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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxide
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Accession:CHEBI:25741 term browser browse the term
Definition:An oxide is a chemical compound of oxygen with other chemical elements.
Synonyms:related_synonym: oxides


show annotations for term's descendants           Sort by:
(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity
multiple interactions		 EXP artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]; artemisinin inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]		 CTD PMID:21778469 PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
arsenite(3-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP70 heat shock protein 70 increases expression
multiple interactions		 EXP arsenite results in increased expression of HSP70 mRNA
HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]		 CTD PMID:32899721 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:32899721 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:32899721 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:32899721 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
calcium oxalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] CTD PMID:25446497 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions		 EXP Calcium Oxalate results in increased activity of CASP9 protein
Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]		 CTD PMID:25446497 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions
decreases expression		 EXP Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] CTD PMID:34147488 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]		 CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin increases abundance
multiple interactions		 EXP SCT protein results in increased abundance of Bicarbonates
[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]		 CTD PMID:3562434
metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Dipyrone results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081 		JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000 		JBrowse link
pitavastatin(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
increases expression		 EXP pitavastatin results in increased activity of NOS3 protein
pitavastatin results in increased expression of NOS3 mRNA		 CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 408
    chemical entity 408
      group 402
        polyatomic entity 401
          heteroatomic molecular entity 351
            oxide 22
              N-oxide + 0
              Se-oxide + 0
              inorganic oxide + 8
              organic oxide + 1
              oxoanion + 13
              peroxides + 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 408
    subatomic particle 408
      composite particle 408
        hadron 408
          baryon 408
            nucleon 408
              atomic nucleus 408
                atom 408
                  main group element atom 401
                    main group molecular entity 401
                      p-block molecular entity 401
                        chalcogen molecular entity 356
                          oxygen molecular entity 354
                            oxide 22
                              N-oxide + 0
                              Se-oxide + 0
                              inorganic oxide + 8
                              organic oxide + 1
                              oxoanion + 13
                              peroxides + 7
paths to the root