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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alprazolam
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Accession:CHEBI:2611 term browser browse the term
Definition:A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Synonyms:exact_synonym: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
 related_synonym: 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C17H13ClN4;   InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3;   InChIKey=VREFGVBLTWBCJP-UHFFFAOYSA-N;   SMILES=Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12;   Xanax
 xref: CAS:28981-97-7;   DrugBank:DB00404;   Drug_Central:136;   HMDB:HMDB0014548;   KEGG:C06817;   KEGG:D00225;   LINCS:LSM-5460
 xref_mesh: MESH:D000525
 xref: PMID:10350361;   PMID:10443648;   PMID:10631626;   PMID:10963939;   PMID:10997633;   PMID:11304902;   PMID:11824768;   PMID:12035937;   PMID:15647704;   PMID:15725773;   PMID:15830221;   PMID:16103667;   PMID:16139113;   PMID:16572266;   PMID:17631455;   PMID:24361783;   PMID:24464531;   PMID:24629629;   PMID:24840273;   PMID:24977401;   PMID:25032127;   PMID:25139178;   PMID:25199955;   PMID:25300043;   PMID:25427652;   PMID:25581490;   PMID:25620535;   PMID:7907366;   PMID:9050091;   Reaxys:1223125;   VSDB:2960;   Wikipedia:Alprazolam

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alprazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein CTD PMID:19490937 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein CTD PMID:19490937 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Alprazolam CTD PMID:12196913 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
affects metabolic processing		 ISO CYP3A4 protein binds to and affects the metabolism of Alprazolam
CYP3A4 protein affects the metabolism of Alprazolam		 CTD PMID:12196913 PMID:15856409 PMID:16042670 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Alprazolam CTD PMID:15903124 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Alprazolam results in decreased expression of IL2 protein CTD PMID:1624223 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Lhb luteinizing hormone subunit beta increases secretion ISO Alprazolam results in increased secretion of LHB protein CTD PMID:7883836 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein CTD PMID:19490937 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545 		JBrowse link
G Ppia peptidylprolyl isomerase A increases hydroxylation ISO PPIA protein results in increased hydroxylation of Alprazolam CTD PMID:15806426 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242 		JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          alprazolam 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organonitrogen heterocyclic compound 17523
                                    benzodiazepine 547
                                      triazolobenzodiazepine 26
                                        alprazolam 14
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