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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phytosteroid
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Accession:CHEBI:26124 term browser browse the term
Synonyms:related_synonym: phytosteroids


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CASP3 caspase 3 increases activity EXP Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
decreases expression
EXP Ecdysterone results in increased expression of HSPA5 mRNA
Ecdysterone results in decreased expression of HSPA5 protein
CTD PMID:29126784 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
brassinolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator decreases expression EXP brassinolide results in decreased expression of BCL2 protein CTD PMID:17557751 PMID:20833159 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP brassinolide results in decreased expression of BCL2L1 protein CTD PMID:20833159 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP brassinolide results in decreased expression of BID protein CTD PMID:20833159 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 increases activity
increases expression
EXP brassinolide results in increased activity of CASP3 protein
brassinolide results in increased expression of CASP3 protein modified form
CTD PMID:17557751 PMID:20833159 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 decreases expression EXP brassinolide results in decreased expression of CCND1 protein CTD PMID:20833159 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP brassinolide results in decreased expression of CDK2 protein CTD PMID:20833159 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP brassinolide results in increased expression of CDKN1A protein CTD PMID:20833159 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases expression EXP brassinolide results in decreased expression of CDKN1B protein CTD PMID:20833159 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
JBrowse link
G ESR1 estrogen receptor 1 decreases expression EXP brassinolide results in decreased expression of ESR1 CTD PMID:20833159 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 affects localization
decreases expression
EXP brassinolide affects the localization of ESR2 protein
brassinolide results in decreased expression of ESR2
CTD PMID:20833159 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G MDM2 MDM2 proto-oncogene decreases expression EXP brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases expression EXP brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G TP53 tumor protein p53 increases expression EXP brassinolide results in increased expression of TP53 protein CTD PMID:20833159 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
cycloartenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:12804013 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CRYZ crystallin zeta multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:12804013 NCBI chr 1:74,705,470...74,733,115
Ensembl chr 1:74,705,482...74,733,408
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein] CTD PMID:12804013 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:12804013 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:12804013 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of XDH protein] CTD PMID:12804013 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
ergosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein] CTD PMID:25833014 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein] CTD PMID:25833014 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 multiple interactions EXP CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol] CTD PMID:18694951 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,112,153...92,134,803
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein] CTD PMID:25833014 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein; [Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA] CTD PMID:25833014 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA] CTD PMID:25833014 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein] CTD PMID:25833014 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein] CTD PMID:25833014 NCBI chr12:10,158,301...10,172,132
Ensembl chr12:10,158,301...10,172,138
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein] CTD PMID:25833014 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein] CTD PMID:25833014 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SIRT1 sirtuin 1 multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:25833014 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G VWF von Willebrand factor multiple interactions ISO [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] CTD PMID:25833014 NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770
JBrowse link
ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
fucosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN1 protein tyrosine phosphatase non-receptor type 1 decreases activity EXP fucosterol results in decreased activity of PTPN1 protein CTD PMID:23994501 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link
phytosterols term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP7B1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCS1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HSD17B7 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA] CTD PMID:18155511 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA] CTD PMID:18155511 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,112,153...92,134,803
JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP7B1 mRNA] CTD PMID:18155511 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
JBrowse link
G FADS1 fatty acid desaturase 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA] CTD PMID:18155511 NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
JBrowse link
G FADS2 fatty acid desaturase 2 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA] CTD PMID:18155511 NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA] CTD PMID:18155511 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCS1 mRNA] CTD PMID:18155511 NCBI chr 5:43,287,470...43,313,477
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HSD17B7 mRNA] CTD PMID:18155511 NCBI chr 1:162,790,702...162,812,823
Ensembl chr 1:162,790,702...162,812,823
JBrowse link
G LPIN1 lipin 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA] CTD PMID:18155511 NCBI chr 2:11,677,544...11,827,409
Ensembl chr 2:11,677,595...11,827,409
JBrowse link
G LTF lactotransferrin multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
JBrowse link
G PPARGC1B PPARG coactivator 1 beta multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA] CTD PMID:18155511 NCBI chr 5:149,730,302...149,857,861
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G SQLE squalene epoxidase multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA] CTD PMID:18155511 NCBI chr 8:124,998,505...125,022,283
Ensembl chr 8:124,998,497...125,022,283
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity
multiple interactions
ISO ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase affects expression EXP ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression EXP ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
JBrowse link
stigmasterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA] CTD PMID:30245210 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 multiple interactions
decreases expression
EXP [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
Stigmasterol results in decreased expression of ABCG5 mRNA
CTD PMID:23454145 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 multiple interactions
decreases expression
EXP [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA
Stigmasterol results in decreased expression of ABCG8 mRNA
CTD PMID:23454145 NCBI chr 2:43,831,942...43,882,988
Ensembl chr 2:43,831,942...43,882,988
JBrowse link
G ACAT1 acetyl-CoA acetyltransferase 1 multiple interactions EXP [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA CTD PMID:23454145 NCBI chr11:108,116,705...108,148,822
Ensembl chr11:108,116,695...108,147,603
JBrowse link
G ANKRD1 ankyrin repeat domain 1 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA CTD PMID:30245210 NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA] CTD PMID:30245210 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA CTD PMID:30245210 NCBI chr 1:190,097,658...190,477,997
Ensembl chr 1:190,097,658...190,478,404
JBrowse link
G CLDN11 claudin 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA] CTD PMID:30245210 NCBI chr 3:170,418,868...170,434,691
Ensembl chr 3:170,418,868...170,454,733
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP Stigmasterol results in increased secretion of CXCL8 protein CTD PMID:23454145 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G DNMT3L DNA methyltransferase 3 like multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA] CTD PMID:30245210 NCBI chr21:44,246,339...44,261,897
Ensembl chr21:44,246,339...44,262,216
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA] CTD PMID:30245210 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FSHR follicle stimulating hormone receptor multiple interactions ISO Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA] CTD PMID:30245210 NCBI chr 2:48,953,161...49,154,527
Ensembl chr 2:48,962,157...49,154,527
JBrowse link
G GABARAP GABA type A receptor-associated protein decreases expression ISO Stigmasterol results in decreased expression of GABARAP mRNA CTD PMID:30245210 NCBI chr17:7,240,008...7,242,449
Ensembl chr17:7,240,008...7,242,449
JBrowse link
G GFRA1 GDNF family receptor alpha 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA] CTD PMID:30245210 NCBI chr10:116,056,925...116,274,705
Ensembl chr10:116,056,925...116,276,803
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
EXP [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA
Stigmasterol results in increased expression of HMGCR mRNA
CTD PMID:23454145 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
JBrowse link
G HOXA5 homeobox A5 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA CTD PMID:30245210 NCBI chr 7:27,141,052...27,143,681
Ensembl chr 7:27,141,052...27,143,681
JBrowse link
G IFI35 interferon induced protein 35 decreases expression ISO Stigmasterol results in decreased expression of IFI35 mRNA CTD PMID:30245210 NCBI chr17:43,006,784...43,014,459
Ensembl chr17:43,006,740...43,014,456
JBrowse link
G IL10 interleukin 10 increases secretion EXP Stigmasterol results in increased secretion of IL10 protein CTD PMID:23454145 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL6 interleukin 6 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:23535395 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KNG1 kininogen 1 multiple interactions EXP [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
JBrowse link
G MYBPC2 myosin binding protein C2 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA CTD PMID:30245210 NCBI chr19:50,432,892...50,466,321
Ensembl chr19:50,432,892...50,466,321
JBrowse link
G NANOG Nanog homeobox decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of NANOG mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NANOG mRNA; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]
CTD PMID:30245210 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23535395 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA; [Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr 7:44,512,440...44,541,651
Ensembl chr 7:44,512,535...44,541,330
JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 multiple interactions
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA] CTD PMID:30245210 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions ISO Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA] CTD PMID:30245210 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 affects response to substance
decreases expression
multiple interactions
ISO NR1H4 gene mutant form affects the susceptibility to Stigmasterol
Stigmasterol results in decreased expression of NR1H4 mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NR1H4 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]
CTD PMID:30245210 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:23535395 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RPL18A ribosomal protein L18a decreases expression ISO Stigmasterol results in decreased expression of RPL18A mRNA CTD PMID:30245210 NCBI chr19:17,859,910...17,863,319
Ensembl chr19:17,859,910...17,864,153
JBrowse link
G RPL31 ribosomal protein L31 decreases expression ISO Stigmasterol results in decreased expression of RPL31 mRNA CTD PMID:30245210 NCBI chr 2:101,002,289...101,019,724
Ensembl chr 2:101,002,229...101,024,032
JBrowse link
G RPL36 ribosomal protein L36 decreases expression ISO Stigmasterol results in decreased expression of RPL36 mRNA CTD PMID:30245210 NCBI chr19:5,690,295...5,691,875
Ensembl chr19:5,674,947...5,691,875
JBrowse link
G RPPH1 ribonuclease P RNA component H1 decreases expression ISO Stigmasterol results in decreased expression of RPPH1 mRNA CTD PMID:30245210 NCBI chr14:20,343,071...20,343,411
Ensembl chr14:20,343,075...20,343,407
JBrowse link
G RPS14 ribosomal protein S14 decreases expression ISO Stigmasterol results in decreased expression of RPS14 mRNA CTD PMID:30245210 NCBI chr 5:150,442,635...150,449,739
Ensembl chr 5:150,442,635...150,449,739
JBrowse link
G RPS27 ribosomal protein S27 decreases expression ISO Stigmasterol results in decreased expression of RPS27 mRNA CTD PMID:30245210 NCBI chr 1:153,990,762...153,992,155
Ensembl chr 1:153,990,762...153,992,155
JBrowse link
G RPS7 ribosomal protein S7 decreases expression ISO Stigmasterol results in decreased expression of RPS7 mRNA CTD PMID:30245210 NCBI chr 2:3,575,260...3,580,920
Ensembl chr 2:3,575,260...3,580,920
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 increases abundance EXP SLCO1B1 SNP results in increased abundance of Stigmasterol CTD PMID:22022402 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G STRA8 stimulated by retinoic acid 8 decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of STRA8 mRNA
GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]
CTD PMID:30245210 NCBI chr 7:135,231,915...135,258,663
Ensembl chr 7:135,231,979...135,258,492
JBrowse link
G TM2D3 TM2 domain containing 3 decreases expression ISO Stigmasterol results in decreased expression of TM2D3 mRNA CTD PMID:30245210 NCBI chr15:101,632,977...101,652,381
Ensembl chr15:101,621,444...101,652,391
JBrowse link
G TNF tumor necrosis factor increases secretion
multiple interactions
EXP
ISO
Stigmasterol results in increased secretion of TNF protein
Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:23454145 PMID:23535395 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G ZBTB16 zinc finger and BTB domain containing 16 decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of ZBTB16 mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]
CTD PMID:30245210 NCBI chr11:114,059,576...114,256,770
Ensembl chr11:114,059,041...114,256,765
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24815
    chemical entity 24785
      molecular entity 24749
        polyatomic entity 24681
          heteroatomic molecular entity 24294
            hydroxides 22930
              organic hydroxy compound 20775
                hydroxy steroid 13235
                  phytosteroid 91
                    brassinosteroid + 16
                    cathasterone + 0
                    phytoecdysteroid + 9
                    phytosterols + 70
                    teasterone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24815
    subatomic particle 24774
      composite particle 24774
        hadron 24774
          baryon 24774
            nucleon 24774
              atomic nucleus 24774
                atom 24774
                  main group element atom 24641
                    p-block element atom 24641
                      carbon group element atom 24436
                        carbon atom 24401
                          organic molecular entity 24401
                            organic molecule 24287
                              organic cyclic compound 23556
                                organic polycyclic compound 17740
                                  steroid 13712
                                    hydroxy steroid 13235
                                      phytosteroid 91
                                        brassinosteroid + 16
                                        cathasterone + 0
                                        phytoecdysteroid + 9
                                        phytosterols + 70
                                        teasterone + 0
paths to the root