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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nucleoside antibiotic
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Accession:CHEBI:25605 term browser browse the term


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adenine arabinoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Vidarabine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
coformycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Faslg Fas ligand multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA CTD PMID:11992407 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gzmb granzyme B multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA CTD PMID:11992407 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein CTD PMID:11992407 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein CTD PMID:11992407 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Prf1 perforin 1 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA CTD PMID:11992407 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
cordycepin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein] CTD PMID:30031108 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein] CTD PMID:24704558 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]; cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:30031108 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein] CTD PMID:21310227 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization
ISO Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]
cordycepin results in increased expression of BAX mRNA; cordycepin results in increased expression of BAX protein
cordycepin affects the localization of BAX protein
CTD PMID:21310227, PMID:21933677, PMID:28987792 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO cordycepin results in decreased expression of BCL2 mRNA; cordycepin results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein]
CTD PMID:21310227, PMID:28987792, PMID:30529626 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein] CTD PMID:21310227 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein] CTD PMID:21310227 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein]
cordycepin results in increased expression of CASP3 mRNA
CTD PMID:21310227, PMID:21933677, PMID:28987792 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage
EXP acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein] CTD PMID:24704558 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein] CTD PMID:21310227 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein]
cordycepin results in increased expression of CASP9 mRNA
CTD PMID:21310227, PMID:21933677, PMID:28987792 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase decreases expression ISO cordycepin results in decreased expression of CAT mRNA CTD PMID:28987792 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] CTD PMID:23690541 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11181506 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation EXP cordycepin results in increased phosphorylation of EIF2A protein CTD PMID:23690541 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO cordycepin results in decreased expression of GPX1 mRNA CTD PMID:28987792 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO cordycepin results in increased expression of MAP1LC3A mRNA CTD PMID:28987792 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:30031108 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein] CTD PMID:24704558 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO cordycepin results in decreased expression of SOD1 mRNA CTD PMID:28987792 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
EXP
ISO
ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]; cordycepin promotes the reaction [Etoposide results in increased expression of TP53 protein]; cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]
cordycepin results in increased expression of TP53 mRNA
CTD PMID:23690541, PMID:24704558, PMID:28987792 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions
ISO cordycepin results in decreased expression of XIAP protein
Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]
CTD PMID:21310227 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
puromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases expression
affects response to substance
ISO
EXP
ABCB1 protein results in increased transport of Puromycin
Puromycin results in increased expression of ABCB1A mRNA; Puromycin results in increased expression of ABCB1A protein
ABCB1A protein affects the susceptibility to Puromycin
CTD PMID:14675146, PMID:20018165 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Puromycin results in increased expression of ABCC1 mRNA CTD PMID:20018165 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]; Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]
CTD PMID:10777561, PMID:25797602 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions EXP Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA] CTD PMID:1953764 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Puromycin affects the localization of BAX protein CTD PMID:18339127 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Puromycin results in decreased expression of BCL2 protein
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]
CTD PMID:21244482 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein] CTD PMID:21244482 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein] CTD PMID:14502240, PMID:21244482 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Puromycin results in increased activity of CASP9 protein CTD PMID:14502240 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Puromycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Puromycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Cd2ap CD2-associated protein decreases expression ISO Puromycin results in decreased expression of CD2AP mRNA CTD PMID:15673299 NCBI chr 9:20,794,680...20,858,438
Ensembl chr 9:20,765,296...20,858,504
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO Puromycin results in decreased expression of CDH3 mRNA CTD PMID:15673299 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Puromycin affects the localization of CTNNB1 protein CTD PMID:15673299 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO [Puromycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Puromycin results in increased expression of CYP1A1 mRNA
CTD PMID:2985607, PMID:15385644 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor affects localization ISO Puromycin affects the localization of DEF6 protein CTD PMID:22829599 NCBI chr20:7,788,120...7,809,011
Ensembl chr20:7,788,084...7,809,560
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Puromycin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Puromycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein] CTD PMID:20525893 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression
ISO Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]
Puromycin results in decreased expression of LDLR mRNA; Puromycin results in decreased expression of LDLR protein
CTD PMID:12524230, PMID:22388943 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mir122 microRNA 122 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR122 mRNA CTD PMID:30682439 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir143 microRNA 143 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR143 mRNA CTD PMID:30682439 NCBI chr18:56,971,273...56,971,377
Ensembl chr18:56,971,273...56,971,377
JBrowse link
G Mir155 microRNA 155 affects expression EXP Puromycin affects the expression of MIR155 CTD PMID:30169741 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir3473 microRNA 3473 multiple interactions EXP Puromycin results in increased expression of and results in increased secretion of MIR3473 mRNA CTD PMID:30682439 NCBI chr13:44,719,335...44,719,401
Ensembl chr13:44,719,335...44,719,401
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Puromycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Optn optineurin multiple interactions ISO OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein] CTD PMID:25096716 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein CTD PMID:19643929 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases secretion
ISO Puromycin results in decreased expression of VEGFA protein
OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]
CTD PMID:20116850, PMID:25096716 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          nucleoside antibiotic 59
            adenine arabinoside + 1
            antelmycin 0
            blasticidin + 0
            coformycins + 6
            cordycepin + 26
            formycin + 0
            gougerotin 0
            nikkomycin + 0
            polyoxin + 0
            puromycin + 31
            puromycins + 31
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.