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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:practolol
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Accession:CHEBI:258351 term browser browse the term
Definition:N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.
Synonyms:exact_synonym: N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
 related_synonym: 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol;   4'-(2-hydroxy-3-(isopropylamino)propoxy)acetanilide;   Formula=C14H22N2O3;   InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17);   InChIKey=DURULFYMVIFBIR-UHFFFAOYSA-N;   N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide;   SMILES=CC(C)NCC(O)COc1ccc(NC(C)=O)cc1;   practololum
 alt_id: CHEBI:101380;   CHEBI:8348
 xref: CAS:6673-35-4;   DrugBank:DB01297;   Drug_Central:3486;   HMDB:HMDB0015411;   KEGG:C11696;   KEGG:D05587;   LINCS:LSM-1531
 xref_mesh: MESH:D011217
 xref: PMID:6827543;   Patent:US3408387;   Wikipedia:Practolol



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practolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenergic receptor, beta 2 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Practolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Ren1 renin 1 structural decreases activity ISO Practolol results in decreased activity of REN protein CTD PMID:6110712 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      application 21755
        pharmaceutical 21163
          drug 21163
            cardiovascular drug 8892
              anti-arrhythmia drug 1494
                practolol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      carboxylic acid 19557
                                        carboacyl group 18293
                                          univalent carboacyl group 18293
                                            carbamoyl group 18104
                                              carboxamide 18104
                                                acetamides 14673
                                                  practolol 4
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