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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrobenzoic acid
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Accession:CHEBI:25553 term browser browse the term
Definition:Any member of the class of benzoic acids with at least one nitro substituent attached to the benzene ring.
Synonyms:related_synonym: nitrobenzoic acids


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5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ANO6 anoctamin 6 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr12:45,216,033...45,440,404
Ensembl chr12:45,215,987...45,440,404
Ensembl chr12:45,215,987...45,440,404
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G BEST1 bestrophin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr11:61,946,722...61,965,515
Ensembl chr11:61,950,063...61,965,515
JBrowse link
G CASP3 caspase 3 decreases expression EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased expression of CASP3 protein CTD PMID:21538933 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCND1 cyclin D1 increases expression EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CCND1 mRNA CTD PMID:21538933 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions
decreases activity
EXP
ISO
5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant form
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein
CTD PMID:15131065 PMID:15277574 PMID:15389550 PMID:15634668 PMID:15802612 PMID:15857825 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CLCN3 chloride voltage-gated channel 3 decreases activity
increases expression
multiple interactions
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CLCN3 protein
5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA
[5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA] which results in decreased susceptibility to Cisplatin
CTD PMID:17699636 PMID:21538933 NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673
JBrowse link
G GPR35 G protein-coupled receptor 35 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 2:240,605,430...240,631,253
Ensembl chr 2:240,605,430...240,631,259
JBrowse link
G IFNG interferon gamma multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide] CTD PMID:9918806 PMID:19446535 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:9918806 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:19446535 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PANX1 pannexin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr11:94,128,841...94,185,596
Ensembl chr11:94,128,841...94,181,968
JBrowse link
G SCT secretin decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr11:626,095...627,692
Ensembl chr11:626,309...627,181
JBrowse link
G SLC16A1 solute carrier family 16 member 1 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] CTD PMID:19023563 NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,013
Ensembl chr 1:112,911,847...112,957,013
JBrowse link
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr19:17,871,394...17,895,175
Ensembl chr19:17,871,945...17,895,174
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:9918806 PMID:10783394 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G VIP vasoactive intestinal peptide multiple interactions EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 6:152,750,797...152,759,765
Ensembl chr 6:152,750,797...152,759,765
JBrowse link
dithionitrobenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor multiple interactions ISO [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Cadmium Chloride promotes the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithionitrobenzoic Acid promotes the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]] CTD PMID:10413299 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ALB albumin multiple interactions
increases reduction
EXP [ALB protein binds to Docosahexaenoic Acids] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Eicosapentaenoic Acid] inhibits the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Myristic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Oleic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to Palmitic Acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein binds to stearic acid] promotes the reaction [ALB protein results in increased reduction of Dithionitrobenzoic Acid]; [ALB protein modified form binds to Myristic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Oleic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to Palmitic Acid] which results in decreased reduction of Dithionitrobenzoic Acid; [ALB protein modified form binds to stearic acid] which results in decreased reduction of Dithionitrobenzoic Acid; [Pyruvaldehyde results in increased oxidation of ALB protein] which results in decreased reduction of Dithionitrobenzoic Acid CTD PMID:25451573 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G MT3 metallothionein 3 affects metabolic processing EXP MT3 protein polymorphism affects the metabolism of Dithionitrobenzoic Acid CTD PMID:14983064 NCBI chr16:56,589,528...56,591,085
Ensembl chr16:56,589,074...56,591,088
JBrowse link
G PTGR1 prostaglandin reductase 1 multiple interactions ISO Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 10-nitro-oleic acid analog]; Dithionitrobenzoic Acid inhibits the reaction [PTGR1 protein results in increased reduction of 15-ketoprostaglandin E2] CTD PMID:23878198 NCBI chr 9:111,549,722...111,599,855
Ensembl chr 9:111,549,722...111,599,893
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions
affects metabolic processing
increases reduction
ISO
EXP
Dinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid
[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Ferrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]
CTD PMID:17229725 PMID:20457604 PMID:21172426 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases reduction EXP TXNRD2 protein results in increased reduction of Dithionitrobenzoic Acid CTD PMID:21172426 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
MC-4379 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions ISO bifenox binds to and results in increased activity of AHR protein CTD PMID:18835618 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AR androgen receptor multiple interactions EXP bifenox inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [bifenox results in increased activity of AR protein] CTD PMID:15064155 PMID:18324785 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO
EXP
bifenox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP bifenox results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24387
    chemical entity 24355
      group 24239
        inorganic group 23041
          nitro group 7670
            nitro compound 7670
              C-nitro compound 7216
                nitrobenzoic acid 30
                  (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                  2-(benzoylamino)-4-nitrobenzoic acid 0
                  2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                  2-nitrobenzoic acid 0
                  2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                  2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                  3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                  3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                  4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                  4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                  4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                  4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                  4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                  4-nitroanthranilic acid + 0
                  4-nitrobenzoic acid + 0
                  4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                  4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                  4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                  4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                  5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                  Fluoroglycofen 0
                  LSM-1300 0
                  LSM-1920 0
                  LSM-4144 0
                  MC-3761 0
                  MC-4379 4
                  MC-5127 0
                  MC-6063 0
                  MC-7181 0
                  Nitrothal-isopropyl 0
                  [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                  dithionitrobenzoic acid 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 24387
    subatomic particle 24344
      composite particle 24344
        hadron 24344
          baryon 24344
            nucleon 24344
              atomic nucleus 24344
                atom 24344
                  main group element atom 24191
                    p-block element atom 24191
                      carbon group element atom 23974
                        carbon atom 23934
                          organic molecular entity 23934
                            organic group 22220
                              organic divalent group 22194
                                organodiyl group 22194
                                  carbonyl group 22177
                                    carbonyl compound 22177
                                      carboxylic acid 21201
                                        aromatic carboxylic acid 11616
                                          benzoic acids 11585
                                            nitrobenzoic acid 30
                                              (2-morpholin-4-yl-2-oxoethyl) 4-methylsulfonyl-3-nitrobenzoate 0
                                              2-(benzoylamino)-4-nitrobenzoic acid 0
                                              2-[[2-[(4,5-dimethoxy-2-nitrophenyl)-oxomethoxy]-1-oxoethyl]amino]-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester 0
                                              2-nitrobenzoic acid 0
                                              2-nitrobenzoic acid [1,1,1,3,3,3-hexafluoro-2-[4-[(4-methylphenyl)sulfonylamino]phenyl]propan-2-yl] ester 0
                                              2-nitrobenzoic acid [[amino(2-pyridinyl)methylidene]amino] ester 0
                                              3-methyl-4-nitrobenzoic acid [[amino(pyridin-4-yl)methylidene]amino] ester 0
                                              3-nitro-4-(1-pyrrolidinyl)benzoic acid [1-(4-ethylanilino)-1-oxopropan-2-yl] ester 0
                                              4-(1-imidazolyl)-3,5-dinitrobenzoic acid methyl ester 0
                                              4-[2-(3,4-dimethoxyphenyl)ethylamino]-3-nitrobenzoic acid 0
                                              4-[[2-(cyclohexylamino)-2-oxoethyl]thio]-3-nitrobenzoic acid methyl ester 0
                                              4-methoxy-3-nitrobenzoic acid (2-anilino-2-oxoethyl) ester 0
                                              4-methyl-3-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              4-methyl-3-nitrobenzoic acid [[1-amino-2-(2-methoxyphenyl)ethylidene]amino] ester 0
                                              4-nitroanthranilic acid + 0
                                              4-nitrobenzoic acid + 0
                                              4-nitrobenzoic acid (3,3,7,8-tetramethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridin-7-ium-9-yl) ester 0
                                              4-nitrobenzoic acid [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl ester 0
                                              4-nitrobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester 0
                                              4-nitrobenzoic acid [6-[[(4-methyl-2-pyrimidinyl)thio]methyl]-4-oxo-3-pyranyl] ester 0
                                              5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
                                              Fluoroglycofen 0
                                              LSM-1300 0
                                              LSM-1920 0
                                              LSM-4144 0
                                              MC-3761 0
                                              MC-4379 4
                                              MC-5127 0
                                              MC-6063 0
                                              MC-7181 0
                                              Nitrothal-isopropyl 0
                                              [2-[4-(2-cyclohexylethyl)piperazin-1-yl]-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate 0
                                              dithionitrobenzoic acid 6
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