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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alantolactone
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Accession:CHEBI:2540 term browser browse the term
Definition:A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.
Synonyms:exact_synonym: (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one
 related_synonym: Alant camphor;   Elecampane camphor;   Eupatal;   Formula=C15H20O2;   Helenine;   InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1;   InChIKey=PXOYOCNNSUAQNS-AGNJHWRGSA-N;   Inula camphor;   SMILES=[H][C@@]12C[C@@]3(C)CCC[C@H](C)C3=C[C@]1([H])C(=C)C(=O)O2
 xref: CAS:546-43-0;   HMDB:HMDB0035906;   KEGG:C09289;   KNApSAcK:C00012893;   LIPID_MAPS_instance:LMPR0103190013
 xref_mesh: MESH:C004363
 xref: PMID:22721982;   PMID:22837216;   PMID:23441067;   PMID:23533997;   PMID:23613107;   PMID:23970102;   PMID:24252419;   PMID:24288468;   PMID:24520052;   PMID:24985175;   PMID:24996657;   PMID:25068579;   PMID:25434800;   PMID:25533522;   PMID:25597476;   Reaxys:5266481


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alantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO alantolactone results in increased expression of BAK1 protein CTD PMID:22721982 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO alantolactone results in decreased expression of BAX protein
alantolactone results in increased expression of BAX protein
CTD PMID:22721982 PMID:24252419 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
ISO alantolactone results in increased expression of BCL2 protein
alantolactone results in decreased expression of BCL2 protein
CTD PMID:22721982 PMID:24252419 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist increases cleavage ISO alantolactone results in increased cleavage of BID protein CTD PMID:22721982 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 increases cleavage ISO alantolactone results in increased cleavage of CASP3 protein CTD PMID:22721982 PMID:24252419 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO alantolactone results in increased cleavage of CASP8 protein CTD PMID:22721982 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
ISO alantolactone results in increased cleavage of CASP9 protein
alantolactone results in increased activity of CASP9 protein
CTD PMID:22721982 PMID:24252419 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alantolactone results in increased cleavage of PARP1 protein CTD PMID:22721982 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prss50 serine protease 50 decreases expression ISO alantolactone results in decreased expression of PRSS50 mRNA; alantolactone results in decreased expression of PRSS50 protein CTD PMID:24252419 NCBI chr 8:110,842,525...110,848,855
Ensembl chr 8:110,842,671...110,848,802
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alantolactone results in decreased expression of RELA protein CTD PMID:22721982 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tp53 tumor protein p53 increases expression ISO alantolactone results in increased expression of TP53 protein CTD PMID:22721982 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          apoptosis inducer 13234
            alantolactone 11
              5alpha-epoxyalantolactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic ester 15892
                                        lactone 11245
                                          terpene lactone 1786
                                            sesquiterpene lactone 1633
                                              alantolactone 11
                                                5alpha-epoxyalantolactone 0
paths to the root