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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:myo-inositol trisphosphate
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Accession:CHEBI:25450 term browser browse the term
Synonyms:related_synonym: myo-inositol trisphosphates


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1D-myo-inositol 1,4,5-trisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases abundance
multiple interactions		 ISO ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases abundance
multiple interactions
increases metabolic processing		 ISO ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
ADRA1B protein results in increased metabolism of Inositol 1,4,5-Trisphosphate		 CTD PMID:9570190 PMID:11278430 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D increases abundance
multiple interactions		 ISO ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7874174 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]] CTD PMID:20691780 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects abundance ISO CHRM1 protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19002953 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
increases abundance		 ISO Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]] CTD PMID:19002953 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance
increases chemical synthesis		 EXP
ISO		 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]		 CTD PMID:1443220 PMID:11911850 PMID:20691780 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of FOS protein CTD PMID:16259952 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions
increases expression		 EXP Cyclosporine promotes the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 mRNA]; Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of GATA4 protein] CTD PMID:16259952 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B decreases abundance ISO HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:15625277 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A multiple interactions ISO benzene 1,2,4-trisphosphate inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate]; Polyphosphates inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] CTD PMID:18574825 NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Inositol 1,4,5-Trisphosphate inhibits the reaction [bisphenol A binds to ITPR1 protein] CTD PMID:33408296 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYC protein CTD PMID:16259952 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Inositol 1,4,5-Trisphosphate results in increased expression of MYH7 mRNA CTD PMID:16259952 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions
increases expression		 EXP Heparin inhibits the reaction [Inositol 1,4,5-Trisphosphate results in increased expression of NFATC3 protein] CTD PMID:16259952 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 affects abundance EXP NPY1R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 affects abundance EXP NPY2R protein affects the abundance of Inositol 1,4,5-Trisphosphate CTD PMID:7742479 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Tnfsf4 TNF superfamily member 4 increases abundance ISO TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:19416722 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        NMR chemical shift reference compound 18103
          phosphoric acid 13923
            phosphoric acid derivative 13829
              organic phosphate 13828
                cyclitol phosphate 75
                  inositol phosphate 75
                    myo-inositol phosphate 75
                      myo-inositol polyphosphate 74
                        myo-inositol trisphosphate 19
                          1D-myo-inositol 1,3,4-trisphosphate 0
                          1D-myo-inositol 1,4,5-trisphosphate + 19
                          1D-myo-inositol 3,4,6-trisphosphate 0
                          1D-myo-inositol bis(diphosphate) trisphosphate + 0
                          Ins(1,4,5)P3 0
                          myo-inositol 1,3,5-trisphosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      chalcogen 19614
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18823
                                pnictogen oxoacid 14983
                                  phosphorus oxoacid 14581
                                    phosphoric acids 13923
                                      phosphoric acid 13923
                                        phosphoric acid derivative 13829
                                          phosphate 13828
                                            organic phosphate 13828
                                              cyclitol phosphate 75
                                                inositol phosphate 75
                                                  myo-inositol phosphate 75
                                                    myo-inositol polyphosphate 74
                                                      myo-inositol trisphosphate 19
                                                        1D-myo-inositol 1,3,4-trisphosphate 0
                                                        1D-myo-inositol 1,4,5-trisphosphate + 19
                                                        1D-myo-inositol 3,4,6-trisphosphate 0
                                                        1D-myo-inositol bis(diphosphate) trisphosphate + 0
                                                        Ins(1,4,5)P3 0
                                                        myo-inositol 1,3,5-trisphosphate 0
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