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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phytosteroid
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Accession:CHEBI:26124 term browser browse the term
Synonyms:related_synonym: phytosteroids



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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ecdysterone results in increased expression of BAX protein CTD PMID:33878320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Ecdysterone affects the expression of BCL2 protein CTD PMID:33878320 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO Ecdysterone results in increased activity of CASP3 protein
Ecdysterone results in increased cleavage of CASP3 protein
CTD PMID:29126784 PMID:33878320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression
ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA
CTD PMID:29126784 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Ecdysterone affects the expression of MTOR protein CTD PMID:33878320 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ecdysterone results in increased cleavage of PARP1 protein CTD PMID:33878320 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sqstm1 sequestosome 1 affects expression ISO Ecdysterone affects the expression of SQSTM1 protein CTD PMID:33878320 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
brassinolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO brassinolide results in decreased expression of BCL2 protein CTD PMID:17557751 PMID:20833159 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO brassinolide results in decreased expression of BCL2L1 protein CTD PMID:20833159 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO brassinolide results in decreased expression of BID protein CTD PMID:20833159 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
ISO brassinolide results in increased activity of CASP3 protein
brassinolide results in increased expression of CASP3 protein modified form
CTD PMID:17557751 PMID:20833159 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO brassinolide results in decreased expression of CCND1 protein CTD PMID:20833159 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO brassinolide results in decreased expression of CCNE1 protein CTD PMID:20833159 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO brassinolide results in decreased expression of CDK2 protein CTD PMID:20833159 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO brassinolide results in decreased expression of CDK4 protein CTD PMID:20833159 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO brassinolide results in increased expression of CDKN1A protein CTD PMID:20833159 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO brassinolide results in decreased expression of CDKN1B protein CTD PMID:20833159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO brassinolide results in decreased expression of ESR1 CTD PMID:20833159 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects localization
decreases expression
ISO brassinolide affects the localization of ESR2 protein
brassinolide results in decreased expression of ESR2
CTD PMID:20833159 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases expression ISO brassinolide results in decreased expression of MDM2 protein CTD PMID:20833159 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO brassinolide results in decreased expression of RB1 protein; brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Tp53 tumor protein p53 increases expression ISO brassinolide results in increased expression of TP53 protein CTD PMID:20833159 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
cycloartenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CAT protein] CTD PMID:12804013 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cryz crystallin zeta multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of CRYZ protein] CTD PMID:12804013 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of G6PD protein] CTD PMID:12804013 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in decreased activity of GSR protein] CTD PMID:12804013 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:12804013 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO cycloartenol inhibits the reaction [Benzoyl Peroxide results in increased activity of XDH protein] CTD PMID:12804013 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
ergosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein] CTD PMID:25833014 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein] CTD PMID:25833014 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol] CTD PMID:18694951 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein] CTD PMID:25833014 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein; [Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA] CTD PMID:25833014 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA] CTD PMID:25833014 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein] CTD PMID:25833014 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein] CTD PMID:25833014 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein] CTD PMID:25833014 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein] CTD PMID:25833014 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:25833014 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Vwf von Willebrand factor multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] CTD PMID:25833014 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
fucosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO fucosterol results in decreased activity of PTPN1 protein CTD PMID:23994501 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
phytosterols term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP7B1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCS1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HSD17B7 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA]; APOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA] CTD PMID:18155511 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP51 mRNA] CTD PMID:18155511 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of CYP7B1 mRNA] CTD PMID:18155511 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS1 mRNA] CTD PMID:18155511 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA] CTD PMID:18155511 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCR mRNA] CTD PMID:18155511 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HMGCS1 mRNA] CTD PMID:18155511 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of HSD17B7 mRNA] CTD PMID:18155511 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Lpin1 lipin 1 multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of LPIN1 mRNA] CTD PMID:18155511 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Ltf lactotransferrin multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Ppargc1b PPARG coactivator 1 beta multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of PPARGC1B mRNA] CTD PMID:18155511 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Sqle squalene epoxidase multiple interactions ISO APOE gene mutant form affects the reaction [Phytosterols results in increased expression of SQLE mRNA] CTD PMID:18155511 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
ponasterone A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases activity
multiple interactions
EXP ponasterone A results in decreased activity of CASP3 protein
L-161982 inhibits the reaction [ponasterone A results in decreased activity of CASP3 protein]
CTD PMID:16396944 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase affects expression ISO ponasterone A affects the expression of FHIT protein CTD PMID:17019711 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP L-161982 inhibits the reaction [ponasterone A results in increased expression of PTGS2 protein] CTD PMID:16396944 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO ponasterone A results in increased expression of UGT1A3 protein CTD PMID:17058234 NCBI chr 9:88,791,216...88,808,465 JBrowse link
stigmasterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA] CTD PMID:30245210 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions
decreases expression
ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
Stigmasterol results in decreased expression of ABCG5 mRNA
CTD PMID:23454145 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions
decreases expression
ISO [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA
Stigmasterol results in decreased expression of ABCG8 mRNA
CTD PMID:23454145 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA CTD PMID:23454145 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA CTD PMID:30245210 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA] CTD PMID:30245210 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Brinp3 BMP/retinoic acid inducible neural specific 3 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA CTD PMID:30245210 NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
JBrowse link
G Cldn11 claudin 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA] CTD PMID:30245210 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA] CTD PMID:30245210 NCBI chr20:10,614,933...10,629,516
Ensembl chr20:10,614,934...10,629,516
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA] CTD PMID:30245210 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA] CTD PMID:30245210 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gabarap GABA type A receptor-associated protein decreases expression ISO Stigmasterol results in decreased expression of GABARAP mRNA CTD PMID:30245210 NCBI chr10:54,714,834...54,717,769
Ensembl chr10:54,714,198...54,717,765
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA] CTD PMID:30245210 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA
Stigmasterol results in increased expression of HMGCR mRNA
CTD PMID:23454145 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hoxa5 homeo box A5 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA CTD PMID:30245210 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Stigmasterol results in decreased expression of IFI35 mRNA CTD PMID:30245210 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Il10 interleukin 10 increases secretion ISO Stigmasterol results in increased secretion of IL10 protein CTD PMID:23454145 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:23535395 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Mybpc2 myosin binding protein C2 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA CTD PMID:30245210 NCBI chr 1:94,994,104...95,017,650
Ensembl chr 1:94,994,104...95,017,584
JBrowse link
G Nanog Nanog homeobox decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of NANOG mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NANOG mRNA; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]
CTD PMID:30245210 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23535395 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA; [Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA] CTD PMID:30245210 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA] CTD PMID:30245210 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
affects response to substance
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of NR1H4 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]
Stigmasterol results in decreased expression of NR1H4 mRNA
CTD PMID:30245210 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:23535395 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rpl18a ribosomal protein L18A decreases expression ISO Stigmasterol results in decreased expression of RPL18A mRNA CTD PMID:30245210 NCBI chr16:18,542,572...18,544,578
Ensembl chr16:18,542,566...18,545,546
JBrowse link
G Rpl31 ribosomal protein L31 decreases expression ISO Stigmasterol results in decreased expression of RPL31 mRNA CTD PMID:30245210 NCBI chr 9:41,647,401...41,650,886
Ensembl chr 9:41,647,426...41,662,129
JBrowse link
G Rpl36 ribosomal protein L36 decreases expression ISO Stigmasterol results in decreased expression of RPL36 mRNA CTD PMID:30245210 NCBI chr 9:1,441,986...1,447,397 JBrowse link
G Rpph1 ribonuclease P RNA component H1 decreases expression ISO Stigmasterol results in decreased expression of RPPH1 mRNA CTD PMID:30245210 NCBI chr15:24,033,679...24,033,935
Ensembl chr15:24,033,662...24,033,959
JBrowse link
G Rps14 ribosomal protein S14 decreases expression ISO Stigmasterol results in decreased expression of RPS14 mRNA CTD PMID:30245210 NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
JBrowse link
G Rps27 ribosomal protein S27 decreases expression ISO Stigmasterol results in decreased expression of RPS27RT mRNA CTD PMID:30245210 NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
JBrowse link
G Rps7 ribosomal protein S7 decreases expression ISO Stigmasterol results in decreased expression of RPS7 mRNA CTD PMID:30245210 NCBI chr 6:45,266,200...45,271,064 JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of STRA8 mRNA
GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]
CTD PMID:30245210 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
JBrowse link
G Tm2d3 TM2 domain containing 3 decreases expression ISO Stigmasterol results in decreased expression of TM2D3 mRNA CTD PMID:30245210 NCBI chr 1:119,264,576...119,277,099
Ensembl chr 1:119,264,576...119,277,099
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Stigmasterol results in increased secretion of TNF protein
Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:23454145 PMID:23535395 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 multiple interactions
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA] CTD PMID:30245210 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      molecular entity 19821
        polyatomic entity 19743
          heteroatomic molecular entity 19685
            hydroxides 19175
              organic hydroxy compound 18666
                hydroxy steroid 12658
                  phytosteroid 93
                    brassinosteroid + 16
                    cathasterone + 0
                    phytoecdysteroid + 14
                    phytosterols + 68
                    teasterone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic polycyclic compound 16539
                                  steroid 13056
                                    hydroxy steroid 12658
                                      phytosteroid 93
                                        brassinosteroid + 16
                                        cathasterone + 0
                                        phytoecdysteroid + 14
                                        phytosterols + 68
                                        teasterone + 0
paths to the root