 1 |
affects expression |
ISO |
Curcumin affects the expression of SCARB1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Scd |
stearoyl-CoA desaturase |
decreases expression affects expression |
ISO EXP |
Curcumin results in decreased expression of SCD mRNA Curcumin affects the expression of SCD1 mRNA; Curcumin affects the expression of SCD1 protein |
CTD |
PMID:20816778 PMID:27208389 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scd2 |
stearoyl-Coenzyme A desaturase 2 |
decreases expression |
EXP |
Curcumin results in decreased expression of SCD2 mRNA |
CTD |
PMID:27208389 |
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NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
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G |
Scrn2 |
secernin 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of SCRN2 mRNA |
CTD |
PMID:17198877 |
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NCBI chr10:82,016,604...82,020,676
Ensembl chr10:82,016,649...82,020,675
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
decreases expression |
ISO |
Curcumin results in decreased expression of SDHA mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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G |
Sele |
selectin E |
multiple interactions affects expression |
EXP ISO |
Curcumin inhibits the reaction [F2 protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein] Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELE protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELE protein] Curcumin affects the expression of SELE protein |
CTD |
PMID:17960570 PMID:18565277 PMID:29244817 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Sell |
selectin L |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SELL mRNA] |
CTD |
PMID:23452621 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Selp |
selectin P |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [F2 protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein] Curcumin inhibits the reaction [Particulate Matter results in increased expression of SELP protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of SELP protein] |
CTD |
PMID:18565277 PMID:29244817 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Septin7 |
septin 7 |
increases expression |
ISO |
Curcumin results in increased expression of SEPTIN7 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243
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G |
Serpinb2 |
serpin family B member 2 |
increases expression |
ISO |
Curcumin results in increased expression of SERPINB2 mRNA |
CTD |
PMID:15713895 |
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NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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G |
Serpinb5 |
serpin family B member 5 |
increases expression multiple interactions |
ISO |
[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of SERPINB5 mRNA; Curcumin results in increased expression of SERPINB5 protein [Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein |
CTD |
PMID:17290611 PMID:19944674 |
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NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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G |
Serpine1 |
serpin family E member 1 |
increases expression multiple interactions |
ISO |
Curcumin results in increased expression of SERPINE1 mRNA Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of SERPINE1 protein] |
CTD |
PMID:15713895 PMID:35716765 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Serpine2 |
serpin family E member 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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G |
Serpinh1 |
serpin family H member 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] |
CTD |
PMID:24704557 |
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NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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G |
Sfpq |
splicing factor proline and glutamine rich |
increases expression |
ISO |
Curcumin results in increased expression of SFPQ mRNA |
CTD |
PMID:17198877 |
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NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
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G |
Sfrp2 |
secreted frizzled-related protein 2 |
decreases expression multiple interactions |
EXP |
Curcumin results in decreased expression of SFRP2 mRNA Curcumin inhibits the reaction [bisphenol A results in increased expression of SFRP2 mRNA] |
CTD |
PMID:25963729 |
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NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
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G |
Sfrp5 |
secreted frizzled-related protein 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of SFRP5 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224
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G |
Sfxn1 |
sideroflexin 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of SFXN1 mRNA |
CTD |
PMID:18421014 |
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NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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G |
Shh |
sonic hedgehog signaling molecule |
multiple interactions |
EXP |
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SHH mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SHH mRNA] |
CTD |
PMID:31612257 |
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NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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G |
Sim2 |
SIM bHLH transcription factor 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of SIM2 protein] |
CTD |
PMID:23333261 |
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NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663
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G |
Sirt1 |
sirtuin 1 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of SIRT1 mRNA Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 mRNA]; Curcumin inhibits the reaction [aristolochic acid I results in decreased expression of SIRT1 protein]; Curcumin inhibits the reaction [Cyclosporine results in decreased expression of SIRT1 protein] |
CTD |
PMID:18403477 PMID:32569592 PMID:36037877 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Sirt3 |
sirtuin 3 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]; Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein] Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]] |
CTD |
PMID:26422756 PMID:28698153 PMID:28951138 |
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NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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G |
Sirt6 |
sirtuin 6 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 mRNA]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT6 protein]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 mRNA]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of ABCA1 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of CCL2 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]] |
CTD |
PMID:33952798 |
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NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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G |
Sirt7 |
sirtuin 7 |
decreases expression |
ISO |
Curcumin results in decreased expression of SIRT7 |
CTD |
PMID:25644192 |
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NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
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G |
Skap2 |
src kinase associated phosphoprotein 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of SKAP2 mRNA |
CTD |
PMID:19555370 |
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NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
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G |
Slc11a2 |
solute carrier family 11 member 2 |
increases expression |
ISO |
Curcumin results in increased expression of SLC11A2 mRNA |
CTD |
PMID:24634837 |
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NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
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G |
Slc16a1 |
solute carrier family 16 member 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of SLC16A1 protein |
CTD |
PMID:21397623 |
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NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc18a2 |
solute carrier family 18 member A2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SLC18A2 protein] |
CTD |
PMID:27966075 |
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NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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G |
Slc1a3 |
solute carrier family 1 member 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA] |
CTD |
PMID:23267840 |
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NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
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G |
Slc20a1 |
solute carrier family 20 member 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC20A1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of SLC2A1 mRNA ATF4 inhibits the reaction [Curcumin results in decreased expression of SLC2A1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SLC2A1 protein] |
CTD |
PMID:21397623 PMID:36640941 |
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NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a2 |
solute carrier family 2 member 2 |
decreases expression multiple interactions |
ISO EXP |
Curcumin results in decreased expression of SLC2A2 mRNA Curcumin inhibits the reaction [Streptozocin results in decreased expression of SLC2A2 protein] |
CTD |
PMID:21397623 PMID:25541178 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:21397623 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Slc2a5 |
solute carrier family 2 member 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of SLC2A5 mRNA |
CTD |
PMID:21397623 |
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NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
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G |
Slc30a1 |
solute carrier family 30 member 1 |
increases expression |
ISO |
Curcumin results in increased expression of SLC30A1 mRNA |
CTD |
PMID:17999991 |
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NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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G |
Slc30a10 |
solute carrier family 30, member 10 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SLC30A10 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
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G |
Slc37a4 |
solute carrier family 37 member 4 |
decreases expression |
ISO |
Curcumin results in decreased expression of SLC37A4 mRNA |
CTD |
PMID:16777101 |
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NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
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G |
Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
ISO |
Curcumin results in increased expression of SLC3A2 mRNA |
CTD |
PMID:17198877 PMID:19183254 |
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NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc48a1 |
solute carrier family 48 member 1 |
increases expression |
ISO |
Curcumin results in increased expression of SLC48A1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024
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G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SLC6A3 protein] |
CTD |
PMID:30463061 |
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NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Curcumin results in increased expression of SLC7A11 mRNA |
CTD |
PMID:17999991 PMID:19183254 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
ISO |
Curcumin results in increased expression of SLCO1A2 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SLPI mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:26648693 |
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NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter]; Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein]; Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein]] |
CTD |
PMID:16959952 PMID:26648693 PMID:32718261 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Smad4 |
SMAD family member 4 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] Curcumin results in decreased expression of SMAD4 mRNA |
CTD |
PMID:16959952 PMID:27237783 |
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NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
EXP |
[Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of SMO mRNA]; Curcumin inhibits the reaction [Cisplatin results in increased expression of SMO mRNA] |
CTD |
PMID:31612257 |
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NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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G |
Smpx |
small muscle protein, X-linked |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SMPX mRNA] |
CTD |
PMID:18200517 |
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NCBI chr X:37,233,209...37,292,266
Ensembl chr X:37,234,294...37,276,708
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G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased expression of SNAI1 protein] |
CTD |
PMID:25656647 PMID:34233590 |
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NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
Curcumin results in decreased expression of SNAI2 protein |
CTD |
PMID:19573523 |
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NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
[Curcumin co-treated with Niacin co-treated with ZM 241385] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]; Curcumin inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:31187328 PMID:31820278 |
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NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Socs3 |
suppressor of cytokine signaling 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of SOCS3 mRNA |
CTD |
PMID:18403477 PMID:25822711 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Socs5 |
suppressor of cytokine signaling 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of SOCS5 protein |
CTD |
PMID:21397623 |
|
NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression |
EXP ISO |
[Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; [Curcumin co-treated with Vitamin E] inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; [Curcumin co-treated with Vitamin E] promotes the reaction [Thyroxine results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [aristolochic acid I results in decreased activity of SOD1 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Thyroxine results in increased activity of SOD1 protein]; Curcumin promotes the reaction [Thyroxine results in decreased activity of SOD1 protein] Curcumin results in increased expression of SOD1 protein Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]; Curcumin inhibits the reaction [quinocetone results in decreased activity of SOD1 protein] Curcumin inhibits the reaction [Aflatoxin B1 results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of SOD1 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of SOD1 mRNA] |
CTD |
PMID:19914224 PMID:25996037 PMID:30934151 PMID:31521693 PMID:35063475 PMID:35817260 PMID:36037877 PMID:36924976 More...
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
affects expression increases expression multiple interactions |
EXP ISO |
Curcumin affects the expression of SOD2 mRNA; Curcumin affects the expression of SOD2 protein Curcumin results in increased expression of SOD2 protein Curcumin results in increased expression of SOD2 mRNA; Curcumin results in increased expression of SOD2 protein 2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA] Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in decreased expression of and results in decreased activity of SOD2 protein]; Curcumin analog inhibits the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of and results in decreased activity of SOD2 protein]; Curcumin analog promotes the reaction [[Sodium Cholate co-treated with Deoxycholic Acid co-treated with Glycocholic Acid co-treated with Taurocholic Acid] results in increased expression of SOD2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of SOD2 protein]; Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]] [Vitamin E co-treated with Curcumin] inhibits the reaction [Thyroxine results in decreased expression of SOD2 mRNA]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased activity of SOD2 protein]; Curcumin inhibits the reaction [Thyroxine results in decreased activity of SOD2 protein]; Curcumin promotes the reaction [Thyroxine results in increased expression of SOD2 protein] |
CTD |
PMID:11543823 PMID:18299980 PMID:19914224 PMID:22316666 PMID:23452621 PMID:25822711 PMID:28951138 PMID:31521693 PMID:34758851 More...
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox2 |
SRY-box transcription factor 2 |
increases expression |
ISO |
Curcumin results in increased expression of SOX2 mRNA; Curcumin results in increased expression of SOX2 protein |
CTD |
PMID:25822711 |
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NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338
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G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions increases expression |
ISO |
[Curcumin co-treated with resveratrol] results in increased expression of SOX9 protein Curcumin results in increased expression of SOX9 protein |
CTD |
PMID:19889203 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Sp1 |
Sp1 transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of SP1 protein |
CTD |
PMID:18347134 PMID:18593936 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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G |
Sp3 |
Sp3 transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of SP3 protein |
CTD |
PMID:18593936 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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G |
Sp4 |
Sp4 transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of SP4 protein |
CTD |
PMID:18593936 |
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NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
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G |
Sparc |
secreted protein acidic and cysteine rich |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SPARC mRNA] |
CTD |
PMID:18200517 |
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NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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G |
Spib |
Spi-B transcription factor |
increases expression |
ISO |
Curcumin results in increased expression of SPIB mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
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G |
Spock1 |
sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 |
increases expression |
ISO |
Curcumin results in increased expression of SPOCK1 mRNA |
CTD |
PMID:21594647 |
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NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Cadmium Chloride results in increased export of SPP1 protein] |
CTD |
PMID:29421648 |
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NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Sqle |
squalene epoxidase |
decreases expression affects expression |
EXP ISO |
Curcumin results in decreased expression of SQLE mRNA Curcumin affects the expression of SQLE mRNA |
CTD |
PMID:27208389 |
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NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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G |
Sqstm1 |
sequestosome 1 |
decreases expression increases expression multiple interactions |
ISO |
Curcumin results in decreased expression of SQSTM1 protein Curcumin results in increased expression of SQSTM1 protein 4-phenylbutyric acid inhibits the reaction [Curcumin results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine results in increased phosphorylation of SQSTM1 protein]; Curcumin inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; Curcumin inhibits the reaction [Tunicamycin results in decreased expression of SQSTM1 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]] |
CTD |
PMID:34634291 PMID:34758851 PMID:36640941 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases expression multiple interactions decreases activity |
ISO |
Curcumin results in decreased expression of SRC protein [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of SRC protein] [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] which results in decreased activity of SRC protein Curcumin analog results in decreased activity of SRC protein; Curcumin results in decreased activity of SRC protein |
CTD |
PMID:16959222 PMID:33617879 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
affects expression multiple interactions decreases expression |
ISO EXP |
Curcumin affects the expression of SREBF1 mRNA; Curcumin affects the expression of SREBF1 protein Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF1 protein] Curcumin results in decreased expression of SREBF1 mRNA |
CTD |
PMID:27208389 PMID:37701206 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
affects expression multiple interactions decreases expression |
ISO EXP |
Curcumin affects the expression of SREBF2 mRNA; Curcumin affects the expression of SREBF2 protein Curcumin inhibits the reaction [bisphenol A results in increased expression of SREBF2 protein] Curcumin results in decreased expression of SREBF2 mRNA |
CTD |
PMID:27208389 PMID:37701206 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
Srm |
spermidine synthase |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SRM mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
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G |
Srsf1 |
serine and arginine rich splicing factor 1 |
increases expression |
ISO |
Curcumin results in increased expression of SRSF1 mRNA |
CTD |
PMID:17999991 |
|
NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
increases expression |
ISO |
Curcumin results in increased expression of SRSF2 mRNA |
CTD |
PMID:17198877 |
|
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
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G |
Srsf3 |
serine and arginine rich splicing factor 3 |
increases expression |
ISO |
Curcumin results in increased expression of SRSF3 mRNA |
CTD |
PMID:17198877 |
|
NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078
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G |
Srsf5 |
serine and arginine rich splicing factor 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of SRSF5 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
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G |
Srsf6 |
serine and arginine rich splicing factor 6 |
increases expression |
ISO |
Curcumin results in increased expression of SRSF6 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT1 protein] Curcumin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:16959222 PMID:21811692 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases expression increases phosphorylation decreases phosphorylation |
ISO EXP |
Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [IFNG protein results in increased expression of and results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Curcumin inhibits the reaction [Trichloroethylene results in increased phosphorylation of STAT3 protein] [Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein] Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of STAT3 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of STAT3 protein] Curcumin results in decreased expression of STAT3 mRNA Curcumin results in increased phosphorylation of STAT3 protein Curcumin results in decreased expression of STAT3 mRNA; Curcumin results in decreased expression of STAT3 protein |
CTD |
PMID:16959222 PMID:17666914 PMID:19383353 PMID:20816778 PMID:25822711 PMID:25963729 PMID:30431687 PMID:33617879 PMID:34233590 PMID:36352148 More...
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Stat4 |
signal transducer and activator of transcription 4 |
multiple interactions |
ISO |
Curcumin promotes the reaction [IFNB1 protein results in increased phosphorylation of STAT4 protein] |
CTD |
PMID:17979888 |
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NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat5a |
signal transducer and activator of transcription 5A |
increases cleavage decreases expression |
ISO |
Curcumin results in increased cleavage of STAT5A protein Curcumin results in decreased expression of STAT5A protein |
CTD |
PMID:16959222 |
|
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Stat5b |
signal transducer and activator of transcription 5B |
increases cleavage decreases expression |
ISO |
Curcumin results in increased cleavage of STAT5B protein Curcumin results in decreased expression of STAT5B protein |
CTD |
PMID:16959222 |
|
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Sts |
steroid sulfatase |
decreases expression |
ISO |
Curcumin results in decreased expression of STS mRNA |
CTD |
PMID:17198877 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Stx3 |
syntaxin 3 |
multiple interactions |
ISO |
[Docosahexaenoic Acids co-treated with Curcumin] results in increased expression of STX3 mRNA |
CTD |
PMID:22911773 |
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NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
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G |
Sulf1 |
sulfatase 1 |
increases expression |
ISO |
Curcumin results in increased expression of SULF1 mRNA; Curcumin results in increased expression of SULF1 protein |
CTD |
PMID:21594647 |
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NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584
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G |
Sulf2 |
sulfatase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SULF2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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G |
Suz12 |
SUZ12 polycomb repressive complex 2 subunit |
decreases expression |
ISO |
Curcumin results in decreased expression of SUZ12 mRNA |
CTD |
PMID:18421014 |
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NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738
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G |
Sycp2 |
synaptonemal complex protein 2 |
increases expression |
ISO |
Curcumin results in increased expression of SYCP2 mRNA |
CTD |
PMID:18421014 |
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NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789
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G |
Syn2 |
synapsin II |
multiple interactions |
ISO |
Curcumin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SYN2 protein] |
CTD |
PMID:32735850 |
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NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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G |
Syngap1 |
synaptic Ras GTPase activating protein 1 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [sodium arsenite results in increased expression of SYNGAP1 protein] |
CTD |
PMID:29723552 |
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NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
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G |
Tada3 |
transcriptional adaptor 3 |
affects expression |
EXP |
Curcumin affects the expression of TADA3 mRNA |
CTD |
PMID:18539377 |
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NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590
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G |
Taldo1 |
transaldolase 1 |
increases expression |
EXP |
Curcumin results in increased expression of TALDO1 mRNA |
CTD |
PMID:18299980 |
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NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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G |
Tbc1d1 |
TBC1 domain family member 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of TBC1D1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499
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G |
Tbc1d8 |
TBC1 domain family, member 8 |
increases expression |
ISO |
Curcumin results in increased expression of TBC1D8 mRNA |
CTD |
PMID:17999991 |
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NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
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G |
Tbk1 |
TANK-binding kinase 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TBK1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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G |
Tbxt |
T-box transcription factor T |
decreases expression |
ISO |
Curcumin results in decreased expression of T mRNA |
CTD |
PMID:27237783 |
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NCBI chr 1:52,298,104...52,309,813
Ensembl chr 1:52,298,099...52,305,864
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G |
Tcf7l2 |
transcription factor 7 like 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein] |
CTD |
PMID:19294764 |
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NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
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G |
Tert |
telomerase reverse transcriptase |
decreases activity |
ISO |
Curcumin results in decreased activity of TERT protein |
CTD |
PMID:17096185 |
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NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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G |
Tet2 |
tet methylcytosine dioxygenase 2 |
increases expression |
ISO |
curcumin increases expression of TET2 mRNA and protein in stomach |
RGD |
PMID:33058920 |
RGD:150429654 |
NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
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G |
Tf |
transferrin |
increases expression |
ISO |
Curcumin results in increased expression of TF mRNA |
CTD |
PMID:15713895 |
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NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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G |
Tfam |
transcription factor A, mitochondrial |
multiple interactions |
EXP |
[Curcumin co-treated with Potassium Dichromate] results in increased expression of TFAM protein |
CTD |
PMID:32980475 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tfeb |
transcription factor EB |
multiple interactions |
ISO |
[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein] |
CTD |
PMID:34758851 |
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NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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G |
Tfrc |
transferrin receptor |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of TFRC mRNA Curcumin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFRC protein] |
CTD |
PMID:17198877 PMID:18340409 PMID:24634837 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions decreases expression decreases activity |
ISO EXP |
Curcumin inhibits the reaction [TGFB1 protein results in increased expression of RARA mRNA] [1,2-Dimethylhydrazine co-treated with Curcumin] results in increased expression of TGFB1 mRNA; Curcumin affects the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] Curcumin results in decreased expression of TGFB1 mRNA; Curcumin results in decreased expression of TGFB1 protein 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; [Arsenic Trioxide co-treated with Curcumin] inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; [Zinc binds to Curcumin] which affects the expression of TGFB1 mRNA; Curcumin analog inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [Cisplatin results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Curcumin inhibits the reaction [TGFB1 protein results in decreased expression of PPARG mRNA]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]] Curcumin results in decreased activity of TGFB1 protein |
CTD |
PMID:8940178 PMID:16751071 PMID:16959952 PMID:17434272 PMID:18006644 PMID:18705752 PMID:19589337 PMID:22982865 PMID:24704557 PMID:26648693 PMID:28700904 PMID:29480285 PMID:31612257 PMID:32718261 PMID:34272803 More...
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
multiple interactions decreases expression |
EXP |
2-chloro-5-nitrobenzanilide inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein] Curcumin results in decreased expression of TGFBR1 mRNA; Curcumin results in decreased expression of TGFBR1 protein |
CTD |
PMID:16959952 PMID:17531121 PMID:17602960 |
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NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tgfbr2 |
transforming growth factor, beta receptor 2 |
multiple interactions decreases expression |
EXP |
Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein] Curcumin results in decreased expression of TGFBR2 mRNA; Curcumin results in decreased expression of TGFBR2 protein |
CTD |
PMID:16959952 PMID:17602960 |
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NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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G |
Tgm2 |
transglutaminase 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGM2 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP ISO |
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TH protein]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of TH protein] Curcumin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] |
CTD |
PMID:19631675 PMID:22704994 PMID:27966075 PMID:30463061 PMID:31187328 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thbs1 |
thrombospondin 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THBS1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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G |
Thy1 |
Thy-1 cell surface antigen |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of THY1 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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G |
Ticam1 |
TIR domain containing adaptor molecule 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
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G |
Ticam2 |
TIR domain containing adaptor molecule 2 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TICAM2 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions decreases expression |
ISO EXP |
Curcumin inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TIMP1 mRNA] Curcumin inhibits the reaction [Cadmium Chloride results in increased export of TIMP1 protein] Curcumin results in decreased expression of TIMP1 protein |
CTD |
PMID:17996675 PMID:18200517 PMID:27363783 PMID:29421648 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions decreases expression |
EXP ISO |
Curcumin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] Curcumin results in decreased expression of TIMP2 protein |
CTD |
PMID:16934674 PMID:17996675 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of and affects the localization of TJP1 protein]; Curcumin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TJP1 protein] |
CTD |
PMID:26191140 PMID:35817260 |
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NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tlr1 |
toll-like receptor 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR1 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
EXP ISO |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 protein] Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TLR2 mRNA] |
CTD |
PMID:22683883 PMID:23452621 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions decreases expression |
ISO EXP |
[Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; [Dexamethasone co-treated with Curcumin] inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [[Lipopolysaccharides binds to TLR4 protein] which results in increased activity of IRF3 protein]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [[Ovalbumin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]] Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR4 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] Curcumin results in decreased expression of TLR4 mRNA; Curcumin results in decreased expression of TLR4 protein |
CTD |
PMID:16678799 PMID:17965732 PMID:19002562 PMID:22683883 PMID:34719837 PMID:34998855 More...
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tmt1a |
thiol methyltransferase 1A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of METTL7A mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
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G |
Tnc |
tenascin C |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression affects expression increases expression |
ISO EXP |
[Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Curcumin inhibits the reaction [[benz(a)anthracene co-treated with TNF protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased phosphorylation of MAPK14 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]; Curcumin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein affects the localization of RELA protein]; Curcumin inhibits the reaction [TNF protein promotes the reaction [Shiga Toxin binds to globotriaosylceramide]]; Curcumin inhibits the reaction [TNF protein results in decreased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in decreased expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Curcumin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ADAM17 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC3 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of MYC mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased localization of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of STAT3 protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; MIR125A mRNA inhibits the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]]; SIRT6 protein promotes the reaction [Curcumin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF protein]] Curcumin results in decreased expression of TNF mRNA; Curcumin results in decreased expression of TNF protein 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; [Sitagliptin Phosphate co-treated with Curcumin] inhibits the reaction [decamethrin results in increased expression of TNF protein]; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; CD40 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]; Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TNF protein]; Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in increased expression of TNF protein]; Curcumin inhibits the reaction [[TNF protein co-treated with IL1B protein] results in increased secretion of CXCL2 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Curcumin inhibits the reaction [Colistin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [decamethrin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Fructose results in increased expression of TNF protein]; Curcumin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of SELP protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; ICAM1 protein affects the reaction [Curcumin affects the reaction [Lipopolysaccharides affects the expression of TNF protein]]; pomegranate fruit rind promotes the reaction [Curcumin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]] Curcumin affects the expression of TNF mRNA; Curcumin affects the expression of TNF protein Curcumin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Curcumin inhibits the reaction [butylbenzyl phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TNF mRNA]]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of TNF protein]; Curcumin inhibits the reaction [sodium arsenite affects the expression of TNF mRNA]; Curcumin inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Curcumin inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; NFE2L2 gene mutant form inhibits the reaction [Curcumin results in decreased expression of TNF mRNA] Curcumin results in increased expression of TNF mRNA |
CTD |
PMID:14555224 PMID:15489888 PMID:16023083 PMID:16219905 PMID:16584726 PMID:16751071 PMID:16782535 PMID:16819191 PMID:16867261 PMID:17151092 PMID:17198877 PMID:17273796 PMID:17276891 PMID:17291458 PMID:17355460 PMID:17383825 PMID:17640567 PMID:17666914 PMID:17887948 PMID:17927689 PMID:17973899 PMID:18001810 PMID:18006644 PMID:18200517 PMID:18357586 PMID:18368483 PMID:18379247 PMID:18403477 PMID:18549505 PMID:18565277 PMID:18752423 PMID:18838107 PMID:19152916 PMID:19188055 PMID:19225048 PMID:19413659 PMID:20712904 PMID:21782934 PMID:22465177 PMID:22683883 PMID:23396138 PMID:23452621 PMID:24760747 PMID:25461551 PMID:25541178 PMID:26713546 PMID:28063877 PMID:28595985 PMID:28700904 PMID:28951138 PMID:29315967 PMID:29480285 PMID:29571711 PMID:29793316 PMID:30016632 PMID:30138604 PMID:31199764 PMID:31407471 PMID:31454128 PMID:31712109 PMID:32718261 PMID:33350580 PMID:33952798 PMID:34272803 PMID:34577062 PMID:34719837 PMID:35549587 PMID:35716765 PMID:35817260 PMID:36156276 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions increases expression |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF10A mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein] |
CTD |
PMID:18226269 PMID:23452621 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Tnfrsf12a |
TNF receptor superfamily member 12A |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFRSF12A mRNA] |
CTD |
PMID:34047412 |
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NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1A protein] |
CTD |
PMID:17666914 PMID:23452621 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B mRNA]; Curcumin inhibits the reaction [TNF protein results in increased expression of TNFRSF1B protein] |
CTD |
PMID:17666914 |
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NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Tnfrsf21 |
TNF receptor superfamily member 21 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Curcumin] results in increased expression of TNFRSF21 protein |
CTD |
PMID:27430728 |
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NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
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G |
Tnfrsf22 |
tumor necrosis factor receptor superfamily, member 22 |
multiple interactions |
ISO |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TNFRSF10C protein |
CTD |
PMID:27430728 |
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NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF10 mRNA]; TNFSF10 protein promotes the reaction [Curcumin results in decreased activity of RELA protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of BCL2L1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CCND1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of CXCL8 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of MMP9 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PTGS2 protein]; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAK1 protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of BAX protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10A protein]; TNFSF10 protein promotes the reaction [Curcumin results in increased expression of TNFRSF10B protein] Curcumin results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:15713895 PMID:16101141 PMID:18226269 PMID:23452621 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [TNFSF11 protein results in increased activity of CHUK protein]; Curcumin inhibits the reaction [TNFSF11 protein results in increased expression of PTGS2 protein] Curcumin inhibits the reaction [IL1A protein results in increased expression of TNFSF11 protein] |
CTD |
PMID:15129424 PMID:18719352 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Tnfsf12 |
TNF superfamily member 12 |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNFSF12 protein] |
CTD |
PMID:34047412 |
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NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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G |
Tnfsf14 |
TNF superfamily member 14 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of TNFSF14 mRNA] |
CTD |
PMID:23452621 |
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NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216
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G |
Tnks |
tankyrase |
decreases expression |
ISO |
Curcumin analog results in decreased expression of TNKS mRNA |
CTD |
PMID:26409325 |
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NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260
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Tnni3 |
troponin I3, cardiac type |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] |
CTD |
PMID:29315967 |
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NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions decreases expression |
ISO |
[Curcumin co-treated with Azacitidine] results in decreased expression of TOP2A mRNA; [sulfinosine co-treated with Curcumin] results in decreased expression of TOP2A mRNA Curcumin analog results in decreased expression of TOP2A mRNA; Curcumin results in decreased expression of TOP2A mRNA |
CTD |
PMID:18348204 PMID:18414057 PMID:26409325 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Top2b |
DNA topoisomerase II beta |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of TOP2B protein] Curcumin analog results in decreased expression of TOP2B mRNA |
CTD |
PMID:21332098 PMID:26409325 |
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NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085
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Tp53 |
tumor protein p53 |
multiple interactions decreases expression increases expression increases phosphorylation increases acetylation affects expression affects localization |
ISO EXP |
[Arsenic Trioxide co-treated with Curcumin] results in increased expression of TP53 protein; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of TP53 protein; [Curcumin co-treated with Metribolone] results in increased phosphorylation of TP53 protein; [piperine co-treated with Curcumin] results in decreased expression of TP53 protein; [Vitamin E co-treated with Curcumin] results in decreased expression of TP53 protein; Curcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of and results in increased activity of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; dorsomorphin inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein]; SB 203580 inhibits the reaction [Curcumin results in increased phosphorylation of TP53 protein] Curcumin analog results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 mRNA; Curcumin results in decreased expression of TP53 protein Curcumin results in increased expression of TRP53 mRNA [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; [Curcumin co-treated with Quercetin] inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TRP53 protein]; Curcumin affects the reaction [KRAS protein affects the localization of TRP53 protein]; Curcumin inhibits the reaction [Benzo(a)pyrene results in decreased acetylation of TRP53 protein]; Curcumin inhibits the reaction [deoxynivalenol results in increased expression of TRP53 protein] [Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein; Curcumin results in increased expression of TP53; Curcumin results in increased expression of TP53 protein [Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Curcumin binds to carboxymethyl-chitosan analog] inhibits the reaction [AGT protein modified form results in decreased degradation of TP53 protein]]; carboxymethyl-chitosan analog promotes the reaction [Curcumin inhibits the reaction [AGT protein modified form results in increased acetylation of TP53 protein]]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]]; Curcumin inhibits the reaction [AGT protein modified form results in increased expression of and results in increased phosphorylation of and results in increased acetylation of TP53 protein]; Curcumin inhibits the reaction [Cyclophosphamide results in increased mutagenesis of TP53 exon]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Curcumin inhibits the reaction [TP53 protein binds to EP300 protein]; Curcumin results in decreased expression of and results in decreased acetylation of TP53 protein Curcumin results in increased acetylation of TP53 protein Curcumin affects the expression of TP53 protein; Curcumin analog affects the expression of TP53 mRNA; Curcumin analog affects the expression of TP53 protein Curcumin affects the localization of TP53 protein |
CTD |
PMID:17041101 PMID:17332930 PMID:19020741 PMID:19227835 PMID:19944674 PMID:21134073 PMID:21519798 PMID:22714040 PMID:23222814 PMID:24211270 PMID:24664296 PMID:24831732 PMID:25256401 PMID:25644192 PMID:25822711 PMID:26409325 PMID:26612707 PMID:27430728 PMID:28681665 PMID:30935902 PMID:33582110 PMID:34047412 PMID:34577062 PMID:35817260 PMID:36352148 More...
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tph1 |
tryptophan hydroxylase 1 |
multiple interactions |
EXP |
[Curcumin co-treated with Chitosan analog] inhibits the reaction [Arsenic results in decreased expression of TPH1 protein] |
CTD |
PMID:22704994 |
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NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Tradd |
TNFRSF1A-associated via death domain |
decreases expression |
ISO |
Curcumin results in decreased expression of TRADD mRNA |
CTD |
PMID:15713895 |
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NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Traf1 |
TNF receptor-associated factor 1 |
multiple interactions decreases expression |
ISO |
Curcumin inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] Curcumin results in decreased expression of TRAF1 protein |
CTD |
PMID:16023083 PMID:16219905 PMID:19372569 |
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NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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G |
Traf2 |
Tnf receptor-associated factor 2 |
increases expression |
ISO |
Curcumin results in increased expression of TRAF2 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Traf3 |
Tnf receptor-associated factor 3 |
increases expression |
ISO |
Curcumin results in increased expression of TRAF3 mRNA |
CTD |
PMID:16101141 |
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NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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G |
Traf6 |
TNF receptor associated factor 6 |
increases expression multiple interactions |
ISO EXP |
Curcumin results in increased expression of TRAF6 mRNA Curcumin inhibits the reaction [[boldenone undecylenate results in increased abundance of boldenone] which results in increased expression of TRAF6 mRNA] |
CTD |
PMID:16101141 PMID:34719837 |
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NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
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Trdmt1 |
tRNA aspartic acid methyltransferase 1 |
increases expression |
ISO |
Curcumin results in increased expression of DNMT2 |
CTD |
PMID:25644192 |
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NCBI chr17:76,601,966...76,646,104
Ensembl chr17:76,610,543...76,645,439
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G |
Trem1 |
triggering receptor expressed on myeloid cells 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of TREM1 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
Curcumin results in increased expression of TRIB3 mRNA |
CTD |
PMID:18719366 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim15 |
tripartite motif containing 15 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TRIM15 mRNA] |
CTD |
PMID:18200517 |
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NCBI chr20:1,700,905...1,710,249
Ensembl chr20:1,700,905...1,710,249
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G |
Trim16 |
tripartite motif-containing 16 |
increases expression |
ISO |
Curcumin results in increased expression of TRIM16 mRNA |
CTD |
PMID:17999991 |
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NCBI chr10:47,485,982...47,509,010
Ensembl chr10:47,486,297...47,551,907
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G |
Trpv6 |
transient receptor potential cation channel, subfamily V, member 6 |
multiple interactions |
ISO |
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA |
CTD |
PMID:20153625 |
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NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017
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G |
Tsc2 |
TSC complex subunit 2 |
decreases phosphorylation |
ISO |
Curcumin results in decreased phosphorylation of TSC2 protein |
CTD |
PMID:18790744 |
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NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
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G |
Tubb3 |
tubulin, beta 3 class III |
multiple interactions increases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in decreased expression of TUBB3 mRNA] Curcumin results in increased expression of TUBB3 mRNA |
CTD |
PMID:25963729 |
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NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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G |
Txnip |
thioredoxin interacting protein |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Aflatoxin B1 results in increased expression of TXNIP mRNA] |
CTD |
PMID:35063475 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression increases oxidation |
ISO EXP |
Curcumin analog results in increased expression of TXNRD1 mRNA; Curcumin results in increased expression of TXNRD1 mRNA Curcumin results in increased oxidation of TXNRD1 protein |
CTD |
PMID:17198877 PMID:18299980 PMID:21782934 PMID:26409325 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Tymp |
thymidine phosphorylase |
decreases expression multiple interactions |
ISO |
Curcumin results in decreased expression of TYMP mRNA; Curcumin results in decreased expression of TYMP protein [Curcumin results in decreased expression of TYMP protein] which results in increased susceptibility to Cisplatin |
CTD |
PMID:21493726 |
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NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874 Ensembl chr 7:120,438,770...120,443,874
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Tyrobp |
transmembrane immune signaling adaptor Tyrobp |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TYROBP mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848
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G |
Uba7 |
ubiquitin-like modifier activating enzyme 7 |
affects expression multiple interactions |
ISO |
Curcumin affects the expression of UBA7 mRNA; Curcumin affects the expression of UBA7 protein Curcumin affects the reaction [Acetylcysteine results in increased expression of UBA7 protein]; Curcumin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of UBA7 protein] |
CTD |
PMID:25649257 |
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NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099
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G |
Ubc |
ubiquitin C |
increases expression |
ISO |
Curcumin results in increased expression of UBC mRNA |
CTD |
PMID:16101141 |
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NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
decreases expression |
ISO |
Curcumin results in decreased expression of UBE2C mRNA |
CTD |
PMID:22258452 |
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NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Ucp1 |
uncoupling protein 1 |
affects expression |
ISO |
Curcumin affects the expression of UCP1 mRNA |
CTD |
PMID:27208389 |
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NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression multiple interactions increases glucuronidation |
ISO EXP |
Curcumin results in increased expression of UGT1A1 mRNA Curcumin analog results in increased expression of UGT1A1 mRNA; Curcumin analog results in increased expression of UGT1A1 protein Curcumin promotes the reaction [Aflatoxin B1 results in increased activity of UGT1A1 protein] UGT1A1 protein results in increased glucuronidation of Curcumin |
CTD |
PMID:14557274 PMID:16819192 PMID:20015472 PMID:26991801 PMID:29228771 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
ISO |
Curcumin results in increased expression of UGT1A6 mRNA |
CTD |
PMID:16819192 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Curcumin |
CTD |
PMID:14557274 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Utp14a |
UTP14A small subunit processome component |
increases expression |
ISO |
Curcumin results in increased expression of UTP14A mRNA |
CTD |
PMID:17198877 |
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NCBI chr X:127,439,282...127,464,634
Ensembl chr X:127,439,268...127,464,633
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G |
Vasp |
vasodilator-stimulated phosphoprotein |
increases expression |
ISO |
Curcumin results in increased expression of VASP mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
affects expression multiple interactions |
ISO EXP |
Curcumin affects the expression of VCAM1 mRNA Curcumin inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [titanium dioxide results in increased expression of VCAM1 protein] Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA] Curcumin analog inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin analog inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Curcumin inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]; Curcumin inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA] |
CTD |
PMID:18752423 PMID:28700904 PMID:29244817 PMID:30431687 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Vcan |
versican |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA] |
CTD |
PMID:18200517 |
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NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
Curcumin promotes the reaction [VDAC1 protein binds to VDAC1 protein] |
CTD |
PMID:28343033 |
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NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
[Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CDKN1A mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; Curcumin binds to and results in increased activity of VDR protein; Curcumin inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Curcumin promotes the reaction [VDR protein binds to NCOA1 protein]; Curcumin promotes the reaction [VDR protein binds to RXRA protein] |
CTD |
PMID:20153625 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Vegfa |
vascular endothelial growth factor A |
affects expression decreases expression multiple interactions |
ISO EXP |
Curcumin affects the expression of VEGFA mRNA Curcumin results in decreased expression of VEGFA mRNA; Curcumin results in decreased expression of VEGFA protein Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] [Curcumin co-treated with Gemcitabine] results in decreased expression of VEGFA protein; Curcumin inhibits the reaction [Dietary Fats results in increased expression of VEGFA mRNA] [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of AKT1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; [bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with terpestacin] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin analog co-treated with Vorinostat] inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; [Curcumin co-treated with Bortezomib] results in decreased expression of VEGFA protein; Curcumin analog inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [IL18 protein results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of VEGFA protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK1 protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of MAPK3 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [VEGFA protein results in increased expression of PTGS2 protein]; Curcumin results in decreased expression of and results in decreased secretion of VEGFA protein; TNFSF10 protein promotes the reaction [Curcumin results in decreased expression of VEGFA protein] |
CTD |
PMID:16219905 PMID:16243823 PMID:16368150 PMID:17440100 PMID:17662242 PMID:17960570 PMID:18226269 PMID:18390174 PMID:18497527 PMID:18593936 PMID:18596194 PMID:19294764 PMID:19297423 PMID:19372569 PMID:19383353 PMID:20554536 PMID:21397623 PMID:23555722 PMID:23845850 PMID:25447407 PMID:35752269 More...
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vhl |
von Hippel-Lindau tumor suppressor |
multiple interactions |
ISO |
VHL protein promotes the reaction [Curcumin results in decreased expression of HIF1A protein] |
CTD |
PMID:18682687 |
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NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
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G |
Vim |
vimentin |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein] Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM mRNA]; Curcumin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of VIM protein] |
CTD |
PMID:25656647 PMID:26191140 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Vip |
vasoactive intestinal peptide |
multiple interactions |
ISO EXP |
Curcumin inhibits the reaction [VIP protein results in increased activity of MMP2 protein]; Curcumin inhibits the reaction [VIP protein results in increased activity of MMP9 protein]; Curcumin inhibits the reaction [VIP protein results in increased expression of CCND1 protein] Curcumin inhibits the reaction [VIP protein results in increased expression of PTGS2 protein] |
CTD |
PMID:17434257 PMID:19189304 |
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NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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G |
Vwf |
von Willebrand factor |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of VWF protein] |
CTD |
PMID:23845850 |
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NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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G |
Wasl |
WASP like actin nucleation promoting factor |
increases expression |
ISO |
Curcumin results in increased expression of WASL mRNA |
CTD |
PMID:18200517 |
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NCBI chr 4:53,083,536...53,132,061
Ensembl chr 4:53,083,536...53,132,022
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G |
Wif1 |
Wnt inhibitory factor 1 |
multiple interactions decreases expression |
EXP |
Curcumin inhibits the reaction [bisphenol A results in increased expression of WIF1 protein] Curcumin results in decreased expression of WIF1 protein |
CTD |
PMID:25963729 |
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NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
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G |
Wnt1 |
Wnt family member 1 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of WNT1 mRNA Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT1 mRNA] |
CTD |
PMID:25963729 |
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NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
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G |
Wnt3 |
Wnt family member 3 |
increases expression multiple interactions |
EXP |
Curcumin results in increased expression of WNT3 mRNA; Curcumin results in increased expression of WNT3 protein Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of WNT3 protein] |
CTD |
PMID:25963729 |
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NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099
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G |
Wt1 |
WT1 transcription factor |
decreases expression |
ISO |
Curcumin results in decreased expression of WT1 mRNA; Curcumin results in decreased expression of WT1 protein |
CTD |
PMID:18034345 PMID:19196508 |
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NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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G |
Wwtr1 |
WW domain containing transcription regulator 1 |
decreases stability multiple interactions |
ISO |
Curcumin results in decreased stability of WWTR1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin results in decreased expression of WWTR1 protein]; Curcumin results in decreased expression of and affects the localization of WWTR1 protein; Curcumin results in increased phosphorylation of and results in decreased stability of WWTR1 protein; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of EPCAM protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of PROM1 protein]; WWTR1 protein inhibits the reaction [Curcumin results in increased susceptibility to Cisplatin] |
CTD |
PMID:33539684 |
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NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
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G |
Xaf1 |
XIAP associated factor 1 |
increases expression |
ISO |
Curcumin results in increased expression of XAF1 mRNA; Curcumin results in increased expression of XAF1 protein |
CTD |
PMID:21594647 |
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NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
Curcumin results in increased expression of XBP1 mRNA |
CTD |
PMID:29723631 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
Curcumin inhibits the reaction [Indomethacin results in increased activity of XDH protein] |
CTD |
PMID:17351913 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions decreases expression |
ISO |
[arsenic trioxide co-treated with Curcumin] results in decreased expression of XIAP protein; [Curcumin co-treated with Doxorubicin] affects the expression of XIAP mRNA; arsenic trioxide promotes the reaction [Curcumin results in decreased expression of XIAP protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of XIAP protein]; Curcumin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein] Curcumin analog results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP mRNA; Curcumin results in decreased expression of XIAP protein |
CTD |
PMID:15911101 PMID:16023083 PMID:16173963 PMID:16219905 PMID:16243823 PMID:17596214 PMID:17671737 PMID:17671742 PMID:19250217 PMID:19372569 PMID:20605902 PMID:20727180 PMID:27430728 More...
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NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Xpo1 |
exportin 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [KRAS protein results in decreased expression of XPO1 protein] |
CTD |
PMID:21519798 |
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NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC1 protein] |
CTD |
PMID:21332098 |
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NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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G |
Xrcc4 |
X-ray repair cross complementing 4 |
multiple interactions |
ISO |
Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 mRNA]; Curcumin inhibits the reaction [Arsenic results in decreased expression of XRCC4 protein] |
CTD |
PMID:21332098 |
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NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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G |
Xrcc5 |
X-ray repair cross complementing 5 |
decreases expression |
ISO |
Curcumin results in decreased expression of XRCC5 mRNA |
CTD |
PMID:17596214 |
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NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018
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G |
Xrcc6 |
X-ray repair cross complementing 6 |
decreases expression |
ISO |
Curcumin results in decreased expression of XRCC6 mRNA |
CTD |
PMID:17596214 |
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NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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G |
Ypel3 |
yippee-like 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of YPEL3 mRNA |
CTD |
PMID:17198877 |
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NCBI chr 1:181,384,385...181,387,706
Ensembl chr 1:181,384,357...181,387,705
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G |
Ywhae |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon |
decreases expression |
ISO |
Curcumin results in decreased expression of YWHAE mRNA; Curcumin results in decreased expression of YWHAE protein |
CTD |
PMID:19294764 |
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NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
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G |
Zfhx3 |
zinc finger homeobox 3 |
decreases expression |
ISO |
Curcumin results in decreased expression of ZFHX3 mRNA |
CTD |
PMID:17198877 |
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NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771
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G |
Zfp287 |
zinc finger protein 287 |
increases expression |
ISO |
Curcumin results in increased expression of ZNF287 mRNA |
CTD |
PMID:18421014 |
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NCBI chr10:47,395,650...47,415,610
Ensembl chr10:47,397,285...47,439,755
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G |
Zfp36l1 |
zinc finger protein 36, C3H type-like 1 |
decreases expression |
ISO |
Curcumin results in decreased expression of ZFP36L1 mRNA |
CTD |
PMID:15713895 |
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NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:20371262 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of ARNT protein] |
CTD |
PMID:18603805 |
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NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
delphinidin results in increased expression of BAD protein |
CTD |
PMID:33955636 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
delphinidin results in increased expression of BAK1 protein |
CTD |
PMID:29451351 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO |
delphinidin results in increased expression of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein] delphinidin results in decreased expression of BAX protein |
CTD |
PMID:15740068 PMID:19818742 PMID:30365941 PMID:33955636 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions increases expression |
ISO |
delphinidin results in decreased expression of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein] delphinidin results in increased expression of BCL2 protein |
CTD |
PMID:15740068 PMID:19818742 PMID:29451351 PMID:30365941 PMID:33955636 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
delphinidin results in decreased expression of BCL2L1 protein |
CTD |
PMID:33955636 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
ISO |
[delphinidin results in increased susceptibility to sodium arsenite] which results in decreased expression of BID protein delphinidin results in decreased expression of BID protein |
CTD |
PMID:25954945 PMID:30125548 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Btg2 |
BTG anti-proliferation factor 2 |
affects expression |
ISO |
delphinidin affects the expression of BTG2 mRNA |
CTD |
PMID:19182879 |
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NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
Casp3 |
caspase 3 |
increases activity increases expression increases cleavage multiple interactions |
ISO |
delphinidin results in increased activity of CASP3 protein delphinidin results in increased expression of CASP3 protein delphinidin results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; [delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP3 protein; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]; delphinidin results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:15740068 PMID:25954945 PMID:29451351 PMID:30125548 PMID:30365941 PMID:33955636 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression |
ISO |
[delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP8 protein; delphinidin results in increased cleavage of and results in increased activity of CASP8 protein delphinidin results in increased expression of CASP8 protein |
CTD |
PMID:25954945 PMID:30125548 PMID:33955636 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases expression |
ISO |
[delphinidin results in increased susceptibility to sodium arsenite] which results in increased cleavage of CASP9 protein; delphinidin results in increased cleavage of and results in increased activity of CASP9 protein delphinidin results in increased expression of CASP9 protein |
CTD |
PMID:25954945 PMID:30125548 PMID:33955636 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases activity |
ISO |
delphinidin results in decreased activity of CAT protein |
CTD |
PMID:33955636 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
delphinidin results in increased expression of CDH1 protein |
CTD |
PMID:29451351 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
delphinidin results in decreased expression of CDH2 protein |
CTD |
PMID:29451351 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cidea |
cell death-inducing DFFA-like effector a |
increases expression |
ISO |
delphinidin results in increased expression of CIDEA mRNA |
CTD |
PMID:19182879 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
delphinidin results in increased expression of CYCS protein |
CTD |
PMID:33955636 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
delphinidin results in decreased activity of CYP1A1 protein |
CTD |
PMID:23419638 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of EGFR protein |
CTD |
PMID:18618485 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of EPAS1 protein] |
CTD |
PMID:18603805 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of ERBB2 protein |
CTD |
PMID:18618485 |
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NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] |
CTD |
PMID:18603805 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hif3a |
hypoxia inducible factor 3 subunit alpha |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of HIF3A protein] |
CTD |
PMID:18603805 |
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NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
delphinidin results in increased expression of HMOX1 protein |
CTD |
PMID:30266311 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:33955636 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
delphinidin results in increased expression of JUN mRNA |
CTD |
PMID:15740068 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:18618485 PMID:29451351 PMID:33955636 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:18618485 PMID:29451351 PMID:33955636 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
delphinidin results in increased phosphorylation of and results in increased activity of MAPK8 protein |
CTD |
PMID:15740068 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
delphinidin promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 protein] |
CTD |
PMID:20371262 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nbn |
nibrin |
increases expression |
ISO |
delphinidin results in increased expression of NBN mRNA |
CTD |
PMID:19182879 |
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NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
decreases activity increases cleavage |
ISO |
delphinidin results in decreased activity of PARP1 protein delphinidin results in increased cleavage of PARP1 protein |
CTD |
PMID:17884996 PMID:29451351 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcbp4 |
poly(rC) binding protein 4 |
affects expression |
ISO |
delphinidin affects the expression of PCBP4 mRNA |
CTD |
PMID:19182879 |
|
NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276
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G |
Pdgfa |
platelet derived growth factor subunit A |
multiple interactions |
ISO |
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] |
CTD |
PMID:16921400 |
|
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] |
CTD |
PMID:16921400 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pgk1 |
phosphoglycerate kinase 1 |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] |
CTD |
PMID:18603805 |
|
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
delphinidin results in decreased expression of SNAI1 protein |
CTD |
PMID:29451351 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
delphinidin results in decreased expression of SNAI2 protein |
CTD |
PMID:29451351 |
|
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
delphinidin results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:33955636 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Malondialdehyde]; delphinidin inhibits the reaction [TGFB1 results in increased abundance of Reactive Oxygen Species]; delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]; delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein] |
CTD |
PMID:20371262 PMID:30365941 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
delphinidin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] |
CTD |
PMID:20371262 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Top1 |
DNA topoisomerase I |
decreases activity |
ISO |
delphinidin results in decreased activity of TOP1 protein |
CTD |
PMID:19182879 |
|
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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G |
Top2a |
DNA topoisomerase II alpha |
decreases activity multiple interactions |
ISO |
delphinidin results in decreased activity of TOP2A protein delphinidin results in decreased susceptibility to [Doxorubicin affects the activity of TOP2A protein]; delphinidin results in decreased susceptibility to [Etoposide affects the activity of TOP2A protein] |
CTD |
PMID:19182879 |
|
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
delphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein] |
CTD |
PMID:16921400 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Asip |
agouti signaling protein |
affects chemical synthesis |
ISO |
A gene affects the chemical synthesis of eumelanin |
CTD |
PMID:8125260 |
|
NCBI chr 3:143,473,584...143,561,170
Ensembl chr 3:143,555,696...143,561,171
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] |
CTD |
PMID:36113623 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in decreased abundance of CAT protein] |
CTD |
PMID:36113623 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Dct |
dopachrome tautomerase |
decreases abundance |
ISO |
DCT gene mutant form results in decreased abundance of eumelanin |
CTD |
PMID:16584806 |
|
NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased abundance of GOT1 protein] |
CTD |
PMID:36113623 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased abundance of GPT protein] |
CTD |
PMID:36113623 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein] |
CTD |
PMID:36113623 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mc1r |
melanocortin 1 receptor |
increases chemical synthesis |
ISO |
MC1R protein results in increased chemical synthesis of eumelanin |
CTD |
PMID:24975581 |
|
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of PCNA protein] |
CTD |
PMID:36113623 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
eumelanin inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein] |
CTD |
PMID:36113623 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
isoliquiritigenin binds to AFP protein |
CTD |
PMID:23013281 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene affects the localization of AHR protein] |
CTD |
PMID:25110319 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases response to substance multiple interactions decreases phosphorylation |
ISO |
AKT1 protein modified form results in decreased susceptibility to isoliquiritigenin isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein] 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; isoliquiritigenin results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein] isoliquiritigenin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:23747687 PMID:25094029 PMID:27117918 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Arg1 |
arginase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of ARG1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
isoliquiritigenin results in increased expression of BAX mRNA; isoliquiritigenin results in increased expression of BAX protein |
CTD |
PMID:11055382 PMID:27702603 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of BCL2 protein |
CTD |
PMID:23747687 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased expression of BCL2L1 protein isoliquiritigenin results in decreased phosphorylation of BCL2L1 protein |
CTD |
PMID:11055382 PMID:15729620 PMID:23747687 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC2 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of BIRC3 protein |
CTD |
PMID:15729620 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP3 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP3 protein isoliquiritigenin results in increased activity of CASP3 protein |
CTD |
PMID:15729620 PMID:16158945 PMID:23747687 PMID:25094029 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
isoliquiritigenin results in increased activity of CASP8 protein |
CTD |
PMID:16158945 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity increases cleavage |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in increased cleavage of CASP9 protein]; isoliquiritigenin results in increased cleavage of and results in increased activity of CASP9 protein isoliquiritigenin results in increased activity of CASP9 protein |
CTD |
PMID:16158945 PMID:23747687 PMID:25094029 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP ISO |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] isoliquiritigenin inhibits the reaction [Paroxetine results in decreased activity of CAT protein] |
CTD |
PMID:25450236 PMID:36740106 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cckar |
cholecystokinin A receptor |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [isoliquiritigenin results in increased expression of CCKAR mRNA] |
CTD |
PMID:27702603 |
|
NCBI chr14:57,292,397...57,300,747
Ensembl chr14:57,292,397...57,300,747
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G |
Ccnd2 |
cyclin D2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCND2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CCNE2 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
isoliquiritigenin results in increased expression of CDKN1A mRNA; isoliquiritigenin results in increased expression of CDKN1A protein |
CTD |
PMID:27702603 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1B mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CDKN1C mRNA |
CTD |
PMID:27702603 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein] |
CTD |
PMID:27117918 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of CHUK protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CXCL10 mRNA] |
CTD |
PMID:25026504 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP17A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of CYP19A1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:25110319 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A2 mRNA]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] isoliquiritigenin results in decreased activity of CYP1A2 protein |
CTD |
PMID:25110319 PMID:29753067 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions increases expression |
ISO |
isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]; isoliquiritigenin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 protein]; isoliquiritigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA]; isoliquiritigenin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] isoliquiritigenin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:25110319 PMID:26134484 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein] |
CTD |
PMID:25450236 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
isoliquiritigenin results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of ERN1 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein] |
CTD |
PMID:27117918 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Gadd45gip1 |
GADD45G interacting protein 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of GADD45GIP1 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr19:23,320,662...23,323,211
Ensembl chr19:23,320,159...23,323,236
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] |
CTD |
PMID:19834288 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Paroxetine results in increased activity of GPT protein] |
CTD |
PMID:36740106 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in decreased activity of GSR protein] |
CTD |
PMID:37561086 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein] |
CTD |
PMID:37561086 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of HMOX1 protein |
CTD |
PMID:23942037 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of HSD17B1 mRNA |
CTD |
PMID:27773742 |
|
NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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|
G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions |
EXP |
[isoliquiritigenin co-treated with Cisplatin] results in increased expression of HSP90B1 protein |
CTD |
PMID:37561086 |
|
NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
EXP |
[Cisplatin co-treated with isoliquiritigenin] results in increased expression of HSPA5 mRNA isoliquiritigenin results in increased expression of HSPA5 mRNA |
CTD |
PMID:37561086 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IFNG protein]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:23942037 PMID:25026504 PMID:26134484 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL10 protein] |
CTD |
PMID:25026504 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1RN protein] |
CTD |
PMID:25026504 |
|
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] |
CTD |
PMID:18295200 PMID:25026504 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of CEBPA protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of FABP4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] |
CTD |
PMID:27117918 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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|
G |
Insr |
insulin receptor |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased phosphorylation of INSR protein] |
CTD |
PMID:27117918 |
|
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Itgam |
integrin subunit alpha M |
multiple interactions increases expression |
ISO |
TEMPOL-H inhibits the reaction [isoliquiritigenin results in increased expression of ITGAM protein] |
CTD |
PMID:24369695 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Melk |
maternal embryonic leucine zipper kinase |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MELK mRNA; isoliquiritigenin results in decreased expression of MELK protein |
CTD |
PMID:36893906 |
|
NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937
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G |
Mfn2 |
mitofusin 2 |
increases expression |
EXP |
isoliquiritigenin results in increased expression of MFN2 protein |
CTD |
PMID:37561086 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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|
G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of MKI67 mRNA; isoliquiritigenin results in decreased expression of MKI67 protein |
CTD |
PMID:27702603 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP2 protein] isoliquiritigenin results in decreased expression of MMP2 mRNA; isoliquiritigenin results in decreased expression of MMP2 protein |
CTD |
PMID:25094029 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; AKT1 protein modified form inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; CAY 10580 inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein] isoliquiritigenin results in decreased expression of MMP9 mRNA; isoliquiritigenin results in decreased expression of MMP9 protein |
CTD |
PMID:25094029 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of NFKB1 protein] |
CTD |
PMID:18295200 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
increases expression multiple interactions decreases phosphorylation |
ISO |
isoliquiritigenin results in increased expression of NFKBIA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of and results in increased phosphorylation of NFKBIA protein] isoliquiritigenin results in decreased phosphorylation of NFKBIA protein |
CTD |
PMID:15729620 PMID:18295200 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of NOS2 protein] |
CTD |
PMID:18295200 PMID:19834288 PMID:25026504 PMID:26134484 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of NQO1 protein |
CTD |
PMID:26473469 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression |
ISO |
isoliquiritigenin results in increased activity of NR1I2 protein isoliquiritigenin results in increased expression of NR1I2 mRNA |
CTD |
PMID:29933105 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
isoliquiritigenin results in increased cleavage of PARP1 protein benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [isoliquiritigenin results in increased cleavage of PARP1 protein] |
CTD |
PMID:23747687 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases phosphorylation |
ISO |
isoliquiritigenin results in decreased phosphorylation of PDK1 protein |
CTD |
PMID:25094029 |
|
NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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|
G |
Pla2g5 |
phospholipase A2, group V |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PLA2G5 mRNA |
CTD |
PMID:23747687 |
|
NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
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|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of PPARG protein] |
CTD |
PMID:27117918 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptger4 |
prostaglandin E receptor 4 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGER4 mRNA; isoliquiritigenin results in decreased expression of PTGER4 protein |
CTD |
PMID:25094029 |
|
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
decreases expression |
ISO |
isoliquiritigenin results in decreased expression of PTGS1 mRNA |
CTD |
PMID:25094029 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO EXP |
isoliquiritigenin results in decreased expression of PTGS2 mRNA isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] |
CTD |
PMID:18295200 PMID:23747687 PMID:25026504 PMID:25450236 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in decreased activity of and results in increased oxidation of PTPN1 protein] |
CTD |
PMID:27117918 |
|
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization multiple interactions decreases activity |
ISO |
isoliquiritigenin affects the localization of RELA protein isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] isoliquiritigenin results in decreased activity of RELA protein |
CTD |
PMID:15729620 PMID:18295200 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions decreases activity |
ISO |
isoliquiritigenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose] isoliquiritigenin results in decreased activity of SLC2A1 protein |
CTD |
PMID:14642735 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [INS1 protein results in increased expression of SLC2A4 protein] |
CTD |
PMID:27117918 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Slc6a3 |
solute carrier family 6 member 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] |
CTD |
PMID:19834288 |
|
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
multiple interactions decreases activity |
EXP |
[isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [isoliquiritigenin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
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G |
Sod2 |
superoxide dismutase 2 |
affects response to substance |
ISO |
SOD2 protein affects the susceptibility to isoliquiritigenin |
CTD |
PMID:23526725 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
isoliquiritigenin results in increased expression of STAR mRNA |
CTD |
PMID:27773742 |
|
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:25026504 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TGFB1 protein] |
CTD |
PMID:25026504 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
isoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of TNF protein]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; isoliquiritigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] isoliquiritigenin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CYP1B1 mRNA] isoliquiritigenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] |
CTD |
PMID:18295200 PMID:25026504 PMID:25450236 PMID:26134484 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
isoliquiritigenin results in increased expression of TRP53 mRNA |
CTD |
PMID:27702603 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases glucuronidation |
ISO |
UGT1A1 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of isoliquiritigenin |
CTD |
PMID:14557274 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
EXP |
isoliquiritigenin inhibits the reaction [Cisplatin results in increased expression of XBP1 mRNA] |
CTD |
PMID:37561086 |
|
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein]; malvidin promotes the reaction [endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:23755222 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
malvidin results in increased expression of BAX protein |
CTD |
PMID:15964118 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
malvidin results in decreased expression of BCL2 protein |
CTD |
PMID:15964118 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
malvidin results in increased activity of CASP3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [malvidin results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [malvidin results in increased activity of CASP3 protein] |
CTD |
PMID:15964118 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Dusp1 |
dual specificity phosphatase 1 |
multiple interactions |
ISO |
malvidin promotes the reaction [endotoxin, Escherichia coli results in increased expression of DUSP1 mRNA]; malvidin promotes the reaction [endotoxin, Escherichia coli results in increased expression of DUSP1 protein] |
CTD |
PMID:23755222 |
|
NCBI chr10:16,680,478...16,683,275
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
malvidin promotes the reaction [[endotoxin, Escherichia coli results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:23755222 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
malvidin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:15964118 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
malvidin results in increased expression of and results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:15964118 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
malvidin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:15964118 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
malvidin results in increased cleavage of PARP1 protein |
CTD |
PMID:15964118 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pde5a |
phosphodiesterase 5A |
decreases activity |
ISO |
malvidin results in decreased activity of PDE5A protein |
CTD |
PMID:15769121 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Pdgfa |
platelet derived growth factor subunit A |
multiple interactions |
ISO |
malvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:16921400 |
|
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
malvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:16921400 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
malvidin inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein] |
CTD |
PMID:23755222 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
multiple interactions |
ISO |
[malvidin-3-glucoside co-treated with petunidin-3-glucoside] results in increased expression of AQP3 mRNA |
CTD |
PMID:33294640 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Car1 |
carbonic anhydrase 1 |
decreases activity |
ISO |
malvidin-3-glucoside results in decreased activity of CA1 protein |
CTD |
PMID:28445001 |
|
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
malvidin-3-glucoside results in decreased activity of CA2 protein |
CTD |
PMID:28445001 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
malvidin-3-glucoside inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:23731018 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Pde5a |
phosphodiesterase 5A |
decreases activity |
ISO |
malvidin-3-glucoside results in decreased activity of PDE5A protein |
CTD |
PMID:15769121 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Sele |
selectin E |
multiple interactions |
ISO |
malvidin-3-glucoside inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:30611791 |
|
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
malvidin-3-glucoside inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] malvidin-3-glucoside inhibits the reaction [TNF protein results in increased expression of SELE protein] |
CTD |
PMID:23731018 PMID:30611791 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Car1 |
carbonic anhydrase 1 |
decreases activity |
ISO |
malvin results in decreased activity of CA1 protein |
CTD |
PMID:28445001 |
|
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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G |
Car2 |
carbonic anhydrase 2 |
decreases activity |
ISO |
malvin results in decreased activity of CA2 protein |
CTD |
PMID:28445001 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:17077530 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
[TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins |
CTD |
PMID:11092760 |
|
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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G |
Cldn3 |
claudin 3 |
multiple interactions |
ISO |
[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] |
CTD |
PMID:23053666 |
|
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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G |
Cldn4 |
claudin 4 |
multiple interactions |
ISO |
[CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] |
CTD |
PMID:23053666 |
|
NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Melanins inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] |
CTD |
PMID:17077530 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Mc1r |
melanocortin 1 receptor |
multiple interactions |
ISO |
[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins |
CTD |
PMID:23872139 |
|
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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G |
Pepd |
peptidase D |
multiple interactions decreases activity |
ISO |
Melanins inhibits the reaction [Gentamicins results in decreased activity of PEPD protein] Melanins results in decreased activity of PEPD protein |
CTD |
PMID:12098580 |
|
NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
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G |
Pld1 |
phospholipase D1 |
multiple interactions |
ISO |
[TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins |
CTD |
PMID:14615486 |
|
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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G |
Pomc |
proopiomelanocortin |
increases chemical synthesis multiple interactions |
ISO |
POMC protein modified form results in increased chemical synthesis of Melanins Quercetin analog inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Melanins] |
CTD |
PMID:26586997 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Tyr |
tyrosinase |
multiple interactions |
ISO |
[CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins; [TYR protein co-treated with ATP7A protein] results in increased abundance of Melanins; [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins; [TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins [Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR |
CTD |
PMID:11092760 PMID:14615486 PMID:20973933 PMID:23053666 PMID:23872139 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
Prodigiosin results in increased expression of ABCC1 mRNA |
CTD |
PMID:15746575 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein] |
CTD |
PMID:36447373 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of BAX protein] |
CTD |
PMID:36447373 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of BCL2 protein] |
CTD |
PMID:36447373 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of BDNF protein] |
CTD |
PMID:36447373 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression decreases response to substance multiple interactions |
ISO |
Prodigiosin results in decreased expression of BIRC5 mRNA; Prodigiosin results in decreased expression of BIRC5 protein BIRC5 results in decreased susceptibility to Prodigiosin Prodigiosin inhibits the reaction [Paclitaxel results in increased expression of BIRC5 protein] |
CTD |
PMID:19133282 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases activity |
ISO EXP |
Prodigiosin results in increased cleavage of CASP3 protein Prodigiosin inhibits the reaction [Aluminum Chloride results in increased activity of CASP3 protein] Acetylcysteine inhibits the reaction [Prodigiosin results in increased activity of CASP3 protein] |
CTD |
PMID:15746575 PMID:31077745 PMID:36447373 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage increases activity |
ISO |
Prodigiosin results in increased cleavage of CASP8 protein Prodigiosin results in increased activity of CASP8 protein |
CTD |
PMID:15746575 PMID:31077745 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage increases activity |
ISO |
Prodigiosin results in increased cleavage of CASP9 protein Prodigiosin results in increased activity of CASP9 protein |
CTD |
PMID:15746575 PMID:19133282 PMID:31077745 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein] |
CTD |
PMID:36447373 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CYBB protein] |
CTD |
PMID:21925195 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased activity of GSR protein] |
CTD |
PMID:36447373 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:36447373 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of IL1B protein] |
CTD |
PMID:36447373 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of JUN protein |
CTD |
PMID:31077745 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:31077745 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Prodigiosin results in increased expression of and results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:31077745 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases phosphorylation |
ISO |
Prodigiosin results in decreased phosphorylation of MAPK8 protein |
CTD |
PMID:31077745 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
decreases phosphorylation |
ISO |
Prodigiosin results in decreased phosphorylation of MAPK9 protein |
CTD |
PMID:31077745 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in decreased expression of NFE2L2 mRNA] |
CTD |
PMID:36447373 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased degradation of NFKBIA protein] |
CTD |
PMID:21925195 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOS2 protein] Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of NOS2 mRNA] |
CTD |
PMID:21925195 PMID:36447373 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Prodigiosin results in increased cleavage of PARP1 protein |
CTD |
PMID:15746575 PMID:19133282 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of PTGS2 protein] |
CTD |
PMID:36447373 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rad51 |
RAD51 recombinase |
multiple interactions decreases response to substance decreases expression |
ISO |
pyrazolanthrone inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA]; SB 203580 inhibits the reaction [Prodigiosin results in decreased expression of RAD51 mRNA] RAD51 protein results in decreased susceptibility to Prodigiosin Prodigiosin results in decreased expression of RAD51 mRNA; Prodigiosin results in decreased expression of RAD51 protein |
CTD |
PMID:22579953 |
|
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Prodigiosin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of RELA protein] Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of RELA protein] |
CTD |
PMID:21925195 PMID:36447373 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sqstm1 |
sequestosome 1 |
increases expression multiple interactions |
ISO |
Prodigiosin results in increased expression of SQSTM1 protein 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Prodigiosin results in increased expression of SQSTM1 protein] |
CTD |
PMID:31077745 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Prodigiosin inhibits the reaction [Aluminum Chloride results in increased expression of TNF protein] |
CTD |
PMID:36447373 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of AHR mRNA Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 PMID:31078726 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:24015256 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atf6 |
activating transcription factor 6 |
increases activity |
EXP |
Pyocyanine results in increased activity of ATF6 protein |
CTD |
PMID:27613716 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of CCL5 mRNA; Pyocyanine results in decreased expression of CCL5 protein |
CTD |
PMID:31078726 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ctnnb1 |
catenin beta 1 |
increases expression |
ISO |
Pyocyanine results in increased expression of CTNNB1 mRNA |
CTD |
PMID:31078726 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
Pyocyanine results in increased expression of CYP1A1 mRNA |
CTD |
PMID:31078726 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of EGFR protein |
CTD |
PMID:24015256 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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|
G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of FABP4 mRNA |
CTD |
PMID:31078726 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of GCLC mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of GCLC mRNA] |
CTD |
PMID:24015256 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
EXP |
Pyocyanine results in increased activity of HSF1 protein |
CTD |
PMID:27613716 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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|
G |
Il10 |
interleukin 10 |
increases expression |
ISO |
Pyocyanine results in increased expression of IL10 protein |
CTD |
PMID:31078726 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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|
G |
Il13 |
interleukin 13 |
decreases expression |
ISO |
Pyocyanine results in decreased expression of IL13 protein |
CTD |
PMID:31078726 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il6 |
interleukin 6 |
increases expression |
ISO |
Pyocyanine results in increased expression of IL6 protein |
CTD |
PMID:31078726 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K1 protein |
CTD |
PMID:24015256 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases phosphorylation |
ISO |
Pyocyanine results in increased phosphorylation of MAP2K2 protein |
CTD |
PMID:24015256 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
Pyocyanine results in increased phosphorylation of MAPK3 protein Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24015256 PMID:24316274 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity |
ISO EXP |
1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein; RTKI cpd inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; trigonelline inhibits the reaction [Pyocyanine results in increased expression of and affects the localization of NFE2L2 protein] Pyocyanine results in increased activity of NFE2L2 protein |
CTD |
PMID:24015256 PMID:27613716 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
Pyocyanine results in increased expression of NQO1 mRNA [Pyocyanine results in increased localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; trigonelline inhibits the reaction [Pyocyanine results in increased expression of NQO1 mRNA] |
CTD |
PMID:24015256 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
Pyocyanine results in decreased expression of PPARG mRNA |
CTD |
PMID:31078726 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Tardbp |
TAR DNA binding protein |
multiple interactions |
ISO |
Pyocyanine promotes the reaction [AHR protein binds to TARDBP promoter] |
CTD |
PMID:28476168 |
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NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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G |
Tnf |
tumor necrosis factor |
increases expression |
ISO |
Pyocyanine results in increased expression of TNF mRNA |
CTD |
PMID:31078726 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ahcy |
adenosylhomocysteinase |
affects expression |
ISO |
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice |
RGD |
PMID:22212488 |
RGD:41410880 |
NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] |
CTD |
PMID:19715544 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Cat |
catalase |
multiple interactions affects expression |
EXP ISO |
tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Vincristine results in decreased expression of CAT protein] Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice tetrahydrocurcumin inhibits the reaction [Acetaminophen results in decreased expression of CAT protein] |
CTD RGD |
PMID:17076682 PMID:25869292 PMID:26102012 PMID:30423402 PMID:22212488 |
RGD:41410880 |
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:26102010 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP1B1 protein] |
CTD |
PMID:26102010 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases expression |
ISO |
tetrahydrocurcumin results in decreased expression of CYP2B10 mRNA |
CTD |
PMID:26102010 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 mRNA]; tetrahydrocurcumin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CYP2C29 protein] |
CTD |
PMID:26102010 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] |
CTD |
PMID:30423402 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] |
CTD |
PMID:30423402 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
EXP |
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein] |
CTD |
PMID:20696151 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Lcat |
lecithin cholesterol acyltransferase |
multiple interactions |
EXP |
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] |
CTD |
PMID:20696151 |
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NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
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G |
Lpl |
lipoprotein lipase |
multiple interactions |
EXP |
[tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein] |
CTD |
PMID:20696151 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP2 protein] |
CTD |
PMID:25502771 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions affects expression |
ISO |
tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of MMP9 protein] Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice |
CTD RGD |
PMID:25502771 PMID:22212488 |
RGD:41410880 |
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mthfr |
methylenetetrahydrofolate reductase |
affects expression |
ISO |
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice |
RGD |
PMID:22212488 |
RGD:41410880 |
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
affects expression |
ISO |
Tetrahydrocurcumin affects expression of protein and mRNA in ischemia/reperfusion CBS+/- mice |
RGD |
PMID:22212488 |
RGD:41410880 |
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein] |
CTD |
PMID:25502771 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
tetrahydrocurcumin inhibits the reaction [Cadmium Chloride results in decreased expression of NOS3 protein] |
CTD |
PMID:25502771 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases expression |
ISO |
tetrahydrocurcumin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] tetrahydrocurcumin results in decreased expression of PTGS2 mRNA |
CTD |
PMID:18507010 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
tetrahydrocurcumin inhibits the reaction [Vincristine results in increased expression of TNF protein] |
CTD |
PMID:26102012 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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