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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phenanthrol
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Accession:CHEBI:25962 term browser browse the term
Synonyms:related_synonym: Formula=C14H10O;   phenanthrenol;   phenanthrols
 xref: CAS:30774-95-9


show annotations for term's descendants           Sort by:
1-hydroxy-1-norresistomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of BAX protein CTD PMID:29596799 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of CASP3 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP3 protein CTD PMID:29596799 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of CASP9 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CASP9 protein CTD PMID:29596799 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of CDKN1A mRNA; 1-hydroxy-1-norresistomycin results in increased expression of CDKN1A protein CTD PMID:29596799 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 1-hydroxy-1-norresistomycin results in decreased expression of MMP2 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP2 protein CTD PMID:29596799 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO 1-hydroxy-1-norresistomycin results in decreased expression of MMP9 mRNA; 1-hydroxy-1-norresistomycin results in decreased expression of MMP9 protein CTD PMID:29596799 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Smim10l2a small integral membrane protein 10 like 2A increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of SMIM10L2A mRNA CTD PMID:29596799 NCBI chr  X:134,151,325...134,154,647 JBrowse link
G Tnf tumor necrosis factor decreases expression ISO 1-hydroxy-1-norresistomycin results in decreased expression of TNF mRNA CTD PMID:29596799 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO 1-hydroxy-1-norresistomycin results in increased expression of TP53 mRNA; 1-hydroxy-1-norresistomycin results in increased expression of TP53 protein CTD PMID:29596799 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
9-phenanthrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano1 anoctamin 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Calcium results in increased activity of ANO1 protein] CTD PMID:25573456 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Ar androgen receptor multiple interactions EXP
ISO		 9-phenanthrol inhibits the reaction [Metribolone binds to AR protein]
9-phenanthrol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:3695475 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G C3 complement C3 increases expression ISO 9-phenanthrol results in increased expression of C3 mRNA CTD PMID:22989670 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance
multiple interactions		 ISO CYP1A1 protein results in increased abundance of 9-phenanthrol
[CYP1A1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance		 ISO [CYP1A2 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP1A2 protein results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases abundance
multiple interactions		 ISO CYP1B1 protein results in increased abundance of 9-phenanthrol
[CYP1B1 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions
increases abundance		 ISO [CYP2A13 protein results in increased oxidation of phenanthrene] which results in increased abundance of 9-phenanthrol
CYP2A13 protein results in increased abundance of 9-phenanthrol		 CTD PMID:27137136 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 9-phenanthrol binds to and results in decreased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions		 ISO ESR2 protein binds to 9-phenanthrol
9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol]		 CTD PMID:22989670 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of FTH1 mRNA] CTD PMID:27246103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gcg glucagon multiple interactions EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein] CTD PMID:29098165 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of ICAM1 protein] CTD PMID:28214884 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ins1 insulin 1 multiple interactions
increases secretion		 EXP 9-phenanthrol inhibits the reaction [[GCG protein co-treated with Glucose] results in increased secretion of INS1 protein]; 9-phenanthrol inhibits the reaction [Glucose results in increased secretion of INS1 protein]
9-phenanthrol results in increased secretion of INS1 protein		 CTD PMID:29098165 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO 9-phenanthrol results in decreased expression of JAG1 mRNA CTD PMID:22989670 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides affects the localization of NFATC1 protein] CTD PMID:27246103 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 9-phenanthrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27246103 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO 9-phenanthrol binds to and affects the activity of NR1I2 protein
9-phenanthrol binds to and results in increased activity of NR1I2 protein		 CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO 9-phenanthrol results in increased expression of NRIP1 mRNA CTD PMID:22989670 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO 9-phenanthrol binds to and affects the activity of PPARG protein
9-phenanthrol binds to and results in increased activity of PPARG protein		 CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO 9-phenanthrol results in decreased activity of SCN5A protein mutant form CTD PMID:30153324 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sele selectin E multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of SELE protein] CTD PMID:28214884 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 9-phenanthrol binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions
decreases activity		 ISO 9-phenanthrol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Glutamic Acid results in increased activity of TRPM4 protein]; 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein]
9-phenanthrol results in decreased activity of TRPM4 protein		 CTD PMID:25047048 PMID:28214884 PMID:31054354 PMID:34335274 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 decreases activity ISO 9-phenanthrol results in decreased activity of TRPM5 protein CTD PMID:18297105 NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO 9-phenanthrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of VCAM1 protein] CTD PMID:28214884 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19825
      biological role 19823
        xenobiotic 18732
          phenanthrenes 303
            phenanthrol 35
              (+)-alternamgin 0
              (-)-alternamgin 0
              (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol 0
              1,7,8-trihydroxy-3-methyl-1,2,3,4,7,12-hexahydrotetraphen-12-one 0
              1-Hydroxypyrene-6,7-oxide 0
              1-Hydroxypyrene-7,8-oxide 0
              1-hydroxy-1-norresistomycin 9
              1-phenanthrol + 0
              12-deoxo-12-hydroxy-8-O-methyltetrangomycin 0
              2,4,5,6-Phenanthrenetetrol 0
              2,6-Dimethoxy-4-phenanthrenol 0
              2-phenanthrol 0
              3,11alpha,12beta,13beta,16-pentahydroxy-11,12-dihydroperylen-6(13H)-one 0
              3,5-Dimethoxy-2,7-phenanthrenediol 0
              3,6-Dimethoxy-4-phenanthrenol 0
              3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[alpha]anthracene 0
              3-phenanthrol 0
              4-phenanthrol 0
              9-Ethoxy-aristololactam 0
              9-phenanthrol + 26
              Agrostophyllin 0
              Altertoxin IX 0
              Altertoxin VII 0
              Altertoxin VIII 0
              Altertoxin X 0
              Altertoxin XI 0
              Aspergiloid F 0
              Aspergiloid G 0
              Asperpyrone E 0
              Aspewentin A 0
              Aspewentin B 0
              Aspewentin G 0
              Aspewentin H 0
              Batatasin I 0
              Benzo[a]pyrene-cis-11,12-dihydrodiol 0
              Benzo[a]pyrene-trans-11,12-dihydrodiol 0
              Benzopyrenomycin 0
              Biruloquinone 0
              Blestriarene B 0
              Butyl xanalterate 0
              Chlorxanthomycin 0
              Clostrubin A 0
              Clostrubin B 0
              Cypripedin 0
              Diplopimarane 0
              Donghaesulfin A 0
              Donghaesulfin B 0
              Dothideomycetide A 0
              Eutypenoid C 0
              Glomephenanthrene A 0
              Gonioffithine 0
              Hydranthomycin 0
              Hypomycin E 0
              Isobatatasin I 0
              Litebamine 0
              Lycodine 0
              Nocardiopsistin A 0
              Penijanthinone A 0
              Penijanthinone B 0
              Phaeosphaerin A 0
              Phaeosphaerin B 0
              Phaeosphaerin C 0
              Phaeosphaerin D 0
              Phaeosphaerin E 0
              Phaeosphaerin F 0
              Protohypericin 0
              Resistomycin 0
              Rubiginone K 0
              Rubiginone L 0
              Thioangucycline A 0
              Thioangucycline B 0
              Urceolatin 0
              Ustilobisorbicillinol A 0
              Vanitaracin A 0
              Vanitaracin B 0
              Xanalteric acid I 0
              Xanalteric acid II 0
              cis-3,4-Phenanthrenedihydrodiol-4-carboxylate 0
              huperzine b 0
              trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19685
                              organic cyclic compound 19496
                                carbocyclic compound 18588
                                  carbopolycyclic compound 17183
                                    carbotricyclic compound 1560
                                      phenanthrenes 303
                                        phenanthrol 35
                                          (+)-alternamgin 0
                                          (-)-alternamgin 0
                                          (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol 0
                                          1,7,8-trihydroxy-3-methyl-1,2,3,4,7,12-hexahydrotetraphen-12-one 0
                                          1-Hydroxypyrene-6,7-oxide 0
                                          1-Hydroxypyrene-7,8-oxide 0
                                          1-hydroxy-1-norresistomycin 9
                                          1-phenanthrol + 0
                                          12-deoxo-12-hydroxy-8-O-methyltetrangomycin 0
                                          2,4,5,6-Phenanthrenetetrol 0
                                          2,6-Dimethoxy-4-phenanthrenol 0
                                          2-phenanthrol 0
                                          3,11alpha,12beta,13beta,16-pentahydroxy-11,12-dihydroperylen-6(13H)-one 0
                                          3,5-Dimethoxy-2,7-phenanthrenediol 0
                                          3,6-Dimethoxy-4-phenanthrenol 0
                                          3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[alpha]anthracene 0
                                          3-phenanthrol 0
                                          4-phenanthrol 0
                                          9-Ethoxy-aristololactam 0
                                          9-phenanthrol + 26
                                          Agrostophyllin 0
                                          Altertoxin IX 0
                                          Altertoxin VII 0
                                          Altertoxin VIII 0
                                          Altertoxin X 0
                                          Altertoxin XI 0
                                          Aspergiloid F 0
                                          Aspergiloid G 0
                                          Asperpyrone E 0
                                          Aspewentin A 0
                                          Aspewentin B 0
                                          Aspewentin G 0
                                          Aspewentin H 0
                                          Batatasin I 0
                                          Benzo[a]pyrene-cis-11,12-dihydrodiol 0
                                          Benzo[a]pyrene-trans-11,12-dihydrodiol 0
                                          Benzopyrenomycin 0
                                          Biruloquinone 0
                                          Blestriarene B 0
                                          Butyl xanalterate 0
                                          Chlorxanthomycin 0
                                          Clostrubin A 0
                                          Clostrubin B 0
                                          Cypripedin 0
                                          Diplopimarane 0
                                          Donghaesulfin A 0
                                          Donghaesulfin B 0
                                          Dothideomycetide A 0
                                          Eutypenoid C 0
                                          Glomephenanthrene A 0
                                          Gonioffithine 0
                                          Hydranthomycin 0
                                          Hypomycin E 0
                                          Isobatatasin I 0
                                          Litebamine 0
                                          Lycodine 0
                                          Nocardiopsistin A 0
                                          Penijanthinone A 0
                                          Penijanthinone B 0
                                          Phaeosphaerin A 0
                                          Phaeosphaerin B 0
                                          Phaeosphaerin C 0
                                          Phaeosphaerin D 0
                                          Phaeosphaerin E 0
                                          Phaeosphaerin F 0
                                          Protohypericin 0
                                          Resistomycin 0
                                          Rubiginone K 0
                                          Rubiginone L 0
                                          Thioangucycline A 0
                                          Thioangucycline B 0
                                          Urceolatin 0
                                          Ustilobisorbicillinol A 0
                                          Vanitaracin A 0
                                          Vanitaracin B 0
                                          Xanalteric acid I 0
                                          Xanalteric acid II 0
                                          cis-3,4-Phenanthrenedihydrodiol-4-carboxylate 0
                                          huperzine b 0
                                          trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene 0
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