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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nitrobenzoic acid
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Accession:CHEBI:25553 term browser browse the term
Definition:Any member of the class of benzoic acids with at least one nitro substituent attached to the benzene ring.
Synonyms:related_synonym: nitrobenzoic acids

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5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394 		JBrowse link
G Ano6 anoctamin 6 decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr15:95,790,843...95,975,472
Ensembl chr15:95,790,843...95,974,751 		JBrowse link
G Aqp3 aquaporin 3 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639 		JBrowse link
G Best1 bestrophin 1 decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr19:9,985,172...10,001,633
Ensembl chr19:9,985,174...10,001,633 		JBrowse link
G Casp3 caspase 3 decreases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased expression of CASP3 protein CTD PMID:21538933 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CCND1 mRNA CTD PMID:21538933 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions
decreases activity		 ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant form
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein		 CTD PMID:15131065 PMID:15277574 PMID:15389550 PMID:15634668 PMID:15802612 PMID:15857825 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768 		JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 decreases activity
increases expression
multiple interactions		 EXP
ISO		 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CLCN3 protein
5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA
[5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA] which results in decreased susceptibility to Cisplatin		 CTD PMID:17699636 PMID:21538933 NCBI chr 8:60,910,389...60,983,317
Ensembl chr 8:60,910,389...60,983,300 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 1:92,948,052...92,986,391
Ensembl chr 1:92,950,865...92,986,391 		JBrowse link
G Ifng interferon gamma multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide] CTD PMID:9918806 PMID:19446535 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:9918806 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:19446535 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Panx1 pannexin 1 decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 9:15,005,785...15,045,478
Ensembl chr 9:15,002,128...15,045,478 		JBrowse link
G Sct secretin decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr 7:141,278,329...141,279,174
Ensembl chr 7:141,278,330...141,279,133 		JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] CTD PMID:19023563 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462 		JBrowse link
G Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr 8:70,882,885...70,892,785
Ensembl chr 8:70,882,889...70,892,757 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:9918806 PMID:10783394 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Vip vasoactive intestinal polypeptide multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr10:5,639,193...5,647,617
Ensembl chr10:5,639,218...5,647,617 		JBrowse link
dithionitrobenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Cadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431 		JBrowse link
G Alb albumin multiple interactions
increases reduction		 ISO [ALB protein binds to Docosahexaenoic Acids] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Eicosapentaenoic Acid] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Myristic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Oleic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Palmitic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to stearic acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein modified form binds to Myristic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Oleic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Palmitic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to stearic acid] which results in decreased reduction of Dithionitrobenzoic Acid; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid CTD PMID:25451573 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602 		JBrowse link
G Mt3 metallothionein 3 affects metabolic processing ISO MT3 protein polymorphism affects the metabolism of Dithionitrobenzoic Acid CTD PMID:14983064 NCBI chr 8:94,152,607...94,154,148
Ensembl chr 8:94,152,607...94,154,146 		JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions ISO Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2] CTD PMID:23878198 NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
affects metabolic processing
increases reduction		 EXP
ISO		 Dinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid
[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Ferrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]		 CTD PMID:17229725 PMID:20457604 PMID:21172426 NCBI chr10:82,833,951...82,897,724
Ensembl chr10:82,833,951...82,897,712 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of Dithionitrobenzoic Acid CTD PMID:21172426 NCBI chr16:18,426,417...18,479,073
Ensembl chr16:18,426,384...18,479,073 		JBrowse link
MC-4379 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP bifenox binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Ar androgen receptor multiple interactions ISO bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [bifenox results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO		 bifenox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO bifenox results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21552
    chemical entity 21550
      group 21410
        inorganic group 20216
          nitro group 7306
            nitro compound 7306
              C-nitro compound 6886
                nitrobenzoic acid 30
                  (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                  2-(benzoylamino)-4-nitrobenzoic acid 0
                  2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                  2-nitrobenzoic acid 0
                  2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                  2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                  3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                  3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                  4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                  4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                  4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                  4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                  4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                  4-nitroanthranilic acid + 0
                  4-nitrobenzoic acid + 0
                  4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                  4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                  4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                  Fluoroglycofen 0
                  LSM-1300 0
                  LSM-1920 0
                  LSM-4144 0
                  MC-3761 0
                  MC-4379 4
                  MC-5127 0
                  MC-6063 0
                  MC-7181 0
                  Nitrothal-isopropyl 0
                  [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                  dithionitrobenzoic acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 21552
    subatomic particle 21537
      composite particle 21537
        hadron 21537
          baryon 21537
            nucleon 21537
              atomic nucleus 21537
                atom 21537
                  main group element atom 21442
                    p-block element atom 21442
                      carbon group element atom 21235
                        carbon atom 21133
                          organic molecular entity 21133
                            organic group 19572
                              organic divalent group 19562
                                organodiyl group 19562
                                  carbonyl group 19543
                                    carbonyl compound 19543
                                      carboxylic acid 19118
                                        aromatic carboxylic acid 11082
                                          benzoic acids 11052
                                            nitrobenzoic acid 30
                                              (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                                              2-(benzoylamino)-4-nitrobenzoic acid 0
                                              2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                                              2-nitrobenzoic acid 0
                                              2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                                              2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                                              3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                                              3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                                              4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                                              4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                                              4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                                              4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                                              4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                                              4-nitroanthranilic acid + 0
                                              4-nitrobenzoic acid + 0
                                              4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                                              4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                                              4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                                              Fluoroglycofen 0
                                              LSM-1300 0
                                              LSM-1920 0
                                              LSM-4144 0
                                              MC-3761 0
                                              MC-4379 4
                                              MC-5127 0
                                              MC-6063 0
                                              MC-7181 0
                                              Nitrothal-isopropyl 0
                                              [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                                              dithionitrobenzoic acid 6
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