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Accession:CHEBI:2540 term browser browse the term
Definition:A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.
Synonyms:exact_synonym: (3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one
 related_synonym: Alant camphor;   Elecampane camphor;   Eupatal;   Formula=C15H20O2;   Helenine;   InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1;   InChIKey=PXOYOCNNSUAQNS-AGNJHWRGSA-N;   Inula camphor;   SMILES=[H][C@@]12C[C@@]3(C)CCC[C@H](C)C3=C[C@]1([H])C(=C)C(=O)O2
 xref: CAS:546-43-0 "ChemIDplus";   CAS:546-43-0 "KEGG COMPOUND";   HMDB:HMDB0035906;   KEGG:C09289;   KNApSAcK:C00012893;   LIPID_MAPS_instance:LMPR0103190013 "LIPID MAPS"
 xref_mesh: MESH:C004363
 xref: PMID:22721982 "Europe PMC";   PMID:22837216 "Europe PMC";   PMID:23441067 "Europe PMC";   PMID:23533997 "Europe PMC";   PMID:23613107 "Europe PMC";   PMID:23970102 "Europe PMC";   PMID:24252419 "Europe PMC";   PMID:24288468 "Europe PMC";   PMID:24520052 "Europe PMC";   PMID:24985175 "Europe PMC";   PMID:24996657 "Europe PMC";   PMID:25068579 "Europe PMC";   PMID:25434800 "Europe PMC";   PMID:25533522 "Europe PMC";   PMID:25597476 "Europe PMC";   Reaxys:5266481 "Reaxys"

show annotations for term's descendants       view all columns           Sort by:
alantolactone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Prss50 serine protease 50 JBrowse link 8 119,134,966 119,141,255 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          apoptosis inducer 10782
            alantolactone 11
              5alpha-epoxyalantolactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic ester 13930
                                        lactone 5862
                                          terpene lactone 1743
                                            sesquiterpene lactone 1596
                                              alantolactone 11
                                                5alpha-epoxyalantolactone 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.