CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pheromone
Accession: CHEBI:26013
browse the term
Definition: A semiochemical used in olfactory communication between organisms of the same species eliciting a change in sexual or social behaviour.
Synonyms: related_synonym: ectohormone; feromone; pheromones
xref: PMID:23988175; Wikipedia:Pheromone
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Acaca
acetyl-CoA carboxylase alpha
multiple interactions decreases expression
ISO
[loliolide co-treated with pinoresinol] results in decreased expression of ACACA protein pinoresinol results in decreased expression of ACACA protein
CTD
PMID:31610126
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
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Fasn
fatty acid synthase
multiple interactions decreases expression
ISO
[loliolide co-treated with pinoresinol] results in decreased expression of FASN protein pinoresinol results in decreased expression of FASN protein
CTD
PMID:31610126
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
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Nr1h2
nuclear receptor subfamily 1, group H, member 2
multiple interactions
ISO
pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H2 protein
CTD
PMID:31610126
NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
multiple interactions
ISO
pinoresinol results in increased ubiquitination of and results in increased degradation of and results in decreased expression of NR1H3 protein
CTD
PMID:31610126
NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
pinoresinol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:21191767
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression multiple interactions
ISO
pinoresinol results in decreased expression of SREBF1 protein [loliolide co-treated with pinoresinol] results in decreased expression of SREBF1 protein
CTD
PMID:31610126
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
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Tnf
tumor necrosis factor
decreases secretion
ISO
pinoresinol results in decreased secretion of TNF protein
CTD
PMID:29740324
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
fluorotelomer alcohols results in increased expression of ABCC3 mRNA
CTD
PMID:38903859
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
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Abcg5
ATP binding cassette subfamily G member 5
decreases expression
EXP
fluorotelomer alcohols results in decreased expression of ABCG5 mRNA
CTD
PMID:38903859
NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
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Acat1
acetyl-CoA acetyltransferase 1
increases expression
EXP
fluorotelomer alcohols results in increased expression of ACAT1 mRNA
CTD
PMID:38903859
NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042
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Acox1
acyl-CoA oxidase 1
increases expression
EXP
fluorotelomer alcohols results in increased expression of ACOX1 mRNA
CTD
PMID:38903859
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136
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Acsl1
acyl-CoA synthetase long-chain family member 1
increases expression
EXP
fluorotelomer alcohols results in increased expression of ACSL1 mRNA
CTD
PMID:38903859
NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023
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Angptl4
angiopoietin-like 4
increases expression
EXP
fluorotelomer alcohols results in increased expression of ANGPTL4 mRNA
CTD
PMID:38903859
NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:15,252,473...15,258,681
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Ccna1
cyclin A1
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CCNA1 mRNA
CTD
PMID:30794351
NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300
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Ccna2
cyclin A2
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CCNA2 mRNA
CTD
PMID:30794351
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
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Ccnd1
cyclin D1
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CCND1 mRNA
CTD
PMID:30794351
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
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Ccne2
cyclin E2
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CCNE2 mRNA
CTD
PMID:30794351
NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
EXP
fluorotelomer alcohols results in decreased expression of CDKN1A mRNA
CTD
PMID:38903859
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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Cebpe
CCAAT/enhancer binding protein epsilon
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CEBPE mRNA
CTD
PMID:30794351
NCBI chr15:32,139,716...32,141,476
Ensembl chr15:32,139,716...32,141,476
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Csf3r
colony stimulating factor 3 receptor
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CSF3R mRNA
CTD
PMID:30794351
NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:143,583,213...143,602,411
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Cxcl3
C-X-C motif chemokine ligand 3
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CXCL1 mRNA
CTD
PMID:30536526
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CYP11A1 mRNA; fluorotelomer alcohols results in decreased expression of CYP11A1 protein
CTD
PMID:20615422
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CYP11B1 mRNA; fluorotelomer alcohols results in decreased expression of CYP11B1 protein
CTD
PMID:20615422
NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:108,719,349...108,725,763
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CYP11B2 mRNA; fluorotelomer alcohols results in decreased expression of CYP11B2 protein
CTD
PMID:20615422
NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of CYP17A1 mRNA; fluorotelomer alcohols results in decreased expression of CYP17A1 protein
CTD
PMID:20615422
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
ISO
fluorotelomer alcohols results in increased expression of CYP19A1 mRNA
CTD
PMID:23142464
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
decreases expression
EXP
fluorotelomer alcohols results in decreased expression of CYP1A2 mRNA
CTD
PMID:38903859
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
fluorotelomer alcohols results in decreased activity of CYP2E1 protein
CTD
PMID:35121066
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
affects expression
EXP
fluorotelomer alcohols affects the expression of CYP7A1 mRNA
CTD
PMID:38903859
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
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Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of ERBB2 mRNA
CTD
PMID:16393665
NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481
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Esr1
estrogen receptor 1
increases activity multiple interactions increases expression
ISO
fluorotelomer alcohols results in increased activity of ESR1 protein fluorotelomer alcohols promotes the reaction [ESR1 protein binds to NCOA2 protein] fluorotelomer alcohols results in increased expression of ESR1 mRNA
CTD
PMID:16393665 PMID:17603182
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354
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Esr2
estrogen receptor 2
multiple interactions increases activity
ISO
fluorotelomer alcohols promotes the reaction [ESR2 protein binds to NCOA2 protein] fluorotelomer alcohols results in increased activity of ESR2 protein
CTD
PMID:17603182
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709
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G0s2
G0/G1switch 2
affects expression
EXP
fluorotelomer alcohols affects the expression of G0S2 mRNA
CTD
PMID:38903859
NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293
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Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of HNF4A mRNA
CTD
PMID:38953992
NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758
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Ifng
interferon gamma
multiple interactions
ISO
fluorotelomer alcohols inhibits the reaction [Mitogens results in increased secretion of IFNG protein]
CTD
PMID:30536526
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
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Igfbp1
insulin-like growth factor binding protein 1
affects expression
EXP
fluorotelomer alcohols affects the expression of IGFBP1 mRNA
CTD
PMID:38903859
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
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Igfbp3
insulin-like growth factor binding protein 3
decreases expression
EXP
fluorotelomer alcohols results in decreased expression of IGFBP3 mRNA
CTD
PMID:38903859
NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944
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Il1b
interleukin 1 beta
multiple interactions affects expression
ISO
fluorotelomer alcohols results in decreased expression of and results in decreased secretion of IL1B protein fluorotelomer alcohols affects the expression of IL1B mRNA
CTD
PMID:30536526
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il6
interleukin 6
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of IL6 mRNA
CTD
PMID:30536526
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Insig1
insulin induced gene 1
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of INSIG1 mRNA
CTD
PMID:38953992
NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778
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Itgam
integrin subunit alpha M
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of ITGAM mRNA
CTD
PMID:30794351
NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
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Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
decreases expression
EXP
fluorotelomer alcohols results in decreased expression of MFSD2A mRNA
CTD
PMID:38903859
NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:140,510,953...140,525,916
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Myc
MYC proto-oncogene, bHLH transcription factor
affects expression
EXP
fluorotelomer alcohols affects the expression of MYC mRNA
CTD
PMID:38903859
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
fluorotelomer alcohols promotes the reaction [ESR1 protein binds to NCOA2 protein]; fluorotelomer alcohols promotes the reaction [ESR2 protein binds to NCOA2 protein]
CTD
PMID:17603182
NCBI chr 5:10,618,712...10,852,776
Ensembl chr 5:10,618,722...10,852,776
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
fluorotelomer alcohols results in increased expression of NQO1 mRNA
CTD
PMID:38903859
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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Pck1
phosphoenolpyruvate carboxykinase 1
affects expression
EXP
fluorotelomer alcohols affects the expression of PCK1 mRNA
CTD
PMID:38903859
NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561
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Pdzk1
PDZ domain containing 1
increases expression
ISO
fluorotelomer alcohols results in increased expression of PDZK1 mRNA
CTD
PMID:16393665
NCBI chr 2:187,064,995...187,096,348
Ensembl chr 2:187,065,013...187,096,806
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Pgr
progesterone receptor
increases expression
ISO
fluorotelomer alcohols results in increased expression of PGR mRNA
CTD
PMID:16393665
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271
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Ppard
peroxisome proliferator-activated receptor delta
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of PPARD mRNA
CTD
PMID:38953992
NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
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Scd
stearoyl-CoA desaturase
increases expression
EXP
fluorotelomer alcohols results in increased expression of SCD mRNA
CTD
PMID:38903859
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785
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Slc22a7
solute carrier family 22 member 7
increases expression
EXP
fluorotelomer alcohols results in increased expression of SLC22A7 mRNA
CTD
PMID:21530637
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
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Spi1
Spi-1 proto-oncogene
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of SPI1 mRNA
CTD
PMID:30794351
NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of STAR mRNA; fluorotelomer alcohols results in decreased expression of STAR protein
CTD
PMID:20615422
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447
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Tat
tyrosine aminotransferase
affects expression
EXP
fluorotelomer alcohols affects the expression of TAT mRNA
CTD
PMID:38903859
NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
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Tff1
trefoil factor 1
increases expression
ISO
fluorotelomer alcohols results in increased expression of TFF1 mRNA
CTD
PMID:16393665
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956
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Tnf
tumor necrosis factor
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of TNF mRNA
CTD
PMID:30536526
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tspo
translocator protein
decreases expression
ISO
fluorotelomer alcohols results in decreased expression of TSPO mRNA
CTD
PMID:23142464
NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; [Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA
CTD
PMID:20361990
NCBI chr 1:90,780,468...90,859,852
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases activity multiple interactions
ISO
androst-16-en-3-ol results in decreased activity of NR1I3 protein 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; [Endosulfan inhibits the reaction [androst-16-en-3-ol results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA
CTD
PMID:20361990
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
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Ocln
occludin
increases cleavage
ISO
actinidine results in increased cleavage of OCLN protein
CTD
PMID:25042511
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411
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Akr1c14
aldo-keto reductase family 1, member C14
increases reduction
EXP
AKR1C14 protein results in increased reduction of Androsterone
CTD
PMID:1922097
NCBI chr17:71,066,197...71,083,184
Ensembl chr17:71,066,200...71,083,157
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Ar
androgen receptor
affects binding
EXP
Androsterone binds to AR protein
CTD
PMID:14565775
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects chemical synthesis
ISO
CYP17A1 protein affects the chemical synthesis of Androsterone
CTD
PMID:14522586
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
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Dhrs11
dehydrogenase/reductase 11
increases reduction
ISO
DHRS11 protein results in increased reduction of Androsterone
CTD
PMID:30926317
NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893
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G6pd
glucose-6-phosphate dehydrogenase
decreases activity
EXP
Androsterone results in decreased activity of G6PD protein
CTD
PMID:7752092
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144
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Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases metabolic processing
ISO
HSD17B12 protein results in increased metabolism of Androsterone
CTD
PMID:17641292
NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Androsterone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
multiple interactions
ISO
Androsterone inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Diethylstilbestrol]
CTD
PMID:23126256
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
multiple interactions
ISO
Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]
CTD
PMID:33290829
NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation
ISO
UGT1A4 protein SNP results in increased glucuronidation of Androsterone analog
CTD
PMID:15708967
NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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Ugt2b
UDP glycosyltransferase 2 family, polypeptide B
increases glucuronidation
EXP
UGT2B protein results in increased glucuronidation of Androsterone
CTD
PMID:2429951
NCBI chr14:20,985,449...21,006,267
Ensembl chr14:20,985,108...21,020,850
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases metabolic processing
ISO
UGT2B17 protein results in increased metabolism of Androsterone
CTD
PMID:8798464
NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
increases glucuronidation decreases activity multiple interactions
ISO
UGT2B7 protein results in increased glucuronidation of Androsterone Androsterone results in decreased activity of UGT2B7 protein Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Diethylstilbestrol]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]
CTD
PMID:11186130 PMID:23126256 PMID:26875642 PMID:33290829
NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
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Kl
Klotho
multiple interactions
ISO
androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
CTD
PMID:14701853
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:5,325,959...5,367,015
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Akr1b15
aldo-keto reductase family 1 member B15
multiple interactions
EXP
[AKR1B8 protein co-treated with NADP] affects the oxidation of n-decyl alcohol
CTD
PMID:18845131
NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349
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Cftr
CF transmembrane conductance regulator
increases activity
ISO
n-decyl alcohol results in increased activity of CFTR protein
CTD
PMID:14967738
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
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Atf3
activating transcription factor 3
increases expression
ISO
Dodecanol analog results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Dodecanol analog results in increased expression of DNAJB4 mRNA
CTD
PMID:27965148
NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Dodecanol analog results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
G
Tyr
tyrosinase
decreases expression
ISO
decaprenoic acid results in decreased expression of TYR protein
CTD
PMID:23286867
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
G
Gna15
G protein subunit alpha 15
increases response to substance multiple interactions
ISO
GNA15 protein results in increased susceptibility to 2-heptanone [GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein
CTD
PMID:15598656
NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,835,357...8,856,268
G
Gnal
G protein subunit alpha L
multiple interactions increases response to substance
ISO
[GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein
CTD
PMID:15598656
NCBI chr18:62,892,257...63,032,510
Ensembl chr18:62,892,226...63,043,129
G
Gstp1
glutathione S-transferase pi 1
decreases activity
ISO
2-heptanone results in decreased activity of GSTP1 protein
CTD
PMID:18409811
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705
G
Or5g29
olfactory receptor family 5 subfamily G member 29
multiple interactions
ISO
[GNA15 protein results in increased susceptibility to 2-heptanone] which results in decreased activity of OR5G26 protein; [GNAL protein results in increased susceptibility to 2-heptanone] which results in increased activity of OR5G26 protein
CTD
PMID:15598656
NCBI chr 3:91,089,444...91,090,388
Ensembl chr 3:91,089,444...91,090,388
G
Akr1b15
aldo-keto reductase family 1 member B15
multiple interactions
EXP
[AKR1B8 protein co-treated with NADP] affects the oxidation of 1-hexanol
CTD
PMID:18845131
NCBI chr 4:63,964,421...63,976,995
Ensembl chr 4:63,960,880...63,978,349
G
Hsf1
heat shock transcription factor 1
increases activity
ISO
mono-n-hexyl phthalate results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
G
Ppara
peroxisome proliferator activated receptor alpha
affects binding
ISO
mono-n-hexyl phthalate binds to PPARA protein
CTD
PMID:23843199
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
G
Ppard
peroxisome proliferator-activated receptor delta
affects binding
ISO
mono-n-hexyl phthalate binds to PPARB protein
CTD
PMID:23843199
NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding
ISO
mono-n-hexyl phthalate binds to PPARG protein
CTD
PMID:23843199
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
G
Agt
angiotensinogen
multiple interactions
EXP
[nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]; nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33212213
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
CTD
PMID:33212213
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]
CTD
PMID:36169646
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
nerolidol results in increased expression of BAX mRNA
CTD
PMID:35357761
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
nerolidol results in decreased expression of BCL2 mRNA
CTD
PMID:35357761
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
G
Casp3
caspase 3
increases expression
ISO
nerolidol results in increased expression of CASP3 mRNA
CTD
PMID:35357761
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
G
Cat
catalase
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; nerolidol inhibits the reaction [AGT protein results in decreased expression of CAT protein]
CTD
PMID:33212213 PMID:36169646
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
G
Ccnd1
cyclin D1
decreases expression
ISO
nerolidol results in decreased expression of CCND1 mRNA
CTD
PMID:35357761
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
G
G6pd
glucose-6-phosphate dehydrogenase
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PD protein]
CTD
PMID:36169646
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144
G
Gck
glucokinase
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GCK protein]
CTD
PMID:36169646
NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]
CTD
PMID:36169646
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
G
Gpx4
glutathione peroxidase 4
multiple interactions
EXP
[nerolidol co-treated with AGT protein] results in increased expression of GPX4 protein
CTD
PMID:33212213
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
G
Il6
interleukin 6
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of IL6 protein]
CTD
PMID:33212213
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
G
Ins1
insulin 1
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]
CTD
PMID:36169646
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
G
Irs1
insulin receptor substrate 1
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of IRS1 protein]
CTD
PMID:36169646
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
CTD
PMID:33212213
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33212213
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
nerolidol results in increased expression of and results in increased phosphorylation of MAPK8 mRNA
CTD
PMID:35357761
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of MMP2 protein]
CTD
PMID:33212213
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
G
Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of MMP9 protein]
CTD
PMID:33212213
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of NOS2 protein]
CTD
PMID:33212213
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD
PMID:33212213
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased phosphorylation of and affects the localization of RELA protein]
CTD
PMID:33212213
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
G
Slc2a4
solute carrier family 2 member 4
multiple interactions
EXP
nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]
CTD
PMID:36169646
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
G
Sod2
superoxide dismutase 2
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]
CTD
PMID:33212213
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
CTD
PMID:33212213
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
G
Tlr4
toll-like receptor 4
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of TLR4 protein]
CTD
PMID:33212213
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
G
Tnf
tumor necrosis factor
multiple interactions
EXP
nerolidol inhibits the reaction [AGT protein results in increased expression of TNF protein]
CTD
PMID:33212213
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
20862
role
20820
biological role
20818
molecular messenger
19442
semiochemical
109
pheromone
108
(1S,6S,7R)-sesquipiperitol
0
(2E,4E,6E)-nonatrienal
0
(2E,4E,6Z)-nonatrienal
0
(6R,7S)-himachala-9,11-diene
0
(7Z)-tricosene
0
(7Z,11Z)-nonacosadiene
0
(E)-non-2-en-1-ol +
0
(E,E)-2,4-hexadienyl acetate
0
(R)-3-[(R)-3-hydroxybutanoyloxy]butanoic acid
0
(R)-3-hydroxybutyric acid +
0
(Z)-hexadec-11-enal
0
(Z)-non-6-en-1-ol
0
(Z)-pentacos-7-ene
0
1-heptadecene
0
2-butyl-3,5-dimethylpyrazine
0
2-isobutylthiazole
0
2-methoxy-4-vinylphenol
0
2-methylhexacosane
0
3-ethyl-2,7-dimethyloctane
0
3-hydroxy-3-methylbut-1-ene
0
5alpha-androst-16-en-3-one
0
5alpha-androst-16-en-3alpha-ol
2
6-oxo-nonan-1-ol
0
7-methylmellein
0
7-methyltricosane
0
7-tricosene +
0
N-acetyl-D-glucosamino-1,5-lactone +
0
actinidine
1
alarm pheromone +
5
androsterone +
14
ascr#1 +
0
ascr#2 +
0
ascr#3 +
0
ascr#4
0
ascr#5
0
ascr#7 +
0
ascr#8
0
bombykol
0
cis-cis-nepetalactol
0
cis-isogeraniol
0
cis-trans-nepetalactone
0
civetone
0
coniferol +
7
decan-1-ol +
52
decan-3-ol
0
dodecan-1-ol +
3
felinine
0
geranic acid
1
geranylgeranyl acetate
0
henicosane +
0
heptacosa-7,11-diene
0
heptan-2-one
4
hexan-3-ol
0
lauryl acrylate
0
lavandulol +
0
linalool oxide pyranoside +
0
nerolidol +
28
nonan-2-ol +
0
nonan-5-ol
0
octan-3-ol
0
palmityl acetate
0
pentadecan-2-ol
0
pentan-3-ol
0
peptide pheromone +
0
phenylacetonitrile +
0
sobralene
0
sulcatol
0
tetradecan-1-ol +
0
tridecan-2-ol
0
trimethylpyrazine
0
trisporic acid
0
undecan-2-ol
0