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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:myxothiazol
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Accession:CHEBI:25461 term browser browse the term
Definition:A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.
Synonyms:exact_synonym: (2E,4R,5S,6E)-3,5-dimethoxy-4-methyl-7-{2'-[(2S,3E,5E)-7-methylocta-3,5-dien-2-yl]-2,4'-bi-1,3-thiazol-4-yl}hepta-2,6-dienamide
 related_synonym: Formula=C25H33N3O3S2;   InChI=1S/C25H33N3O3S2/c1-16(2)9-7-8-10-17(3)24-28-20(15-33-24)25-27-19(14-32-25)11-12-21(30-5)18(4)22(31-6)13-23(26)29/h7-18,21H,1-6H3,(H2,26,29)/b9-7+,10-8+,12-11+,22-13+/t17?,18-,21+/m1/s1;   InChIKey=XKTFQMCPGMTBMD-YCSHSZEBSA-N;   Myxothiazol A;   SMILES=CO[C@@H](\\C=C\\c1csc(n1)-c1csc(n1)C(C)\\C=C\\C=C\\C(C)C)[C@@H](C)C(\\OC)=C/C(N)=O
 xref: CAS:76706-55-3;   DrugBank:DB04741;   KEGG:C15674;   KNApSAcK:C00018319
 xref_mesh: MESH:C030517
 xref: PDBeChem:MYX



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myxothiazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd36 CD36 molecule multiple interactions ISO myxothiazol inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Epas1 endothelial PAS domain protein 1 multiple interactions EXP myxothiazol inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:18353899 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Il6 interleukin 6 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:23867654 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased activity of NFAT5 protein] CTD PMID:16303854 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
JBrowse link
G P2rx2 purinergic receptor P2X 2 multiple interactions EXP myxothiazol promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein] CTD PMID:19793987 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein] CTD PMID:17087917 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA] CTD PMID:23867654 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slc6a12 solute carrier family 6 member 12 multiple interactions ISO myxothiazol inhibits the reaction [Sodium Chloride results in increased expression of SLC6A12 mRNA] CTD PMID:16303854 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO myxothiazol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:11264281 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO myxothiazol results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO myxothiazol results in increased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            myxothiazol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        carboacyl group 17481
                                          univalent carboacyl group 17481
                                            carbamoyl group 17297
                                              carboxamide 17297
                                                monocarboxylic acid amide 15014
                                                  myxothiazol 12
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