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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alendronic acid
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Accession:CHEBI:2567 term browser browse the term
Definition:A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Synonyms:exact_synonym: (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
 related_synonym: (4-Amino-1-hydroxybutylidene)bisphosphonic acid;   Alendronate;   Formula=C4H13NO7P2;   InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);   InChIKey=OGSPWJRAVKPPFI-UHFFFAOYSA-N;   SMILES=NCCCC(O)(P(O)(O)=O)P(O)(O)=O;   acide alendronique;   acido alendronico;   acidum alendronicum
 xref: Beilstein:2275403;   CAS:66376-36-1;   DrugBank:DB00630;   Drug_Central:112;   HMDB:HMDB0001915;   KEGG:C07752;   KEGG:D07119;   LINCS:LSM-5831
 xref_mesh: MESH:D019386
 xref: MetaCyc:ALENDRONATE;   PDBeChem:AHD;   PMID:12657258;   PMID:16626694;   PMID:19630066;   PMID:24676887;   PMID:25315260;   PMID:25442070;   PMID:25445446;   PMID:25461393;   PMID:25577217;   PMID:25592133;   PMID:25595570;   PMID:25603732;   PMID:25619515;   PMID:25636638;   PMID:25639838;   Patent:BE903519;   Patent:US4705651;   Reaxys:2275403;   Wikipedia:Alendronic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:50647


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alendronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Alendronate inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:30481507 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions EXP Alendronate inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA] CTD PMID:27387537, PMID:29649498 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 affects expression EXP Alendronate affects the expression of ADCYAP1 mRNA CTD PMID:16079270 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein] CTD PMID:30481507 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 affects expression EXP Alendronate affects the expression of ATP1A1 mRNA CTD PMID:16079270 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Alendronate inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] CTD PMID:30481507 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein] CTD PMID:30291735 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp9 caspase 9 multiple interactions ISO TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein] CTD PMID:19405951 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Alendronate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:30291735, PMID:30481507 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd3g CD3g molecule affects expression EXP Alendronate affects the expression of CD3G mRNA CTD PMID:16079270 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901
JBrowse link
G Cdh2 cadherin 2 affects expression EXP Alendronate affects the expression of CDH2 mRNA CTD PMID:16079270 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh6 cadherin 6 affects expression EXP Alendronate affects the expression of CDH6 mRNA CTD PMID:16079270 NCBI chr 2:63,100,723...63,246,618
Ensembl chr 2:63,101,739...63,166,509
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 affects expression EXP Alendronate affects the expression of CDK5RAP3 mRNA CTD PMID:16079270 NCBI chr10:84,780,644...84,789,800
Ensembl chr10:84,780,608...84,789,832
JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression EXP Alendronate affects the expression of COL11A1 mRNA CTD PMID:16079270 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Col5a1 collagen type V alpha 1 chain affects expression EXP Alendronate affects the expression of COL5A1 mRNA CTD PMID:16079270 NCBI chr 3:6,430,180...6,581,010
Ensembl chr 3:6,430,201...6,578,882
JBrowse link
G Col5a2 collagen type V alpha 2 chain affects expression EXP Alendronate affects the expression of COL5A2 mRNA CTD PMID:16079270 NCBI chr 9:52,091,088...52,238,735
Ensembl chr 9:52,092,511...52,238,564
JBrowse link
G Cpe carboxypeptidase E affects expression EXP Alendronate affects the expression of CPE mRNA CTD PMID:16079270 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Crybb2 crystallin, beta B2 affects expression EXP Alendronate affects the expression of CRYBB2 mRNA CTD PMID:16079270 NCBI chr12:49,577,580...49,588,555
Ensembl chr12:49,578,633...49,588,555
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Alendronate affects the expression of CYP2A1 mRNA CTD PMID:16079270 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression EXP Alendronate affects the expression of DUSP6 mRNA CTD PMID:16079270 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 affects expression EXP Alendronate affects the expression of EGLN3 mRNA CTD PMID:16079270 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Fdps farnesyl diphosphate synthase decreases activity ISO Alendronate results in decreased activity of FDPS protein CTD PMID:11160603 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Fgf9 fibroblast growth factor 9 affects expression EXP Alendronate affects the expression of FGF9 mRNA CTD PMID:16079270 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 affects expression EXP Alendronate affects the expression of FKBP3 mRNA CTD PMID:16079270 NCBI chr 6:86,810,865...86,822,115
Ensembl chr 6:86,810,809...86,822,094
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 affects expression EXP Alendronate affects the expression of GABRG1 mRNA CTD PMID:16079270 NCBI chr14:39,964,502...40,051,306
Ensembl chr14:39,964,588...40,049,354
JBrowse link
G Ghrh growth hormone releasing hormone affects expression EXP Alendronate affects the expression of GHRH mRNA CTD PMID:16079270 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Ghrhr growth hormone releasing hormone receptor affects expression EXP Alendronate affects the expression of GHRHR mRNA CTD PMID:16079270 NCBI chr 4:85,587,321...85,602,389
Ensembl chr 4:85,588,595...85,601,666
JBrowse link
G Gnb1 G protein subunit beta 1 affects expression EXP Alendronate affects the expression of GNB1 mRNA CTD PMID:16079270 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Alendronate affects the expression of HAL mRNA CTD PMID:16079270 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hmgb1 high mobility group box 1 affects expression EXP Alendronate affects the expression of HMGB1 mRNA CTD PMID:16079270 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hoxa1 homeobox A1 affects expression EXP Alendronate affects the expression of HOXA1 mRNA CTD PMID:16079270 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases prenylation ISO Alendronate results in decreased prenylation of HRAS protein CTD PMID:9556058 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Htr5a 5-hydroxytryptamine receptor 5A affects expression EXP Alendronate affects the expression of HTR5A mRNA CTD PMID:16079270 NCBI chr 4:199,916...209,599
Ensembl chr 4:199,916...209,599
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 affects expression EXP Alendronate affects the expression of IDH2 mRNA CTD PMID:16079270 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
Alendronate results in increased expression of IL1B protein
Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]
[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Alendronate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]; Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Menthol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
CTD PMID:17375077, PMID:20304105, PMID:20804833, PMID:21430599, PMID:30481507 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:17375077 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Alendronate inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:30481507 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh5 potassium voltage-gated channel subfamily H member 5 affects expression EXP Alendronate affects the expression of KCNH5 mRNA CTD PMID:16079270 NCBI chr 6:97,872,831...98,157,087
Ensembl chr 6:97,872,831...98,157,087
JBrowse link
G Lox lysyl oxidase affects expression EXP Alendronate affects the expression of LOX mRNA CTD PMID:16079270 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects expression EXP Alendronate affects the expression of MAPK14 mRNA CTD PMID:16079270 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
affects expression
decreases secretion
ISO
EXP
Alendronate results in decreased expression of MMP2 mRNA
Alendronate affects the expression of MMP2 mRNA
Alendronate results in decreased secretion of MMP2 protein
CTD PMID:15049011, PMID:16079270 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Muc1 mucin 1, cell surface associated affects expression EXP Alendronate affects the expression of MUC1 mRNA CTD PMID:16079270 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Myl9 myosin light chain 9 affects expression EXP Alendronate affects the expression of MYL9 mRNA CTD PMID:16079270 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 affects expression EXP Alendronate affects the expression of NECTIN1 mRNA CTD PMID:16079270 NCBI chr 8:48,094,233...48,198,499
Ensembl chr 8:48,094,673...48,157,305
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:17375077 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Olr1696 olfactory receptor 1696 affects expression EXP Alendronate affects the expression of OLR1696 mRNA CTD PMID:16079270 NCBI chr20:878,460...879,425 JBrowse link
G Pcolce procollagen C-endopeptidase enhancer affects expression EXP Alendronate affects the expression of PCOLCE mRNA CTD PMID:16079270 NCBI chr12:22,153,995...22,160,311
Ensembl chr12:22,153,983...22,160,337
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 affects expression EXP Alendronate affects the expression of PEX5 mRNA CTD PMID:16079270 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects expression EXP Alendronate affects the expression of PHLPP mRNA CTD PMID:16079270 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 affects expression EXP Alendronate affects the expression of PIAS3 mRNA CTD PMID:16079270 NCBI chr 2:198,821,377...198,831,533
Ensembl chr 2:198,823,366...198,836,372
JBrowse link
G Pigr polymeric immunoglobulin receptor affects expression EXP Alendronate affects the expression of PIGR mRNA CTD PMID:16079270 NCBI chr13:47,564,176...47,592,093
Ensembl chr13:47,572,219...47,591,699
JBrowse link
G Plpp1 phospholipid phosphatase 1 affects expression EXP Alendronate affects the expression of PLPP1 mRNA CTD PMID:16079270 NCBI chr 2:44,664,076...44,726,820
Ensembl chr 2:44,664,124...44,726,689
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
EXP Alendronate results in decreased activity of PON1 protein
[Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate
CTD PMID:27387541 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Psap prosaposin affects expression EXP Alendronate affects the expression of PSAP mRNA CTD PMID:16079270 NCBI chr20:29,831,302...29,856,876
Ensembl chr20:29,831,314...29,856,875
JBrowse link
G Psme1 proteasome activator subunit 1 affects expression EXP Alendronate affects the expression of PSME1 mRNA CTD PMID:16079270 NCBI chr15:34,256,071...34,258,947
Ensembl chr15:34,256,071...34,258,947
JBrowse link
G Ptgfrn prostaglandin F2 receptor inhibitor affects expression EXP Alendronate affects the expression of PTGFRN mRNA CTD PMID:16079270 NCBI chr 2:203,423,143...203,494,391
Ensembl chr 2:203,423,143...203,494,391
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] CTD PMID:17375077 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO Alendronate results in decreased prenylation of RAP1A protein CTD PMID:11595616 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rara retinoic acid receptor, alpha affects expression EXP Alendronate affects the expression of RARA mRNA CTD PMID:16079270 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA] CTD PMID:29649498 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 affects expression EXP Alendronate affects the expression of SCN4A mRNA CTD PMID:16079270 NCBI chr10:94,505,026...94,557,803
Ensembl chr10:94,505,026...94,557,764
JBrowse link
G Serpine2 serpin family E member 2 affects expression EXP Alendronate affects the expression of SERPINE2 mRNA CTD PMID:16079270 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Serpinh1 serpin family H member 1 affects expression EXP Alendronate affects the expression of SERPINH1 mRNA CTD PMID:16079270 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc18a2 solute carrier family 18 member A2 affects expression EXP Alendronate affects the expression of SLC18A2 mRNA CTD PMID:16079270 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects expression EXP Alendronate affects the expression of SLC19A1 mRNA CTD PMID:16079270 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects expression EXP Alendronate affects the expression of SLC6A4 mRNA CTD PMID:16079270 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Slit1 slit guidance ligand 1 affects expression EXP Alendronate affects the expression of SLIT1 mRNA CTD PMID:16079270 NCBI chr 1:260,843,481...260,992,366
Ensembl chr 1:260,843,483...260,992,366
JBrowse link
G Snn stannin affects expression EXP Alendronate affects the expression of SNN mRNA CTD PMID:16079270 NCBI chr10:4,635,897...4,644,570
Ensembl chr10:4,635,898...4,644,570
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression EXP Alendronate affects the expression of SPARC mRNA CTD PMID:16079270 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage ISO Alendronate results in increased cleavage of STK4 protein CTD PMID:14502240 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Alendronate co-treated with zoledronic acid] results in increased expression of TGFB1 protein CTD PMID:18504149 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression EXP Alendronate affects the expression of TIMP1 mRNA CTD PMID:16079270 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of TNF protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein] CTD PMID:21430599, PMID:30481507 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein] CTD PMID:27387537 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO
EXP
TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein]
Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]
CTD PMID:19405951, PMID:27387537, PMID:29649498 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnni3 troponin I3, cardiac type affects expression EXP Alendronate affects the expression of TNNI3 mRNA CTD PMID:16079270 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Vdr vitamin D receptor affects response to substance
multiple interactions
ISO VDR gene polymorphism affects the susceptibility to Alendronate
VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Estrogens, Conjugated (USP) co-treated with Medroxyprogesterone Acetate]; VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Raloxifene Hydrochloride]
CTD PMID:12608943, PMID:15739035 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            bone density conservation agent 5970
              alendronic acid 79
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            inorganic hydride 17430
                              pnictogen hydride 17402
                                nitrogen hydride 17245
                                  azane 16962
                                    ammonia 16961
                                      organic amino compound 16960
                                        primary amino compound 7873
                                          alendronic acid 79
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.