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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylacetaldehydes
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Accession:CHEBI:25973 term browser browse the term


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2-phenylpropanal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstm1 glutathione S-transferase, mu 1 multiple interactions
decreases activity		 ISO GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTM1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTM1 protein		 CTD PMID:11368548 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity
multiple interactions		 ISO GSTP1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTP1 protein
GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]		 CTD PMID:11368548 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions		 ISO 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa		 CTD PMID:21238438 PMID:21514317 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
phenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO phenylacetaldehyde results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases secretion ISO phenylacetaldehyde results in increased secretion of CXCL8 protein CTD PMID:17118622 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO phenylacetaldehyde results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Phenylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) increases reduction ISO AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) increases reduction ISO AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the reduction of Phenylglyoxal CTD PMID:18845131 NCBI chr 6:34,331,081...34,345,396
Ensembl chr 6:34,331,054...34,345,398 		JBrowse link
G Dhrs11 dehydrogenase/reductase (SDR family) member 11 increases reduction ISO DHRS11 protein results in increased reduction of Phenylglyoxal CTD PMID:30926317 NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820 		JBrowse link
G Fut8 fucosyltransferase 8 multiple interactions
decreases activity		 ISO Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr12:77,284,204...77,522,772
Ensembl chr12:77,284,899...77,523,112 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21849
    role 21849
      application 21400
        solvent 17809
          formic acid 8960
            formyl group 8933
              aldehyde 8933
                phenylacetaldehydes 12
                  (2E)-5-methyl-2-phenylhex-2-enal 0
                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                  (4-Methylphenyl)acetaldehyde 0
                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                  (4-hydroxyphenyl)acetaldehyde 0
                  (Z)-4-hydroxyphenylacetaldehyde 0
                  2-Phenyl-2-pentenal 0
                  2-Phenylmalonaldehyde 0
                  2-hydroxyphenylacetaldehyde 0
                  2-phenylpropanal 2
                  3,4-dihydroxyphenylacetaldehyde 3
                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                  3-Carbamoyl-2-phenylpropionaldehyde 0
                  4-hydroxy-3-nitrophenylacetaldehyde 0
                  Atropaldehyde 0
                  Phenylglyoxal 5
                  phenylacetaldehyde + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 21849
    subatomic particle 21837
      composite particle 21855
        hadron 21837
          baryon 21837
            nucleon 21837
              atomic nucleus 21837
                atom 21837
                  main group element atom 21776
                    p-block element atom 21776
                      carbon group element atom 21573
                        carbon atom 21512
                          organic molecular entity 21493
                            organic group 20001
                              organic divalent group 19988
                                organodiyl group 19988
                                  carbonyl group 19981
                                    carbonyl compound 19981
                                      carboxylic acid 19325
                                        carboacyl group 18221
                                          univalent carboacyl group 18221
                                            formyl group 8933
                                              aldehyde 8933
                                                phenylacetaldehydes 12
                                                  (2E)-5-methyl-2-phenylhex-2-enal 0
                                                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                                                  (4-Methylphenyl)acetaldehyde 0
                                                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                                                  (4-hydroxyphenyl)acetaldehyde 0
                                                  (Z)-4-hydroxyphenylacetaldehyde 0
                                                  2-Phenyl-2-pentenal 0
                                                  2-Phenylmalonaldehyde 0
                                                  2-hydroxyphenylacetaldehyde 0
                                                  2-phenylpropanal 2
                                                  3,4-dihydroxyphenylacetaldehyde 3
                                                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                                                  3-Carbamoyl-2-phenylpropionaldehyde 0
                                                  4-hydroxy-3-nitrophenylacetaldehyde 0
                                                  Atropaldehyde 0
                                                  Phenylglyoxal 5
                                                  phenylacetaldehyde + 3
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