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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:myxothiazol
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Accession:CHEBI:25461 term browser browse the term
Definition:A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.
Synonyms:exact_synonym: (2E,4R,5S,6E)-3,5-dimethoxy-4-methyl-7-{2'-[(2S,3E,5E)-7-methylocta-3,5-dien-2-yl]-2,4'-bi-1,3-thiazol-4-yl}hepta-2,6-dienamide
 related_synonym: Formula=C25H33N3O3S2;   InChI=1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13+/t17?,18-,21+/m1/s1;   InChIKey=XKTFQMCPGMTBMD-YCSHSZEBSA-N;   Myxothiazol A;   SMILES=CO[C@@H](\\C=C\\c1csc(n1)-c1csc(n1)C(C)\\C=C\\C=C\\C(C)C)[C@@H](C)C(\\OC)=C/C(N)=O
 xref: CAS:76706-55-3;   DrugBank:DB04741;   KEGG:C15674;   KNApSAcK:C00018319
 xref_mesh: MESH:C030517
 xref: PDBeChem:MYX


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myxothiazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule multiple interactions ISO myxothiazol inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP myxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Il6 interleukin 6 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:23867654 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein] CTD PMID:16303854 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:19793987 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein] CTD PMID:17087917 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA] CTD PMID:23867654 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slc6a12 solute carrier family 6 member 12 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] CTD PMID:16303854 NCBI chr 4:153,921,199...153,941,333
Ensembl chr 4:153,921,115...153,941,391
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO myxothiazol results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO myxothiazol results in increased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            myxothiazol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  myxothiazol 12
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