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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nucleoside antibiotic
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Accession:CHEBI:25605 term browser browse the term

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adenine arabinoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Vidarabine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
coformycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Faslg Fas ligand multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of FASL mRNA CTD PMID:11992407 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gzmb granzyme B multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of GZMB mRNA CTD PMID:11992407 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Ifng interferon gamma multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IFNG protein CTD PMID:11992407 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of IL2 protein CTD PMID:11992407 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Prf1 perforin 1 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of PRF1 mRNA CTD PMID:11992407 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Adenosine co-treated with Coformycin] results in decreased expression of TNFSF10 mRNA CTD PMID:11992407 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
cordycepin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein] CTD PMID:30031108 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein] CTD PMID:24704558 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]]; cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]; cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:30031108 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein] CTD PMID:21310227 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization		 ISO Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein]
cordycepin results in increased expression of BAX mRNA; cordycepin results in increased expression of BAX protein
cordycepin affects the localization of BAX protein		 CTD PMID:21310227 PMID:21933677 PMID:28987792 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO cordycepin results in decreased expression of BCL2 mRNA; cordycepin results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein]		 CTD PMID:21310227 PMID:28987792 PMID:30529626 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein] CTD PMID:21310227 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein] CTD PMID:21310227 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein]
cordycepin results in increased expression of CASP3 mRNA		 CTD PMID:21310227 PMID:21933677 PMID:28987792 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases cleavage		 EXP acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein] CTD PMID:24704558 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein] CTD PMID:21310227 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 ISO Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein]
cordycepin results in increased expression of CASP9 mRNA		 CTD PMID:21310227 PMID:21933677 PMID:28987792 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression ISO cordycepin results in decreased expression of CAT mRNA CTD PMID:28987792 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA] CTD PMID:23690541 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA] CTD PMID:23690541 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11181506 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation EXP cordycepin results in increased phosphorylation of EIF2A protein CTD PMID:23690541 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO cordycepin results in decreased expression of GPX1 mRNA CTD PMID:28987792 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO cordycepin results in increased expression of MAP1LC3A mRNA CTD PMID:28987792 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP cordycepin inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:30031108 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ADORA2A mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein] CTD PMID:24704558 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO cordycepin results in decreased expression of SOD1 mRNA CTD PMID:28987792 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein]; cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 EXP
ISO		 ADORA2A mutant form inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]; cordycepin promotes the reaction [Etoposide results in increased expression of TP53 protein]; cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of CASP7 protein]; TP53 mutant form inhibits the reaction [cordycepin results in increased cleavage of PARP1 protein]; ZM 241385 inhibits the reaction [cordycepin results in increased phosphorylation of and results in increased expression of TP53 protein]
cordycepin results in increased expression of TP53 mRNA		 CTD PMID:23690541 PMID:24704558 PMID:28987792 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions		 ISO cordycepin results in decreased expression of XIAP protein
Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein]		 CTD PMID:21310227 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
puromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases expression
affects response to substance		 ISO
EXP		 ABCB1 protein results in increased transport of Puromycin
Puromycin results in increased expression of ABCB1A mRNA; Puromycin results in increased expression of ABCB1A protein
ABCB1A protein affects the susceptibility to Puromycin		 CTD PMID:14675146 PMID:20018165 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Puromycin results in increased expression of ABCC1 mRNA CTD PMID:20018165 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]; Puromycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]		 CTD PMID:10777561 PMID:25797602 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions EXP Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ALDH3A1 mRNA] CTD PMID:1953764 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Puromycin affects the localization of BAX protein CTD PMID:18339127 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Puromycin results in decreased expression of BCL2 protein
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]		 CTD PMID:21244482 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein] CTD PMID:21244482 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein] CTD PMID:14502240 PMID:21244482 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Puromycin results in increased activity of CASP9 protein CTD PMID:14502240 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Puromycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Puromycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Cd2ap CD2-associated protein decreases expression ISO Puromycin results in decreased expression of CD2AP mRNA CTD PMID:15673299 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdh3 cadherin 3 decreases expression ISO Puromycin results in decreased expression of CDH3 mRNA CTD PMID:15673299 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Ctnnb1 catenin beta 1 affects localization ISO Puromycin affects the localization of CTNNB1 protein CTD PMID:15673299 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO [Puromycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Puromycin results in increased expression of CYP1A1 mRNA		 CTD PMID:2985607 PMID:15385644 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Def6 DEF6 guanine nucleotide exchange factor affects localization ISO Puromycin affects the localization of DEF6 protein CTD PMID:22829599 NCBI chr20:6,268,614...6,290,030
Ensembl chr20:6,268,601...6,289,961 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Puromycin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Puromycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Puromycin inhibits the reaction [nickel sulfate results in increased expression of IRF1 protein] CTD PMID:20525893 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression		 ISO Puromycin inhibits the reaction [GW 707 results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR mRNA]; Puromycin inhibits the reaction [Quercetin results in increased expression of LDLR protein]
Puromycin results in decreased expression of LDLR mRNA; Puromycin results in decreased expression of LDLR protein		 CTD PMID:12524230 PMID:22388943 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir122 microRNA 122 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR122 mRNA CTD PMID:30682439 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir143 microRNA 143 multiple interactions EXP Puromycin results in decreased expression of and results in decreased secretion of MIR143 mRNA CTD PMID:30682439 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir155 microRNA 155 affects expression EXP Puromycin affects the expression of MIR155 CTD PMID:30169741 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir3473 microRNA 3473 multiple interactions EXP Puromycin results in increased expression of and results in increased secretion of MIR3473 mRNA CTD PMID:30682439 NCBI chr13:39,499,246...39,499,312
Ensembl chr13:39,499,246...39,499,312 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Puromycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Optn optineurin multiple interactions ISO OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein] CTD PMID:25096716 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein CTD PMID:19643929 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of PTGER4 protein; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions ISO [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R mRNA; [Puromycin co-treated with PTGS2 protein] results in increased expression of TBXA2R protein CTD PMID:19643929 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Puromycin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
increases secretion		 ISO Puromycin results in decreased expression of VEGFA protein
OPTN protein affects the reaction [Puromycin results in increased secretion of VEGFA protein]		 CTD PMID:20116850 PMID:25096716 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          nucleoside antibiotic 59
            adenine arabinoside + 1
            antelmycin 0
            blasticidin + 0
            coformycins + 6
            cordycepin + 26
            formycin + 0
            gougerotin 0
            nikkomycin + 0
            nucleocidin 0
            polyoxin + 0
            puromycin + 31
            puromycins + 31
paths to the root