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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenylacetaldehydes
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Accession:CHEBI:25973 term browser browse the term


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2-phenylpropanal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA1 glutathione S-transferase alpha 1 decreases activity
multiple interactions		 EXP GSTA1 protein results in decreased activity of hydratropic aldehyde
GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]		 CTD PMID:11368548 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity
multiple interactions		 EXP GSTM1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTM1 protein
GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]		 CTD PMID:11368548 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
decreases activity		 EXP GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]
GSTP1 protein results in decreased activity of hydratropic aldehyde; hydratropic aldehyde results in decreased activity of GSTP1 protein		 CTD PMID:11368548 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 affects binding ISO 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G TH tyrosine hydroxylase affects binding
multiple interactions
decreases activity		 ISO 3,4-dihydroxyphenylacetaldehyde binds to TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa		 CTD PMID:21238438 PMID:21514317 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
phenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C2 aldo-keto reductase family 1 member C2 increases expression EXP phenylacetaldehyde results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP phenylacetaldehyde results in increased secretion of CXCL8 protein CTD PMID:17118622 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G TNF tumor necrosis factor increases secretion EXP phenylacetaldehyde results in increased secretion of TNF protein CTD PMID:17118622 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
Phenylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 increases reduction EXP AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases reduction EXP AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284 		JBrowse link
G DHRS11 dehydrogenase/reductase 11 increases reduction EXP DHRS11 protein results in increased reduction of Phenylglyoxal CTD PMID:30926317 NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804 		JBrowse link
G FUT8 fucosyltransferase 8 multiple interactions
decreases activity		 EXP Fucose analog inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [Phenylglyoxal results in decreased activity of FUT8 protein] CTD PMID:12770769 NCBI chr14:65,356,842...65,744,121
Ensembl chr14:65,410,592...65,744,121 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        solvent 18724
          formic acid 10007
            formyl group 9969
              aldehyde 9969
                phenylacetaldehydes 12
                  (2E)-5-methyl-2-phenylhex-2-enal 0
                  (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                  (4-Methylphenyl)acetaldehyde 0
                  (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                  (4-hydroxyphenyl)acetaldehyde 0
                  (Z)-4-hydroxyphenylacetaldehyde 0
                  2-Phenyl-2-pentenal 0
                  2-Phenyl-4-pentenal 0
                  2-Phenylmalonaldehyde 0
                  2-hydroxyphenylacetaldehyde 0
                  2-phenylpropanal 3
                  3,4-dihydroxyphenylacetaldehyde 3
                  3-(2-Furanyl)-2-phenyl-2-propenal 0
                  3-Carbamoyl-2-phenylpropionaldehyde 0
                  4-hydroxy-3-nitrophenylacetaldehyde 0
                  Atropaldehyde 0
                  Hypofuran B 0
                  Phenylglyoxal 4
                  phenylacetaldehyde + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      carboacyl group 20055
                                        univalent carboacyl group 20055
                                          formyl group 9969
                                            aldehyde 9969
                                              phenylacetaldehydes 12
                                                (2E)-5-methyl-2-phenylhex-2-enal 0
                                                (2Z)-4-Methyl-2-phenyl-2-pentenal 0
                                                (4-Methylphenyl)acetaldehyde 0
                                                (4-hydroxy-3-methoxyphenyl)acetaldehyde 0
                                                (4-hydroxyphenyl)acetaldehyde 0
                                                (Z)-4-hydroxyphenylacetaldehyde 0
                                                2-Phenyl-2-pentenal 0
                                                2-Phenyl-4-pentenal 0
                                                2-Phenylmalonaldehyde 0
                                                2-hydroxyphenylacetaldehyde 0
                                                2-phenylpropanal 3
                                                3,4-dihydroxyphenylacetaldehyde 3
                                                3-(2-Furanyl)-2-phenyl-2-propenal 0
                                                3-Carbamoyl-2-phenylpropionaldehyde 0
                                                4-hydroxy-3-nitrophenylacetaldehyde 0
                                                Atropaldehyde 0
                                                Hypofuran B 0
                                                Phenylglyoxal 4
                                                phenylacetaldehyde + 3
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