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ONTOLOGY REPORT - ANNOTATIONS


Term:alprazolam
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Accession:CHEBI:2611 term browser browse the term
Definition:A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.
Synonyms:exact_synonym: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
 related_synonym: 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C17H13ClN4;   InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3;   InChIKey=VREFGVBLTWBCJP-UHFFFAOYSA-N;   SMILES=Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12;   Xanax
 xref: CAS:28981-97-7;   DrugBank:DB00404;   Drug_Central:136;   HMDB:HMDB0014548;   KEGG:C06817;   KEGG:D00225;   LINCS:LSM-5460
 xref_mesh: MESH:D000525
 xref: PMID:10350361;   PMID:10443648;   PMID:10631626;   PMID:10963939;   PMID:10997633;   PMID:11304902;   PMID:11824768;   PMID:12035937;   PMID:15647704;   PMID:15725773;   PMID:15830221;   PMID:16103667;   PMID:16139113;   PMID:16572266;   PMID:17631455;   PMID:24361783;   PMID:24464531;   PMID:24629629;   PMID:24840273;   PMID:24977401;   PMID:25032127;   PMID:25139178;   PMID:25199955;   PMID:25300043;   PMID:25427652;   PMID:25581490;   PMID:25620535;   PMID:7907366;   PMID:9050091;   Reaxys:1223125;   VSDB:2960;   Wikipedia:Alprazolam


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alprazolam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 JBrowse link 12 18,679,809 18,709,397 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6480464
G Ppia peptidylprolyl isomerase A JBrowse link 14 86,673,775 86,677,443 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Trh thyrotropin releasing hormone JBrowse link 4 124,110,716 124,113,242 RGD:6480464
G Trhr thyrotropin releasing hormone receptor JBrowse link 7 83,113,641 83,153,520 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        xenobiotic 18398
          alprazolam 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic molecule 19461
                              organic cyclic compound 19222
                                organic heterocyclic compound 18339
                                  organonitrogen heterocyclic compound 17207
                                    benzodiazepine 533
                                      triazolobenzodiazepine 25
                                        alprazolam 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.