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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alprazolam
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Accession:CHEBI:2611 term browser browse the term
Definition:A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Synonyms:exact_synonym: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
 related_synonym: 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C17H13ClN4;   InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3;   InChIKey=VREFGVBLTWBCJP-UHFFFAOYSA-N;   SMILES=Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12;   Xanax
 xref: CAS:28981-97-7;   DrugBank:DB00404;   Drug_Central:136;   HMDB:HMDB0014548;   KEGG:C06817;   KEGG:D00225;   LINCS:LSM-5460
 xref_mesh: MESH:D000525
 xref: PMID:10350361;   PMID:10443648;   PMID:10631626;   PMID:10963939;   PMID:10997633;   PMID:11304902;   PMID:11824768;   PMID:12035937;   PMID:15647704;   PMID:15725773;   PMID:15830221;   PMID:16103667;   PMID:16139113;   PMID:16572266;   PMID:17631455;   PMID:24361783;   PMID:24464531;   PMID:24629629;   PMID:24840273;   PMID:24977401;   PMID:25032127;   PMID:25139178;   PMID:25199955;   PMID:25300043;   PMID:25427652;   PMID:25581490;   PMID:25620535;   PMID:7907366;   PMID:9050091;   Reaxys:1223125;   VSDB:2960;   Wikipedia:Alprazolam


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alprazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein CTD PMID:19490937 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein CTD PMID:19490937 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing		 ISO CYP3A4 protein binds to and affects the metabolism of Alprazolam
CYP3A4 protein affects the metabolism of Alprazolam		 CTD PMID:12196913 PMID:15856409 PMID:16042670 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of Alprazolam CTD PMID:12196913 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Alprazolam CTD PMID:15903124 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Alprazolam results in decreased expression of IL2 protein CTD PMID:1624223 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Lhb luteinizing hormone subunit beta increases secretion ISO Alprazolam results in increased secretion of LHB protein CTD PMID:7883836 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein CTD PMID:19490937 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Alprazolam results in decreased expression of PLCB1 mRNA; Alprazolam results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Ppia peptidylprolyl isomerase A increases hydroxylation ISO PPIA protein results in increased hydroxylation of Alprazolam CTD PMID:15806426 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Alprazolam inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Alprazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309 		JBrowse link
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Path 1
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  CHEBI ontology 19800
    role 19751
      biological role 19751
        xenobiotic 18436
          alprazolam 14
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organonitrogen heterocyclic compound 17661
                                    benzodiazepine 548
                                      triazolobenzodiazepine 28
                                        alprazolam 14
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