myo-inositol hexakisphosphates - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	myo-inositol hexakisphosphates	go back to main search page
Accession:	CHEBI:25445	browse the term

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Rat (56) Mouse (55) Human (55) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (56)

myo-inositol hexakisphosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases activity

Phytic Acid results in decreased activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

caspase 3

multiple interactions

Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]

PMID:12540492 PMID:14766669

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A mRNA]; Phytic Acid inhibits the reaction [Glucose results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression

Phytic Acid results in decreased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

multiple interactions
affects methylation

Phytic Acid inhibits the reaction [Ethylnitrosourea results in decreased expression of CDKN2A]
Phytic Acid affects the methylation of CDKN2A promoter

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

G

collagen type I alpha 1 chain

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cathepsin B

multiple interactions

Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

epidermal growth factor receptor

multiple interactions

Phytic Acid inhibits the reaction [Asbestos, Crocidolite results in decreased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

euchromatic histone lysine methyltransferase 2

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein]

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein]

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

forkhead box O1

multiple interactions

[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

glucose-6-phosphate dehydrogenase

multiple interactions

[Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

galactosidase, beta 1

multiple interactions

Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GLB1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of GLB1 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased expression of GLB1 protein]

PMID:25560919 PMID:38000455

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glucuronidase, beta

multiple interactions

Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

interleukin 1 beta

multiple interactions

Phytic Acid inhibits the reaction [Glucose results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

decreases activity
multiple interactions

Phytic Acid results in decreased activity of MAPK1 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]

PMID:15868430 PMID:21203465 PMID:38000455

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases activity
multiple interactions

Phytic Acid results in decreased activity of MAPK3 protein
[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]]; Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]

PMID:15868430 PMID:21203465 PMID:38000455

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 101a

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR101A mRNA

NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410

G

microRNA 10a

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR10A mRNA

NCBI chr10:81,283,171...81,283,280
Ensembl chr10:81,283,171...81,283,280

G

microRNA 138-1

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in decreased expression of MIR138-1 mRNA]

NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064

G

microRNA 181c

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR181C mRNA

NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628

G

microRNA 20b

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR20B mRNA

NCBI chr X:132,422,211...132,422,282
Ensembl chr X:132,422,211...132,422,282

G

microRNA 21

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 214

multiple interactions

[Resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR214 mRNA

NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481

G

microRNA 25

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR25 mRNA

NCBI chr12:17,042,932...17,043,015
Ensembl chr12:17,042,932...17,043,015

G

microRNA 27b

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in decreased expression of MIR27B mRNA

NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529

G

microRNA 324

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR324 mRNA

NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766

G

microRNA 339

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR339 mRNA

NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641

G

microRNA 450a-1

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR450A1 mRNA

NCBI chr X:132,801,380...132,801,470
Ensembl chr X:132,801,380...132,801,470

G

microRNA 760

multiple interactions

[resveratrol co-treated with Phytic Acid co-treated with ferulic acid co-treated with Quercetin] results in increased expression of MIR760 mRNA

NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695

G

mutL homolog 1

multiple interactions
affects methylation

Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]
Phytic Acid affects the methylation of MLH1 promoter

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

N-acetyl-alpha-glucosaminidase

multiple interactions

Phytic Acid inhibits the reaction [Isoproterenol results in increased activity of NAGLU protein]

NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972

G

NFE2 like bZIP transcription factor 2

multiple interactions

Phytic Acid inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

poly (ADP-ribose) polymerase 1

multiple interactions

Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of PARP1 protein]; Phytic Acid inhibits the reaction [Smoke analog results in increased activity of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate dehydrogenase kinase 4

multiple interactions

[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNA

NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850

G

PPARG coactivator 1 alpha

multiple interactions

[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, delta

multiple interactions

Phytic Acid results in increased expression of and results in increased activity of and affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin-endoperoxide synthase 2

multiple interactions
affects methylation

Phytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of PTGS2]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of PTGS2 protein]
Phytic Acid affects the methylation of PTGS2 promoter

PMID:21154115 PMID:22797328

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

decreases phosphorylation

Phytic Acid results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of RELA protein]
Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]

PMID:22797328 PMID:38000455

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

secreted phosphoprotein 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 mRNA]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

signal transducer and activator of transcription 3

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of and results in increased phosphorylation of STAT3 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of STAT3 mRNA]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

SUV39H1 histone lysine methyltransferase

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein]

NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

multiple interactions

Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of SUV39H1 protein]

NCBI chr X:141,792,589...141,795,257

G

toll-like receptor 4

multiple interactions

Phytic Acid inhibits the reaction [Glucose results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

Phytic Acid inhibits the reaction [Glucose results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 protein]]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Asbestos, Amosite results in increased expression of TP53 protein]; Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 mRNA]; Phytic Acid inhibits the reaction [Glucose results in increased expression of TP53 protein]

PMID:16357363 PMID:38000455

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

uncoupling protein 3

multiple interactions

[resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

xanthine dehydrogenase

decreases activity

Phytic Acid results in decreased activity of XDH protein

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
role	19904
application	19741
NMR chemical shift reference compound	18097
phosphoric acid	13926
phosphoric acid derivative	13832
organic phosphate	13831
cyclitol phosphate	75
inositol phosphate	75
myo-inositol phosphate	75
myo-inositol polyphosphate	74
myo-inositol hexakisphosphates	56
myo-inositol hexakisphosphate	56
Path 2
Term	Annotations
CHEBI ontology	19932
subatomic particle	19930
composite particle	19930
hadron	19930
baryon	19930
nucleon	19930
atomic nucleus	19930
atom	19930
main group element atom	19876
p-block element atom	19876
chalcogen	19624
oxygen atom	19594
oxygen molecular entity	19594
hydroxides	19394
oxoacid	18815
pnictogen oxoacid	14986
phosphorus oxoacid	14583
phosphoric acids	13926
phosphoric acid	13926
phosphoric acid derivative	13832
phosphate	13831
organic phosphate	13831
cyclitol phosphate	75
inositol phosphate	75
myo-inositol phosphate	75
myo-inositol polyphosphate	74
myo-inositol hexakisphosphates	56
myo-inositol hexakisphosphate	56

paths to the root