Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,7-dimethylxanthine
go back to main search page
Accession:CHEBI:25858 term browser browse the term
Definition:A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals.
Synonyms:related_synonym: 3,7-Dihydro-1,7-dimethyl-1H-purine-2,6-dione;   Formula=C7H8N4O2;   InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13);   InChIKey=QUNWUDVFRNGTCO-UHFFFAOYSA-N;   Paraxanthine;   SMILES=Cn1cnc2[nH]c(=O)n(C)c(=O)c12;   p-Xanthine
 alt_id: CHEBI:34067
 xref: CAS:611-59-6;   HMDB:HMDB0001860;   KEGG:C13747;   LINCS:LSM-20962
 xref_mesh: MESH:C021183
 xref: MetaCyc:1-7-DIMETHYLXANTHINE;   PMID:10416066;   PMID:10572151;   PMID:10593655;   PMID:10877011;   PMID:11090584;   PMID:1128545;   PMID:12110375;   PMID:16870158;   PMID:17655324;   PMID:18621927;   PMID:20004571;   PMID:20614853;   PMID:20853468;   PMID:21380987;   PMID:22770225;   PMID:2882985;   PMID:3371146;   PMID:3798364;   PMID:7920690;   PMID:7977734;   PMID:8529334;   PMID:9920286;   Reaxys:197907;   Wikipedia:Paraxanthine


show annotations for term's descendants           Sort by:
 
1,7-dimethylxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor multiple interactions ISO ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA] CTD PMID:22701600 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Apcs amyloid P component, serum multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of APCS protein] CTD PMID:19962977 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA] CTD PMID:19962977 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL2 mRNA] CTD PMID:19962977 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases metabolic processing
multiple interactions
affects metabolic processing
increases chemical synthesis
ISO CYP1A2 protein results in increased hydroxylation of 1,7-dimethylxanthine
CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1-methylxanthine; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine
CYP1A2 protein affects the metabolism of 1,7-dimethylxanthine
CYP1A2 protein results in increased chemical synthesis of 1,7-dimethylxanthine
CTD PMID:1302044 PMID:15980104 PMID:19215233 PMID:31132250 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases expression
ISO 1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein; ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA] CTD PMID:22701600 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]
CTD PMID:19962977 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of MPO protein] CTD PMID:19962977 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions
increases metabolic processing
ISO [NAT2 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 5-acetylamino-6-formylamino-3-methyluracil CTD PMID:19215233 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NFKBIA mRNA] CTD PMID:19962977 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]
1,7-dimethylxanthine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]
CTD PMID:19962977 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            central nervous system drug 16522
              central nervous system stimulant 6864
                1,7-dimethylxanthine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      imidazopyrimidine 5611
                                        purines 5609
                                          aminopurine 4427
                                            2-aminopurines 4032
                                              guanine 3996
                                                xanthine 3906
                                                  methylxanthine 1145
                                                    dimethylxanthine 540
                                                      1,7-dimethylxanthine 11
paths to the root