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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylacetaldehydes
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Accession:CHEBI:25973 term browser browse the term


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2-phenylpropanal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
decreases activity		 ISO GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTA1 protein results in decreased activity of hydratropic aldehyde		 CTD PMID:11368548 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity
multiple interactions		 ISO GSTM1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTM1 protein
GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]		 CTD PMID:11368548 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases activity		 ISO GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTP1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTP1 protein		 CTD PMID:11368548 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions		 EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa		 CTD PMID:21238438 PMID:21514317 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
phenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO phenylacetaldehyde results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO phenylacetaldehyde results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Phenylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction ISO AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases reduction ISO AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of Phenylglyoxal CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions
decreases activity		 ISO Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        solvent 17024
          formic acid 9042
            formyl group 9004
              aldehyde 9004
                phenylacetaldehydes 11
                  (2E)-5-methyl-2-phenylhex-2-enal 0
                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                  (4-Methylphenyl)acetaldehyde 0
                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                  (4-hydroxyphenyl)acetaldehyde 0
                  (Z)-4-hydroxyphenylacetaldehyde 0
                  2-Phenyl-2-pentenal 0
                  2-Phenyl-4-pentenal 0
                  2-Phenylmalonaldehyde 0
                  2-hydroxyphenylacetaldehyde 0
                  2-phenylpropanal 3
                  3,4-dihydroxyphenylacetaldehyde 3
                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                  3-Carbamoyl-2-phenylpropionaldehyde 0
                  4-hydroxy-3-nitrophenylacetaldehyde 0
                  Atropaldehyde 0
                  Hypofuran B 0
                  Phenylglyoxal 4
                  phenylacetaldehyde + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          formyl group 9004
                                            aldehyde 9004
                                              phenylacetaldehydes 11
                                                (2E)-5-methyl-2-phenylhex-2-enal 0
                                                (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                                                (4-Methylphenyl)acetaldehyde 0
                                                (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                                                (4-hydroxyphenyl)acetaldehyde 0
                                                (Z)-4-hydroxyphenylacetaldehyde 0
                                                2-Phenyl-2-pentenal 0
                                                2-Phenyl-4-pentenal 0
                                                2-Phenylmalonaldehyde 0
                                                2-hydroxyphenylacetaldehyde 0
                                                2-phenylpropanal 3
                                                3,4-dihydroxyphenylacetaldehyde 3
                                                3-(2-Furanyl)-2-phenyl-2-propenal 0
                                                3-Carbamoyl-2-phenylpropionaldehyde 0
                                                4-hydroxy-3-nitrophenylacetaldehyde 0
                                                Atropaldehyde 0
                                                Hypofuran B 0
                                                Phenylglyoxal 4
                                                phenylacetaldehyde + 2
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