organooxygen heterocyclic antibiotic - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	organooxygen heterocyclic antibiotic	go back to main search page
Accession:	CHEBI:25807	browse the term

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Rat (103) Mouse (104) Human (107) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (103)

alborixin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

alborixin results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

alborixin results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases cleavage

alborixin results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

alborixin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

alborixin results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

poly (ADP-ribose) polymerase 1

increases cleavage

alborixin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

D-cycloserine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

Cycloserine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

DNA-damage inducible transcript 3

multiple interactions

Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

early growth response 1

increases expression

Cycloserine results in increased expression of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

homer scaffold protein 1

multiple interactions

Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

mitogen activated protein kinase 1

multiple interactions

Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

poly (ADP-ribose) polymerase 1

multiple interactions

Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

frenolicin B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

frenolicin B binds to and results in decreased activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions

frenolicin B results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

glutaredoxin 3

multiple interactions

[frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Reactive Oxygen Species; frenolicin B binds to and results in decreased activity of GLRX3 protein; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peroxiredoxin 1

multiple interactions

[frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; frenolicin B binds to and results in decreased activity of PRDX1 protein; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

ribosomal protein S6 kinase B1

decreases phosphorylation

frenolicin B results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

fumagillin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions

fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

methionyl aminopeptidase 1

decreases activity
multiple interactions

fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434

G

methionyl aminopeptidase 2

multiple interactions
decreases activity

fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

PMID:14534293 PMID:15516829 PMID:15682466

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

telomerase reverse transcriptase

multiple interactions

fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA]

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions

[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

furazolidone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BRCA1, DNA repair associated

multiple interactions
increases expression

Curcumin inhibits the reaction [Furazolidone results in increased expression of BRCA1 protein]

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

caspase 3

multiple interactions
increases activity

CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

multiple interactions
increases expression

Curcumin inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein

PMID:23112108 PMID:26095818 PMID:27996348

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

multiple interactions
increases expression

GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein

PMID:23112108 PMID:26095818

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin-dependent kinase 6

increases expression
multiple interactions

Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]

PMID:23112108 PMID:26095818

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

multiple interactions
increases expression

Curcumin inhibits the reaction [Furazolidone results in increased expression of CHEK1 protein]

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Furazolidone results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Curcumin inhibits the reaction [Furazolidone results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

heme oxygenase 1

multiple interactions
increases expression

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]

PMID:26687534 PMID:27996348

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Furazolidone results in increased expression of HSPA5 protein
Curcumin inhibits the reaction [Furazolidone results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

insulin-like growth factor 1

multiple interactions

IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Furazolidone results in increased phosphorylation of MAPK1 protein
Curcumin inhibits the reaction [Furazolidone results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Curcumin promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]

PMID:26687534 PMID:27996348

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

Kalafungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

kalafungin binds to and results in decreased activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

lasalocid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin, beta

increases expression

Lasalocid results in increased expression of ACTB protein

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

annexin A1

increases expression

Lasalocid results in increased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

increases expression

Lasalocid results in increased expression of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

desmoplakin

increases expression

Lasalocid results in increased expression of DSP protein

NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800

G

heterogeneous nuclear ribonucleoprotein A1

increases expression

Lasalocid results in increased expression of HNRNPA1 protein

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein A2/B1

increases expression

Lasalocid results in increased expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heat shock protein family B (small) member 1

increases expression

Lasalocid results in increased expression of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

involucrin

increases expression

Lasalocid results in increased expression of IVL protein

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

G

junction plakoglobin

increases expression

Lasalocid results in increased expression of JUP protein

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

G

keratin 5

increases expression

Lasalocid results in increased expression of KRT5 protein

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

microtubule-associated protein tau

decreases expression

Lasalocid results in decreased expression of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

plakophilin 1

increases expression

Lasalocid results in increased expression of PKP1 protein

NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465

G

periplakin

increases expression

Lasalocid results in increased expression of PPL protein

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

S100 calcium binding protein A10

increases expression

Lasalocid results in increased expression of S100A10 protein

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium binding protein A11

increases expression

Lasalocid results in increased expression of S100A11 protein

NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044

G

S100 calcium binding protein A16

increases expression

Lasalocid results in increased expression of S100A16 protein

NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117

G

serpin family B member 2

increases expression

Lasalocid results in increased expression of SERPINB2 protein

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

small proline-rich protein 1A

increases expression

Lasalocid results in increased expression of SPRR1A protein

NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063

G

small proline-rich protein 1B

increases expression

Lasalocid results in increased expression of SPRR1B protein

NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567

G

small proline-rich protein 2D

increases expression

Lasalocid results in increased expression of SPRR2D protein

NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679

Medermycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

medermycin binds to and results in decreased activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

monensin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions

Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-40)]; Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]
Monensin inhibits the reaction [Ketamine results in decreased expression of and results in increased cleavage of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATPase copper transporting alpha

multiple interactions

Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin]

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

beta-secretase 1

multiple interactions

Monensin inhibits the reaction [Ketamine results in increased expression of and affects the localization of BACE1 protein]

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2 interacting protein 3

increases expression

Monensin results in increased expression of BNIP3 protein

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

caspase 3

multiple interactions
increases activity

Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases activity

Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

colony stimulating factor 2

multiple interactions

Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

epidermal growth factor

multiple interactions

[EGF protein co-treated with Monensin] results in increased expression of MYC mRNA

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

interleukin 6

decreases secretion

Monensin results in decreased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

decreases degradation

Monensin results in decreased degradation of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[EGF protein co-treated with Monensin] results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

poly (ADP-ribose) polymerase 1

increases cleavage

Monensin results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

solute carrier family 6 member 2

multiple interactions

Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]]

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

G

solute carrier family 6 member 3

multiple interactions

Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

multiple interactions

Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]]

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

transient receptor potential cation channel, subfamily M, member 2

decreases expression
increases expression
multiple interactions

Monensin results in decreased expression of TRPM2 protein alternative form
Monensin results in increased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

zinc finger E-box binding homeobox 1

increases response to substance

ZEB1 protein results in increased susceptibility to Monensin

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

nitrofurantoin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions
decreases activity

Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 4

decreases activity

Nitrofurantoin results in decreased activity of ABCB4 protein

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily G member 2

affects transport
affects abundance
multiple interactions
increases secretion
increases transport
affects response to substance
increases export

ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
ABCG2 protein results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased transport of Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
ABCG2 affects the susceptibility to Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 protein results in increased export of Nitrofurantoin

PMID:15709111 PMID:15722455 PMID:17093006 PMID:17785426 PMID:18799806 More...

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

angiotensinogen

decreases activity

Nitrofurantoin results in decreased activity of AGT protein

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aldolase, fructose-bisphosphate A

increases expression

Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

catalase

decreases activity

Nitrofurantoin results in decreased activity of CAT protein

PMID:1313237 PMID:9000262

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

ciliary neurotrophic factor

multiple interactions

Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]

NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose

PMID:1313237 PMID:1901343 PMID:9000262

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hypoxia inducible factor 1 subunit alpha

increases activity

Nitrofurantoin results in increased activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression

Nitrofurantoin results in increased expression of HMOX1 mRNA

PMID:7626009 PMID:11841787

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock transcription factor 1

increases activity

Nitrofurantoin results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 8

increases expression

Nitrofurantoin results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Nitrofurantoin results in increased expression of JUN mRNA

PMID:7626009 PMID:11841787

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

LIM and cysteine-rich domains 1

increases expression

Nitrofurantoin results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; Nitrofurantoin results in increased expression of and affects the localization of NFE2L2 protein; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases response to substance
affects reduction

NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

orosomucoid 1

increases expression

Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

cytochrome p450 oxidoreductase

increases metabolic processing
multiple interactions
affects metabolic processing

POR protein results in increased metabolism of Nitrofurantoin
POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein]
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]

PMID:6802140 PMID:18206659 PMID:34021431

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

signal transducer and activator of transcription 1

multiple interactions

Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
increases activity
increases expression

Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA

PMID:11841787 PMID:15748169

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 2

increases expression

Nitrofurantoin results in increased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

nitrofurazone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin E1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

glycogen synthase kinase 3 beta

affects binding

Nitrofurazone binds to GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

HRas proto-oncogene, GTPase

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

interferon gamma

multiple interactions

[Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

increases expression

Nitrofurazone results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

iodotyrosine deiodinase

multiple interactions

Nitrofurazone inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]

NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

luteinizing hormone subunit beta

decreases expression

Nitrofurazone results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

microRNA 128-1

increases expression

Nitrofurazone results in increased expression of MIR128-1 mRNA

NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530

G

MYC proto-oncogene, bHLH transcription factor

increases expression
multiple interactions

Nitrofurazone results in increased expression of MYC mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

cytochrome p450 oxidoreductase

multiple interactions

[Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole]

PMID:6802140 PMID:15488632

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

prolactin

decreases expression

Nitrofurazone results in decreased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

transforming growth factor alpha

increases expression
multiple interactions

Nitrofurazone results in increased expression of TGFA mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

tumor necrosis factor

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

increases mutagenesis

Nitrofurazone results in increased mutagenesis of TP53 gene

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
biological role	19785
antimicrobial agent	18104
heterocyclic antibiotic	3012
organooxygen heterocyclic antibiotic	103
D-cycloserine +	8
aranotin	0
aurasperone A	0
benzoisochromanequinone +	6
fumagillin +	5
furagin	0
myxopyronin A	0
nanaomycin A	0
nitrofuran antibiotic +	52
nitrofurantoin	24
polyether antibiotic +	41
prefumagillin	0
thermorubin	0
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
p-block element atom	19759
carbon group element atom	19708
carbon atom	19734
organic molecular entity	19705
organic molecule	19658
organic cyclic compound	19471
organic heterocyclic compound	18862
heterocyclic antibiotic	3012
organooxygen heterocyclic antibiotic	103
D-cycloserine +	8
aranotin	0
aurasperone A	0
benzoisochromanequinone +	6
fumagillin +	5
furagin	0
myxopyronin A	0
nanaomycin A	0
nitrofuran antibiotic +	52
nitrofurantoin	24
polyether antibiotic +	41
prefumagillin	0
thermorubin	0

paths to the root