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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organooxygen heterocyclic antibiotic
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Accession:CHEBI:25807 term browser browse the term



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alborixin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO alborixin results in increased expression of BAX protein CTD PMID:27378626 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alborixin results in decreased expression of BCL2 protein CTD PMID:27378626 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases cleavage ISO alborixin results in increased cleavage of CASP3 protein CTD PMID:27378626 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO alborixin results in increased activity of CASP8 protein CTD PMID:27378626 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO alborixin results in increased activity of CASP9 protein CTD PMID:27378626 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alborixin results in increased cleavage of PARP1 protein CTD PMID:27378626 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
D-cycloserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 increases expression EXP Cycloserine results in increased expression of EGR1 protein CTD PMID:19144966 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] CTD PMID:12464447 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA] CTD PMID:12464447 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11903061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11903061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
frenolicin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO frenolicin B binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO frenolicin B results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]
CTD PMID:30661989 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Glrx3 glutaredoxin 3 multiple interactions ISO [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Reactive Oxygen Species; frenolicin B binds to and results in decreased activity of GLRX3 protein; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein] CTD PMID:30661989 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; frenolicin B binds to and results in decreased activity of PRDX1 protein; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO frenolicin B results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30661989 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
fumagillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA] CTD PMID:15682466 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Metap1 methionyl aminopeptidase 1 decreases activity
multiple interactions
ISO fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434
JBrowse link
G Metap2 methionyl aminopeptidase 2 multiple interactions
decreases activity
EXP
ISO
fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein
CTD PMID:14534293 PMID:15516829 PMID:15682466 NCBI chr 7:28,412,771...28,440,458
Ensembl chr 7:28,411,608...28,440,434
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions EXP fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA] CTD PMID:15682466 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma multiple interactions ISO [fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein CTD PMID:14534293 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
JBrowse link
furazolidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein] CTD PMID:26687534 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]
Furazolidone results in increased expression of CCND1 mRNA; Furazolidone results in increased expression of CCND1 protein
CTD PMID:23112108 PMID:26095818 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]
Furazolidone results in increased expression of CCND3 mRNA; Furazolidone results in increased expression of CCND3 protein
CTD PMID:23112108 PMID:26095818 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions
ISO Furazolidone results in increased expression of CDK6 mRNA; Furazolidone results in increased expression of CDK6 protein
GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
CTD PMID:23112108 PMID:26095818 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
decreases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased activity of CASP3 protein]; CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein]; Furazolidone promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]
Furazolidone results in increased expression of CDKN1A mRNA
Furazolidone results in decreased expression of CDKN1A protein
CTD PMID:26687534 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Furazolidone results in increased activity of CYP1A1 protein CTD PMID:8619122 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND1 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CCND3 protein]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]; GADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]
Furazolidone results in increased expression of GADD45A
CTD PMID:26095818 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of HMOX1 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of HMOX1 protein] CTD PMID:26687534 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 protein inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein] CTD PMID:26687534 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO CDKN1A mutant form inhibits the reaction [Furazolidone results in increased expression of NFE2L2 protein]; CDKN1A protein promotes the reaction [Furazolidone results in increased expression of NFE2L2 protein] CTD PMID:26687534 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO CDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]
Furazolidone results in increased cleavage of PARP1 protein
CTD PMID:26687534 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
Medermycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO medermycin binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
monensin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha multiple interactions ISO Monensin inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] CTD PMID:17510416 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO Monensin results in increased expression of BNIP3 protein CTD PMID:30718715 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP3 protein] CTD PMID:20799912 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Lithium inhibits the reaction [Monensin results in increased activity of CASP7 protein] CTD PMID:20799912 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Monensin inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Monensin inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Monensin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Monensin results in increased cleavage of PARP1 protein CTD PMID:30718715 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]] CTD PMID:29908239 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Monensin promotes the reaction [para-methyl-4-methylaminorex inhibits the reaction [SLC6A4 protein results in increased uptake of Serotonin]] CTD PMID:29908239 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 decreases expression
increases expression
multiple interactions
ISO Monensin results in decreased expression of TRPM2 protein alternative form
Monensin results in increased expression of TRPM2 protein alternative form
Lithium inhibits the reaction [Monensin results in increased expression of TRPM2 protein alternative form]
CTD PMID:20799912 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases response to substance ISO ZEB1 protein results in increased susceptibility to Monensin CTD PMID:30718715 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
nitrofurantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Nitrofurantoin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Nitrofurantoin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Nitrofurantoin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
increases export
affects abundance
multiple interactions
increases transport
affects response to substance
increases secretion
ISO
EXP
ABCG2 protein affects the transport of Nitrofurantoin
ABCG2 protein results in increased export of Nitrofurantoin
ABCG2 protein affects the abundance of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
ABCG2 affects the susceptibility to Nitrofurantoin
ABCG2 results in increased secretion of Nitrofurantoin
ABCG2 protein results in increased secretion of Nitrofurantoin
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
CTD PMID:15709111 PMID:15722455 PMID:17093006 PMID:17785426 PMID:18799806 More... NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Agt angiotensinogen decreases activity EXP Nitrofurantoin results in decreased activity of AGT protein CTD PMID:1313237 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Nitrofurantoin results in increased expression of ALDOA mRNA; Nitrofurantoin results in increased expression of ALDOA protein CTD PMID:11841787 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Cat catalase decreases activity ISO
EXP
Nitrofurantoin results in decreased activity of CAT protein CTD PMID:1313237 PMID:9000262 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]] CTD PMID:15748169 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Nitrofurantoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein] CTD PMID:34021431 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP
ISO
Nitrofurantoin results in decreased activity of GSR protein
[Nitrofurantoin co-treated with GSR protein] affects the metabolism of Glucose
CTD PMID:1313237 PMID:1901343 PMID:9000262 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity EXP Nitrofurantoin results in increased activity of HIF1A protein CTD PMID:11841787 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Nitrofurantoin results in increased expression of HMOX1 mRNA CTD PMID:7626009 PMID:11841787 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Nitrofurantoin results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Nitrofurantoin results in increased expression of HSPA8 mRNA CTD PMID:7626009 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Nitrofurantoin results in increased expression of JUN mRNA CTD PMID:7626009 PMID:11841787 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Nitrofurantoin results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; Nitrofurantoin results in increased expression of and affects the localization of NFE2L2 protein; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein] CTD PMID:34021431 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases response to substance
affects reduction
ISO NQO1 protein results in increased susceptibility to Nitrofurantoin
NQO1 protein affects the reduction of Nitrofurantoin
CTD PMID:9310146 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Nitrofurantoin results in increased expression of ORM1 mRNA; Nitrofurantoin results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Por cytochrome p450 oxidoreductase increases metabolic processing
multiple interactions
affects metabolic processing
ISO
EXP
POR protein results in increased metabolism of Nitrofurantoin
POR protein affects the reaction [Nitrofurantoin results in increased expression of GCLC protein]; POR protein affects the reaction [Nitrofurantoin results in increased expression of NFE2L2 protein]
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]; NADP affects the reaction [POR protein affects the metabolism of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [POR protein results in increased metabolism of Misonidazole]
CTD PMID:6802140 PMID:18206659 PMID:34021431 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]] CTD PMID:15748169 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases activity
increases expression
ISO
EXP
Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Rotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]
Nitrofurantoin results in increased activity of STAT3 protein
Nitrofurantoin results in increased expression of STAT3 mRNA
CTD PMID:11841787 PMID:15748169 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Nitrofurantoin results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO Nitrofurantoin results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
nitrofurazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of CCNE1 mRNA] CTD PMID:15945272 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP Nitrofurazone binds to GSK3B protein CTD PMID:18222664 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of HRAS mRNA] CTD PMID:15945272 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Nitrofurazone results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Nitrofurazone co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Nitrofurazone inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of JUN mRNA] CTD PMID:15945272 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Nitrofurazone results in decreased expression of LHB protein CTD PMID:11548123 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP Nitrofurazone results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
EXP Nitrofurazone results in increased expression of MYC mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of MYC mRNA]
CTD PMID:15945272 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [Nitrofurazone co-treated with POR protein co-treated with Copper] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine; Nitrofurazone inhibits the reaction [POR protein results in increased metabolism of Misonidazole] CTD PMID:6802140 PMID:15488632 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prl prolactin decreases expression EXP Nitrofurazone results in decreased expression of PRL protein CTD PMID:11548123 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Tgfa transforming growth factor alpha increases expression
multiple interactions
EXP Nitrofurazone results in increased expression of TGFA mRNA
Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TGFA mRNA]
CTD PMID:15945272 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Nitrofurazone results in increased expression of TNF mRNA] CTD PMID:15945272 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO Nitrofurazone results in increased mutagenesis of TP53 gene CTD PMID:15488632 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        antimicrobial agent 17482
          heterocyclic antibiotic 1643
            organooxygen heterocyclic antibiotic 78
              D-cycloserine + 7
              aranotin 0
              aurasperone A 0
              benzoisochromanequinone + 6
              fumagillin + 5
              furagin 0
              myxopyronin A 0
              nanaomycin A 0
              nitrofuran antibiotic + 48
              nitrofurantoin 25
              polyether antibiotic + 19
              thermorubin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  heterocyclic antibiotic 1643
                                    organooxygen heterocyclic antibiotic 78
                                      D-cycloserine + 7
                                      aranotin 0
                                      aurasperone A 0
                                      benzoisochromanequinone + 6
                                      fumagillin + 5
                                      furagin 0
                                      myxopyronin A 0
                                      nanaomycin A 0
                                      nitrofuran antibiotic + 48
                                      nitrofurantoin 25
                                      polyether antibiotic + 19
                                      thermorubin 0
paths to the root