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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrobenzoic acid
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Accession:CHEBI:25553 term browser browse the term
Definition:Any member of the class of benzoic acids with at least one nitro substituent attached to the benzene ring.
Synonyms:related_synonym: nitrobenzoic acids


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5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Ano6 anoctamin 6 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Best1 bestrophin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:226,033,146...226,049,893
Ensembl chr 1:226,030,875...226,049,929
JBrowse link
G Casp3 caspase 3 decreases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased expression of CASP3 protein CTD PMID:21538933 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CCND1 mRNA CTD PMID:21538933 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant form
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein
CTD PMID:15131065 PMID:15277574 PMID:15389550 PMID:15634668 PMID:15802612 PMID:15857825 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clcn3 chloride voltage-gated channel 3 decreases activity
increases expression
multiple interactions
ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CLCN3 protein
5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA
[5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA] which results in decreased susceptibility to Cisplatin
CTD PMID:17699636 PMID:21538933 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
JBrowse link
G Ifng interferon gamma multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide] CTD PMID:9918806 PMID:19446535 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:9918806 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:19446535 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Panx1 Pannexin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Sct secretin decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] CTD PMID:19023563 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:9918806 PMID:10783394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link
dithionitrobenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Cadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Alb albumin multiple interactions
increases reduction
ISO [ALB protein binds to Docosahexaenoic Acids] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Eicosapentaenoic Acid] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Myristic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Oleic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Palmitic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to stearic acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein modified form binds to Myristic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Oleic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Palmitic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to stearic acid] which results in decreased reduction of Dithionitrobenzoic Acid; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid CTD PMID:25451573 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Mt3 metallothionein 3 affects metabolic processing ISO MT3 protein polymorphism affects the metabolism of Dithionitrobenzoic Acid CTD PMID:14983064 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2] CTD PMID:23878198 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
affects metabolic processing
increases reduction
ISO
EXP
Dinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid
[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Ferrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]
CTD PMID:17229725 PMID:20457604 PMID:21172426 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of Dithionitrobenzoic Acid CTD PMID:21172426 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254
JBrowse link
MC-4379 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO bifenox binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions ISO bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [bifenox results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO bifenox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO bifenox results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19877
    chemical entity 19877
      group 19789
        inorganic group 19223
          nitro group 7293
            nitro compound 7293
              C-nitro compound 6893
                nitrobenzoic acid 30
                  (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                  2-(benzoylamino)-4-nitrobenzoic acid 0
                  2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                  2-nitrobenzoic acid 0
                  2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                  2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                  3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                  3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                  4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                  4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                  4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                  4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                  4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                  4-nitroanthranilic acid + 0
                  4-nitrobenzoic acid + 0
                  4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                  4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                  4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                  Fluoroglycofen 0
                  LSM-1300 0
                  LSM-1920 0
                  LSM-4144 0
                  MC-3761 0
                  MC-4379 4
                  MC-5127 0
                  MC-6063 0
                  MC-7181 0
                  Nitrothal-isopropyl 0
                  [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                  dithionitrobenzoic acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19877
    subatomic particle 19875
      composite particle 19875
        hadron 19875
          baryon 19875
            nucleon 19875
              atomic nucleus 19875
                atom 19875
                  main group element atom 19765
                    p-block element atom 19765
                      carbon group element atom 19670
                        carbon atom 19659
                          organic molecular entity 19659
                            organic group 18571
                              organic divalent group 18562
                                organodiyl group 18562
                                  carbonyl group 18471
                                    carbonyl compound 18471
                                      carboxylic acid 18147
                                        aromatic carboxylic acid 10921
                                          benzoic acids 10890
                                            nitrobenzoic acid 30
                                              (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                                              2-(benzoylamino)-4-nitrobenzoic acid 0
                                              2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                                              2-nitrobenzoic acid 0
                                              2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                                              2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                                              3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                                              3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                                              4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                                              4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                                              4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                                              4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                                              4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                                              4-nitroanthranilic acid + 0
                                              4-nitrobenzoic acid + 0
                                              4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                                              4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                                              4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                                              Fluoroglycofen 0
                                              LSM-1300 0
                                              LSM-1920 0
                                              LSM-4144 0
                                              MC-3761 0
                                              MC-4379 4
                                              MC-5127 0
                                              MC-6063 0
                                              MC-7181 0
                                              Nitrothal-isopropyl 0
                                              [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                                              dithionitrobenzoic acid 6
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