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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:octadecatrienoic acid
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Accession:CHEBI:25633 term browser browse the term
Definition:Any trienoic fatty acid having eighteen carbons.
Synonyms:related_synonym: 18:3;   C18:3;   Formula=C18H30O2;   Octadecatriensaeure
 cyclic_relationship: is_conjugate_acid_of CHEBI:36434


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1,2,3-trilinolenoylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO trilinolenin results in decreased expression of ABCA1 mRNA CTD PMID:18356535 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO trilinolenin results in decreased expression of ABCG5 mRNA CTD PMID:18356535 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO trilinolenin results in decreased expression of ABCG8 mRNA CTD PMID:18356535 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO trilinolenin results in decreased expression of CYP27A1 mRNA CTD PMID:18356535 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO trilinolenin results in increased expression of HMGCR mRNA CTD PMID:18356535 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO trilinolenin results in increased expression of MTTP mRNA CTD PMID:18356535 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO trilinolenin results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO trilinolenin results in decreased expression of SCD1 mRNA CTD PMID:8729090 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
9,11,13-octadecatrienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO eleostearic acid results in decreased expression of BCL2 protein CTD PMID:15961301 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP eleostearic acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein]; eleostearic acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
eleostearic acid results in decreased activity of CAT protein
CTD PMID:20851731 PMID:21382362 PMID:22269903 PMID:23422533 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO eleostearic acid results in increased expression of GADD45A protein CTD PMID:15961301 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP eleostearic acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] CTD PMID:22269903 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP eleostearic acid results in decreased activity of GSR protein CTD PMID:23422533 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO eleostearic acid results in increased expression of PPARG mRNA; eleostearic acid results in increased expression of PPARG protein CTD PMID:15961301 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tp53 tumor protein p53 increases expression ISO eleostearic acid results in increased expression of TP53 protein CTD PMID:15961301 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
alpha-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO alpha-Linolenic Acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mRNA] CTD PMID:15307955 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression EXP alpha-Linolenic Acid results in decreased expression of ACACA mRNA CTD PMID:14563831 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acly ATP citrate lyase decreases expression EXP alpha-Linolenic Acid results in decreased expression of ACLY mRNA CTD PMID:14563831 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Bche butyrylcholinesterase increases expression
increases secretion
ISO alpha-Linolenic Acid results in increased expression of BCHE mRNA
alpha-Linolenic Acid results in increased secretion of BCHE protein
CTD PMID:27106529 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cat catalase multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of CAT protein] CTD PMID:22269903 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of CCL2 protein]] CTD PMID:29423081 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP alpha-Linolenic Acid results in decreased expression of CEBPB mRNA CTD PMID:14563831 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO alpha-Linolenic Acid results in increased expression of CPT1A mRNA CTD PMID:15307955 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of CYBB protein] CTD PMID:30672636 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO alpha-Linolenic Acid results in decreased activity of CYP1A2 protein CTD PMID:16978661 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO CYP2C19 protein results in increased metabolism of [alpha-Linolenic Acid co-treated with NADP]
alpha-Linolenic Acid results in decreased activity of CYP2C19 protein
CTD PMID:16978661 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO alpha-Linolenic Acid results in decreased activity of CYP2E1 protein CTD PMID:16978661 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO alpha-Linolenic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO alpha-Linolenic Acid results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO alpha-Linolenic Acid results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO alpha-Linolenic Acid results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions ISO [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated; [[alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA] which affects the abundance of Fatty Acids, Unsaturated; [alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA; [alpha-Linolenic Acid co-treated with Testosterone] results in decreased expression of FADS1 mRNA; fulvestrant inhibits the reaction [[alpha-Linolenic Acid co-treated with Estradiol] results in increased expression of FADS1 mRNA] CTD PMID:19576517 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fasn fatty acid synthase decreases expression EXP alpha-Linolenic Acid results in decreased expression of FASN mRNA CTD PMID:14563831 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO alpha-Linolenic Acid results in increased activity of GCLC protein
alpha-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GPT protein] CTD PMID:22269903 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression
multiple interactions
ISO alpha-Linolenic Acid results in increased expression of GSTA1 mRNA
NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of GSTA1 mRNA]
CTD PMID:28555106 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
alpha-Linolenic Acid results in increased expression of HMOX1 mRNA
alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of HMOX1 mRNA]]
CTD PMID:17092368 PMID:30672636 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IFNG protein]] CTD PMID:29423081 PMID:30672636 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in increased expression of IL1B protein
alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IL1B protein]
CTD PMID:16305726 PMID:30672636 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Eicosapentaenoic Acid co-treated with Docosahexaenoic Acids co-treated with alpha-Linolenic Acid] results in decreased expression of IL4 protein CTD PMID:16305726 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of IL6 mRNA]] CTD PMID:29423081 PMID:30672636 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO alpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA] CTD PMID:15307955 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 mRNA]; NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of CYP2A6 protein]; NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of GSTA1 mRNA]
alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of NFE2L2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]]
CTD PMID:28555106 PMID:30672636 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 mRNA]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of NOS2 protein]] CTD PMID:29423081 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NQO1 mRNA]] CTD PMID:30672636 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO alpha-Linolenic Acid binds to and results in increased activity of NR1H2 protein CTD PMID:16731579 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
affects binding
ISO alpha-Linolenic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
alpha-Linolenic Acid binds to NR1H4 protein
CTD PMID:15307955 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Glucose deficiency co-treated with alpha-Linolenic Acid] results in increased expression of PCK1 mRNA CTD PMID:8536680 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Plin2 perilipin 2 increases expression EXP
ISO
alpha-Linolenic Acid results in increased expression of PLIN2 mRNA; alpha-Linolenic Acid results in increased expression of PLIN2 protein CTD PMID:16489205 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects abundance
increases expression
EXP
ISO
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein
PPARA protein affects the abundance of alpha-Linolenic Acid
alpha-Linolenic Acid results in increased expression of PPARA mRNA
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Calcitriol promotes the reaction [alpha-Linolenic Acid results in increased expression of PPARA mRNA]
alpha-Linolenic Acid binds to and results in increased activity of PPARA protein; Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of alpha-Linolenic Acid]
CTD PMID:10403814 PMID:16731579 PMID:18154422 PMID:19667161 PMID:23619606 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
multiple interactions
ISO
EXP
alpha-Linolenic Acid results in increased expression of PPARD mRNA; Calcitriol results in increased expression of [alpha-Linolenic Acid results in increased expression of PPARD mRNA]
alpha-Linolenic Acid binds to and results in increased activity of PPARB protein
CTD PMID:16731579 PMID:19667161 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
increases activity
multiple interactions
ISO
EXP
alpha-Linolenic Acid results in increased expression of PPARG mRNA
alpha-Linolenic Acid results in increased activity of PPARG protein
alpha-Linolenic Acid binds to and results in increased activity of PPARG protein
CTD PMID:16731579 PMID:18154422 PMID:20696231 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
decreases expression
ISO
EXP
alpha-Linolenic Acid results in increased expression of PTGS2 mRNA
alpha-Linolenic Acid results in increased expression of PTGS2 protein
alpha-Linolenic Acid results in decreased expression of PTGS2 mRNA
CTD PMID:14563831 PMID:17092368 PMID:22476691 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
affects binding
ISO alpha-Linolenic Acid binds to and results in increased activity of RXRA protein
alpha-Linolenic Acid binds to RXRA protein
CTD PMID:16258897 PMID:16731579 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP alpha-Linolenic Acid results in decreased expression of SREBF1 mRNA CTD PMID:14563831 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]] CTD PMID:29423081 PMID:30672636 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP [alpha-Linolenic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein CTD PMID:17038422 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP alpha-Linolenic Acid results in increased expression of UCP2 mRNA CTD PMID:11341955 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of VCAM1 protein]] CTD PMID:29423081 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdr vitamin D receptor increases expression
multiple interactions
ISO alpha-Linolenic Acid results in increased expression of VDR mRNA
[Calcitriol co-treated with alpha-Linolenic Acid] results in increased expression of VDR mRNA
CTD PMID:19667161 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
cholesteryl linolenate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate CTD PMID:24777581 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lipg lipase G, endothelial type multiple interactions
increases abundance
ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate
LIPG gene mutant form results in increased abundance of cholesteryl linolenate
CTD PMID:24777581 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
gamma-linolenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO gamma-Linolenic Acid results in increased expression of AKR1C4 mRNA CTD PMID:20664735 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Apoh apolipoprotein H decreases expression ISO gamma-Linolenic Acid results in decreased expression of APOH mRNA CTD PMID:20664735 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Ar androgen receptor multiple interactions ISO gamma-Linolenic Acid inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of ASAH1 mRNA CTD PMID:20664735 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Casp3 caspase 3 increases activity ISO gamma-Linolenic Acid results in increased activity of CASP3 protein CTD PMID:16857180 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNA2 protein CTD PMID:15318936 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CCNE1 protein CTD PMID:15318936 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of CDK1 protein CTD PMID:15318936 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cldn5 claudin 5 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of CLDN5 protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of CLDN5 protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of CLDN5 protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of CLDN5 protein CTD PMID:16514648 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Clta clathrin, light chain A increases expression ISO gamma-Linolenic Acid results in increased expression of CLTA mRNA CTD PMID:20664735 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO gamma-Linolenic Acid results in increased expression of FTH1 mRNA CTD PMID:20664735 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
increases expression
ISO gamma-Linolenic Acid results in increased activity of GCLC protein
gamma-Linolenic Acid results in increased expression of GCLC mRNA
CTD PMID:17092368 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression ISO gamma-Linolenic Acid results in increased expression of GRK5 mRNA CTD PMID:20664735 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Hexb hexosaminidase subunit beta increases expression ISO gamma-Linolenic Acid results in increased expression of HEXB mRNA CTD PMID:20664735 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of HMOX1 mRNA; gamma-Linolenic Acid results in increased expression of HMOX1 protein CTD PMID:17092368 PMID:20664735 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il2 interleukin 2 affects expression ISO gamma-Linolenic Acid affects the expression of IL2 protein CTD PMID:9415022 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO gamma-Linolenic Acid results in decreased expression of JUNB protein CTD PMID:15318936 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kynu kynureninase decreases expression ISO gamma-Linolenic Acid results in decreased expression of KYNU mRNA CTD PMID:20664735 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G LOC103690190 histone H2A type 1-E decreases expression ISO gamma-Linolenic Acid results in decreased expression of H2AC6 mRNA CTD PMID:20664735 NCBI chr17:42,707,863...42,708,420 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MAPK3 protein CTD PMID:15318936 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp11 matrix metallopeptidase 11 decreases expression ISO gamma-Linolenic Acid results in decreased expression of MMP11 mRNA CTD PMID:20664735 NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO gamma-Linolenic Acid results in decreased expression of MYC protein CTD PMID:15318936 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ocln occludin multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of OCLN protein; [gamma-Linolenic Acid co-treated with Iodine] results in increased expression of and results in increased localization of OCLN protein; [Selenium co-treated with gamma-Linolenic Acid] results in increased expression of and results in increased localization of OCLN protein; gamma-Linolenic Acid results in increased expression of and results in increased localization of OCLN protein CTD PMID:16514648 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gamma-Linolenic Acid results in increased cleavage of PARP1 protein CTD PMID:10403056 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO gamma-Linolenic Acid results in decreased expression of PCNA mRNA CTD PMID:20664735 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression ISO gamma-Linolenic Acid results in decreased expression of PDLIM1 mRNA CTD PMID:20664735 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Plin2 perilipin 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PLIN2 mRNA CTD PMID:20664735 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARA protein CTD PMID:10403814 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO gamma-Linolenic Acid binds to and results in increased activity of PPARG protein CTD PMID:15318936 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGR1 mRNA CTD PMID:20664735 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO gamma-Linolenic Acid results in increased expression of PTGS2 mRNA CTD PMID:17092368 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO gamma-Linolenic Acid results in decreased expression of SKP2 mRNA CTD PMID:20664735 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO gamma-Linolenic Acid results in increased expression of SLC3A2 mRNA CTD PMID:20664735 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO gamma-Linolenic Acid results in increased expression of ST13 mRNA CTD PMID:20664735 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO gamma-Linolenic Acid results in decreased expression of TFF3 mRNA CTD PMID:20664735 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [gamma-Linolenic Acid co-treated with Iodine co-treated with Selenium] results in increased expression of and results in increased localization of TJP1 protein CTD PMID:16514648 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO gamma-Linolenic Acid results in decreased expression of TNF protein CTD PMID:9415022 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP gamma-Linolenic Acid inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17038422 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXN mRNA CTD PMID:20664735 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO gamma-Linolenic Acid results in increased expression of TXNRD1 mRNA CTD PMID:20664735 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
soybean oil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects expression EXP Soybean Oil affects the expression of ABCB11 mRNA CTD PMID:15770074 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects expression EXP Soybean Oil affects the expression of ABCB1B mRNA CTD PMID:15770074 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects expression EXP Soybean Oil affects the expression of ABCB4 mRNA CTD PMID:15770074 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects expression EXP Soybean Oil affects the expression of ABCC1 mRNA CTD PMID:15770074 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects expression EXP Soybean Oil affects the expression of ABCC2 mRNA CTD PMID:15770074 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 affects expression EXP Soybean Oil affects the expression of ABCC5 mRNA CTD PMID:15770074 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects expression EXP Soybean Oil affects the expression of ABCC6 mRNA CTD PMID:15770074 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases activity EXP Soybean Oil results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Soybean Oil results in increased expression of BCL2 protein CTD PMID:15309441 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase increases activity EXP Soybean Oil results in increased activity of CAT protein CTD PMID:12781854 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Soybean Oil results in increased expression of CCND1 mRNA CTD PMID:21088903 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 affects expression EXP Soybean Oil affects the expression of CYP4A1 mRNA CTD PMID:16079505 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Soybean Oil results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein] CTD PMID:11600134 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity EXP Soybean Oil results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Il12b interleukin 12B decreases expression ISO Soybean Oil results in decreased expression of IL12B mRNA CTD PMID:10065739 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Slc22a1 solute carrier family 22 member 1 affects expression EXP Soybean Oil affects the expression of SLC22A1 mRNA CTD PMID:15770074 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a7 solute carrier family 22 member 7 affects expression EXP Soybean Oil affects the expression of SLC22A7 mRNA CTD PMID:15770074 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          carbon atom 19630
            organic molecular entity 19630
              lipid 17491
                fatty acid 16008
                  long-chain fatty acid 1791
                    octadecatrienoic acid 106
                      (5Z,9Z,12Z)-octadecatrienoic acid + 0
                      11,13,15-octadecatrienoic acid + 0
                      9,11,14-octadecatrienoic acid + 0
                      9,11,15-octadecatrienoic acid + 0
                      HOTrE + 0
                      conjugated linolenic acid + 7
                      lamenallenic acid + 0
                      linolenic acid + 103
                      monoacylglycerol 18:3 + 0
                      sphingomyelin d18:1/18:3 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fatty acid 16008
                                            unsaturated fatty acid 951
                                              polyunsaturated fatty acid 687
                                                trienoic fatty acid 120
                                                  fatty acid 18:3 106
                                                    octadecatrienoic acid 106
                                                      (5Z,9Z,12Z)-octadecatrienoic acid + 0
                                                      11,13,15-octadecatrienoic acid + 0
                                                      9,11,14-octadecatrienoic acid + 0
                                                      9,11,15-octadecatrienoic acid + 0
                                                      HOTrE + 0
                                                      conjugated linolenic acid + 7
                                                      lamenallenic acid + 0
                                                      linolenic acid + 103
                                                      monoacylglycerol 18:3 + 0
                                                      sphingomyelin d18:1/18:3 0
paths to the root