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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:molybdenum molecular entity
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Accession:CHEBI:25370 term browser browse the term
Synonyms:related_synonym: molybdenum compounds;   molybdenum molecular entities

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molybdate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP molybdate inhibits the reaction [Potassium Chloride inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]] CTD PMID:3015922 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ca4 carbonic anhydrase 4 decreases activity ISO molybdate results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067 		JBrowse link
G Ca5a carbonic anhydrase 5A decreases activity ISO molybdate results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:54,731,829...54,761,697
Ensembl chr19:54,731,859...54,761,670 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO molybdate results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO molybdate results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Insr insulin receptor multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of INSR protein; [molybdate co-treated with Vanadates co-treated with INS1 protein] results in increased phosphorylation of INSR protein CTD PMID:1321133 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irs4 insulin receptor substrate 4 multiple interactions EXP [molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein; molybdate promotes the reaction [[Vanadates co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein]; Vanadates promotes the reaction [[molybdate co-treated with INS1 protein] results in increased phosphorylation of IRS4 protein] CTD PMID:1321133 NCBI chr  X:113,003,824...113,018,088 JBrowse link
G Ivl involucrin decreases expression ISO molybdate results in decreased expression of IVL protein CTD PMID:7848924 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP molybdate results in increased expression of NR3C1 protein CTD PMID:3015922 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of molybdate CTD PMID:15065880 NCBI chr 2:236,605,695...236,680,772
Ensembl chr 2:236,605,695...236,680,772 		JBrowse link
molybdenum trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd80 Cd80 molecule increases secretion ISO molybdenum chloride results in increased secretion of CD80 protein CTD PMID:19844976 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO molybdenum chloride results in increased secretion of IL1B protein CTD PMID:19844976 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion ISO molybdenum chloride results in increased secretion of IL6 protein CTD PMID:19844976 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO molybdenum chloride results in increased secretion of TNF protein CTD PMID:19844976 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
molybdenum trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions		 ISO molybdenum trioxide results in decreased activity of CAT protein
chromous chloride affects the reaction [molybdenum trioxide results in decreased activity of CAT protein]; molybdenum trioxide affects the reaction [chromous chloride results in decreased activity of CAT protein]		 CTD PMID:30389395 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO molybdenum trioxide results in increased activity of NQO1 protein
molybdenum trioxide results in increased expression of NQO1 mRNA		 CTD PMID:9029048 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
sodium molybdate (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO
EXP		 sodium molybdate(VI) promotes the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
sodium molybdate(VI) results in increased activity of AHR protein		 CTD PMID:3040233 PMID:8079350 PMID:8395819 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
tetrathiomolybdate(2-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO tetrathiomolybdate results in increased phosphorylation of ACACA protein CTD PMID:24218578 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AGTR2 mRNA CTD PMID:19323979 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Angpt2 angiopoietin 2 increases expression ISO tetrathiomolybdate analog results in increased expression of ANGPT2 mRNA CTD PMID:19323979 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects binding		 ISO [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO tetrathiomolybdate analog results in decreased expression of AQP1 mRNA CTD PMID:19323979 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [Oxygen deficiency affects the localization of ATP7A protein] CTD PMID:19351718 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [ATP7B gene mutant form results in increased abundance of Copper] CTD PMID:11803042 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2 protein CTD PMID:19323979 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of BCL2L11 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of BCL2L11 protein CTD PMID:22276220 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bcl2l2 Bcl2-like 2 increases expression ISO tetrathiomolybdate analog results in increased expression of BCL2L2 mRNA; tetrathiomolybdate analog results in increased expression of BCL2L2 protein CTD PMID:19323979 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP3 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP3 protein CTD PMID:22276220 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein CTD PMID:22276220 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CCL2 protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of CCL2 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of CCL2 protein]		 CTD PMID:15541506 PMID:21724870 PMID:24225134 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression EXP tetrathiomolybdate results in increased expression of CCS protein CTD PMID:21784888 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404 		JBrowse link
G Cd40 CD40 molecule increases expression ISO tetrathiomolybdate analog results in increased expression of CD40 mRNA CTD PMID:19323979 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tetrathiomolybdate analog results in increased expression of CDKN1A protein CTD PMID:19323979 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein] CTD PMID:16242529 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression ISO tetrathiomolybdate analog results in increased expression of COX5B mRNA CTD PMID:19323979 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040 		JBrowse link
G Cp ceruloplasmin decreases activity
decreases expression
decreases secretion
multiple interactions		 ISO
EXP		 tetrathiomolybdate results in decreased activity of CP protein
tetrathiomolybdate results in decreased expression of CP protein
tetrathiomolybdate results in decreased secretion of CP protein
tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of CP protein]		 CTD PMID:10656425 PMID:12624602 PMID:21724870 PMID:21784888 PMID:24013775 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP tetrathiomolybdate results in decreased expression of CPT1A mRNA CTD PMID:21784888 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of CRABP2 mRNA CTD PMID:19323979 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505 		JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression ISO tetrathiomolybdate analog results in increased expression of CREBZF mRNA CTD PMID:19323979 NCBI chr 1:156,290,215...156,296,891
Ensembl chr 1:156,294,519...156,296,161 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO tetrathiomolybdate analog results in increased expression of CXCR4 mRNA CTD PMID:19323979 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18480265 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eln elastin multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ELN protein CTD PMID:22276220 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Fbln1 fibulin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 protein CTD PMID:22276220 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468 		JBrowse link
G Fbln5 fibulin 5 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 NCBI chr 6:125,644,797...125,723,957
Ensembl chr 6:125,644,804...125,723,944 		JBrowse link
G Fbn1 fibrillin 1 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBN1 protein CTD PMID:22276220 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120 		JBrowse link
G Fgf1 fibroblast growth factor 1 decreases secretion ISO tetrathiomolybdate results in decreased secretion of FGF1 protein CTD PMID:18400376 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]] CTD PMID:18480265 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO tetrathiomolybdate analog results in increased expression of GPX3 mRNA CTD PMID:19323979 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO tetrathiomolybdate analog results in increased expression of GSR mRNA CTD PMID:19323979 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein]; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of HIF1A protein CTD PMID:22276220 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP tetrathiomolybdate results in decreased expression of HMGCS2 mRNA CTD PMID:21784888 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO tetrathiomolybdate analog results in decreased expression of RHAMM mRNA CTD PMID:19323979 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 tetrathiomolybdate results in decreased expression of HMOX1 protein
tetrathiomolybdate analog results in increased expression of HMOX1 mRNA; tetrathiomolybdate analog results in increased expression of HMOX1 protein
[tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]		 CTD PMID:19323979 PMID:21784888 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of ICAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of ICAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO tetrathiomolybdate inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18480265 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1A protein] CTD PMID:21724870 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:16242529 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of IL2 protein] CTD PMID:16242529 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression
multiple interactions		 ISO tetrathiomolybdate analog results in decreased expression of IL2RA mRNA
tetrathiomolybdate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]		 CTD PMID:19323979 PMID:23134680 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA] CTD PMID:21724870 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO tetrathiomolybdate analog results in decreased expression of ITGB4 mRNA CTD PMID:19323979 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078 		JBrowse link
G Itgb6 integrin subunit beta 6 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of ITGB6 mRNA CTD PMID:22276220 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 increases expression ISO tetrathiomolybdate analog results in increased expression of JAG1 mRNA CTD PMID:19323979 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770 		JBrowse link
G Klf2 Kruppel-like factor 2 decreases expression ISO tetrathiomolybdate analog results in decreased expression of KLF2 mRNA CTD PMID:19323979 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037 		JBrowse link
G Lox lysyl oxidase multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of LOX protein CTD PMID:22276220 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK1 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK1 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]
tetrathiomolybdate analog results in increased phosphorylation of MAPK1 protein		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein
tetrathiomolybdate analog results in increased phosphorylation of MAPK3 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; Hydrogen Peroxide inhibits the reaction [tetrathiomolybdate results in decreased phosphorylation of MAPK3 protein]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; Vanadates inhibits the reaction [tetrathiomolybdate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]		 CTD PMID:18480265 PMID:19323979 PMID:22276220 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] CTD PMID:25671100 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO tetrathiomolybdate analog affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:19323979 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tetrathiomolybdate results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein CTD PMID:24225134 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO tetrathiomolybdate results in decreased expression of PCNA protein CTD PMID:24614111 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO tetrathiomolybdate results in decreased expression of PDGFRB protein CTD PMID:18480265 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP tetrathiomolybdate results in decreased expression of PPARA mRNA CTD PMID:21784888 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of PTGS2 mRNA CTD PMID:19323979 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased phosphorylation of PTK2 protein CTD PMID:22276220 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein] CTD PMID:18480265 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression		 ISO [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter] CTD PMID:22172574 PMID:22914438 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases response to substance ISO SLC31A2 mRNA results in decreased susceptibility to tetrathiomolybdate CTD PMID:24522273 NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO tetrathiomolybdate analog results in increased expression of SLC7A11 mRNA CTD PMID:19323979 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
affects localization
decreases activity
multiple interactions		 EXP
ISO		 tetrathiomolybdate results in decreased expression of SOD1 protein
tetrathiomolybdate analog affects the localization of SOD1 protein
tetrathiomolybdate results in decreased activity of SOD1 protein
[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in decreased abundance of Hydrogen Peroxide; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; Vanadates inhibits the reaction [[tetrathiomolybdate results in decreased activity of SOD1 protein] inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]
tetrathiomolybdate analog results in decreased expression of SOD1 mRNA		 CTD PMID:18480265 PMID:19323979 PMID:21784888 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO tetrathiomolybdate analog results in increased expression of SOD2 mRNA; tetrathiomolybdate analog results in increased expression of SOD2 protein CTD PMID:19323979 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases expression
increases activity		 ISO [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein; tetrathiomolybdate promotes the reaction [SP1 protein binds to SLC31A1 promoter]; tetrathiomolybdate promotes the reaction [SP1 protein binds to SP1 promoter]
tetrathiomolybdate results in increased expression of SP1; tetrathiomolybdate results in increased expression of SP1 mRNA
tetrathiomolybdate results in increased activity of SP1 protein		 CTD PMID:22172574 PMID:22914438 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sp3 Sp3 transcription factor decreases expression ISO tetrathiomolybdate results in decreased expression of SP3 CTD PMID:22172574 NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial decreases expression EXP tetrathiomolybdate results in decreased expression of TFB1M mRNA CTD PMID:21784888 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein] CTD PMID:15541506 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tetrathiomolybdate inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:15541506 PMID:16242529 PMID:21724870 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:16242529 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of TP53 protein CTD PMID:22276220 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO tetrathiomolybdate analog results in increased expression of TXNRD1 mRNA CTD PMID:19323979 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of and results in increased expression of VCAM1 protein]
tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 mRNA]; tetrathiomolybdate inhibits the reaction [Copper Sulfate results in increased expression of VCAM1 protein]		 CTD PMID:21724870 PMID:24225134 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 EXP [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA mRNA; [Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of VEGFA protein
tetrathiomolybdate results in decreased expression of VEGFA protein		 CTD PMID:16277669 PMID:22276220 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      molecular entity 19872
        transition element molecular entity 16457
          chromium group molecular entity 6340
            molybdenum molecular entity 90
              elemental molybdenum + 0
              molybdenum coordination entity + 90
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  metal atom 17312
                    transition element atom 16772
                      d-block element atom 16763
                        chromium group element atom 7546
                          chromium group molecular entity 6340
                            molybdenum molecular entity 90
                              elemental molybdenum + 0
                              molybdenum coordination entity + 90
paths to the root