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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitrites
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Accession:CHEBI:25549 term browser browse the term
Synonyms:xref_mesh: MESH:D009573


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nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein modified form results in increased abundance of Nitrites CTD PMID:28299329 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ak1 adenylate kinase 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Cp ceruloplasmin increases abundance
multiple interactions
ISO
EXP
CP protein results in increased abundance of Nitrites
SN50 peptide inhibits the reaction [CP protein results in increased abundance of Nitrites]
SB 203580 inhibits the reaction [CP protein results in increased abundance of Nitrites]
CTD PMID:17727827 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cs citrate synthase multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of CS protein CTD PMID:22892143 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [Gentamicins results in increased expression of EDNRB protein] which results in increased abundance of Nitrites CTD PMID:15200423 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Epo erythropoietin increases abundance
multiple interactions
ISO EPO protein results in increased abundance of Nitrites
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]
CTD PMID:23384249 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fcer2 Fc fragment of IgE receptor II affects chemical synthesis ISO FCER2 protein affects the chemical synthesis of Nitrites CTD PMID:11500085 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions
increases abundance
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]
2,2'-dihydroxychalcone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; Industrial Waste inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitrites]; isoliquiritigenin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; pyrrolidine dithiocarbamic acid inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; sulforafan inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [[Curcumin co-treated with piperine] inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [sulforafan inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Tosyllysine Chloromethyl Ketone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:10532951 PMID:10903806 PMID:10967106 PMID:12845421 PMID:17727827 PMID:19071154 PMID:19457078 PMID:21396992 PMID:23942037 PMID:24412304 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases secretion
increases chemical synthesis
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; 8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [Glucosamine co-treated with Chondroitin Sulfates] inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; [IL1B protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; [SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitrites]; Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]; cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased secretion of Nitrites]; Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitrites]
[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites; sulforafan inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]
IL1B protein results in increased abundance of Nitrites; IL1B results in increased abundance of Nitrites
CTD PMID:8904084 PMID:9436821 PMID:10532951 PMID:10903806 PMID:10967106 PMID:17605605 PMID:18077487 PMID:19071154 PMID:21954917 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites] CTD PMID:9918806 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lpo lactoperoxidase multiple interactions ISO [LPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of Nitrites CTD PMID:22434701 NCBI chr10:75,100,385...75,120,247
Ensembl chr10:75,100,385...75,120,247
JBrowse link
G Mst1r macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [nickel sulfate results in increased abundance of Nitrites] CTD PMID:11751209 NCBI chr 8:116,686,601...116,700,132
Ensembl chr 8:116,686,601...116,700,132
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
NFE2L2 protein inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Nitrites co-treated with Oxygen deficiency] results in increased expression of NFE2L2 mRNA
CTD PMID:22892143 PMID:23942037 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[linsidomine results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites; [Plant Extracts inhibits the reaction [linsidomine results in increased expression of NOS2 protein]] which results in decreased chemical synthesis of Nitrites
[[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites; [Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Oxidopamine results in increased expression of NOS2 protein] which results in increased secretion of Nitrites; [pimagedine inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]] which results in decreased secretion of Nitrites; [testosterone enanthate results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]
[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; [Zymosan results in increased expression of NOS2 protein] which results in increased abundance of Nitrites; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Chlorogenic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dronabinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Flurbiprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitrites]; ganglioside, GD1a analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1a inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Hydrolyzable Tannins inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]; neurostatin inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Prazosin inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; protocatechuic acid inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; trisialoganglioside GT1 analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; trisialoganglioside GT1 inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ZM 230487 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites]
CTD PMID:7532384 PMID:8700141 PMID:11405284 PMID:11454666 PMID:17566059 PMID:19439816 PMID:20026373 PMID:20463352 PMID:21397656 PMID:21401295 PMID:23174672 PMID:31202640 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP
[NOS3 intron polymorphism co-treated with Methylmercury Compounds] results in decreased abundance of Nitrites
[[Uranium results in decreased activity of NOS2 protein] co-treated with [Uranium results in increased activity of NOS3 protein]] results in decreased abundance of Nitrites
CTD PMID:17566059 PMID:22134029 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO NT5E protein affects the reaction [nimesulide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of Nitrites]] CTD PMID:27188793 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [GW 7647 binds to and results in increased activity of PPARA protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites] CTD PMID:17891158 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of and results in decreased acetylation of PPARGC1A protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA; PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA]; splitomicin inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP PRKAA2 mutant form inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of PPARGC1A mRNA] CTD PMID:22892143 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein; [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA; P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA] CTD PMID:22892143 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [[SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites] which results in increased chemical synthesis of Nitrogen Dioxide; [SOD1 protein results in increased metabolism of Hydrogen Peroxide] which results in increased oxidation of Nitrites; Nitrites promotes the reaction [SOD1 protein results in increased metabolism of Hydrogen Peroxide] CTD PMID:19243126 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Nitrites co-treated with Oxygen deficiency] results in increased expression of TFAM mRNA CTD PMID:22892143 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites] CTD PMID:19573522 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases abundance
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; TNF protein promotes the reaction [Endotoxins results in increased abundance of Nitrites]
TNF protein results in increased abundance of Nitrites
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites; IFNG protein promotes the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Amobarbital]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Deferoxamine]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of diethyl maleate]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Rotenone]; Triglycerides inhibits the reaction [TNF protein affects the abundance of Nitrites]
CTD PMID:7532384 PMID:9918806 PMID:15659313 PMID:16140881 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
isobutyl nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf1 fibroblast growth factor 1 increases expression ISO isobutyl nitrite results in increased expression of FGF1 mRNA CTD PMID:16288974 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgf4 fibroblast growth factor 4 increases expression ISO isobutyl nitrite results in increased expression of FGF4 mRNA CTD PMID:16288974 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isobutyl nitrite results in increased expression of HMOX1 mRNA CTD PMID:16288974 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO isobutyl nitrite results in increased expression of HSPA4 mRNA CTD PMID:16288974 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Pf4 platelet factor 4 increases expression ISO isobutyl nitrite results in increased expression of PF4 mRNA CTD PMID:16288974 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO isobutyl nitrite results in increased expression of SMAD7 mRNA CTD PMID:16288974 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO isobutyl nitrite results in increased expression of VEGFA mRNA CTD PMID:16288974 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO isobutyl nitrite results in increased expression of VEGFD mRNA CTD PMID:16288974 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
sodium nitrite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO [Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein
CTD PMID:12414318 PMID:26231821 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp1 acid phosphatase 1 increases activity ISO Sodium Nitrite results in increased activity of ACP1 protein CTD PMID:26231821 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]
CTD PMID:28266762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases activity ISO Sodium Nitrite results in increased activity of AMPD3 protein CTD PMID:26231821 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
CTD PMID:28000380 PMID:28266762 PMID:28833918 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:28833918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
increases activity
ISO Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein
CTD PMID:26231821 PMID:31476334 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Sodium Nitrite results in increased expression of CCNB1 protein CTD PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Sodium Nitrite results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Crp C-reactive protein multiple interactions
increases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein] CTD PMID:28266762 PMID:28833918 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Sodium Nitrite results in decreased activity of G6PD protein CTD PMID:26231821 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Sodium Nitrite results in decreased activity of GSR protein CTD PMID:26231821 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Sodium Nitrite results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]
CTD PMID:28000380 PMID:28266762 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
ISO Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
CTD PMID:16581224 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Sodium Nitrite results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Sodium Nitrite results in increased secretion of IL6 protein
Sodium Nitrite results in increased expression of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:16581224 PMID:28266762 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ldhb lactate dehydrogenase B increases activity ISO Sodium Nitrite results in increased activity of LDHB protein CTD PMID:26231821 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Sodium Nitrite results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Sodium Nitrite results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Smad2 SMAD family member 2 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]
CTD PMID:28000380 PMID:28266762 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Sodium Nitrite results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
CTD PMID:28266762 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO
EXP
Sodium Nitrite results in increased expression of TNF mRNA
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
Sodium Nitrite results in increased secretion of TNF protein
CTD PMID:16581224 PMID:28266762 PMID:28833918 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
EXP Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]
CTD PMID:28266762 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          nitrogen atom 18613
            nitrogen molecular entity 18613
              nitrites 58
                nitrite esters + 8
                nitrite salt + 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      chalcogen 19425
                        oxygen atom 19387
                          oxygen molecular entity 19387
                            hydroxides 19113
                              oxoacid 18243
                                pnictogen oxoacid 10293
                                  nitrogen oxoacid 275
                                    nitrous acid 58
                                      nitrites 58
                                        nitrite esters + 8
                                        nitrite salt + 29
paths to the root