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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylacetaldehydes
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Accession:CHEBI:25973 term browser browse the term



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2-phenylpropanal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA1 glutathione S-transferase alpha 1 decreases activity
multiple interactions
EXP GSTA1 protein results in decreased activity of hydratropic aldehyde
GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
CTD PMID:11368548 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity
multiple interactions
EXP GSTM1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTM1 protein
GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
CTD PMID:11368548 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
decreases activity
EXP GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTP1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTP1 protein
CTD PMID:11368548 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G GSTM1 glutathione S-transferase mu 1 affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G TH tyrosine hydroxylase affects binding
decreases activity
multiple interactions
ISO 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438 PMID:21514317 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815
JBrowse link
phenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP phenylacetaldehyde results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP phenylacetaldehyde results in increased secretion of CXCL8 protein CTD PMID:17118622 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G TNF tumor necrosis factor increases secretion EXP phenylacetaldehyde results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
Phenylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 increases reduction EXP AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases reduction EXP AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1B15 aldo-keto reductase family 1 member B15 multiple interactions ISO [AKR1B8 protein co-treated with NADP] affects the reduction of Phenylglyoxal CTD PMID:18845131 NCBI chr 7:134,549,110...134,579,869
Ensembl chr 7:134,549,110...134,579,875
JBrowse link
G DHRS11 dehydrogenase/reductase 11 increases reduction EXP DHRS11 protein results in increased reduction of Phenylglyoxal CTD PMID:30926317 NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804
JBrowse link
G FUT8 fucosyltransferase 8 multiple interactions
decreases activity
EXP Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr14:65,356,842...65,744,121
Ensembl chr14:65,410,592...65,744,121
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25458
    role 25399
      application 24570
        solvent 18219
          formic acid 9812
            formyl group 9785
              aldehyde 9785
                phenylacetaldehydes 13
                  (2E)-5-methyl-2-phenylhex-2-enal 0
                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                  (4-Methylphenyl)acetaldehyde 0
                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                  (4-hydroxyphenyl)acetaldehyde 0
                  (Z)-4-hydroxyphenylacetaldehyde 0
                  2-Phenyl-2-pentenal 0
                  2-Phenylmalonaldehyde 0
                  2-hydroxyphenylacetaldehyde 0
                  2-phenylpropanal 3
                  3,4-dihydroxyphenylacetaldehyde 3
                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                  3-Carbamoyl-2-phenylpropionaldehyde 0
                  4-hydroxy-3-nitrophenylacetaldehyde 0
                  Atropaldehyde 0
                  Phenylglyoxal 5
                  phenylacetaldehyde + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 25458
    subatomic particle 25427
      composite particle 25433
        hadron 25427
          baryon 25427
            nucleon 25427
              atomic nucleus 25427
                atom 25427
                  main group element atom 25279
                    p-block element atom 25279
                      carbon group element atom 24839
                        carbon atom 24821
                          organic molecular entity 24815
                            organic group 22985
                              organic divalent group 22963
                                organodiyl group 22963
                                  carbonyl group 22957
                                    carbonyl compound 22957
                                      carboxylic acid 22033
                                        carboacyl group 19893
                                          univalent carboacyl group 19893
                                            formyl group 9785
                                              aldehyde 9785
                                                phenylacetaldehydes 13
                                                  (2E)-5-methyl-2-phenylhex-2-enal 0
                                                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                                                  (4-Methylphenyl)acetaldehyde 0
                                                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                                                  (4-hydroxyphenyl)acetaldehyde 0
                                                  (Z)-4-hydroxyphenylacetaldehyde 0
                                                  2-Phenyl-2-pentenal 0
                                                  2-Phenylmalonaldehyde 0
                                                  2-hydroxyphenylacetaldehyde 0
                                                  2-phenylpropanal 3
                                                  3,4-dihydroxyphenylacetaldehyde 3
                                                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                                                  3-Carbamoyl-2-phenylpropionaldehyde 0
                                                  4-hydroxy-3-nitrophenylacetaldehyde 0
                                                  Atropaldehyde 0
                                                  Phenylglyoxal 5
                                                  phenylacetaldehyde + 3
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